Incidental Mutation 'R0544:Ncor1'
ID |
44697 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ncor1
|
Ensembl Gene |
ENSMUSG00000018501 |
Gene Name |
nuclear receptor co-repressor 1 |
Synonyms |
Rxrip13, 5730405M06Rik, A230020K14Rik, N-CoR |
MMRRC Submission |
038736-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R0544 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
62207132-62348200 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 62224602 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glycine to Valine
at position 1210
(G1210V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000122654
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018645]
[ENSMUST00000037575]
[ENSMUST00000101066]
[ENSMUST00000101067]
[ENSMUST00000155712]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000018645
AA Change: G1940V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000018645 Gene: ENSMUSG00000018501 AA Change: G1940V
Domain | Start | End | E-Value | Type |
low complexity region
|
51 |
74 |
N/A |
INTRINSIC |
Pfam:GPS2_interact
|
150 |
239 |
1.4e-37 |
PFAM |
coiled coil region
|
302 |
329 |
N/A |
INTRINSIC |
low complexity region
|
349 |
366 |
N/A |
INTRINSIC |
SANT
|
437 |
485 |
2.76e-7 |
SMART |
coiled coil region
|
507 |
544 |
N/A |
INTRINSIC |
low complexity region
|
593 |
617 |
N/A |
INTRINSIC |
SANT
|
624 |
672 |
3.29e-14 |
SMART |
low complexity region
|
710 |
731 |
N/A |
INTRINSIC |
low complexity region
|
771 |
788 |
N/A |
INTRINSIC |
low complexity region
|
888 |
899 |
N/A |
INTRINSIC |
low complexity region
|
987 |
995 |
N/A |
INTRINSIC |
low complexity region
|
1002 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1049 |
N/A |
INTRINSIC |
internal_repeat_2
|
1061 |
1298 |
1.62e-6 |
PROSPERO |
internal_repeat_2
|
1299 |
1515 |
1.62e-6 |
PROSPERO |
low complexity region
|
1516 |
1527 |
N/A |
INTRINSIC |
coiled coil region
|
1712 |
1749 |
N/A |
INTRINSIC |
low complexity region
|
1834 |
1848 |
N/A |
INTRINSIC |
low complexity region
|
1969 |
1980 |
N/A |
INTRINSIC |
low complexity region
|
2036 |
2055 |
N/A |
INTRINSIC |
PDB:3N00|B
|
2064 |
2084 |
4e-7 |
PDB |
low complexity region
|
2086 |
2101 |
N/A |
INTRINSIC |
low complexity region
|
2157 |
2168 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
2267 |
2290 |
2e-8 |
PDB |
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000037575
AA Change: G886V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000038900 Gene: ENSMUSG00000018501 AA Change: G886V
Domain | Start | End | E-Value | Type |
low complexity region
|
28 |
41 |
N/A |
INTRINSIC |
low complexity region
|
461 |
472 |
N/A |
INTRINSIC |
coiled coil region
|
658 |
695 |
N/A |
INTRINSIC |
low complexity region
|
780 |
794 |
N/A |
INTRINSIC |
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
low complexity region
|
982 |
1001 |
N/A |
INTRINSIC |
PDB:3N00|B
|
1010 |
1030 |
2e-7 |
PDB |
low complexity region
|
1032 |
1047 |
N/A |
INTRINSIC |
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
1212 |
1235 |
2e-8 |
PDB |
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000101066
AA Change: G1940V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000098627 Gene: ENSMUSG00000018501 AA Change: G1940V
Domain | Start | End | E-Value | Type |
low complexity region
|
51 |
