Incidental Mutation 'R5768:Or5ac15'
ID 446404
Institutional Source Beutler Lab
Gene Symbol Or5ac15
Ensembl Gene ENSMUSG00000063020
Gene Name olfactory receptor family 5 subfamily AC member 15
Synonyms MOR182-13, MOR182-7P, GA_x54KRFPKG5P-55348161-55347241, Olfr194
MMRRC Submission 043368-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R5768 (G1)
Quality Score 217
Status Validated
Chromosome 16
Chromosomal Location 58939511-58940431 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) TGAAGAAGAA to TGAAGAA at 58940335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072608] [ENSMUST00000213228] [ENSMUST00000216519]
AlphaFold L7N1Y8
Predicted Effect probably benign
Transcript: ENSMUST00000072608
SMART Domains Protein: ENSMUSP00000072407
Gene: ENSMUSG00000063020

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 1.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213228
Predicted Effect probably benign
Transcript: ENSMUST00000216519
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 G A 5: 8,177,426 (GRCm39) T561I probably benign Het
Akp3 T C 1: 87,054,844 (GRCm39) I393T probably damaging Het
Atxn10 A T 15: 85,277,621 (GRCm39) I363F probably benign Het
BC004004 A T 17: 29,501,709 (GRCm39) S83C probably damaging Het
Bin1 T A 18: 32,559,264 (GRCm39) probably null Het
Cacna1c A G 6: 118,674,641 (GRCm39) I541T probably damaging Het
Cand1 A G 10: 119,046,910 (GRCm39) V860A probably benign Het
Ccdc69 T C 11: 54,945,856 (GRCm39) N50S possibly damaging Het
Cd209d T A 8: 3,921,968 (GRCm39) T235S probably benign Het
Cdhr3 G T 12: 33,096,685 (GRCm39) T591K possibly damaging Het
Cherp C T 8: 73,216,957 (GRCm39) D658N probably damaging Het
Clip4 T A 17: 72,113,494 (GRCm39) probably null Het
Cryzl1 C T 16: 91,492,242 (GRCm39) V195M probably damaging Het
Cst11 A T 2: 148,612,387 (GRCm39) Y83* probably null Het
Ddb2 T C 2: 91,042,337 (GRCm39) S419G possibly damaging Het
Ddi2 A T 4: 141,412,901 (GRCm39) L4M probably damaging Het
Dip2b C A 15: 100,055,826 (GRCm39) P393T probably benign Het
Dnmt3a G A 12: 3,935,660 (GRCm39) probably null Het
Elf5 C T 2: 103,279,367 (GRCm39) S196L probably damaging Het
Eps15 C G 4: 109,220,373 (GRCm39) probably null Het
Fra10ac1 T C 19: 38,195,734 (GRCm39) E163G probably benign Het
Gc T C 5: 89,589,125 (GRCm39) T213A probably damaging Het
Grpel1 A T 5: 36,622,503 (GRCm39) probably benign Het
Gsdme G A 6: 50,196,280 (GRCm39) Q377* probably null Het
Hira T C 16: 18,753,768 (GRCm39) probably benign Het
Hsd11b1 T A 1: 192,922,554 (GRCm39) I168F probably damaging Het
Htr6 G A 4: 138,789,015 (GRCm39) R347W probably damaging Het
Ipp A C 4: 116,367,967 (GRCm39) T67P probably damaging Het
Lrfn5 G A 12: 61,886,509 (GRCm39) R99Q probably benign Het
Madd T A 2: 90,998,174 (GRCm39) I649F probably damaging Het
Map2k7 T A 8: 4,295,757 (GRCm39) D368E probably benign Het
Mppe1 T G 18: 67,358,889 (GRCm39) T360P possibly damaging Het
