Incidental Mutation 'R5745:Vmn2r45'
ID 445747
Institutional Source Beutler Lab
Gene Symbol Vmn2r45
Ensembl Gene ENSMUSG00000090662
Gene Name vomeronasal 2, receptor 45
Synonyms
MMRRC Submission 043198-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R5745 (G1)
Quality Score 126
Status Not validated
Chromosome 7
Chromosomal Location 8470525-8489075 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 8483075 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 405 (I405L)
Ref Sequence ENSEMBL: ENSMUSP00000129466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164845]
AlphaFold L7N2B5
Predicted Effect probably benign
Transcript: ENSMUST00000164845
AA Change: I405L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: I405L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 469 4.5e-26 PFAM
Pfam:NCD3G 512 565 6.4e-21 PFAM
Pfam:7tm_3 598 833 2.1e-54 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik G A 5: 139,364,073 (GRCm38) R74W probably damaging Het
4933407L21Rik T G 1: 85,931,274 (GRCm38) probably null Het
Adcy8 A T 15: 64,920,471 (GRCm38) I212N possibly damaging Het
Cobll1 T C 2: 65,098,457 (GRCm38) T879A probably damaging Het
Copb2 T C 9: 98,574,111 (GRCm38) S233P probably damaging Het
Cpa5 T A 6: 30,630,437 (GRCm38) M330K probably damaging Het
Dgcr8 A T 16: 18,280,443 (GRCm38) N361K probably benign Het
Dmxl1 A G 18: 49,846,586 (GRCm38) E96G probably benign Het
Dock8 T A 19: 25,130,397 (GRCm38) N830K probably benign Het
Ephb1 C T 9: 102,195,434 (GRCm38) D49N probably benign Het
Fam19a1 G A 6: 96,649,185 (GRCm38) R128Q probably damaging Het
Fer1l6 A G 15: 58,571,389 (GRCm38) I514V probably benign Het
Fpr1 A G 17: 17,877,082 (GRCm38) I215T probably benign Het
Hectd4 G A 5: 121,353,502 (GRCm38) V3668M possibly damaging Het
Ighv3-4 T A 12: 114,253,768 (GRCm38) I68L probably benign Het
Intu A G 3: 40,692,972 (GRCm38) probably null Het
Kel C T 6: 41,699,027 (GRCm38) G243E probably damaging Het
Mycbp2 A C 14: 103,156,453 (GRCm38) S2781A possibly damaging Het
Myom2 T A 8: 15,122,705 (GRCm38) S1211T probably benign Het
Nrp1 A T 8: 128,468,448 (GRCm38) I462F probably benign Het
Olfr787 T A 10: 129,463,438 (GRCm38) I254N probably damaging Het
Olfr958 T C 9: 39,550,691 (GRCm38) Y60C probably damaging Het
Pcsk1 A C 13: 75,131,960 (GRCm38) S635R probably benign Het
Pms1 A T 1: 53,207,702 (GRCm38) Y280* probably null Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,579,920 (GRCm38) probably benign Het
Sema3b C A 9: 107,601,429 (GRCm38) A356S probably damaging Het
Shoc2 C A 19: 54,029,892 (GRCm38) T485K probably benign Het
Slc7a7 G A 14: 54,377,835 (GRCm38) S235L possibly damaging Het
Smcr8 A T 11: 60,784,151 (GRCm38) T918S probably benign Het
Tle3 C A 9: 61,414,851 (GRCm38) F719L probably damaging Het
Vmn2r57 A T 7: 41,448,471 (GRCm38) H57Q possibly damaging Het
Other mutations in Vmn2r45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn2r45 APN 7 8,485,623 (GRCm38) missense probably benign 0.00
IGL01322:Vmn2r45 APN 7 8,481,333 (GRCm38) missense possibly damaging 0.49
IGL01402:Vmn2r45 APN 7 8,481,468 (GRCm38) missense probably damaging 0.98
IGL01404:Vmn2r45 APN 7 8,481,468 (GRCm38) missense probably damaging 0.98
IGL01529:Vmn2r45 APN 7 8,483,494 (GRCm38) missense probably benign
IGL01596:Vmn2r45 APN 7 8,483,273 (GRCm38) missense probably damaging 0.98
IGL01646:Vmn2r45 APN 7 8,483,338 (GRCm38) missense probably benign 0.18
IGL01819:Vmn2r45 APN 7 8,485,557 (GRCm38) missense probably benign 0.00
IGL02096:Vmn2r45 APN 7 8,481,444 (GRCm38) missense probably damaging 0.99
IGL02130:Vmn2r45 APN 7 8,483,557 (GRCm38) missense possibly damaging 0.46
IGL02409:Vmn2r45 APN 7 8,485,728 (GRCm38) missense probably benign 0.03
IGL02517:Vmn2r45 APN 7 8,483,186 (GRCm38) nonsense probably null
IGL02633:Vmn2r45 APN 7 8,485,729 (GRCm38) missense probably benign 0.01