74 |
N/A |
INTRINSIC |
coiled coil region
|
176 |
217 |
N/A |
INTRINSIC |
coiled coil region
|
302 |
329 |
N/A |
INTRINSIC |
low complexity region
|
349 |
366 |
N/A |
INTRINSIC |
SANT
|
437 |
485 |
2.76e-7 |
SMART |
coiled coil region
|
507 |
544 |
N/A |
INTRINSIC |
low complexity region
|
593 |
617 |
N/A |
INTRINSIC |
SANT
|
624 |
672 |
3.29e-14 |
SMART |
low complexity region
|
710 |
731 |
N/A |
INTRINSIC |
low complexity region
|
771 |
788 |
N/A |
INTRINSIC |
low complexity region
|
888 |
899 |
N/A |
INTRINSIC |
low complexity region
|
987 |
995 |
N/A |
INTRINSIC |
low complexity region
|
1002 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1036 |
1049 |
N/A |
INTRINSIC |
internal_repeat_2
|
1061 |
1298 |
1.62e-6 |
PROSPERO |
internal_repeat_2
|
1299 |
1515 |
1.62e-6 |
PROSPERO |
low complexity region
|
1516 |
1527 |
N/A |
INTRINSIC |
coiled coil region
|
1712 |
1749 |
N/A |
INTRINSIC |
low complexity region
|
1834 |
1848 |
N/A |
INTRINSIC |
low complexity region
|
1969 |
1980 |
N/A |
INTRINSIC |
low complexity region
|
2036 |
2055 |
N/A |
INTRINSIC |
PDB:3N00|B
|
2064 |
2084 |
4e-7 |
PDB |
low complexity region
|
2086 |
2101 |
N/A |
INTRINSIC |
low complexity region
|
2157 |
2168 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
2267 |
2290 |
2e-8 |
PDB |
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000101067
AA Change: G1873V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000098628 Gene: ENSMUSG00000018501 AA Change: G1873V
Domain | Start | End | E-Value | Type |
low complexity region
|
51 |
74 |
N/A |
INTRINSIC |
coiled coil region
|
176 |
217 |
N/A |
INTRINSIC |
coiled coil region
|
302 |
329 |
N/A |
INTRINSIC |
low complexity region
|
349 |
366 |
N/A |
INTRINSIC |
SANT
|
437 |
485 |
2.76e-7 |
SMART |
coiled coil region
|
507 |
544 |
N/A |
INTRINSIC |
low complexity region
|
593 |
617 |
N/A |
INTRINSIC |
SANT
|
624 |
672 |
3.29e-14 |
SMART |
low complexity region
|
716 |
734 |
N/A |
INTRINSIC |
low complexity region
|
838 |
849 |
N/A |
INTRINSIC |
low complexity region
|
937 |
945 |
N/A |
INTRINSIC |
low complexity region
|
952 |
963 |
N/A |
INTRINSIC |
low complexity region
|
986 |
999 |
N/A |
INTRINSIC |
low complexity region
|
1448 |
1459 |
N/A |
INTRINSIC |
coiled coil region
|
1645 |
1682 |
N/A |
INTRINSIC |
low complexity region
|
1767 |
1781 |
N/A |
INTRINSIC |
low complexity region
|
1902 |
1913 |
N/A |
INTRINSIC |
low complexity region
|
1969 |
1988 |
N/A |
INTRINSIC |
PDB:3N00|B
|
1997 |
2017 |
4e-7 |
PDB |
low complexity region
|
2019 |
2034 |
N/A |
INTRINSIC |
low complexity region
|
2089 |
2100 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
2199 |
2222 |
2e-8 |
PDB |
low complexity region
|
2243 |
2256 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000121709
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131911
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000155712
AA Change: G1210V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000122654 Gene: ENSMUSG00000018501 AA Change: G1210V
Domain | Start | End | E-Value | Type |
low complexity region
|
26 |
47 |
N/A |
INTRINSIC |
low complexity region
|
87 |
104 |
N/A |
INTRINSIC |
low complexity region
|
204 |
215 |
N/A |
INTRINSIC |
low complexity region
|
303 |
311 |
N/A |
INTRINSIC |
low complexity region
