Incidental Mutation 'R5766:Or13a25'
ID 446278
Institutional Source Beutler Lab
Gene Symbol Or13a25
Ensembl Gene ENSMUSG00000059136
Gene Name olfactory receptor family 13 subfamily A member 25
Synonyms GA_x6K02T2PBJ9-42813436-42814368, Olfr539, MOR253-4
MMRRC Submission 044424-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R5766 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 140247202-140248161 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 140247266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 22 (V22E)
Ref Sequence ENSEMBL: ENSMUSP00000077990 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078967] [ENSMUST00000210973] [ENSMUST00000218865]
AlphaFold Q8VGL9
Predicted Effect probably benign
Transcript: ENSMUST00000078967
AA Change: V22E

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000077990
Gene: ENSMUSG00000059136
AA Change: V22E

Pfam:7tm_4 40 316 6.5e-50 PFAM
Pfam:7tm_1 50 299 4.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210973
AA Change: V15E
Predicted Effect probably benign
Transcript: ENSMUST00000218865
AA Change: V15E

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219579
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219853
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,182,439 (GRCm39) V343A probably damaging Het
AI429214 TCCCTGATGAAC TC 8: 37,461,383 (GRCm39) probably null Het
Arid2 A G 15: 96,270,086 (GRCm39) T1400A probably benign Het
Arrdc1 G A 2: 24,816,417 (GRCm39) T184I probably damaging Het
Aspm T C 1: 139,406,740 (GRCm39) F1876L probably damaging Het
Calhm1 C T 19: 47,132,142 (GRCm39) V158I probably benign Het
Caly T C 7: 139,650,310 (GRCm39) K211E probably benign Het
Cenpe T C 3: 134,954,174 (GRCm39) L1677P probably damaging Het
Cttnbp2 A G 6: 18,381,032 (GRCm39) V1388A possibly damaging Het
Dgkd C T 1: 87,808,171 (GRCm39) R80* probably null Het
Dnah3 A T 7: 119,577,445 (GRCm39) I2072N probably damaging Het
Dnah8 A G 17: 30,909,235 (GRCm39) I1020M probably benign Het
Drc3 T C 11: 60,284,647 (GRCm39) V484A probably benign Het
Efcab8 A G 2: 153,622,912 (GRCm39) D27G possibly damaging Het
Fat4 G A 3: 38,943,617 (GRCm39) G837R probably damaging Het
Fcgbpl1 G A 7: 27,836,754 (GRCm39) W224* probably null Het
Fgb A T 3: 82,953,483 (GRCm39) C96S probably damaging Het
Flt4 G C 11: 49,517,513 (GRCm39) W278C possibly damaging Het
Fmnl2 T C 2: 52,991,466 (GRCm39) V327A probably damaging Het
Fras1 A T 5: 96,879,548 (GRCm39) Y2455F possibly damaging Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm13872 T A 2: 102,568,254 (GRCm39) I88N probably damaging Het
Hoxa6 A G 6: 52,185,394 (GRCm39) S71P probably benign Het
Hunk T A 16: 90,250,627 (GRCm39) C148S probably damaging Het
Ighv1-18 A C 12: 114,646,527 (GRCm39) S26A probably damaging Het
Impg2 T G 16: 56,080,183 (GRCm39) D553E possibly damaging Het
Ints1 A G 5: 139,757,900 (GRCm39) I266T probably benign Het
Kpna3 G T 14: 61,640,463 (GRCm39) T33K probably benign Het
Lamb1 A G 12: 31,349,930 (GRCm39) D622G probably damaging Het
Lamp3 T C 16: 19,520,067 (GRCm39) T39A probably damaging Het
Mnt C T 11: 74,733,904 (GRCm39) probably benign Het
