Mutagenetix > Incidental Mutations

Incidental Mutation 'R0029:Lipm'

44599

Institutional Source

Beutler Lab

Gene Symbol

Lipm

Ensembl Gene

ENSMUSG00000056078

Gene Name

lipase, family member M

Synonyms

Lipl3, 4632427C23Rik

MMRRC Submission

038323-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.491) question?

Stock #

R0029 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34100943-34122687 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 34116548 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025685]

Predicted Effect

probably benign
Transcript: ENSMUST00000025685

SMART Domains

Protein: ENSMUSP00000025685
Gene: ENSMUSG00000056078

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	49	111	3.3e-26	PFAM
Pfam:Abhydrolase_1	92	393	2.6e-29	PFAM
Pfam:Abhydrolase_5	93	387	2.5e-10	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 93.6%

Validation Efficiency

94% (48/51)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930415O20Rik	T	C	15: 98,585,309		probably null	Het
Abca15	T	C	7: 120,346,002	F434L	probably benign	Het
Abt1	A	T	13: 23,422,508	F141Y	possibly damaging	Het
Anapc15-ps	A	G	10: 95,672,995	I141T	probably damaging	Het
Avl9	G	T	6: 56,736,483	R242L	probably benign	Het
Axin2	A	G	11: 108,924,047	T254A	probably benign	Het
Ciz1	A	G	2: 32,371,419		probably benign	Het
Cpa4	A	G	6: 30,585,045	Y276C	probably damaging	Het
Cpt1a	A	G	19: 3,381,674	D698G	probably benign	Het
Crebbp	T	C	16: 4,117,443	T861A	probably damaging	Het
Dpy19l2	T	A	9: 24,558,101	D753V	probably damaging	Het
Exosc7	A	T	9: 123,119,237		probably benign	Het
Fbxw28	T	A	9: 109,328,289	D244V	probably damaging	Het
Fgd5	A	G	6: 92,067,558	D1260G	probably benign	Het
Gapvd1	T	A	2: 34,678,141	I1404F	probably damaging	Het
Gas7	A	G	11: 67,643,337	S88G	probably benign	Het
Hk1	T	C	10: 62,315,394	D57G	probably damaging	Het
Il23r	A	C	6: 67,478,945		probably null	Het
Impg1	T	C	9: 80,398,371	D138G	probably damaging	Het
Itga2	G	A	13: 114,870,496	S432L	possibly damaging	Het
Kirrel2	A	G	7: 30,453,165		probably benign	Het
Lrpap1	T	C	5: 35,097,677	N205S	possibly damaging	Het
Mboat4	T	G	8: 34,120,209	F87V	probably damaging	Het
Nadsyn1	G	C	7: 143,806,078	Q386E	probably benign	Het
Nell1	G	A	7: 50,120,715		probably benign	Het
Olfr209	T	C	16: 59,361,541	R226G	probably benign	Het
Olfr955	T	A	9: 39,470,660	E22V	probably benign	Het
Pard3	G	T	8: 127,426,758		probably benign	Het
Per2	C	A	1: 91,423,712	R1024L	possibly damaging	Het
Phf11c	T	C	14: 59,384,915	D216G	probably benign	Het
Polk	G	A	13: 96,516,670	T74I	probably damaging	Het
Prmt6	T	C	3: 110,249,898	I358M	probably benign	Het
Psmb7	T	A	2: 38,633,907	H152L	probably damaging	Het
Ralgps1	A	T	2: 33,141,019	D498E	probably benign	Het
Slc26a2	G	A	18: 61,202,310	P24S	possibly damaging	Het
Slc4a11	A	G	2: 130,688,054	F268S	probably damaging	Het
Stk38	T	C	17: 28,982,138	E188G	probably benign	Het
Sulf2	T	C	2: 166,116,973	N105S	possibly damaging	Het
Sult2a3	T	A	7: 14,073,074	M228L	probably benign	Het
Svil	C	A	18: 5,063,286	D852E	probably benign	Het
Tcaf2	A	T	6: 42,630,159	L287*	probably null	Het
Tmem132e	A	T	11: 82,444,761	I890F	probably damaging	Het
Tmem63a	A	G	1: 180,962,466	Y401C	probably benign	Het
Ttn	T	C	2: 76,766,506	E20021G	probably damaging	Het
Ubac1	G	T	2: 26,021,443	T31N	probably benign	Het
Usp29	T	C	7: 6,961,581	L141P	probably damaging	Het
Vmn1r179	A	T	7: 23,929,205	I274F	probably benign	Het
Vmn1r204	A	G	13: 22,556,418	Y73C	probably benign	Het
Vmn2r2	T	C	3: 64,116,944	I739V	probably benign	Het
Wisp1	C	T	15: 66,912,864	R129C	probably damaging	Het

Other mutations in Lipm

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01624:Lipm	APN	19	34121145	missense	probably damaging	1.00
IGL01789:Lipm	APN	19	34118747	missense	probably damaging	1.00
IGL01878:Lipm	APN	19	34116511	missense	possibly damaging	0.63
IGL01897:Lipm	APN	19	34121308	missense	probably damaging	1.00
IGL02713:Lipm	APN	19	34101170	start codon destroyed	probably null	0.77
R0352:Lipm	UTSW	19	34112875	splice site	probably benign
R0565:Lipm	UTSW	19	34116506	missense	probably benign	0.00
R0815:Lipm	UTSW	19	34118761	missense	probably benign	0.13
R1658:Lipm	UTSW	19	34116447	missense	probably benign
R2990:Lipm	UTSW	19	34116486	missense	probably benign	0.03
R4758:Lipm	UTSW	19	34101170	start codon destroyed	possibly damaging	0.59
R5446:Lipm	UTSW	19	34117887	missense	possibly damaging	0.92
R5468:Lipm	UTSW	19	34109554	splice site	probably null
R5905:Lipm	UTSW	19	34111911	missense	probably benign
R6066:Lipm	UTSW	19	34112974	missense	probably damaging	1.00
R6437:Lipm	UTSW	19	34121257	missense	probably damaging	1.00
R6722:Lipm	UTSW	19	34121265	missense	probably benign	0.00
R6927:Lipm	UTSW	19	34101163	start gained	probably benign
R7007:Lipm	UTSW	19	34112097	missense	probably damaging	1.00
R7031:Lipm	UTSW	19	34116471	missense	probably benign
R7081:Lipm	UTSW	19	34121323	missense	possibly damaging	0.90
R7092:Lipm	UTSW	19	34121358	missense	possibly damaging	0.75
R7419:Lipm	UTSW	19	34116481	missense	probably benign	0.09
R7426:Lipm	UTSW	19	34116198	missense	possibly damaging	0.56
R7772:Lipm	UTSW	19	34117891	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GATCAAGGTATGTGATACCCAGGCG -3'
(R):5'- AGTTCCCTCGTGGAGTACAGAGATG -3'

Sequencing Primer
(F):5'- CTCTGTCTGCAAAAAAGTCTTCCAG -3'
(R):5'- CCTACAATCTGTCAAGTAAGGGTCTG -3'

Posted On

2013-06-11