|
318 |
329 |
N/A |
INTRINSIC |
low complexity region
|
352 |
365 |
N/A |
INTRINSIC |
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
coiled coil region
|
982 |
1019 |
N/A |
INTRINSIC |
low complexity region
|
1104 |
1118 |
N/A |
INTRINSIC |
low complexity region
|
1239 |
1250 |
N/A |
INTRINSIC |
low complexity region
|
1306 |
1325 |
N/A |
INTRINSIC |
PDB:3N00|B
|
1334 |
1354 |
3e-7 |
PDB |
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
low complexity region
|
1427 |
1438 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
1537 |
1560 |
2e-8 |
PDB |
low complexity region
|
1581 |
1594 |
N/A |
INTRINSIC |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000156740
AA Change: G875V
|
SMART Domains |
Protein: ENSMUSP00000125458 Gene: ENSMUSG00000018501 AA Change: G875V
Domain | Start | End | E-Value | Type |
low complexity region
|
18 |
31 |
N/A |
INTRINSIC |
low complexity region
|
451 |
462 |
N/A |
INTRINSIC |
coiled coil region
|
647 |
684 |
N/A |
INTRINSIC |
low complexity region
|
770 |
784 |
N/A |
INTRINSIC |
low complexity region
|
905 |
916 |
N/A |
INTRINSIC |
low complexity region
|
972 |
991 |
N/A |
INTRINSIC |
PDB:3N00|B
|
1000 |
1020 |
2e-7 |
PDB |
low complexity region
|
1022 |
1037 |
N/A |
INTRINSIC |
low complexity region
|
1092 |
1103 |
N/A |
INTRINSIC |
PDB:2OVM|B
|
1202 |
1225 |
2e-8 |
PDB |
low complexity region
|
1246 |
1259 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161281
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161767
|
Meta Mutation Damage Score |
0.4392 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
98% (97/99) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010] PHENOTYPE: Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 96 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9930012K11Rik |
A |
T |
14: 70,394,763 (GRCm39) |
F130L |
probably benign |
Het |
Aatf |
C |
T |
11: 84,313,831 (GRCm39) |
R511Q |
probably benign |
Het |
Acot12 |
A |
T |
13: 91,932,775 (GRCm39) |
D516V |
probably benign |
Het |
Adgrb2 |
T |
C |
4: 129,911,335 (GRCm39) |
V1207A |
probably damaging |
Het |
Akap9 |
A |
G |
5: 4,119,185 (GRCm39) |
D3564G |
probably benign |
Het |
Arl8b |
C |
T |
6: 108,760,189 (GRCm39) |
|
probably benign |
Het |
Atf6b |
T |
C |
17: 34,867,273 (GRCm39) |
|
probably null |
Het |
Atrn |
G |
A |
2: 130,828,746 (GRCm39) |
G1097D |
probably damaging |
Het |
Btbd6 |
A |
G |
12: 112,940,702 (GRCm39) |
E61G |
probably damaging |
Het |
Car15 |
A |
G |
16: 17,653,680 (GRCm39) |
|
probably benign |
Het |
Car5b |
G |
A |
X: 162,762,297 (GRCm39) |
R282C |
probably damaging |
Het |
Carmil2 |
C |
T |
8: 106,417,867 (GRCm39) |
A654V |
probably damaging |
Het |
Ccdc88b |
A |
G |
19: 6,834,634 (GRCm39) |
L124P |
probably damaging |
Het |
Ccnd1 |
A |
G |
7: 144,491,023 (GRCm39) |
|
probably benign |
Het |
Cenph |
A |
G |
13: 100,909,249 (GRCm39) |
S53P |
probably damaging |
Het |
Chrm3 |
T |
A |
13: 9,927,615 (GRCm39) |
I474F |
probably damaging |
Het |
Cln8 |
T |
A |
8: 14,946,769 (GRCm39) |
V261E |
probably benign |
Het |
Coa6 |
A |
G |
8: 127,149,499 (GRCm39) |
D25G |
probably benign |
Het |
Col4a1 |
T |
G |
8: 11,276,487 (GRCm39) |
|
probably benign |
Het |
Cpxm1 |
T |
C |
2: 130,235,055 (GRCm39) |
H588R |
probably damaging |
Het |
Cul7 |
T |
C |
