Incidental Mutation 'R5795:Ankrd24'
ID 447186
Institutional Source Beutler Lab
Gene Symbol Ankrd24
Ensembl Gene ENSMUSG00000054708
Gene Name ankyrin repeat domain 24
Synonyms 4631433D01Rik, D10Bur2e, 5730519E19Rik
MMRRC Submission 043386-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.730) question?
Stock # R5795 (G1)
Quality Score 223
Status Not validated
Chromosome 10
Chromosomal Location 81464374-81483444 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to A at 81480937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140398 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119336] [ENSMUST00000123993] [ENSMUST00000189672]
AlphaFold Q80VM7
Predicted Effect probably benign
Transcript: ENSMUST00000119336
SMART Domains Protein: ENSMUSP00000112932
Gene: ENSMUSG00000054708

DomainStartEndE-ValueType
Blast:ANK 18 48 1e-6 BLAST
ANK 52 81 2.92e-2 SMART
ANK 85 114 7.53e-5 SMART
ANK 118 149 4.07e-1 SMART
ANK 151 180 2.92e-2 SMART
ANK 184 213 3.97e-4 SMART
low complexity region 240 250 N/A INTRINSIC
low complexity region 269 283 N/A INTRINSIC
internal_repeat_2 488 606 4.87e-8 PROSPERO
internal_repeat_2 597 713 4.87e-8 PROSPERO
low complexity region 718 736 N/A INTRINSIC
coiled coil region 747 895 N/A INTRINSIC
Blast:ANK 950 977 3e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000123305
Predicted Effect probably benign
Transcript: ENSMUST00000123993
SMART Domains Protein: ENSMUSP00000117975
Gene: ENSMUSG00000054708

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Blast:ANK 48 78 2e-8 BLAST
Predicted Effect unknown
Transcript: ENSMUST00000132458
AA Change: A73D
SMART Domains Protein: ENSMUSP00000121709
Gene: ENSMUSG00000054708
AA Change: A73D

DomainStartEndE-ValueType
coiled coil region 1 94 N/A INTRINSIC
Blast:ANK 142 175 3e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137978
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142390
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154707
Predicted Effect probably benign
Transcript: ENSMUST00000189672
SMART Domains Protein: ENSMUSP00000140398
Gene: ENSMUSG00000096856

DomainStartEndE-ValueType
KRAB 4 66 1.5e-18 SMART
ZnF_C2H2 104 126 6.4e-6 SMART
ZnF_C2H2 132 154 4.4e-8 SMART
ZnF_C2H2 160 182 1.5e-5 SMART
ZnF_C2H2 188 210 3.5e-6 SMART
ZnF_C2H2 216 238 2.9e-6 SMART
ZnF_C2H2 244 266 3e-5 SMART
ZnF_C2H2 272 294 7.7e-6 SMART
ZnF_C2H2 300 322 2e-5 SMART
ZnF_C2H2 328 350 1.4e-6 SMART
ZnF_C2H2 356 378 1.4e-4 SMART
ZnF_C2H2 384 406 9.4e-6 SMART
ZnF_C2H2 412 434 4.3e-5 SMART
ZnF_C2H2 440 462 2e-6 SMART
ZnF_C2H2 468 490 3.7e-4 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 A G 9: 104,186,688 (GRCm39) V261A probably benign Het
Adipor1 C A 1: 134,352,641 (GRCm39) N137K probably damaging Het
Ahnak A T 19: 8,989,746 (GRCm39) K3677* probably null Het
Appl1 G T 14: 26,664,773 (GRCm39) P420Q probably benign Het
