Incidental Mutation 'R5745:Vmn2r57'
ID 445748
Institutional Source Beutler Lab
Gene Symbol Vmn2r57
Ensembl Gene ENSMUSG00000066537
Gene Name vomeronasal 2, receptor 57
Synonyms EG269902
MMRRC Submission 043198-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R5745 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 41399732-41448641 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41448471 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 57 (H57Q)
Ref Sequence ENSEMBL: ENSMUSP00000125817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]
AlphaFold L7N269
Predicted Effect probably benign
Transcript: ENSMUST00000094532
Predicted Effect possibly damaging
Transcript: ENSMUST00000165029
AA Change: H57Q

PolyPhen 2 Score 0.508 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: H57Q

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.4e-44 PFAM
Pfam:NCD3G 514 567 2.7e-23 PFAM
Pfam:7tm_3 600 835 1.8e-52 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik G A 5: 139,364,073 (GRCm38) R74W probably damaging Het
4933407L21Rik T G 1: 85,931,274 (GRCm38) probably null Het
Adcy8 A T 15: 64,920,471 (GRCm38) I212N possibly damaging Het
Cobll1 T C 2: 65,098,457 (GRCm38) T879A probably damaging Het
Copb2 T C 9: 98,574,111 (GRCm38) S233P probably damaging Het
Cpa5 T A 6: 30,630,437 (GRCm38) M330K probably damaging Het
Dgcr8 A T 16: 18,280,443 (GRCm38) N361K probably benign Het
Dmxl1 A G 18: 49,846,586 (GRCm38) E96G probably benign Het
Dock8 T A 19: 25,130,397 (GRCm38) N830K probably benign Het
Ephb1 C T 9: 102,195,434 (GRCm38) D49N probably benign Het
Fer1l6 A G 15: 58,571,389 (GRCm38) I514V probably benign Het
Fpr1 A G 17: 17,877,082 (GRCm38) I215T probably benign Het
Hectd4 G A 5: 121,353,502 (GRCm38) V3668M possibly damaging Het
Ighv3-4 T A 12: 114,253,768 (GRCm38) I68L probably benign Het
Intu A G 3: 40,692,972 (GRCm38) probably null Het
Kel C T 6: 41,699,027 (GRCm38) G243E probably damaging Het
Mycbp2 A C 14: 103,156,453 (GRCm38) S2781A possibly damaging Het
Myom2 T A 8: 15,122,705 (GRCm38) S1211T probably benign Het
Nrp1 A T 8: 128,468,448 (GRCm38) I462F probably benign Het
Or10d3 T C 9: 39,550,691 (GRCm38) Y60C probably damaging Het
Or6c5c T A 10: 129,463,438 (GRCm38) I254N probably damaging Het
Pcsk1 A C 13: 75,131,960 (GRCm38) S635R probably benign Het
Pms1 A T 1: 53,207,702 (GRCm38) Y280* probably null Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,579,920 (GRCm38) probably benign Het
Sema3b C A 9: 107,601,429 (GRCm38) A356S probably damaging Het
Shoc2 C A 19: 54,029,892 (GRCm38) T485K probably benign Het
Slc7a7 G A 14: 54,377,835 (GRCm38) S235L possibly damaging Het
Smcr8 A T 11: 60,784,151 (GRCm38) T918S probably benign Het
Tafa1 G A 6: 96,649,185 (GRCm38) R128Q probably damaging Het
Tle3 C A 9: 61,414,851 (GRCm38) F719L probably damaging Het
Vmn2r45 T A 7: 8,483,075 (GRCm38) I405L probably benign Het
Other mutations in Vmn2r57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Vmn2r57 APN 7 41,428,785 (GRCm38) missense probably benign
IGL01108:Vmn2r57 APN 7 41,427,584 (GRCm38) missense probably benign 0.01
IGL01112:Vmn2r57 APN 7 41,425,043 (GRCm38) missense probably damaging 1.00
IGL01516:Vmn2r57 APN 7 41,399,946 (GRCm38) missense probably damaging 1.00
IGL01880:Vmn2r57 APN 7 41,400,195 (GRCm38) missense possibly damaging 0.73
IGL02117:Vmn2r57 APN 7 41,400,450 (GRCm38) missense probably benign 0.00
IGL02500:Vmn2r57 APN 7 41,428,226 (GRCm38) missense probably benign
IGL02801:Vmn2r57 APN 7 41,448,632 (GRCm38) missense probably benign 0.13
IGL02993:Vmn2r57 APN 7 41,428,074 (GRCm38) missense probably benign 0.04
IGL02996:Vmn2r57 APN 7 41,399,741 (GRCm38) missense probably benign 0.02
R0008:Vmn2r57 UTSW 7 41,400,652 (GRCm38) missense probably damaging 1.00
R0032:Vmn2r57 UTSW 7 41,399,733 (GRCm38) splice site probably null
R0305:Vmn2r57 UTSW 7 41,427,543 (GRCm38) missense probably benign 0.00