17: 46,974,470 (GRCm39) |
L1516P |
possibly damaging |
Het |
Dcdc5 |
A |
G |
2: 106,181,909 (GRCm39) |
|
noncoding transcript |
Het |
Ddx5 |
T |
C |
11: 106,673,288 (GRCm39) |
|
probably benign |
Het |
Dhx16 |
C |
A |
17: 36,192,551 (GRCm39) |
P161Q |
probably benign |
Het |
Dpy19l1 |
A |
T |
9: 24,396,406 (GRCm39) |
|
probably benign |
Het |
Fastkd5 |
A |
G |
2: 130,457,216 (GRCm39) |
V458A |
probably damaging |
Het |
Fhit |
A |
G |
14: 9,870,172 (GRCm38) |
V99A |
probably damaging |
Het |
Fndc3a |
A |
T |
14: 72,795,062 (GRCm39) |
|
probably benign |
Het |
Foxd4 |
A |
T |
19: 24,877,182 (GRCm39) |
S339R |
possibly damaging |
Het |
Gm10842 |
T |
A |
11: 105,037,880 (GRCm39) |
D54E |
unknown |
Het |
Gns |
T |
A |
10: 121,212,172 (GRCm39) |
Y94* |
probably null |
Het |
Gp2 |
A |
G |
7: 119,053,719 (GRCm39) |
W81R |
probably benign |
Het |
Hdac5 |
T |
G |
11: 102,086,922 (GRCm39) |
Q46P |
probably damaging |
Het |
Homer2 |
A |
C |
7: 81,299,426 (GRCm39) |
V13G |
probably damaging |
Het |
Irs3 |
A |
G |
5: 137,642,101 (GRCm39) |
S446P |
probably benign |
Het |
Ism2 |
G |
T |
12: 87,332,113 (GRCm39) |
D141E |
probably damaging |
Het |
Jak1 |
T |
A |
4: 101,048,822 (GRCm39) |
M19L |
probably benign |
Het |
Kcnd3 |
C |
A |
3: 105,566,075 (GRCm39) |
R419S |
probably damaging |
Het |
Lamb1 |
T |
C |
12: 31,332,694 (GRCm39) |
F272S |
probably damaging |
Het |
Ldlrad2 |
T |
G |
4: 137,299,579 (GRCm39) |
T82P |
possibly damaging |
Het |
Lrp2 |
T |
C |
2: 69,322,275 (GRCm39) |
K1885E |
probably benign |
Het |
Mbd5 |
T |
C |
2: 49,147,221 (GRCm39) |
V477A |
possibly damaging |
Het |
Mrps33 |
A |
T |
6: 39,782,488 (GRCm39) |
M11K |
possibly damaging |
Het |
Mylk |
G |
C |
16: 34,699,845 (GRCm39) |
E403Q |
possibly damaging |
Het |
Myom2 |
T |
A |
8: 15,119,796 (GRCm39) |
V184E |
probably damaging |
Het |
Nlrp4a |
A |
G |
7: 26,156,555 (GRCm39) |
D760G |
probably benign |
Het |
Noc4l |
A |
G |
5: 110,798,989 (GRCm39) |
V231A |
possibly damaging |
Het |
Or2at1 |
T |
C |
7: 99,416,867 (GRCm39) |
I166T |
probably benign |
Het |
Or4c112 |
T |
C |
2: 88,854,170 (GRCm39) |
Y59C |
probably damaging |
Het |
Or4f14 |
A |
T |
2: 111,742,905 (GRCm39) |
Y123* |
probably null |
Het |
Or4n4b |
A |
T |
14: 50,536,139 (GRCm39) |
V209E |
probably benign |
Het |
Or52ab7 |
T |
A |
7: 102,977,858 (GRCm39) |
I55N |
probably damaging |
Het |
Or5b98 |
A |
G |
19: 12,931,066 (GRCm39) |
T38A |
possibly damaging |
Het |
Or5h25 |
T |
A |
16: 58,930,588 (GRCm39) |
K128N |
probably benign |
Het |
Or8k23 |
T |
C |
2: 86,186,007 (GRCm39) |
T240A |
probably damaging |
Het |
Padi4 |
GCTGCGTACCTCCAC |
GC |
4: 140,475,760 (GRCm39) |
|
probably benign |
Het |
Patj |
T |
A |
4: 98,457,347 (GRCm39) |
M1283K |
probably damaging |
Het |
Pkd1 |
C |
T |
17: 24,804,657 (GRCm39) |
T790I |
probably damaging |
Het |
Plod3 |
C |
A |
5: 137,020,465 (GRCm39) |
T526K |
probably benign |
Het |
Plxnb2 |
C |
A |
15: 89,042,816 (GRCm39) |
|
probably benign |
Het |
Polr1g |
G |
T |
7: 19,093,066 (GRCm39) |
P38Q |
probably damaging |
Het |
Pramel1 |
T |
A |
4: 143,124,175 (GRCm39) |
D283E |
possibly damaging |
Het |
Prpf40a |
T |
C |
2: 53,031,663 (GRCm39) |
|
probably benign |
Het |
Psg23 |
A |
T |
7: 18,348,607 (GRCm39) |
Y67N |
probably damaging |
Het |
Rftn1 |
T |
A |
17: 50,301,289 (GRCm39) |
