Incidental Mutation 'R5777:Or4f58'
ID 446744
Institutional Source Beutler Lab
Gene Symbol Or4f58
Ensembl Gene ENSMUSG00000109403
Gene Name olfactory receptor family 4 subfamily F member 58
Synonyms MOR245-21, GA_x6K02T2Q125-73069292-73068354, Olfr1311
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R5777 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 111851259-111852197 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 111851876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 108 (G108R)
Ref Sequence ENSEMBL: ENSMUSP00000150617 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000208536] [ENSMUST00000213602] [ENSMUST00000215321]
AlphaFold Q8VET0
Predicted Effect probably damaging
Transcript: ENSMUST00000099601
AA Change: G108R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097196
Gene: ENSMUSG00000074948
AA Change: G108R

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 1.9e-43 PFAM
Pfam:7tm_1 41 287 3e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208536
AA Change: G108R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213602
AA Change: G108R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215321
AA Change: G108R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216319
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrp T C 8: 106,294,000 (GRCm39) E41G probably benign Het
Amph A T 13: 19,230,186 (GRCm39) N45Y probably damaging Het
Atp11a T A 8: 12,882,522 (GRCm39) L470Q probably damaging Het
C130073F10Rik T A 4: 101,747,946 (GRCm39) Y76F possibly damaging Het
Casp12 A T 9: 5,354,548 (GRCm39) I306F probably benign Het
Cobll1 A T 2: 64,933,612 (GRCm39) M460K probably benign Het
Col6a4 A T 9: 105,890,895 (GRCm39) L1800I possibly damaging Het
Ctdsp1 T C 1: 74,433,227 (GRCm39) V131A probably damaging Het
Ctnna3 A G 10: 64,511,664 (GRCm39) H618R probably benign Het
Dhx38 C A 8: 110,283,534 (GRCm39) V538L possibly damaging Het
Dtwd1 A G 2: 126,001,733 (GRCm39) D151G probably damaging Het
Fbxw28 A G 9: 109,167,604 (GRCm39) L51P probably damaging Het
Gm4781 C T 10: 100,232,831 (GRCm39) noncoding transcript Het
Gm5134 C A 10: 75,840,594 (GRCm39) F479L probably benign Het
H2bc27 A G 11: 58,839,835 (GRCm39) K24E probably benign Het
Hexa T G 9: 59,468,243 (GRCm39) V290G probably damaging Het
Ifi206 C T 1: 173,308,928 (GRCm39) R356K possibly damaging Het
Kcnj12 G A 11: 60,961,277 (GRCm39) R525Q possibly damaging Het
Lrp2 A T 2: 69,285,869 (GRCm39) I3774N probably damaging Het
Msh4 C A 3: 153,569,076 (GRCm39) M832I probably benign Het
Myh10 A G 11: 68,676,685 (GRCm39) E852G probably damaging Het
Ndufaf1 A T 2: 119,490,963 (GRCm39) C32* probably null Het
Nos2 A G 11: 78,830,978 (GRCm39) E387G probably null Het
Or55b10 A G 7: 102,143,178 (GRCm39) V268A probably benign Het
Or5h27 T A 16: 59,006,266 (GRCm39) L193F unknown Het
Or7a36 A C 10: 78,820,512 (GRCm39) D296A possibly damaging Het
Or7g29 A T 9: 19,287,014 (GRCm39) H54Q probably benign Het
Or8j3c A G 2: 86,253,669 (GRCm39) V117A probably benign Het
P3h3 T C 6: 124,832,921 (GRCm39) T211A probably benign Het
Pcdh7 A G 5: 57,876,856 (GRCm39) N137S probably damaging Het
Pgf T C 12: 85,216,148 (GRCm39) T157A possibly damaging Het
Prex1 T C 2: 166,428,579 (GRCm39) D714G probably damaging Het
Scn7a T C 2: 66,522,913 (GRCm39) I930M probably damaging Het
Siglecg T C 7: 43,058,837 (GRCm39) S197P possibly damaging Het
Skint7 T A 4: 111,845,289 (GRCm39) I367N probably benign Het
Slfn5 A T 11: 82,851,830 (GRCm39) D652V probably damaging Het
Stx1b G A 7: 127,410,090 (GRCm39) Q3* probably null Het
Tex35 T C 1: 156,934,777 (GRCm39) M46V probably benign Het
Tkt A C 14: 30,280,733 (GRCm39) T55P possibly damaging Het
Trim30c T C 7: 104,032,538 (GRCm39) R263G probably benign Het
U2af2 G A 7: 5,069,450 (GRCm39) R33Q probably benign Het
Washc4 T A 10: 83,391,469 (GRCm39) V182D probably damaging Het
Xirp2 T C 2: 67,340,348 (GRCm39) V863A possibly damaging Het
Zfp976 T G 7: 42,263,504 (GRCm39) H111P probably benign Het
Zfp982 A T 4: 147,595,321 (GRCm39) N48Y probably damaging Het
Other mutations in Or4f58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Or4f58 APN 2 111,851,477 (GRCm39) missense probably damaging 1.00
IGL02626:Or4f58 APN 2 111,851,458 (GRCm39) missense probably damaging 1.00
R0499:Or4f58 UTSW 2 111,851,777 (GRCm39) missense probably damaging 1.00
R1511:Or4f58 UTSW 2 111,851,749 (GRCm39) missense probably benign 0.00
R3439:Or4f58 UTSW 2 111,851,792 (GRCm39) missense possibly damaging 0.95
R4564:Or4f58 UTSW 2 111,852,112 (GRCm39) missense possibly damaging 0.80
R4756:Or4f58 UTSW 2 111,851,332 (GRCm39) missense possibly damaging 0.52
R4776:Or4f58 UTSW 2 111,851,276 (GRCm39) missense probably benign 0.01
R5936:Or4f58 UTSW 2 111,851,932 (GRCm39) missense probably benign 0.38
R6283:Or4f58 UTSW 2 111,851,605 (GRCm39) missense possibly damaging 0.91
R6368:Or4f58 UTSW 2 111,851,896 (GRCm39) missense probably damaging 0.99
R6484:Or4f58 UTSW 2 111,851,764 (GRCm39) nonsense probably null
R7373:Or4f58 UTSW 2 111,851,787 (GRCm39) missense probably benign
R9223:Or4f58 UTSW 2 111,851,517 (GRCm39) missense possibly damaging 0.78
X0065:Or4f58 UTSW 2 111,851,980 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAACAAAAGCTAGTTGGGCC -3'
(R):5'- CCTCCATGTTCTACATAGCGAGTG -3'

Sequencing Primer
(F):5'- TTGGGCCACTGAGTGAATAAGTCC -3'
(R):5'- CCATGTTCTACATAGCGAGTGTGATG -3'
Posted On 2016-12-15