Msi2 A G 11: 88,608,564 (GRCm39) F2L probably damaging Het
Nectin3 T C 16: 46,279,180 (GRCm39) Q266R probably damaging Het
Nfasc T C 1: 132,532,883 (GRCm39) H691R probably benign Het
Oprm1 G A 10: 6,739,026 (GRCm39) G51D probably damaging Het
Or4c117 T C 2: 88,955,793 (GRCm39) E94G probably benign Het
Papss2 G A 19: 32,638,119 (GRCm39) probably null Het
Pi4ka T C 16: 17,172,736 (GRCm39) K549E probably benign Het
Plekha6 A G 1: 133,208,116 (GRCm39) T596A probably benign Het
Polr2f A G 15: 79,035,845 (GRCm39) D117G probably damaging Het
Psd T C 19: 46,301,178 (GRCm39) E381G possibly damaging Het
Rfx6 G A 10: 51,602,976 (GRCm39) R831H probably damaging Het
Rpp25l A T 4: 41,712,649 (GRCm39) L42Q probably damaging Het
Ryr3 T C 2: 112,583,442 (GRCm39) M2810V probably benign Het
Sdk1 C A 5: 142,129,626 (GRCm39) L1616I probably benign Het
Spock2 T A 10: 59,962,029 (GRCm39) F215I probably damaging Het
Susd2 C T 10: 75,473,853 (GRCm39) A581T probably damaging Het
Tchh A T 3: 93,353,488 (GRCm39) E976V unknown Het
Tgfbr3 T C 5: 107,297,761 (GRCm39) E213G probably benign Het
Tmed1 T C 9: 21,420,619 (GRCm39) D71G probably benign Het
Tmtc4 T A 14: 123,170,565 (GRCm39) K527N possibly damaging Het
Zfhx2 T C 14: 55,311,822 (GRCm39) T291A probably benign Het
Other mutations in Or5ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01807:Or5ac15 APN 16 58,939,936 (GRCm39) missense possibly damaging 0.94
IGL02098:Or5ac15 APN 16 58,940,433 (GRCm39) utr 5 prime probably benign
IGL02276:Or5ac15 APN 16 58,940,378 (GRCm39) missense probably benign 0.01
IGL03122:Or5ac15 APN 16 58,939,801 (GRCm39) missense probably benign 0.00
R0781:Or5ac15 UTSW 16 58,940,187 (GRCm39) missense probably damaging 0.97
R1162:Or5ac15 UTSW 16 58,939,735 (GRCm39) missense probably damaging 0.99
R1526:Or5ac15 UTSW 16 58,940,293 (GRCm39) missense probably damaging 1.00
R1654:Or5ac15 UTSW 16 58,940,052 (GRCm39) missense possibly damaging 0.50
R4379:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R4380:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R5771:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5942:Or5ac15 UTSW 16 58,940,039 (GRCm39) nonsense probably null
R6131:Or5ac15 UTSW 16 58,940,256 (GRCm39) missense probably damaging 1.00
R6539:Or5ac15 UTSW 16 58,940,114 (GRCm39) missense probably damaging 0.99
R6621:Or5ac15 UTSW 16 58,940,287 (GRCm39) missense probably benign 0.19
R7642:Or5ac15 UTSW 16 58,940,011 (GRCm39) missense possibly damaging 0.94
R8308:Or5ac15 UTSW 16 58,939,899 (GRCm39) missense probably damaging 1.00
R8863:Or5ac15 UTSW 16 58,939,712 (GRCm39) nonsense probably null
RF009:Or5ac15 UTSW 16 58,940,274 (GRCm39) missense probably damaging 0.99
Z1177:Or5ac15 UTSW 16 58,939,735 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAACATTCTGTAGTTGCACTGGATC -3'
(R):5'- CACTCCATCTTGTTTGAAACTTGG -3'

Sequencing Primer
(F):5'- ATATTGGGCCATGCATTCAGAG -3'
(R):5'- CCATCTTGTTTGAAACTTGGTAATG -3'
Posted On 2016-11-21