Incidental Mutation 'R5750:Or6c215'
ID 445974
Institutional Source Beutler Lab
Gene Symbol Or6c215
Ensembl Gene ENSMUSG00000063173
Gene Name olfactory receptor family 6 subfamily C member 215
Synonyms GA_x6K02T2PULF-11481207-11480248, MOR110-6, Olfr811
MMRRC Submission 043356-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5750 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129637433-129638392 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 129637489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 302 (V302M)
Ref Sequence ENSEMBL: ENSMUSP00000149970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076437] [ENSMUST00000215058] [ENSMUST00000217571]
AlphaFold Q8VFI1
Predicted Effect probably benign
Transcript: ENSMUST00000076437
AA Change: V302M

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000075768
Gene: ENSMUSG00000063173
AA Change: V302M

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.1e-51 PFAM
Pfam:7tm_1 39 288 1.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215058
AA Change: V302M

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216283
Predicted Effect probably benign
Transcript: ENSMUST00000217571
AA Change: V302M

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agmat G A 4: 141,476,998 (GRCm39) V135I probably benign Het
Agr3 T C 12: 35,996,941 (GRCm39) Y72H probably benign Het
Ankhd1 T A 18: 36,757,955 (GRCm39) M883K probably benign Het
Cpeb1 A T 7: 81,086,099 (GRCm39) D9E probably benign Het
Creb3l1 C T 2: 91,816,608 (GRCm39) V386M possibly damaging Het
Dnlz C T 2: 26,241,423 (GRCm39) V102M probably damaging Het
Esp4 C T 17: 40,913,286 (GRCm39) T51M probably benign Het
Fap C A 2: 62,359,058 (GRCm39) C443F probably damaging Het
Fbxo17 G A 7: 28,436,897 (GRCm39) R284H probably damaging Het
Fpr1 T A 17: 18,097,525 (GRCm39) I155F probably benign Het
Fshr T A 17: 89,293,669 (GRCm39) L336F probably benign Het
Gna15 G A 10: 81,345,230 (GRCm39) Q212* probably null Het
Hk1 A G 10: 62,110,245 (GRCm39) F785L possibly damaging Het
Ints8 T A 4: 11,241,654 (GRCm39) Q263L possibly damaging Het
Itgax T C 7: 127,743,878 (GRCm39) F880L probably benign Het
Kcnq4 A C 4: 120,572,246 (GRCm39) V327G probably damaging Het
Kdm4a A G 4: 117,999,396 (GRCm39) probably benign Het
Leng8 C T 7: 4,145,119 (GRCm39) S173L probably benign Het
Lrrc37a C T 11: 103,348,923 (GRCm39) D2591N unknown Het
Macrod2 T A 2: 141,357,240 (GRCm39) S179T probably benign Het
Map4k2 T A 19: 6,401,367 (GRCm39) S612R probably benign Het
Mast2 A G 4: 116,166,086 (GRCm39) probably benign Het
Micall2 C T 5: 139,701,456 (GRCm39) probably null Het
Miga2 T A 2: 30,261,577 (GRCm39) W191R probably damaging Het
Mterf1b T C 5: 4,246,683 (GRCm39) I108T probably damaging Het
Myh2 A G 11: 67,082,254 (GRCm39) I1319V probably benign Het
Nalcn T C 14: 123,809,450 (GRCm39) E234G probably benign Het
Ncoa4 T A 14: 31,899,264 (GRCm39) C602* probably null Het
Ntrk2 C A 13: 58,956,736 (GRCm39) P65Q probably benign Het
Or52z15 G A 7: 103,332,362 (GRCm39) V136I possibly damaging Het
P3h1 A T 4: 119,095,863 (GRCm39) I324F probably damaging Het
Peli2 G T 14: 48,493,632 (GRCm39) V285L possibly damaging Het
Qser1 A G 2: 104,619,268 (GRCm39) S515P probably damaging Het
Rnf31 C T 14: 55,836,143 (GRCm39) R721C probably damaging Het
Rps5 A G 7: 12,659,334 (GRCm39) K42E probably damaging Het
Rufy4 A T 1: 74,172,068 (GRCm39) T264S probably benign Het
Shq1 A T 6: 100,588,775 (GRCm39) V259D possibly damaging Het
Slc22a3 T C 17: 12,652,395 (GRCm39) I410V probably benign Het
Stx5a T C 19: 8,732,501 (GRCm39) probably benign Het
Syne1 G T 10: 5,289,209 (GRCm39) H1430Q probably benign Het
Tasor2 G A 13: 3,623,642 (GRCm39) Q1421* probably null Het
Tmem126b A C 7: 90,118,865 (GRCm39) V141G probably damaging Het
