Incidental Mutation 'R5791:Adam25'
ID 446976
Institutional Source Beutler Lab
Gene Symbol Adam25
Ensembl Gene ENSMUSG00000071937
Gene Name a disintegrin and metallopeptidase domain 25 (testase 2)
Synonyms testase 2
MMRRC Submission 043207-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R5791 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 40752208-40756176 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to C at 40754220 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Histidine at position 174 (Q174H)
Ref Sequence ENSEMBL: ENSMUSP00000094420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096663]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096663
AA Change: Q174H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000094420
Gene: ENSMUSG00000071937
AA Change: Q174H

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 53 179 3.4e-21 PFAM
Pfam:Reprolysin_5 220 398 1.6e-16 PFAM
Pfam:Reprolysin_4 220 407 2.5e-13 PFAM
Pfam:Reprolysin 221 410 5.6e-46 PFAM
Pfam:Reprolysin_2 222 399 9.7e-14 PFAM
Pfam:Reprolysin_3 246 366 1e-18 PFAM
DISIN 428 503 3.33e-39 SMART
ACR 504 640 8.95e-74 SMART
transmembrane domain 706 728 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipor2 A T 6: 119,361,905 (GRCm38) M129K possibly damaging Het
AI314180 C T 4: 58,814,027 (GRCm38) E1360K possibly damaging Het
AI314180 T A 4: 58,822,111 (GRCm38) D1152V probably damaging Het
Arhgap29 T A 3: 122,014,245 (GRCm38) M616K probably damaging Het
Calcrl A T 2: 84,351,265 (GRCm38) F180I probably damaging Het
Cdh4 T C 2: 179,895,767 (GRCm38) V864A probably damaging Het
Cep78 A G 19: 15,961,072 (GRCm38) F504S probably benign Het
Coasy A G 11: 101,084,385 (GRCm38) probably null Het
Dnah3 T C 7: 119,931,473 (GRCm38) N751S probably benign Het
Eea1 T A 10: 96,019,995 (GRCm38) N631K probably benign Het
Fam149b A G 14: 20,351,326 (GRCm38) K27R probably damaging Het
Fbxw26 A G 9: 109,745,153 (GRCm38) W42R probably damaging Het
Gas6 A G 8: 13,470,217 (GRCm38) probably null Het
Gfral C T 9: 76,197,046 (GRCm38) R228Q probably benign Het
Gm11595 G A 11: 99,772,555 (GRCm38) R100C unknown Het
Gmppa T C 1: 75,442,255 (GRCm38) V324A possibly damaging Het
Gstm2 C T 3: 107,984,128 (GRCm38) probably null Het
Kcng3 A G 17: 83,588,210 (GRCm38) S276P probably benign Het
Lrrd1 T C 5: 3,851,254 (GRCm38) S520P probably benign Het
Lrrn2 A G 1: 132,937,767 (GRCm38) N190S probably benign Het
Lrwd1 G C 5: 136,131,033 (GRCm38) A392G probably benign Het
Mab21l2 A G 3: 86,546,737 (GRCm38) Y319H probably damaging Het
Ndufv3 A G 17: 31,527,408 (GRCm38) N91D probably benign Het
Nfatc2 T A 2: 168,536,393 (GRCm38) M451L probably benign Het
Olfr980 A T 9: 40,006,734 (GRCm38) S72T probably damaging Het
Pcdhgb2 G T 18: 37,692,340 (GRCm38) V795F possibly damaging Het
Pdcd11 T A 19: 47,110,991 (GRCm38) M843K possibly damaging Het
Pla2g4c T A 7: 13,339,692 (GRCm38) N221K probably benign Het
Ppox T C 1: 171,277,312 (GRCm38) Y422C probably damaging Het
Retreg3 A G 11: 101,100,943 (GRCm38) S55P probably damaging Het
Rnf103 C A 6: 71,508,925 (GRCm38) T180K probably damaging Het
Tbl3 A T 17: 24,704,434 (GRCm38) L307H probably damaging Het
Tex26 A T 5: 149,439,775 (GRCm38) probably null Het
Tln2 A T 9: 67,386,605 (GRCm38) I247K probably damaging Het
Txlnb T C 10: 17,799,128 (GRCm38) S10P probably benign Het
Vwde C A 6: 13,195,986 (GRCm38) E347* probably null Het
Wasf1 G A 10: 40,926,574 (GRCm38) R75Q probably damaging Het
Zfp14 A G 7: 30,038,262 (GRCm38) S433P probably damaging Het
Zfp647 G T 15: 76,918,006 (GRCm38) A2E unknown Het
Other mutations in Adam25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Adam25 APN 8 40,754,921 (GRCm38) missense probably benign
