Incidental Mutation 'R5770:Or2y14'
ID 446507
Institutional Source Beutler Lab
Gene Symbol Or2y14
Ensembl Gene ENSMUSG00000044170
Gene Name olfactory receptor family 2 subfamily Y member 14
Synonyms Olfr1384, MOR256-23, GA_x6K02T2QP88-5922712-5921756
MMRRC Submission 043370-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5770 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49404445-49405478 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49405419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 318 (E318G)
Ref Sequence ENSEMBL: ENSMUSP00000149183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060434] [ENSMUST00000213776]
AlphaFold Q8VFA8
Predicted Effect unknown
Transcript: ENSMUST00000060434
AA Change: E318G
SMART Domains Protein: ENSMUSP00000051954
Gene: ENSMUSG00000044170
AA Change: E318G

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 161 4.3e-6 PFAM
Pfam:7tm_1 40 313 2.7e-22 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000213776
AA Change: E318G
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 93% (64/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030C10Rik T C 12: 20,865,460 (GRCm39) noncoding transcript Het
Abhd8 A G 8: 71,909,972 (GRCm39) V392A probably benign Het
Alpk3 A G 7: 80,728,310 (GRCm39) E480G probably benign Het
Ankfy1 C G 11: 72,651,082 (GRCm39) H1011D probably damaging Het
Aoc3 T G 11: 101,222,578 (GRCm39) Y271* probably null Het
Bcl9 T C 3: 97,122,491 (GRCm39) I103V probably benign Het
Cgnl1 C T 9: 71,552,769 (GRCm39) probably null Het
Cyp2c23 T A 19: 44,010,018 (GRCm39) D109V probably damaging Het
Cyp2j13 A T 4: 95,965,669 (GRCm39) W13R probably benign Het
D630003M21Rik T C 2: 158,037,500 (GRCm39) probably benign Het
Desi2 A T 1: 178,084,061 (GRCm39) probably benign Het
Dll3 T C 7: 27,998,434 (GRCm39) E177G possibly damaging Het
Ern2 C T 7: 121,779,130 (GRCm39) G238D possibly damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm6133 A G 18: 78,393,464 (GRCm39) K153E probably benign Het
Gpr68 A T 12: 100,845,080 (GRCm39) Y155N probably benign Het
Hcrtr2 T A 9: 76,166,948 (GRCm39) I130F probably damaging Het
Hk1 T C 10: 62,122,228 (GRCm39) K489R probably benign Het
Ints13 T C 6: 146,456,571 (GRCm39) N425S probably damaging Het
Itpkc T C 7: 26,912,413 (GRCm39) D578G probably damaging Het
Kcns3 A G 12: 11,142,250 (GRCm39) S150P probably benign Het
Khdrbs3 T A 15: 68,921,312 (GRCm39) probably null Het
Kif11 A G 19: 37,379,313 (GRCm39) I335V probably benign Het
Lrrn4 C G 2: 132,714,076 (GRCm39) C290S probably damaging Het
Macrod2 T C 2: 141,074,102 (GRCm39) probably benign Het
Mgam A G 6: 40,646,738 (GRCm39) N688S probably benign Het
Myh8 G A 11: 67,188,026 (GRCm39) E933K probably damaging Het
Nat8f5 T C 6: 85,794,657 (GRCm39) Y101C probably damaging Het
Nhlrc1 A G 13: 47,168,188 (GRCm39) V23A probably benign Het
Nkx2-3 T A 19: 43,602,972 (GRCm39) F193I probably damaging Het
Nlrp4b T A 7: 10,449,414 (GRCm39) V172E probably benign Het
Nmrk1 G T 19: 18,622,438 (GRCm39) R172S probably benign Het
Nudcd3 T C 11: 6,063,286 (GRCm39) D201G probably damaging Het
Oprm1 G A 10: 6,739,026 (GRCm39) G51D probably damaging Het
Or10g9b C T 9: 39,917,634 (GRCm39) V204I probably benign Het