Bmp8b C A 4: 123,015,761 (GRCm39) F249L possibly damaging Het
Brat1 G T 5: 140,698,827 (GRCm39) A275S probably benign Het
C5ar1 T C 7: 15,982,319 (GRCm39) K234E possibly damaging Het
Cblif A G 19: 11,737,740 (GRCm39) T384A probably damaging Het
Ccs A G 19: 4,883,367 (GRCm39) probably null Het
Chmp5 T G 4: 40,950,562 (GRCm39) probably null Het
Chrna3 T A 9: 54,922,552 (GRCm39) T419S probably benign Het
Crocc TCTGAGCTGCTGAGCTGC TCTGAGCTGC 4: 140,769,118 (GRCm39) probably null Het
Csf3 G T 11: 98,592,853 (GRCm39) C72F probably damaging Het
Dbndd1 A G 8: 124,236,619 (GRCm39) I83T probably damaging Het
Ercc6 A G 14: 32,248,309 (GRCm39) K287E probably damaging Het
F5 C T 1: 163,979,578 (GRCm39) T16I probably benign Het
Hephl1 C T 9: 14,981,056 (GRCm39) G792E probably damaging Het
Hmmr T A 11: 40,612,733 (GRCm39) D158V probably damaging Het
Hsd11b1 A G 1: 192,922,940 (GRCm39) S76P possibly damaging Het
Ilvbl T C 10: 78,412,978 (GRCm39) S167P probably benign Het
Irf7 G A 7: 140,845,029 (GRCm39) P118L probably damaging Het
Lama1 A G 17: 68,103,722 (GRCm39) N1981S probably benign Het
Lrp4 A G 2: 91,304,816 (GRCm39) D224G probably benign Het
Mink1 T C 11: 70,498,616 (GRCm39) Y594H possibly damaging Het
Minpp1 G A 19: 32,491,557 (GRCm39) V412M probably damaging Het
Muc5b G A 7: 141,425,478 (GRCm39) V4708M possibly damaging Het
Mycl G A 4: 122,890,415 (GRCm39) E34K probably damaging Het
Oaf T A 9: 43,135,241 (GRCm39) D179V probably damaging Het
Ogfod2 G A 5: 124,252,824 (GRCm39) G278D probably damaging Het
Or2h1 A G 17: 37,404,661 (GRCm39) L35P probably damaging Het
Or5b12 A G 19: 12,897,188 (GRCm39) F162L possibly damaging Het
Paf1 T G 7: 28,096,043 (GRCm39) M250R probably damaging Het
Pcdh8 T C 14: 80,008,420 (GRCm39) T48A possibly damaging Het
Pdzph1 A G 17: 59,192,862 (GRCm39) V1096A possibly damaging Het
Polr3b T C 10: 84,512,875 (GRCm39) S586P probably damaging Het
Polr3b A T 10: 84,464,116 (GRCm39) E25D probably benign Het
Sfi1 A ATCTTCCCAAAGCCAGTGC 11: 3,103,384 (GRCm39) probably benign Het
Slc28a2b T C 2: 122,348,475 (GRCm39) M274T possibly damaging Het
Slc31a2 T C 4: 62,215,289 (GRCm39) V112A probably damaging Het
Spire1 A T 18: 67,628,265 (GRCm39) S412T probably benign Het
Tanc1 A G 2: 59,637,926 (GRCm39) T876A possibly damaging Het
Tango6 T A 8: 107,444,709 (GRCm39) L538H probably damaging Het
Tas2r125 G A 6: 132,886,621 (GRCm39) G3D probably damaging Het
Tbc1d32 A T 10: 56,091,158 (GRCm39) M125K possibly damaging Het
Traf5 T C 1: 191,731,807 (GRCm39) S345G probably benign Het
Ush2a A T 1: 188,175,594 (GRCm39) I1231F probably benign Het
Vmn2r104 G T 17: 20,250,372 (GRCm39) T633N probably benign Het
Vmn2r104 A G 17: 20,250,544 (GRCm39) S576P possibly damaging Het
Vmn2r105 A T 17: 20,448,998 (GRCm39) C60S probably benign Het
Zfp316 A T 5: 143,248,594 (GRCm39) D217E unknown Het
Zfp456 A T 13: 67,515,039 (GRCm39) D222E probably benign Het
