|Institutional Source||Beutler Lab|
|Gene Name||PHD finger protein 2|
|Is this an essential gene?||Possibly non essential (E-score: 0.359)|
|Stock #||R5792 (G1)|
|Chromosomal Location||48801750-48871119 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 48820042 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000047308 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000035540]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||95% (56/59)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body weight, decreased adipocity and impaired adipogenesis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Phf2||
(F):5'- CCAAACAGGTCAGTTGTCTCTC -3'
(R):5'- TTTGGGTGACATCAAGCCC -3'
(F):5'- CCCCTCTCTGCCCAGGAAC -3'
(R):5'- TGACATCAAGCCCGGGGG -3'