Or13a18 A G 7: 140,190,856 (GRCm39) Y259C probably damaging Het
Or2t44 G A 11: 58,677,420 (GRCm39) R120H probably benign Het
Or4c12b T A 2: 89,646,893 (GRCm39) D68E probably damaging Het
Or56a3 A T 7: 104,740,102 (GRCm39) I248N probably damaging Het
Or5ac23 A T 16: 59,149,514 (GRCm39) Y119* probably null Het
Pcdh15 T A 10: 74,021,177 (GRCm39) Y130* probably null Het
Pcdh9 G A 14: 94,124,379 (GRCm39) T597I probably damaging Het
Pcdhb19 A G 18: 37,631,090 (GRCm39) N295S possibly damaging Het
Pcnx3 T C 19: 5,731,607 (GRCm39) probably benign Het
Pdzph1 A T 17: 59,186,146 (GRCm39) I1215N probably damaging Het
Phf21a C T 2: 92,182,199 (GRCm39) T405I possibly damaging Het
Pkd1l2 C A 8: 117,781,757 (GRCm39) G763W probably damaging Het
Prox2 A G 12: 85,134,154 (GRCm39) F591L probably benign Het
Robo3 T A 9: 37,330,497 (GRCm39) H1033L possibly damaging Het
Sdha A T 13: 74,471,239 (GRCm39) C222* probably null Het
Sec16a T C 2: 26,304,402 (GRCm39) D2303G probably damaging Het
Shoc1 T C 4: 59,092,466 (GRCm39) I238M probably benign Het
Slc16a5 A G 11: 115,363,604 (GRCm39) K422E possibly damaging Het
Slc22a30 A T 19: 8,363,891 (GRCm39) M232K probably damaging Het
Slc35b3 A T 13: 39,121,734 (GRCm39) F300I probably damaging Het
Spata2l A G 8: 123,962,459 (GRCm39) V34A probably damaging Het
Susd2 C T 10: 75,473,853 (GRCm39) A581T probably damaging Het
Tecta T A 9: 42,256,885 (GRCm39) Q1597L possibly damaging Het
Tgfb1i1 A T 7: 127,847,719 (GRCm39) probably benign Het
Ticam1 TCACACA TCACA 17: 56,577,629 (GRCm39) probably null Het
Tpm3-rs7 A G 14: 113,552,807 (GRCm39) T234A probably benign Het
Usp20 A G 2: 30,907,520 (GRCm39) Y684C probably damaging Het
Zc3h4 T A 7: 16,163,536 (GRCm39) M585K unknown Het
Zfp292 A G 4: 34,806,747 (GRCm39) I2099T probably damaging Het
Other mutations in Or2y14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2y14 APN 11 49,404,737 (GRCm39) missense probably damaging 0.98
IGL02972:Or2y14 APN 11 49,404,918 (GRCm39) missense probably damaging 1.00
R0157:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R1106:Or2y14 UTSW 11 49,404,519 (GRCm39) missense probably damaging 1.00
R1213:Or2y14 UTSW 11 49,405,421 (GRCm39) makesense probably null
R3768:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R4191:Or2y14 UTSW 11 49,404,639 (GRCm39) missense probably damaging 1.00
R4708:Or2y14 UTSW 11 49,405,216 (GRCm39) nonsense probably null
R5443:Or2y14 UTSW 11 49,405,262 (GRCm39) missense probably damaging 0.98
R6245:Or2y14 UTSW 11 49,404,992 (GRCm39) missense possibly damaging 0.94
R6336:Or2y14 UTSW 11 49,405,369 (GRCm39) missense probably damaging 0.99
R7652:Or2y14 UTSW 11 49,404,512 (GRCm39) missense probably damaging 1.00
R8070:Or2y14 UTSW 11 49,404,941 (GRCm39) missense probably damaging 1.00
R8147:Or2y14 UTSW 11 49,405,050 (GRCm39) missense probably benign 0.02
R9289:Or2y14 UTSW 11 49,404,635 (GRCm39) missense probably damaging 1.00
R9551:Or2y14 UTSW 11 49,404,942 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTATCCACACGTATTCTGGTAGTG -3'
(R):5'- GAGAAGATGTGATTGGCTTACATAC -3'

Sequencing Primer
(F):5'- CCACACGTATTCTGGTAGTGAAGGG -3'
(R):5'- ATGATAATTAGAGCAGTCTGGATTTG -3'
Posted On 2016-11-21