IGL01977:Adam25 APN 8 40,755,097 (GRCm38) missense probably benign 0.00
IGL02098:Adam25 APN 8 40,755,643 (GRCm38) missense probably benign 0.12
IGL02233:Adam25 APN 8 40,755,386 (GRCm38) missense probably damaging 1.00
IGL02458:Adam25 APN 8 40,753,807 (GRCm38) missense probably benign 0.01
IGL02527:Adam25 APN 8 40,753,748 (GRCm38) missense possibly damaging 0.78
IGL02632:Adam25 APN 8 40,755,200 (GRCm38) missense possibly damaging 0.90
IGL02995:Adam25 APN 8 40,753,723 (GRCm38) missense probably benign 0.00
H8786:Adam25 UTSW 8 40,754,224 (GRCm38) missense probably benign 0.00
R0062:Adam25 UTSW 8 40,754,792 (GRCm38) missense probably damaging 1.00
R0062:Adam25 UTSW 8 40,754,792 (GRCm38) missense probably damaging 1.00
R0189:Adam25 UTSW 8 40,755,430 (GRCm38) missense probably damaging 1.00
R0505:Adam25 UTSW 8 40,755,224 (GRCm38) missense probably damaging 1.00
R0532:Adam25 UTSW 8 40,755,950 (GRCm38) missense probably benign 0.00
R0699:Adam25 UTSW 8 40,755,974 (GRCm38) missense probably benign
R0972:Adam25 UTSW 8 40,755,131 (GRCm38) missense probably damaging 1.00
R1053:Adam25 UTSW 8 40,754,731 (GRCm38) missense probably benign 0.30
R1079:Adam25 UTSW 8 40,755,476 (GRCm38) missense possibly damaging 0.87
R1872:Adam25 UTSW 8 40,755,226 (GRCm38) nonsense probably null
R1933:Adam25 UTSW 8 40,754,885 (GRCm38) missense probably benign 0.01
R1934:Adam25 UTSW 8 40,754,885 (GRCm38) missense probably benign 0.01
R4061:Adam25 UTSW 8 40,753,782 (GRCm38) missense possibly damaging 0.67
R4702:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4703:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4705:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4859:Adam25 UTSW 8 40,754,543 (GRCm38) missense probably benign 0.01
R5015:Adam25 UTSW 8 40,754,634 (GRCm38) missense probably benign 0.22
R5249:Adam25 UTSW 8 40,755,954 (GRCm38) missense probably benign
R5628:Adam25 UTSW 8 40,755,710 (GRCm38) missense probably benign 0.00
R6439:Adam25 UTSW 8 40,754,590 (GRCm38) missense possibly damaging 0.92
R6693:Adam25 UTSW 8 40,754,531 (GRCm38) missense probably damaging 1.00
R7041:Adam25 UTSW 8 40,754,084 (GRCm38) missense probably benign 0.04
R7101:Adam25 UTSW 8 40,755,401 (GRCm38) missense probably benign 0.00
R7531:Adam25 UTSW 8 40,753,877 (GRCm38) missense probably damaging 0.99
R7600:Adam25 UTSW 8 40,755,817 (GRCm38) missense probably benign 0.01
R7634:Adam25 UTSW 8 40,754,846 (GRCm38) missense probably benign 0.00
R7964:Adam25 UTSW 8 40,755,539 (GRCm38) missense probably damaging 0.99
R8017:Adam25 UTSW 8 40,754,087 (GRCm38) missense possibly damaging 0.56
R8021:Adam25 UTSW 8 40,754,759 (GRCm38) missense probably damaging 1.00
R8499:Adam25 UTSW 8 40,755,152 (GRCm38) missense probably damaging 1.00
R8686:Adam25 UTSW 8 40,755,484 (GRCm38) missense probably benign 0.44
R8715:Adam25 UTSW 8 40,754,062 (GRCm38) missense probably benign 0.00
R8847:Adam25 UTSW 8 40,753,709 (GRCm38) missense probably benign
R8921:Adam25 UTSW 8 40,754,673 (GRCm38) nonsense probably null
R9120:Adam25 UTSW 8 40,756,104 (GRCm38) utr 3 prime probably benign
R9158:Adam25 UTSW 8 40,755,608 (GRCm38) missense probably damaging 1.00
R9339:Adam25 UTSW 8 40,753,874 (GRCm38) missense probably damaging 1.00
R9348:Adam25 UTSW 8 40,755,916 (GRCm38) missense probably benign
R9454:Adam25 UTSW 8 40,754,449 (GRCm38) missense probably damaging 0.99
R9492:Adam25 UTSW 8 40,753,699 (GRCm38) start codon destroyed probably benign 0.12
R9680:Adam25 UTSW 8 40,755,202 (GRCm38) missense probably damaging 1.00
RF006:Adam25 UTSW 8 40,755,797 (GRCm38) missense probably benign
Predicted Primers
Posted On 2016-12-15