Trim52 C A 14: 106,344,932 (GRCm39) Q197K probably benign Het
Tshz1 A G 18: 84,032,086 (GRCm39) L774P possibly damaging Het
Ttn T C 2: 76,602,031 (GRCm39) S10217G possibly damaging Het
Unc45a A G 7: 79,984,571 (GRCm39) V228A probably benign Het
Unc93a2 C T 17: 7,637,130 (GRCm39) V133I probably benign Het
Vwa2 G T 19: 56,897,663 (GRCm39) G656V probably benign Het
Xpo5 T C 17: 46,529,556 (GRCm39) probably null Het
Zeb2 T A 2: 44,887,530 (GRCm39) Q494L probably damaging Het
Other mutations in Or6c215
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00945:Or6c215 APN 10 129,637,776 (GRCm39) missense possibly damaging 0.64
IGL01957:Or6c215 APN 10 129,638,119 (GRCm39) missense probably damaging 1.00
IGL02394:Or6c215 APN 10 129,638,182 (GRCm39) missense possibly damaging 0.90
IGL02451:Or6c215 APN 10 129,637,702 (GRCm39) nonsense probably null
IGL03111:Or6c215 APN 10 129,637,947 (GRCm39) missense probably benign 0.00
IGL03369:Or6c215 APN 10 129,638,340 (GRCm39) missense probably damaging 0.99
R0704:Or6c215 UTSW 10 129,638,172 (GRCm39) missense probably benign 0.01
R1393:Or6c215 UTSW 10 129,637,801 (GRCm39) missense probably benign 0.22
R1941:Or6c215 UTSW 10 129,638,281 (GRCm39) missense probably benign 0.00
R1994:Or6c215 UTSW 10 129,637,530 (GRCm39) missense probably damaging 1.00
R3427:Or6c215 UTSW 10 129,637,720 (GRCm39) missense possibly damaging 0.85
R4296:Or6c215 UTSW 10 129,638,169 (GRCm39) missense probably damaging 0.97
R4937:Or6c215 UTSW 10 129,637,932 (GRCm39) missense probably benign 0.31
R5016:Or6c215 UTSW 10 129,637,662 (GRCm39) missense probably benign 0.01
R5615:Or6c215 UTSW 10 129,637,636 (GRCm39) missense probably damaging 1.00
R5662:Or6c215 UTSW 10 129,638,176 (GRCm39) missense possibly damaging 0.83
R6109:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6109:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6110:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6110:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6117:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6117:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6119:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6119:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6120:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6120:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6124:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6124:Or6c215 UTSW 10 129,637,690 (GRCm39) missense probably damaging 1.00
R6395:Or6c215 UTSW 10 129,638,013 (GRCm39) missense probably damaging 1.00
R6440:Or6c215 UTSW 10 129,637,837 (GRCm39) missense probably damaging 1.00
R6559:Or6c215 UTSW 10 129,637,533 (GRCm39) missense probably damaging 1.00
R6707:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6708:Or6c215 UTSW 10 129,637,689 (GRCm39) missense probably damaging 1.00
R6868:Or6c215 UTSW 10 129,638,037 (GRCm39) missense probably damaging 1.00
R8024:Or6c215 UTSW 10 129,637,812 (GRCm39) missense probably damaging 1.00
R8956:Or6c215 UTSW 10 129,638,222 (GRCm39) missense possibly damaging 0.90
R9012:Or6c215 UTSW 10 129,637,471 (GRCm39) missense probably benign
R9029:Or6c215 UTSW 10 129,637,926 (GRCm39) missense probably damaging 1.00
R9030:Or6c215 UTSW 10 129,637,926 (GRCm39) missense probably damaging 1.00
R9038:Or6c215 UTSW 10 129,637,564 (GRCm39) missense probably damaging 0.98
R9389:Or6c215 UTSW 10 129,637,540 (GRCm39) missense probably damaging 1.00
R9663:Or6c215 UTSW 10 129,637,497 (GRCm39) missense probably benign 0.03
Z1177:Or6c215 UTSW 10 129,638,178 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGTACTCACATTCTAAAGTTAGGGAG -3'
(R):5'- CTGTACCTCCCACATGGTTG -3'

Sequencing Primer
(F):5'- TTCTAAAGTTAGGGAGATGTACTGAG -3'
(R):5'- GTACCTCCCACATGGTTGTTGTC -3'
Posted On 2016-11-21