R0469:Vmn2r57 UTSW 7 41,427,792 (GRCm38) missense possibly damaging 0.58
R0510:Vmn2r57 UTSW 7 41,427,792 (GRCm38) missense possibly damaging 0.58
R0847:Vmn2r57 UTSW 7 41,428,801 (GRCm38) missense probably benign 0.00
R1025:Vmn2r57 UTSW 7 41,427,804 (GRCm38) missense probably benign 0.24
R1081:Vmn2r57 UTSW 7 41,428,211 (GRCm38) missense possibly damaging 0.47
R1479:Vmn2r57 UTSW 7 41,427,830 (GRCm38) missense possibly damaging 0.45
R1579:Vmn2r57 UTSW 7 41,400,124 (GRCm38) missense probably benign 0.38
R1764:Vmn2r57 UTSW 7 41,400,643 (GRCm38) missense probably damaging 1.00
R1848:Vmn2r57 UTSW 7 41,428,107 (GRCm38) missense probably damaging 1.00
R2006:Vmn2r57 UTSW 7 41,448,577 (GRCm38) missense probably benign 0.00
R2197:Vmn2r57 UTSW 7 41,428,825 (GRCm38) critical splice acceptor site probably null
R2242:Vmn2r57 UTSW 7 41,428,074 (GRCm38) missense probably benign 0.00
R2394:Vmn2r57 UTSW 7 41,400,195 (GRCm38) missense possibly damaging 0.73
R3937:Vmn2r57 UTSW 7 41,428,130 (GRCm38) missense probably damaging 0.97
R4193:Vmn2r57 UTSW 7 41,428,239 (GRCm38) missense probably benign
R4423:Vmn2r57 UTSW 7 41,426,640 (GRCm38) missense probably damaging 1.00
R4865:Vmn2r57 UTSW 7 41,400,468 (GRCm38) missense probably damaging 1.00
R4947:Vmn2r57 UTSW 7 41,400,495 (GRCm38) missense probably damaging 1.00
R5042:Vmn2r57 UTSW 7 41,428,662 (GRCm38) missense probably benign 0.06
R5084:Vmn2r57 UTSW 7 41,426,550 (GRCm38) critical splice donor site probably null
R5177:Vmn2r57 UTSW 7 41,400,240 (GRCm38) missense probably benign 0.31
R5192:Vmn2r57 UTSW 7 41,427,939 (GRCm38) missense probably damaging 0.96
R5289:Vmn2r57 UTSW 7 41,399,974 (GRCm38) missense probably damaging 0.99
R6051:Vmn2r57 UTSW 7 41,448,472 (GRCm38) missense probably benign 0.00
R6155:Vmn2r57 UTSW 7 41,428,690 (GRCm38) missense probably benign 0.14
R6248:Vmn2r57 UTSW 7 41,399,860 (GRCm38) missense probably benign
R6381:Vmn2r57 UTSW 7 41,428,818 (GRCm38) missense probably benign 0.08
R7019:Vmn2r57 UTSW 7 41,428,665 (GRCm38) missense probably damaging 1.00
R7126:Vmn2r57 UTSW 7 41,399,794 (GRCm38) missense possibly damaging 0.93
R7146:Vmn2r57 UTSW 7 41,448,471 (GRCm38) missense possibly damaging 0.51
R7215:Vmn2r57 UTSW 7 41,400,286 (GRCm38) missense probably benign 0.00
R7432:Vmn2r57 UTSW 7 41,426,724 (GRCm38) missense probably benign 0.01
R7633:Vmn2r57 UTSW 7 41,425,089 (GRCm38) missense possibly damaging 0.76
R7811:Vmn2r57 UTSW 7 41,425,015 (GRCm38) nonsense probably null
R8025:Vmn2r57 UTSW 7 41,426,759 (GRCm38) missense probably benign 0.00
R8332:Vmn2r57 UTSW 7 41,400,253 (GRCm38) missense probably benign 0.01
R8345:Vmn2r57 UTSW 7 41,427,544 (GRCm38) missense possibly damaging 0.81
R8360:Vmn2r57 UTSW 7 41,400,216 (GRCm38) missense probably damaging 1.00
R8738:Vmn2r57 UTSW 7 41,427,596 (GRCm38) missense probably benign 0.00
R8758:Vmn2r57 UTSW 7 41,428,739 (GRCm38) missense probably damaging 1.00
R8955:Vmn2r57 UTSW 7 41,400,147 (GRCm38) missense possibly damaging 0.64
R8985:Vmn2r57 UTSW 7 41,399,835 (GRCm38) missense probably benign
R9108:Vmn2r57 UTSW 7 41,428,768 (GRCm38) missense possibly damaging 0.87
R9160:Vmn2r57 UTSW 7 41,426,735 (GRCm38) missense possibly damaging 0.48
R9354:Vmn2r57 UTSW 7 41,400,239 (GRCm38) missense probably benign 0.01
R9566:Vmn2r57 UTSW 7 41,427,665 (GRCm38) missense probably benign 0.32
R9633:Vmn2r57 UTSW 7 41,426,582 (GRCm38) missense probably benign 0.00
X0026:Vmn2r57 UTSW 7 41,428,561 (GRCm38) missense possibly damaging 0.91
X0026:Vmn2r57 UTSW 7 41,428,125 (GRCm38) missense probably benign 0.03
X0065:Vmn2r57 UTSW 7 41,427,971 (GRCm38) missense probably benign 0.09
Z1176:Vmn2r57 UTSW 7 41,400,498 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTCAGAAGTACCAGATCATACTTAG -3'
(R):5'- ATCCATCAGTCTTATGGATGGGC -3'

Sequencing Primer
(F):5'- TCAATTCATCTGGCATTACAAGC -3'
(R):5'- CCATCAGTCTTATGGATGGGCATATG -3'
Posted On 2016-11-21