Q242L |
possibly damaging |
Het |
Rp1l1 |
A |
T |
14: 64,269,515 (GRCm39) |
E1700D |
probably benign |
Het |
Scube3 |
T |
C |
17: 28,383,127 (GRCm39) |
F435S |
probably damaging |
Het |
Sdk2 |
T |
C |
11: 113,671,836 (GRCm39) |
Y2104C |
probably damaging |
Het |
Septin11 |
A |
G |
5: 93,313,227 (GRCm39) |
E358G |
possibly damaging |
Het |
Sh3bp1 |
T |
C |
15: 78,789,975 (GRCm39) |
L246P |
probably damaging |
Het |
Sis |
T |
C |
3: 72,858,975 (GRCm39) |
Y352C |
probably damaging |
Het |
Skint1 |
T |
C |
4: 111,878,562 (GRCm39) |
S165P |
probably damaging |
Het |
Skint10 |
C |
T |
4: 112,586,008 (GRCm39) |
|
probably benign |
Het |
Slc1a2 |
A |
T |
2: 102,586,417 (GRCm39) |
R340S |
probably damaging |
Het |
Slc26a3 |
C |
A |
12: 31,497,739 (GRCm39) |
Q48K |
probably benign |
Het |
Slc5a2 |
A |
T |
7: 127,869,171 (GRCm39) |
Y317F |
probably damaging |
Het |
Sorbs3 |
T |
A |
14: 70,431,375 (GRCm39) |
T262S |
probably benign |
Het |
Tas2r118 |
G |
T |
6: 23,969,400 (GRCm39) |
S220R |
probably damaging |
Het |
Terf2ip |
C |
A |
8: 112,741,974 (GRCm39) |
Q223K |
possibly damaging |
Het |
Tespa1 |
A |
G |
10: 130,196,680 (GRCm39) |
Q206R |
probably damaging |
Het |
Tex10 |
T |
C |
4: 48,462,766 (GRCm39) |
|
probably null |
Het |
Tle1 |
T |
A |
4: 72,043,227 (GRCm39) |
K547N |
probably damaging |
Het |
Tmem131l |
T |
A |
3: 83,805,853 (GRCm39) |
Q1530L |
probably damaging |
Het |
Tomm20l |
A |
G |
12: 71,169,851 (GRCm39) |
E145G |
possibly damaging |
Het |
Tra2a |
C |
T |
6: 49,227,885 (GRCm39) |
|
probably benign |
Het |
Trim32 |
G |
A |
4: 65,531,491 (GRCm39) |
R16Q |
probably damaging |
Het |
Trim37 |
T |
A |
11: 87,036,328 (GRCm39) |
Y121* |
probably null |
Het |
Tube1 |
C |
T |
10: 39,016,941 (GRCm39) |
|
probably null |
Het |
Usp6nl |
T |
A |
2: 6,425,820 (GRCm39) |
V187D |
probably damaging |
Het |
Vmn1r13 |
T |
C |
6: 57,187,248 (GRCm39) |
F136L |
probably benign |
Het |
Vmn1r201 |
A |
T |
13: 22,659,316 (GRCm39) |
I177F |
probably benign |
Het |
Vmn1r203 |
A |
T |
13: 22,708,443 (GRCm39) |
T75S |
possibly damaging |
Het |
Vmn1r225 |
C |
T |
17: 20,722,718 (GRCm39) |
S53L |
probably benign |
Het |
Xab2 |
A |
T |
8: 3,660,994 (GRCm39) |
W707R |
probably damaging |
Het |
Zfp808 |
T |
C |
13: 62,317,248 (GRCm39) |
|
probably benign |
Het |
Zng1 |
A |
G |
19: 24,926,575 (GRCm39) |
Y159H |
possibly damaging |
Het |
|
Other mutations in Ncor1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01067:Ncor1
|
APN |
11 |
62,283,354 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01343:Ncor1
|
APN |
11 |
62,216,312 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01392:Ncor1
|
APN |
11 |
62,231,420 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01402:Ncor1
|
APN |
11 |
62,231,300 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01714:Ncor1
|
APN |
11 |
62,225,410 (GRCm39) |
missense |
possibly damaging |
0.58 |
IGL01772:Ncor1
|
APN |
11 |
62,240,173 (GRCm39) |
intron |
probably benign |
|
IGL01889:Ncor1
|
APN |
11 |
62,225,427 (GRCm39) |
missense |
possibly damaging |
0.69 |
IGL02058:Ncor1
|
APN |
11 |
62,235,463 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02065:Ncor1
|
APN |
11 |
62,310,435 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02073:Ncor1
|
APN |
11 |
