Incidental Mutation 'V8831:H2bc11'
ID 44632
Institutional Source Beutler Lab
Gene Symbol H2bc11
Ensembl Gene ENSMUSG00000069300
Gene Name H2B clustered histone 11
Synonyms Hist1h2bj
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.279) question?
Stock # V8831 () of strain 710
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 22227368-22227828 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to C at 22227451 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091741] [ENSMUST00000102977] [ENSMUST00000110452]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000091741
SMART Domains Protein: ENSMUSP00000089335
Gene: ENSMUSG00000069301

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102977
SMART Domains Protein: ENSMUSP00000100042
Gene: ENSMUSG00000060639

DomainStartEndE-ValueType
H4 16 90 2.59e-29 SMART
Predicted Effect unknown
Transcript: ENSMUST00000110452
AA Change: A18P
SMART Domains Protein: ENSMUSP00000106082
Gene: ENSMUSG00000069300
AA Change: A18P

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 4.64e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198508
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsa1 A G 12: 87,316,697 (GRCm39) N107S probably damaging Het
Arhgap23 A G 11: 97,347,371 (GRCm39) I690V probably benign Het
Bard1 G A 1: 71,127,376 (GRCm39) P78S probably damaging Het
Ccar1 G A 10: 62,583,185 (GRCm39) T976I unknown Het
Cdc7 T A 5: 107,116,776 (GRCm39) N50K probably benign Het
Cep85 C T 4: 133,883,380 (GRCm39) E170K possibly damaging Het
Cpsf2 C T 12: 101,969,400 (GRCm39) R757C probably damaging Het
Csmd3 A T 15: 48,321,092 (GRCm39) D239E probably damaging Het
Dnah7b T G 1: 46,412,458 (GRCm39) Y4022* probably null Het
Elmo3 A G 8: 106,033,693 (GRCm39) N179S probably benign Het
H2-T24 T A 17: 36,328,216 (GRCm39) Q89L probably damaging Het
Irak4 T C 15: 94,459,365 (GRCm39) I327T probably damaging Het
Itpr2 A T 6: 146,287,380 (GRCm39) L157Q probably damaging Het
Lama1 G A 17: 68,059,878 (GRCm39) D656N probably benign Het
Lrrc72 G T 12: 36,258,656 (GRCm39) T67K possibly damaging Het
Map2 T G 1: 66,455,004 (GRCm39) I1298S probably damaging Het
Mroh2a T TN 1: 88,183,889 (GRCm39) probably null Het
Ndst1 G A 18: 60,835,999 (GRCm39) A428V probably damaging Het
Obsl1 G A 1: 75,486,756 (GRCm38) T1764M probably benign Het
Or2w1b T C 13: 21,300,173 (GRCm39) Y104H possibly damaging Het
Or5k14 G T 16: 58,693,438 (GRCm39) T25K probably benign Het
Or5p4 C T 7: 107,680,742 (GRCm39) A247V probably benign Het
Plxna1 A G 6: 89,334,119 (GRCm39) V170A probably damaging Het
Rfx6 G A 10: 51,594,304 (GRCm39) probably null Het
Shprh G A 10: 11,062,606 (GRCm39) D1238N probably damaging Het
Slc15a2 A G 16: 36,772,445 (GRCm38) M179T probably benign Het
Slc9c1 A T 16: 45,398,262 (GRCm39) I676F possibly damaging Het
Smoc1 A G 12: 81,215,029 (GRCm39) D305G probably damaging Het
Spdef C T 17: 27,937,051 (GRCm39) R184H probably damaging Het
Stxbp4 C T 11: 90,371,497 (GRCm39) A535T probably benign Het
Tcp11l1 C G 2: 104,515,829 (GRCm39) V345L probably benign Het
Ticam1 TC T 17: 56,576,969 (GRCm39) 708 probably null Het
Ttc28 A T 5: 111,248,578 (GRCm39) Y177F probably benign Het
Ugt2b34 A T 5: 87,054,533 (GRCm39) Y83N probably benign Het
Vmn2r30 G A 7: 7,337,148 (GRCm39) R163C probably benign Het
Xirp1 T G 9: 120,016,907 (GRCm38) Q970P probably benign Het
Other mutations in H2bc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02559:H2bc11 APN 13 22,227,533 (GRCm39) missense possibly damaging 0.87
IGL02862:H2bc11 APN 13 22,227,515 (GRCm39) missense possibly damaging 0.81
R4716:H2bc11 UTSW 13 22,227,533 (GRCm39) missense possibly damaging 0.87
R4850:H2bc11 UTSW 13 22,227,421 (GRCm39) unclassified probably benign
R4851:H2bc11 UTSW 13 22,227,421 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GCCTTAGTGACAACTGTACGTTCCC -3'
(R):5'- TCACGAACGAGTTCATGATGCCC -3'

Sequencing Primer
(F):5'- TTGGGCCAAAGCCTATATGAC -3'
(R):5'- CATGGCCTTGGAGGAGATACC -3'
Posted On 2013-06-11