IGL02940:Vmn2r45 APN 7 8,472,370 (GRCm38) missense probably damaging 0.99
IGL03281:Vmn2r45 APN 7 8,483,604 (GRCm38) missense probably damaging 1.00
IGL03358:Vmn2r45 APN 7 8,471,716 (GRCm38) missense probably damaging 1.00
BB004:Vmn2r45 UTSW 7 8,483,514 (GRCm38) missense probably benign
BB014:Vmn2r45 UTSW 7 8,483,514 (GRCm38) missense probably benign
R0382:Vmn2r45 UTSW 7 8,483,099 (GRCm38) missense probably benign 0.06
R0532:Vmn2r45 UTSW 7 8,471,821 (GRCm38) missense probably damaging 0.99
R0932:Vmn2r45 UTSW 7 8,475,381 (GRCm38) missense probably damaging 1.00
R1125:Vmn2r45 UTSW 7 8,485,543 (GRCm38) missense probably benign 0.00
R1580:Vmn2r45 UTSW 7 8,471,747 (GRCm38) missense possibly damaging 0.95
R1817:Vmn2r45 UTSW 7 8,472,373 (GRCm38) missense probably damaging 1.00
R1996:Vmn2r45 UTSW 7 8,472,025 (GRCm38) missense probably damaging 1.00
R2050:Vmn2r45 UTSW 7 8,472,022 (GRCm38) missense probably damaging 1.00
R2284:Vmn2r45 UTSW 7 8,485,766 (GRCm38) missense probably benign 0.02
R4019:Vmn2r45 UTSW 7 8,471,581 (GRCm38) nonsense probably null
R4227:Vmn2r45 UTSW 7 8,483,278 (GRCm38) missense probably damaging 0.98
R4381:Vmn2r45 UTSW 7 8,471,913 (GRCm38) nonsense probably null
R4618:Vmn2r45 UTSW 7 8,483,437 (GRCm38) missense probably benign 0.00
R4624:Vmn2r45 UTSW 7 8,481,342 (GRCm38) missense probably damaging 1.00
R4704:Vmn2r45 UTSW 7 8,483,536 (GRCm38) nonsense probably null
R4735:Vmn2r45 UTSW 7 8,483,473 (GRCm38) missense probably damaging 1.00
R4868:Vmn2r45 UTSW 7 8,481,481 (GRCm38) missense probably benign 0.06
R4983:Vmn2r45 UTSW 7 8,483,117 (GRCm38) missense probably damaging 0.99
R5246:Vmn2r45 UTSW 7 8,483,252 (GRCm38) missense probably benign 0.00
R5430:Vmn2r45 UTSW 7 8,483,334 (GRCm38) nonsense probably null
R5504:Vmn2r45 UTSW 7 8,483,177 (GRCm38) missense probably benign 0.03
R5511:Vmn2r45 UTSW 7 8,471,833 (GRCm38) missense probably benign 0.19
R5814:Vmn2r45 UTSW 7 8,471,476 (GRCm38) missense probably benign 0.00
R6223:Vmn2r45 UTSW 7 8,483,302 (GRCm38) missense probably benign
R6267:Vmn2r45 UTSW 7 8,472,208 (GRCm38) missense probably benign 0.26
R6623:Vmn2r45 UTSW 7 8,471,501 (GRCm38) missense probably benign 0.09
R6999:Vmn2r45 UTSW 7 8,483,220 (GRCm38) missense probably benign
R7242:Vmn2r45 UTSW 7 8,485,613 (GRCm38) nonsense probably null
R7491:Vmn2r45 UTSW 7 8,481,343 (GRCm38) missense probably benign 0.27
R7620:Vmn2r45 UTSW 7 8,483,223 (GRCm38) nonsense probably null
R7719:Vmn2r45 UTSW 7 8,483,461 (GRCm38) missense probably damaging 0.99
R7720:Vmn2r45 UTSW 7 8,483,461 (GRCm38) missense probably damaging 0.99
R7853:Vmn2r45 UTSW 7 8,482,988 (GRCm38) missense possibly damaging 0.90
R7873:Vmn2r45 UTSW 7 8,483,075 (GRCm38) missense probably benign 0.00
R7882:Vmn2r45 UTSW 7 8,483,410 (GRCm38) missense possibly damaging 0.82
R7927:Vmn2r45 UTSW 7 8,483,514 (GRCm38) missense probably benign
R8684:Vmn2r45 UTSW 7 8,483,512 (GRCm38) missense probably damaging 0.99
R8780:Vmn2r45 UTSW 7 8,481,372 (GRCm38) missense possibly damaging 0.94
R8811:Vmn2r45 UTSW 7 8,471,882 (GRCm38) missense probably damaging 1.00
R8893:Vmn2r45 UTSW 7 8,485,620 (GRCm38) missense probably damaging 1.00
R9043:Vmn2r45 UTSW 7 8,471,905 (GRCm38) missense possibly damaging 0.92
R9208:Vmn2r45 UTSW 7 8,483,299 (GRCm38) missense probably damaging 1.00
R9327:Vmn2r45 UTSW 7 8,471,533 (GRCm38) missense probably damaging 1.00
R9586:Vmn2r45 UTSW 7 8,483,051 (GRCm38) missense probably benign 0.01
R9599:Vmn2r45 UTSW 7 8,475,458 (GRCm38) critical splice acceptor site probably null
U24488:Vmn2r45 UTSW 7 8,472,362 (GRCm38) missense probably damaging 1.00
Z1088:Vmn2r45 UTSW 7 8,471,485 (GRCm38) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TTGTGTGCTCTGTATAAAACCACAC -3'
(R):5'- TGGTTCCATCTCAGAAACACAG -3'

Sequencing Primer
(F):5'- ACCACACATTTTCATTGCTAATCTG -3'
(R):5'- TGAAGACTCAGCATCTACC -3'
Posted On 2016-11-21