62,249,743 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02176:Ncor1
|
APN |
11 |
62,220,485 (GRCm39) |
unclassified |
probably benign |
|
IGL02288:Ncor1
|
APN |
11 |
62,240,229 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02348:Ncor1
|
APN |
11 |
62,224,485 (GRCm39) |
splice site |
probably benign |
|
IGL02608:Ncor1
|
APN |
11 |
62,264,040 (GRCm39) |
missense |
probably benign |
0.07 |
laggard
|
UTSW |
11 |
62,260,130 (GRCm39) |
missense |
probably damaging |
1.00 |
Shortstep
|
UTSW |
11 |
62,225,367 (GRCm39) |
missense |
probably damaging |
1.00 |
LCD18:Ncor1
|
UTSW |
11 |
62,419,782 (GRCm38) |
critical splice acceptor site |
probably benign |
|
PIT4382001:Ncor1
|
UTSW |
11 |
62,235,489 (GRCm39) |
missense |
probably damaging |
0.96 |
PIT4576001:Ncor1
|
UTSW |
11 |
62,224,543 (GRCm39) |
missense |
probably damaging |
0.99 |
R0026:Ncor1
|
UTSW |
11 |
62,329,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R0038:Ncor1
|
UTSW |
11 |
62,283,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R0038:Ncor1
|
UTSW |
11 |
62,283,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R0103:Ncor1
|
UTSW |
11 |
62,233,871 (GRCm39) |
missense |
possibly damaging |
0.85 |
R0103:Ncor1
|
UTSW |
11 |
62,233,871 (GRCm39) |
missense |
possibly damaging |
0.85 |
R0144:Ncor1
|
UTSW |
11 |
62,283,421 (GRCm39) |
missense |
probably damaging |
1.00 |
R0427:Ncor1
|
UTSW |
11 |
62,301,746 (GRCm39) |
missense |
probably damaging |
1.00 |
R0501:Ncor1
|
UTSW |
11 |
62,264,148 (GRCm39) |
missense |
possibly damaging |
0.73 |
R0544:Ncor1
|
UTSW |
11 |
62,224,603 (GRCm39) |
missense |
probably damaging |
1.00 |
R0563:Ncor1
|
UTSW |
11 |
62,234,056 (GRCm39) |
missense |
probably damaging |
0.97 |
R1074:Ncor1
|
UTSW |
11 |
62,283,377 (GRCm39) |
missense |
probably damaging |
0.99 |
R1266:Ncor1
|
UTSW |
11 |
62,224,866 (GRCm39) |
missense |
probably damaging |
0.98 |
R1444:Ncor1
|
UTSW |
11 |
62,294,632 (GRCm39) |
missense |
probably damaging |
1.00 |
R1452:Ncor1
|
UTSW |
11 |
62,225,457 (GRCm39) |
missense |
probably damaging |
1.00 |
R1534:Ncor1
|
UTSW |
11 |
62,269,330 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1710:Ncor1
|
UTSW |
11 |
62,313,831 (GRCm39) |
missense |
probably damaging |
1.00 |
R1762:Ncor1
|
UTSW |
11 |
62,275,610 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1771:Ncor1
|
UTSW |
11 |
62,217,938 (GRCm39) |
missense |
probably damaging |
1.00 |
R1864:Ncor1
|
UTSW |
11 |
62,272,245 (GRCm39) |
missense |
probably damaging |
1.00 |
R1902:Ncor1
|
UTSW |
11 |
62,228,984 (GRCm39) |
missense |
probably damaging |
1.00 |
R1906:Ncor1
|
UTSW |
11 |
62,240,211 (GRCm39) |
missense |
possibly damaging |
0.81 |
R2009:Ncor1
|
UTSW |
11 |
62,216,427 (GRCm39) |
missense |
probably benign |
0.43 |
R3708:Ncor1
|
UTSW |
11 |
62,235,513 (GRCm39) |
missense |
probably damaging |
1.00 |
R3825:Ncor1
|
UTSW |
11 |
62,264,183 (GRCm39) |
missense |
probably benign |
0.00 |
R3923:Ncor1
|
UTSW |
11 |
62,216,442 (GRCm39) |
missense |
probably damaging |
1.00 |
R3966:Ncor1
|
UTSW |
11 |
62,235,583 (GRCm39) |
missense |
probably damaging |
1.00 |
R4049:Ncor1
|
UTSW |
11 |
62,220,494 (GRCm39) |
splice site |
probably null |
|
R4350:Ncor1
|
UTSW |
11 |
62,301,644 (GRCm39) |
critical splice donor site |
probably null |
|
R4351:Ncor1
|
UTSW |
11 |
62,301,644 (GRCm39) |