Msh4 A G 3: 153,573,477 (GRCm39) S726P probably damaging Het
Pah A C 10: 87,403,209 (GRCm39) K195Q probably damaging Het
Pdc T A 1: 150,209,251 (GRCm39) *245K probably null Het
Pdzd8 A T 19: 59,288,972 (GRCm39) H809Q possibly damaging Het
Plekhd1 A T 12: 80,769,140 (GRCm39) I467L probably benign Het
Ppp2ca A G 11: 52,004,014 (GRCm39) D57G probably damaging Het
Ralgapa1 A T 12: 55,867,551 (GRCm39) M1K probably null Het
Rfx2 T A 17: 57,110,587 (GRCm39) D133V probably benign Het
Scfd2 A T 5: 74,623,312 (GRCm39) L407Q probably damaging Het
Scp2d1 T A 2: 144,665,957 (GRCm39) S99T possibly damaging Het
Sec63 A T 10: 42,677,677 (GRCm39) N261I probably damaging Het
Slc8a1 T C 17: 81,956,390 (GRCm39) Y216C probably damaging Het
Son T A 16: 91,461,875 (GRCm39) probably benign Het
Syce1 T C 7: 140,357,894 (GRCm39) E285G probably damaging Het
Taar7a G T 10: 23,869,260 (GRCm39) S40R probably benign Het
Ube3a A T 7: 58,925,807 (GRCm39) D216V possibly damaging Het
Vgll2 A G 10: 51,903,659 (GRCm39) D174G probably damaging Het
Vmn2r17 A T 5: 109,575,139 (GRCm39) T149S possibly damaging Het
Zbtb39 G T 10: 127,578,557 (GRCm39) C377F probably damaging Het
Zfp820 T A 17: 22,038,983 (GRCm39) N115I probably damaging Het
Zfp948 T C 17: 21,805,078 (GRCm39) S23P probably benign Het
Other mutations in Or13a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Or13a25 APN 7 140,247,854 (GRCm39) missense probably benign 0.01
IGL01610:Or13a25 APN 7 140,247,584 (GRCm39) missense probably damaging 1.00
IGL02959:Or13a25 APN 7 140,247,463 (GRCm39) missense probably damaging 1.00
IGL03406:Or13a25 APN 7 140,247,424 (GRCm39) missense probably damaging 1.00
R0671:Or13a25 UTSW 7 140,247,590 (GRCm39) missense probably damaging 1.00
R1771:Or13a25 UTSW 7 140,248,048 (GRCm39) missense probably benign
R1934:Or13a25 UTSW 7 140,247,951 (GRCm39) nonsense probably null
R1985:Or13a25 UTSW 7 140,247,734 (GRCm39) missense probably damaging 1.00
R2962:Or13a25 UTSW 7 140,247,862 (GRCm39) missense probably benign
R4239:Or13a25 UTSW 7 140,247,496 (GRCm39) missense probably benign 0.07
R4240:Or13a25 UTSW 7 140,247,496 (GRCm39) missense probably benign 0.07
R4360:Or13a25 UTSW 7 140,247,730 (GRCm39) missense probably damaging 0.98
R4841:Or13a25 UTSW 7 140,247,502 (GRCm39) missense probably damaging 1.00
R4842:Or13a25 UTSW 7 140,247,502 (GRCm39) missense probably damaging 1.00
R4851:Or13a25 UTSW 7 140,247,226 (GRCm39) missense probably benign
R5325:Or13a25 UTSW 7 140,247,705 (GRCm39) missense probably benign 0.33
R6363:Or13a25 UTSW 7 140,247,995 (GRCm39) missense possibly damaging 0.93
R6836:Or13a25 UTSW 7 140,248,093 (GRCm39) missense possibly damaging 0.86
R7777:Or13a25 UTSW 7 140,247,854 (GRCm39) missense probably benign 0.01
R7920:Or13a25 UTSW 7 140,247,814 (GRCm39) missense possibly damaging 0.92
R8134:Or13a25 UTSW 7 140,247,680 (GRCm39) missense possibly damaging 0.90
R8712:Or13a25 UTSW 7 140,248,052 (GRCm39) missense possibly damaging 0.89
R9095:Or13a25 UTSW 7 140,247,813 (GRCm39) missense probably damaging 1.00
R9158:Or13a25 UTSW 7 140,247,547 (GRCm39) missense possibly damaging 0.76
R9603:Or13a25 UTSW 7 140,247,794 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-11-21