Incidental Mutation 'R5792:Or1n2'
ID 447003
Institutional Source Beutler Lab
Gene Symbol Or1n2
Ensembl Gene ENSMUSG00000055088
Gene Name olfactory receptor family 1 subfamily N member 2
Synonyms GA_x6K02T2NLDC-33601476-33602429, MOR127-4, Olfr354
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R5792 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 36796960-36797913 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36797113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 52 (I52V)
Ref Sequence ENSEMBL: ENSMUSP00000149298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]
AlphaFold Q8VGJ8
Predicted Effect probably benign
Transcript: ENSMUST00000068475
AA Change: I52V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088
AA Change: I52V

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2.1e-62 PFAM
Pfam:7tm_1 44 293 2.9e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121665
Predicted Effect probably benign
Transcript: ENSMUST00000217479
AA Change: I52V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218102
Meta Mutation Damage Score 0.2846 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 95% (56/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik A T 7: 40,642,945 (GRCm39) I296F possibly damaging Het
Adamts19 C T 18: 58,970,584 (GRCm39) T56M possibly damaging Het
Axdnd1 T G 1: 156,169,459 (GRCm39) E802D probably damaging Het
Birc6 T C 17: 74,938,048 (GRCm39) V2630A probably benign Het
Capn5 A T 7: 97,780,402 (GRCm39) F323I probably benign Het
Ccn1 T C 3: 145,354,413 (GRCm39) D166G probably benign Het
Cdc25b A G 2: 131,033,679 (GRCm39) E206G probably damaging Het
Cmah T G 13: 24,640,898 (GRCm39) N382K probably benign Het
Col11a1 A T 3: 113,925,242 (GRCm39) D25V probably damaging Het
Cyp2d41-ps G T 15: 82,663,421 (GRCm39) noncoding transcript Het
Cyp3a59 A G 5: 146,036,661 (GRCm39) K288E possibly damaging Het
Dclre1a A C 19: 56,518,022 (GRCm39) I1019S probably damaging Het
Fat2 G T 11: 55,153,151 (GRCm39) A3687D possibly damaging Het
Flg2 T A 3: 93,110,804 (GRCm39) V944E unknown Het
Galntl5 T C 5: 25,403,461 (GRCm39) V177A possibly damaging Het
Gm12695 T C 4: 96,616,520 (GRCm39) T438A probably benign Het
Gm14295 A T 2: 176,502,807 (GRCm39) N766Y probably benign Het
Gm15433 T A 1: 84,941,833 (GRCm39) noncoding transcript Het
Gm2431 C T 7: 141,812,069 (GRCm39) G8E unknown Het
Gm5435 T A 12: 82,542,200 (GRCm39) noncoding transcript Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Grip1 T C 10: 119,821,385 (GRCm39) I350T probably benign Het
Guf1 T A 5: 69,717,829 (GRCm39) F196I probably damaging Het
Kcng4 G T 8: 120,353,018 (GRCm39) D297E probably damaging Het
Khdrbs2 G A 1: 32,511,773 (GRCm39) R246Q probably damaging Het
Layn T C 9: 50,979,461 (GRCm39) E148G probably damaging Het
Lrig3 T A 10: 125,845,788 (GRCm39) V739E probably damaging Het
Lyg1 A G 1: 37,986,348 (GRCm39) W129R probably benign Het
Nup210l C T 3: 90,107,164 (GRCm39) T1567I probably damaging Het
Nus1 T A 10: 52,305,352 (GRCm39) L12* probably null Het
Odad2 T C 18: 7,217,965 (GRCm39) N583S probably benign Het
Or6a2 A T 7: 106,600,650 (GRCm39) V139D possibly damaging Het
Otop1 A G 5: 38,455,260 (GRCm39) N218S probably benign Het
Pcif1 T A 2: 164,727,299 (GRCm39) N90K probably damaging Het
Phf2 T C 13: 48,973,518 (GRCm39) probably null Het
Piezo2 T A 18: 63,279,927 (GRCm39) I215F probably damaging Het
Pitpnm2 G T 5: 124,268,384 (GRCm39) C553* probably null Het
Prdm1 A G 10: 44,326,224 (GRCm39) V115A probably damaging Het
Prkdc A G 16: 15,634,616 (GRCm39) D3587G probably damaging Het
Sez6l A T 5: 112,569,890 (GRCm39) Y883* probably null Het
Sh3rf2 A C 18: 42,244,203 (GRCm39) H223P probably damaging Het
Slco1a5 C T 6: 142,187,839 (GRCm39) C500Y probably damaging Het
Slf1 T A 13: 77,214,856 (GRCm39) H610L probably benign Het
Syn3 T C 10: 86,130,492 (GRCm39) *244W probably null Het
Sytl2 A T 7: 90,024,897 (GRCm39) D295V probably damaging Het
Tnfrsf1a T A 6: 125,335,040 (GRCm39) C44S probably damaging Het
Ttc6 T G 12: 57,719,990 (GRCm39) L854V possibly damaging Het
Ttn T C 2: 76,596,602 (GRCm39) I18358V probably benign Het
Vmn2r108 A G 17: 20,683,398 (GRCm39) V602A probably damaging Het
Zap70 A G 1: 36,818,090 (GRCm39) probably benign Het
Zfhx2 T C 14: 55,304,303 (GRCm39) E1227G possibly damaging Het
Znhit3 G A 11: 84,806,910 (GRCm39) probably null Het
Zpbp2 A G 11: 98,442,236 (GRCm39) probably benign Het
Other mutations in Or1n2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01942:Or1n2 APN 2 36,797,869 (GRCm39) missense probably benign
IGL02573:Or1n2 APN 2 36,797,566 (GRCm39) missense probably damaging 1.00
P0027:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
R0040:Or1n2 UTSW 2 36,797,470 (GRCm39) missense probably damaging 1.00
R0610:Or1n2 UTSW 2 36,797,671 (GRCm39) missense probably damaging 1.00
R0760:Or1n2 UTSW 2 36,797,233 (GRCm39) missense probably benign 0.25
R1727:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R2972:Or1n2 UTSW 2 36,797,416 (GRCm39) missense probably benign 0.03
R4671:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R4750:Or1n2 UTSW 2 36,797,728 (GRCm39) missense probably benign 0.13
R5043:Or1n2 UTSW 2 36,796,977 (GRCm39) missense probably benign 0.01
R5400:Or1n2 UTSW 2 36,797,833 (GRCm39) missense probably damaging 1.00
R5543:Or1n2 UTSW 2 36,797,369 (GRCm39) missense possibly damaging 0.75
R6639:Or1n2 UTSW 2 36,797,690 (GRCm39) missense probably damaging 1.00
R6876:Or1n2 UTSW 2 36,797,834 (GRCm39) missense probably damaging 1.00
R7965:Or1n2 UTSW 2 36,796,953 (GRCm39) start gained probably benign
R8351:Or1n2 UTSW 2 36,797,149 (GRCm39) missense probably benign 0.00
R8859:Or1n2 UTSW 2 36,797,516 (GRCm39) missense possibly damaging 0.63
T0722:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
Z1176:Or1n2 UTSW 2 36,797,713 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CAATTCCACATAGTTCTGGCAATAC -3'
(R):5'- ATGCCATCACAGCCAGAAGG -3'

Sequencing Primer
(F):5'- CCACATAGTTCTGGCAATACAAATTC -3'
(R):5'- AAGGCAGTTGTCGAGGCC -3'
Posted On 2016-12-15