Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00497:Tha1'

4463

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tha1

Ensembl Gene

ENSMUSG00000017713

Gene Name

threonine aldolase 1

Synonyms

GLY1, 1300017K07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL00497

Quality Score

Status

Chromosome

Chromosomal Location

117758778-117764307 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 117761831 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000033230 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033230]

AlphaFold

Q6XPS7

Predicted Effect

probably benign
Transcript: ENSMUST00000033230

SMART Domains

Protein: ENSMUSP00000033230
Gene: ENSMUSG00000017713

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:Beta_elim_lyase	42	334	4.6e-91	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125607

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138354

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153989

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579G24Rik	G	A	3: 79,538,598 (GRCm39)		probably benign	Het
Aatk	C	T	11: 119,901,012 (GRCm39)	R1128Q	probably benign	Het
Acot6	C	T	12: 84,156,212 (GRCm39)	R387C	probably damaging	Het
Adam11	A	G	11: 102,660,973 (GRCm39)	E118G	probably damaging	Het
Adcyap1r1	G	A	6: 55,449,264 (GRCm39)	V73I	probably damaging	Het
Apol8	T	C	15: 77,634,214 (GRCm39)	T121A	probably damaging	Het
Bltp2	A	G	11: 78,163,759 (GRCm39)	N1076D	probably damaging	Het
Ccdc91	C	A	6: 147,508,485 (GRCm39)	Q404K	unknown	Het
Cpt1b	T	C	15: 89,306,496 (GRCm39)	K294R	probably benign	Het
Dnah6	A	C	6: 73,172,744 (GRCm39)	V238G	probably damaging	Het
Dscaml1	T	C	9: 45,663,536 (GRCm39)	S1920P	probably damaging	Het
Gcfc2	A	T	6: 81,934,951 (GRCm39)	I737L	probably benign	Het
Gmeb1	A	G	4: 131,955,296 (GRCm39)	V293A	probably benign	Het
Gpi-ps	T	C	8: 5,690,563 (GRCm39)		noncoding transcript	Het
Hibch	A	G	1: 52,924,349 (GRCm39)		probably benign	Het
Ifnab	A	G	4: 88,609,419 (GRCm39)	Y16H	probably benign	Het
Il17rc	T	C	6: 113,451,132 (GRCm39)	V155A	probably damaging	Het
Lrr1	A	G	12: 69,221,356 (GRCm39)	H166R	probably benign	Het
Map4k5	G	T	12: 69,892,506 (GRCm39)	A141E	probably damaging	Het
Mettl17	A	T	14: 52,126,292 (GRCm39)	K233N	probably damaging	Het
Mon2	A	G	10: 122,862,204 (GRCm39)	L740S	probably damaging	Het
Mpdz	A	C	4: 81,253,979 (GRCm39)	I1051S	probably benign	Het
Mroh8	A	G	2: 157,058,834 (GRCm39)	F944S	probably damaging	Het
Myh13	A	G	11: 67,233,314 (GRCm39)	Y611C	probably damaging	Het
Npat	A	G	9: 53,478,100 (GRCm39)	N951D	possibly damaging	Het
Osmr	T	C	15: 6,876,547 (GRCm39)	S126G	probably benign	Het
Parp14	T	C	16: 35,655,206 (GRCm39)	Y1755C	probably damaging	Het
Phf14	T	C	6: 11,941,423 (GRCm39)		probably benign	Het
Prex2	T	A	1: 11,256,876 (GRCm39)	M1196K	possibly damaging	Het
Prkd1	A	T	12: 50,430,264 (GRCm39)	D614E	probably damaging	Het
Ptprm	A	G	17: 67,124,967 (GRCm39)	L794P	probably damaging	Het
Rb1	C	T	14: 73,502,038 (GRCm39)	R449H	probably damaging	Het
Scfd1	A	G	12: 51,474,652 (GRCm39)	D469G	probably benign	Het
Serpinb1c	T	C	13: 33,067,958 (GRCm39)	K213E	probably damaging	Het
Sgo1	A	G	17: 53,984,130 (GRCm39)		probably benign	Het
Slc11a1	A	G	1: 74,421,057 (GRCm39)		probably null	Het
Snw1	A	G	12: 87,499,350 (GRCm39)		probably null	Het
Stac3	T	C	10: 127,339,533 (GRCm39)	I143T	probably damaging	Het
Tcta	A	T	9: 108,183,115 (GRCm39)	L10Q	probably damaging	Het
Trmt1	T	C	8: 85,422,138 (GRCm39)	M254T	possibly damaging	Het
Trps1	T	A	15: 50,524,703 (GRCm39)	M887L	possibly damaging	Het
Zfyve28	A	G	5: 34,400,539 (GRCm39)	V53A	probably damaging	Het

Other mutations in Tha1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01434:Tha1	APN	11	117,759,425 (GRCm39)	missense	probably benign	0.31
IGL01658:Tha1	APN	11	117,762,438 (GRCm39)	missense	probably damaging	1.00
R0437:Tha1	UTSW	11	117,759,401 (GRCm39)	missense	probably benign	0.17
R0671:Tha1	UTSW	11	117,763,983 (GRCm39)	splice site	probably benign
R1958:Tha1	UTSW	11	117,760,179 (GRCm39)	unclassified	probably benign
R2127:Tha1	UTSW	11	117,760,600 (GRCm39)	missense	probably damaging	0.98
R3416:Tha1	UTSW	11	117,764,026 (GRCm39)	missense	possibly damaging	0.67
R4825:Tha1	UTSW	11	117,760,205 (GRCm39)	missense	probably damaging	1.00
R5145:Tha1	UTSW	11	117,760,502 (GRCm39)	missense	probably damaging	1.00
R5266:Tha1	UTSW	11	117,760,502 (GRCm39)	missense	probably damaging	1.00
R5267:Tha1	UTSW	11	117,760,502 (GRCm39)	missense	probably damaging	1.00
R5339:Tha1	UTSW	11	117,761,908 (GRCm39)	missense	possibly damaging	0.87
R5858:Tha1	UTSW	11	117,764,210 (GRCm39)	missense	unknown
R6820:Tha1	UTSW	11	117,762,504 (GRCm39)	missense	probably benign	0.00
R7399:Tha1	UTSW	11	117,760,516 (GRCm39)	missense	possibly damaging	0.86
R7706:Tha1	UTSW	11	117,760,281 (GRCm39)	missense	probably damaging	1.00
R7905:Tha1	UTSW	11	117,761,893 (GRCm39)	missense	possibly damaging	0.91
R8094:Tha1	UTSW	11	117,759,323 (GRCm39)	missense	probably benign	0.00
R8322:Tha1	UTSW	11	117,759,493 (GRCm39)	missense	probably damaging	0.97
R9145:Tha1	UTSW	11	117,759,512 (GRCm39)	missense	probably damaging	1.00
R9703:Tha1	UTSW	11	117,761,863 (GRCm39)	missense	probably damaging	0.96

Posted On

2012-04-20