critical splice donor site |
probably null |
|
R4359:Ncor1
|
UTSW |
11 |
62,249,736 (GRCm39) |
missense |
probably damaging |
1.00 |
R4712:Ncor1
|
UTSW |
11 |
62,235,660 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Ncor1
|
UTSW |
11 |
62,269,438 (GRCm39) |
missense |
probably benign |
0.26 |
R4863:Ncor1
|
UTSW |
11 |
62,283,464 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4875:Ncor1
|
UTSW |
11 |
62,324,437 (GRCm39) |
small deletion |
probably benign |
|
R4956:Ncor1
|
UTSW |
11 |
62,231,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R4993:Ncor1
|
UTSW |
11 |
62,234,167 (GRCm39) |
missense |
probably damaging |
1.00 |
R5079:Ncor1
|
UTSW |
11 |
62,236,063 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5144:Ncor1
|
UTSW |
11 |
62,240,290 (GRCm39) |
missense |
probably damaging |
1.00 |
R5223:Ncor1
|
UTSW |
11 |
62,229,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R5243:Ncor1
|
UTSW |
11 |
62,229,788 (GRCm39) |
missense |
probably damaging |
1.00 |
R5271:Ncor1
|
UTSW |
11 |
62,231,371 (GRCm39) |
missense |
probably damaging |
1.00 |
R5285:Ncor1
|
UTSW |
11 |
62,283,475 (GRCm39) |
missense |
probably damaging |
1.00 |
R5533:Ncor1
|
UTSW |
11 |
62,233,837 (GRCm39) |
missense |
probably benign |
0.00 |
R5580:Ncor1
|
UTSW |
11 |
62,280,604 (GRCm39) |
nonsense |
probably null |
|
R5593:Ncor1
|
UTSW |
11 |
62,260,130 (GRCm39) |
missense |
probably damaging |
1.00 |
R5609:Ncor1
|
UTSW |
11 |
62,249,679 (GRCm39) |
splice site |
probably null |
|
R5632:Ncor1
|
UTSW |
11 |
62,229,060 (GRCm39) |
missense |
possibly damaging |
0.85 |
R5830:Ncor1
|
UTSW |
11 |
62,235,589 (GRCm39) |
missense |
possibly damaging |
0.71 |
R5896:Ncor1
|
UTSW |
11 |
62,274,016 (GRCm39) |
missense |
probably damaging |
1.00 |
R5973:Ncor1
|
UTSW |
11 |
62,240,136 (GRCm39) |
splice site |
probably null |
|
R6013:Ncor1
|
UTSW |
11 |
62,211,903 (GRCm39) |
missense |
probably benign |
|
R6019:Ncor1
|
UTSW |
11 |
62,263,987 (GRCm39) |
missense |
probably benign |
0.00 |
R6032:Ncor1
|
UTSW |
11 |
62,264,147 (GRCm39) |
missense |
possibly damaging |
0.54 |
R6032:Ncor1
|
UTSW |
11 |
62,264,147 (GRCm39) |
missense |
possibly damaging |
0.54 |
R6075:Ncor1
|
UTSW |
11 |
62,208,675 (GRCm39) |
missense |
probably damaging |
1.00 |
R6091:Ncor1
|
UTSW |
11 |
62,310,443 (GRCm39) |
missense |
probably damaging |
0.98 |
R6248:Ncor1
|
UTSW |
11 |
62,257,808 (GRCm39) |
missense |
probably damaging |
1.00 |
R6281:Ncor1
|
UTSW |
11 |
62,264,371 (GRCm39) |
missense |
possibly damaging |
0.71 |
R6351:Ncor1
|
UTSW |
11 |
62,264,124 (GRCm39) |
missense |
probably benign |
0.30 |
R6469:Ncor1
|
UTSW |
11 |
62,234,128 (GRCm39) |
missense |
probably damaging |
1.00 |
R6502:Ncor1
|
UTSW |
11 |
62,272,240 (GRCm39) |
nonsense |
probably null |
|
R6614:Ncor1
|
UTSW |
11 |
62,221,645 (GRCm39) |
missense |
probably benign |
0.01 |
R6650:Ncor1
|
UTSW |
11 |
62,225,367 (GRCm39) |
missense |
probably damaging |
1.00 |
R6765:Ncor1
|
UTSW |
11 |
62,264,272 (GRCm39) |
missense |
probably benign |
0.01 |
R6852:Ncor1
|
UTSW |
11 |
62,234,071 (GRCm39) |
missense |
probably damaging |
0.97 |
R6909:Ncor1
|
UTSW |
11 |
62,220,312 (GRCm39) |
missense |
probably damaging |
1.00 |
R6965:Ncor1
|
UTSW |
11 |
62,244,059 (GRCm39) |
critical splice donor site |
probably null |
