Incidental Mutation 'R5793:Tsga10'
ID 447055
Institutional Source Beutler Lab
Gene Symbol Tsga10
Ensembl Gene ENSMUSG00000060771
Gene Name testis specific 10
Synonyms Mtsga10, 4933432N21Rik
MMRRC Submission 043208-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R5793 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 37793857-37905510 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37874540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 115 (M115K)
Ref Sequence ENSEMBL: ENSMUSP00000142218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041815] [ENSMUST00000088072] [ENSMUST00000114902] [ENSMUST00000123082] [ENSMUST00000151735] [ENSMUST00000193669] [ENSMUST00000155852]
AlphaFold Q6NY15
Predicted Effect possibly damaging
Transcript: ENSMUST00000041815
AA Change: M115K

PolyPhen 2 Score 0.767 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000048859
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000088072
AA Change: M115K

PolyPhen 2 Score 0.767 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000085391
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000114902
AA Change: M115K

PolyPhen 2 Score 0.767 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000110552
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000123082
AA Change: M115K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141261
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 157 N/A INTRINSIC
low complexity region 159 170 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134024
Predicted Effect probably damaging
Transcript: ENSMUST00000151735
AA Change: M115K

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000120554
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 229 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000193669
AA Change: M115K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000142218
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 157 N/A INTRINSIC
low complexity region 159 170 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000155852
AA Change: M115K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141630
Gene: ENSMUSG00000060771
AA Change: M115K

