Incidental Mutation 'R5745:Or6c5c'
ID 445759
Institutional Source Beutler Lab
Gene Symbol Or6c5c
Ensembl Gene ENSMUSG00000096497
Gene Name olfactory receptor family 6 subfamily C member 5C
Synonyms MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
MMRRC Submission 043198-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5745 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129297809-129299485 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129299307 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 254 (I254N)
Ref Sequence ENSEMBL: ENSMUSP00000149391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077836] [ENSMUST00000213329]
AlphaFold Q7TRI1
Predicted Effect probably damaging
Transcript: ENSMUST00000077836
AA Change: I254N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077005
Gene: ENSMUSG00000096497
AA Change: I254N

Pfam:7tm_4 29 306 4e-49 PFAM
Pfam:7tm_1 39 288 2.1e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213329
AA Change: I254N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082I17Rik G A 5: 139,349,828 (GRCm39) R74W probably damaging Het
4933407L21Rik T G 1: 85,858,995 (GRCm39) probably null Het
Adcy8 A T 15: 64,792,320 (GRCm39) I212N possibly damaging Het
Cobll1 T C 2: 64,928,801 (GRCm39) T879A probably damaging Het
Copb2 T C 9: 98,456,164 (GRCm39) S233P probably damaging Het
Cpa5 T A 6: 30,630,436 (GRCm39) M330K probably damaging Het
Dgcr8 A T 16: 18,098,307 (GRCm39) N361K probably benign Het
Dmxl1 A G 18: 49,979,653 (GRCm39) E96G probably benign Het
Dock8 T A 19: 25,107,761 (GRCm39) N830K probably benign Het
Ephb1 C T 9: 102,072,633 (GRCm39) D49N probably benign Het
Fer1l6 A G 15: 58,443,238 (GRCm39) I514V probably benign Het
Fpr1 A G 17: 18,097,344 (GRCm39) I215T probably benign Het
Hectd4 G A 5: 121,491,565 (GRCm39) V3668M possibly damaging Het
Ighv3-4 T A 12: 114,217,388 (GRCm39) I68L probably benign Het
Intu A G 3: 40,647,402 (GRCm39) probably null Het
Kel C T 6: 41,675,961 (GRCm39) G243E probably damaging Het
Mycbp2 A C 14: 103,393,889 (GRCm39) S2781A possibly damaging Het
Myom2 T A 8: 15,172,705 (GRCm39) S1211T probably benign Het
Nrp1 A T 8: 129,194,929 (GRCm39) I462F probably benign Het
Or10d3 T C 9: 39,461,987 (GRCm39) Y60C probably damaging Het
Pcsk1 A C 13: 75,280,079 (GRCm39) S635R probably benign Het
Pms1 A T 1: 53,246,861 (GRCm39) Y280* probably null Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,127 (GRCm39) probably benign Het
Sema3b C A 9: 107,478,628 (GRCm39) A356S probably damaging Het
Shoc2 C A 19: 54,018,323 (GRCm39) T485K probably benign Het
Slc7a7 G A 14: 54,615,292 (GRCm39) S235L possibly damaging Het
Smcr8 A T 11: 60,674,977 (GRCm39) T918S probably benign Het
Tafa1 G A 6: 96,626,146 (GRCm39) R128Q probably damaging Het
Tle3 C A 9: 61,322,133 (GRCm39) F719L probably damaging Het
Vmn2r45 T A 7: 8,486,074 (GRCm39) I405L probably benign Het
Vmn2r57 A T 7: 41,097,895 (GRCm39) H57Q possibly damaging Het
Other mutations in Or6c5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0384:Or6c5c UTSW 10 129,298,909 (GRCm39) nonsense probably null
R1851:Or6c5c UTSW 10 129,299,370 (GRCm39) missense probably damaging 1.00
R2211:Or6c5c UTSW 10 129,298,809 (GRCm39) missense probably damaging 1.00
R3613:Or6c5c UTSW 10 129,298,937 (GRCm39) missense probably benign 0.29
R3701:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R3702:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R4496:Or6c5c UTSW 10 129,299,430 (GRCm39) missense possibly damaging 0.93
R6791:Or6c5c UTSW 10 129,299,023 (GRCm39) missense probably benign 0.00
R7190:Or6c5c UTSW 10 129,298,626 (GRCm39) missense probably benign 0.00
R7278:Or6c5c UTSW 10 129,298,620 (GRCm39) missense probably damaging 1.00
R7313:Or6c5c UTSW 10 129,298,856 (GRCm39) missense probably damaging 0.98
R7369:Or6c5c UTSW 10 129,299,390 (GRCm39) missense probably benign
R7824:Or6c5c UTSW 10 129,298,665 (GRCm39) missense probably damaging 1.00
R7851:Or6c5c UTSW 10 129,299,429 (GRCm39) missense probably benign 0.36
R8961:Or6c5c UTSW 10 129,299,225 (GRCm39) missense probably damaging 1.00
R9635:Or6c5c UTSW 10 129,299,463 (GRCm39) missense probably benign 0.00
R9775:Or6c5c UTSW 10 129,298,677 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-11-21