|
R7054:Ncor1
|
UTSW |
11 |
62,275,619 (GRCm39) |
missense |
probably null |
|
R7248:Ncor1
|
UTSW |
11 |
62,275,598 (GRCm39) |
missense |
possibly damaging |
0.89 |
R7352:Ncor1
|
UTSW |
11 |
62,224,737 (GRCm39) |
missense |
probably damaging |
0.99 |
R7396:Ncor1
|
UTSW |
11 |
62,234,044 (GRCm39) |
missense |
probably damaging |
0.99 |
R7434:Ncor1
|
UTSW |
11 |
62,274,025 (GRCm39) |
missense |
probably damaging |
0.99 |
R7552:Ncor1
|
UTSW |
11 |
62,264,250 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7565:Ncor1
|
UTSW |
11 |
62,292,091 (GRCm39) |
missense |
probably damaging |
1.00 |
R7575:Ncor1
|
UTSW |
11 |
62,274,082 (GRCm39) |
missense |
probably benign |
0.21 |
R7622:Ncor1
|
UTSW |
11 |
62,208,794 (GRCm39) |
missense |
probably benign |
0.00 |
R7664:Ncor1
|
UTSW |
11 |
62,289,154 (GRCm39) |
missense |
probably damaging |
1.00 |
R7814:Ncor1
|
UTSW |
11 |
62,224,752 (GRCm39) |
missense |
probably damaging |
0.99 |
R7963:Ncor1
|
UTSW |
11 |
62,225,359 (GRCm39) |
missense |
probably benign |
0.28 |
R7990:Ncor1
|
UTSW |
11 |
62,240,321 (GRCm39) |
critical splice acceptor site |
probably null |
|
R8302:Ncor1
|
UTSW |
11 |
62,224,681 (GRCm39) |
missense |
probably benign |
0.00 |
R8334:Ncor1
|
UTSW |
11 |
62,274,070 (GRCm39) |
missense |
probably damaging |
0.99 |
R8512:Ncor1
|
UTSW |
11 |
62,324,437 (GRCm39) |
small deletion |
probably benign |
|
R8728:Ncor1
|
UTSW |
11 |
62,221,685 (GRCm39) |
missense |
probably benign |
0.04 |
R8777:Ncor1
|
UTSW |
11 |
62,324,494 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777:Ncor1
|
UTSW |
11 |
62,324,492 (GRCm39) |
missense |
probably benign |
0.03 |
R8777-TAIL:Ncor1
|
UTSW |
11 |
62,324,494 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777-TAIL:Ncor1
|
UTSW |
11 |
62,324,492 (GRCm39) |
missense |
probably benign |
0.03 |
R8821:Ncor1
|
UTSW |
11 |
62,260,234 (GRCm39) |
missense |
probably benign |
0.07 |
R8831:Ncor1
|
UTSW |
11 |
62,260,234 (GRCm39) |
missense |
probably benign |
0.07 |
R8988:Ncor1
|
UTSW |
11 |
62,233,871 (GRCm39) |
nonsense |
probably null |
|
R9111:Ncor1
|
UTSW |
11 |
62,280,585 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9147:Ncor1
|
UTSW |
11 |
62,224,672 (GRCm39) |
missense |
probably damaging |
1.00 |
R9391:Ncor1
|
UTSW |
11 |
62,216,376 (GRCm39) |
nonsense |
probably null |
|
R9467:Ncor1
|
UTSW |
11 |
62,324,448 (GRCm39) |
small insertion |
probably benign |
|
R9467:Ncor1
|
UTSW |
11 |
62,324,437 (GRCm39) |
small insertion |
probably benign |
|
R9510:Ncor1
|
UTSW |
11 |
62,324,442 (GRCm39) |
small insertion |
probably benign |
|
R9511:Ncor1
|
UTSW |
11 |
62,324,449 (GRCm39) |
small insertion |
probably benign |
|
R9560:Ncor1
|
UTSW |
11 |
62,263,948 (GRCm39) |
missense |
possibly damaging |
0.96 |
R9687:Ncor1
|
UTSW |
11 |
62,260,193 (GRCm39) |
missense |
possibly damaging |
0.93 |
X0065:Ncor1
|
UTSW |
11 |
62,249,817 (GRCm39) |
missense |
probably benign |
0.23 |
X0065:Ncor1
|
UTSW |
11 |
62,245,395 (GRCm39) |
critical splice donor site |
probably null |
|
Z1176:Ncor1
|
UTSW |
11 |
62,329,342 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GTTACAGTTCAGAAGCCCCTCTTCC -3'
(R):5'- TCAGCAGCAGTTAGTGAACAGCAG -3'
Sequencing Primer
(F):5'- TCATACCAGGATGGGCTTTAC -3'
(R):5'- TGAACAGCAGCAGCTAGAGC -3'
|
Posted On |
2013-06-11 |