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 157 N/A INTRINSIC
low complexity region 159 170 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12 C A 11: 70,133,879 (GRCm39) R522L probably benign Het
Arfgef1 A T 1: 10,279,753 (GRCm39) D271E probably benign Het
Arg1 C T 10: 24,796,540 (GRCm39) V96M probably benign Het
Axin1 T C 17: 26,362,282 (GRCm39) S209P probably damaging Het
B4galnt3 A G 6: 120,185,865 (GRCm39) probably null Het
Cdh23 T A 10: 60,141,907 (GRCm39) D3058V probably damaging Het
Chd9 A G 8: 91,728,384 (GRCm39) T794A probably damaging Het
Ckap5 C T 2: 91,450,180 (GRCm39) T1891I possibly damaging Het
Cspg4b G T 13: 113,457,556 (GRCm39) V1201L possibly damaging Het
Dzank1 T C 2: 144,348,144 (GRCm39) I207M probably benign Het
Fkbp9 G A 6: 56,850,498 (GRCm39) probably null Het
Gm4781 T A 10: 100,232,529 (GRCm39) noncoding transcript Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Gtpbp6 G A 5: 110,255,094 (GRCm39) L33F probably benign Het
Hsd11b1 A C 1: 192,924,492 (GRCm39) F27V probably damaging Het
Ift172 A T 5: 31,434,292 (GRCm39) I482N possibly damaging Het
Kcnma1 C T 14: 23,359,103 (GRCm39) probably null Het
Ly6g2 T C 15: 75,093,493 (GRCm39) probably benign Het
Myh9 T C 15: 77,653,077 (GRCm39) Q1420R probably benign Het
Ncam2 G A 16: 81,372,991 (GRCm39) V569I possibly damaging Het
Nsd1 T C 13: 55,395,819 (GRCm39) V1140A probably benign Het
Ogdhl T A 14: 32,054,730 (GRCm39) L226Q probably damaging Het
Or51a24 T C 7: 103,734,237 (GRCm39) T17A probably benign Het
Orc2 T C 1: 58,536,547 (GRCm39) M1V probably null Het
Padi2 T C 4: 140,660,501 (GRCm39) L327P probably benign Het
Palb2 T C 7: 121,726,860 (GRCm39) N337D probably benign Het
Pard3b A T 1: 61,807,132 (GRCm39) H49L probably damaging Het
Pigz T C 16: 31,764,285 (GRCm39) S448P probably benign Het
Ppfia4 A G 1: 134,239,844 (GRCm39) V911A probably damaging Het
Prr5 T A 15: 84,656,223 (GRCm39) M408K probably benign Het
Qser1 T C 2: 104,593,205 (GRCm39) Y1604C probably damaging Het
Rpgrip1l A G 8: 91,987,400 (GRCm39) S886P probably benign Het
Sdk2 T C 11: 113,759,778 (GRCm39) I408V possibly damaging Het
Sema7a A T 9: 57,867,540 (GRCm39) R431W probably damaging Het
Slc22a30 T A 19: 8,314,183 (GRCm39) Y501F possibly damaging Het
Slitrk5 T A 14: 111,917,345 (GRCm39) V323D probably damaging Het
Snap47 C T 11: 59,329,018 (GRCm39) E95K probably damaging Het
Tbc1d9 A T 8: 83,998,069 (GRCm39) I1209F probably damaging Het
Tek T A 4: 94,708,333 (GRCm39) M297K probably benign Het
Tmem132e T A 11: 82,335,684 (GRCm39) I922N probably damaging Het
Tmx2 T C 2: 84,506,501 (GRCm39) R64G probably damaging Het
Trim68 A T 7: 102,333,560 (GRCm39) S41T possibly damaging Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Vmn2r84 C T 10: 130,221,754 (GRCm39) C822Y probably damaging Het
Wdr72 C T 9: 74,117,625 (GRCm39) A779V probably benign Het
Zfp580 A T 7: 5,055,891 (GRCm39) probably benign Het
Zfp772 G A 7: 7,207,283 (GRCm39) T136I probably benign Het
Other mutations in Tsga10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00573:Tsga10 APN 1 37,846,151 (GRCm39) missense probably damaging 0.99
IGL00579:Tsga10 APN 1 37,874,534 (GRCm39) missense probably damaging 1.00
IGL00837:Tsga10 APN 1 37,840,992 (GRCm39) splice site probably benign
IGL01577:Tsga10 APN 1 37,874,538 (GRCm39) missense possibly damaging 0.85
IGL01727:Tsga10 APN 1 37,874,355 (GRCm39) missense probably damaging 1.00
IGL02037:Tsga10 APN 1 37,846,098 (GRCm39) missense probably benign 0.05
IGL02510:Tsga10 APN 1 37,800,066 (GRCm39) missense possibly damaging 0.89
R0346:Tsga10 UTSW 1 37,879,600 (GRCm39) missense possibly damaging 0.65
R0789:Tsga10 UTSW 1 37,840,868 (GRCm39) missense possibly damaging 0.87
R0961:Tsga10 UTSW 1 37,800,509 (GRCm39) critical splice donor site probably null
R1370:Tsga10 UTSW 1 37,874,534 (GRCm39) missense probably damaging 1.00
R1440:Tsga10 UTSW 1 37,858,680 (GRCm39) missense probably damaging 1.00
R1827:Tsga10 UTSW 1 37,874,661 (GRCm39) missense probably damaging 1.00
R2504:Tsga10 UTSW 1 37,854,758 (GRCm39) missense probably damaging 1.00
R3104:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3105:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3106:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3824:Tsga10 UTSW 1 37,873,278 (GRCm39) missense possibly damaging 0.73
R3825:Tsga10 UTSW 1 37,873,278 (GRCm39) missense possibly damaging 0.73
R4560:Tsga10 UTSW 1 37,846,163 (GRCm39) missense probably benign 0.00
R4773:Tsga10 UTSW 1 37,874,606 (GRCm39) missense probably damaging 1.00
R4927:Tsga10 UTSW 1 37,840,931 (GRCm39) missense probably damaging 1.00
R5036:Tsga10 UTSW 1 37,823,049 (GRCm39) missense possibly damaging 0.65
R5326:Tsga10 UTSW 1 37,800,598 (GRCm39) missense probably damaging 1.00
R5345:Tsga10 UTSW 1 37,802,392 (GRCm39) missense probably damaging 1.00
R5503:Tsga10 UTSW 1 37,800,028 (GRCm39) makesense probably null
R5542:Tsga10 UTSW 1 37,800,598 (GRCm39) missense probably damaging 1.00
R6340:Tsga10 UTSW 1 37,874,266 (GRCm39) intron probably benign
R7096:Tsga10 UTSW 1 37,879,695 (GRCm39) missense probably damaging 0.98
R7130:Tsga10 UTSW 1 37,822,965 (GRCm39) missense probably damaging 1.00
R7401:Tsga10 UTSW 1 37,873,268 (GRCm39) missense probably null 1.00
R7609:Tsga10 UTSW 1 37,843,974 (GRCm39) splice site probably null
R7649:Tsga10 UTSW 1 37,874,229 (GRCm39) missense unknown
R7773:Tsga10 UTSW 1 37,874,323 (GRCm39) missense unknown
R8242:Tsga10 UTSW 1 37,846,182 (GRCm39) missense probably benign 0.28
R8379:Tsga10 UTSW 1 37,840,959 (GRCm39) missense probably benign 0.00
R9205:Tsga10 UTSW 1 37,880,359 (GRCm39) start gained probably benign
R9252:Tsga10 UTSW 1 37,873,364 (GRCm39) missense probably benign 0.35
Predicted Primers PCR Primer
(F):5'- GTTGTGAACTGTGCACTCCAG -3'
(R):5'- TCTGGTTTCAGTTTTAACAACCTGG -3'

Sequencing Primer
(F):5'- AACTGTGCACTCCAGCTCCTC -3'
(R):5'- TCAGTTTTAACAACCTGGATATACTG -3'
Posted On 2016-12-15