Other mutations in Ankrd24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00776:Ankrd24 APN 10 81,478,979 (GRCm39) unclassified probably benign
IGL00809:Ankrd24 APN 10 81,478,901 (GRCm39) unclassified probably benign
IGL01021:Ankrd24 APN 10 81,470,995 (GRCm39) splice site probably null
IGL01073:Ankrd24 APN 10 81,475,156 (GRCm39) missense possibly damaging 0.76
IGL01875:Ankrd24 APN 10 81,465,571 (GRCm39) unclassified probably benign
IGL03083:Ankrd24 APN 10 81,474,483 (GRCm39) missense probably benign
IGL03335:Ankrd24 APN 10 81,482,967 (GRCm39) missense probably benign 0.18
R0129:Ankrd24 UTSW 10 81,474,163 (GRCm39) missense probably damaging 1.00
R0243:Ankrd24 UTSW 10 81,470,778 (GRCm39) missense probably damaging 1.00
R0522:Ankrd24 UTSW 10 81,472,189 (GRCm39) splice site probably benign
R0607:Ankrd24 UTSW 10 81,474,142 (GRCm39) missense probably damaging 0.98
R0707:Ankrd24 UTSW 10 81,478,547 (GRCm39) unclassified probably benign
R1472:Ankrd24 UTSW 10 81,470,754 (GRCm39) missense probably damaging 1.00
R1766:Ankrd24 UTSW 10 81,474,472 (GRCm39) missense probably benign 0.13
R1852:Ankrd24 UTSW 10 81,478,775 (GRCm39) unclassified probably benign
R1891:Ankrd24 UTSW 10 81,479,342 (GRCm39) unclassified probably benign
R2137:Ankrd24 UTSW 10 81,482,143 (GRCm39) missense probably damaging 1.00
R3790:Ankrd24 UTSW 10 81,478,513 (GRCm39) unclassified probably benign
R4798:Ankrd24 UTSW 10 81,479,149 (GRCm39) unclassified probably benign
R4952:Ankrd24 UTSW 10 81,482,982 (GRCm39) missense probably benign 0.01
R5068:Ankrd24 UTSW 10 81,475,699 (GRCm39) missense possibly damaging 0.87
R5237:Ankrd24 UTSW 10 81,478,379 (GRCm39) unclassified probably benign
R5418:Ankrd24 UTSW 10 81,480,776 (GRCm39) unclassified probably benign
R7188:Ankrd24 UTSW 10 81,472,224 (GRCm39) nonsense probably null
R7614:Ankrd24 UTSW 10 81,474,523 (GRCm39) missense unknown
R7750:Ankrd24 UTSW 10 81,482,628 (GRCm39) missense possibly damaging 0.72
R8004:Ankrd24 UTSW 10 81,474,191 (GRCm39) missense unknown
R8190:Ankrd24 UTSW 10 81,474,152 (GRCm39) missense unknown
R8415:Ankrd24 UTSW 10 81,475,947 (GRCm39) missense unknown
R8670:Ankrd24 UTSW 10 81,465,526 (GRCm39) start gained probably benign
R8898:Ankrd24 UTSW 10 81,478,352 (GRCm39) missense unknown
R9475:Ankrd24 UTSW 10 81,478,133 (GRCm39) critical splice acceptor site probably null
R9593:Ankrd24 UTSW 10 81,475,898 (GRCm39) missense unknown
R9744:Ankrd24 UTSW 10 81,482,951 (GRCm39) missense possibly damaging 0.70
R9780:Ankrd24 UTSW 10 81,482,196 (GRCm39) missense possibly damaging 0.73
RF001:Ankrd24 UTSW 10 81,479,405 (GRCm39) unclassified probably benign
RF011:Ankrd24 UTSW 10 81,479,405 (GRCm39) unclassified probably benign
RF037:Ankrd24 UTSW 10 81,479,407 (GRCm39) nonsense probably null
RF061:Ankrd24 UTSW 10 81,479,401 (GRCm39) nonsense probably null
Z1088:Ankrd24 UTSW 10 81,474,490 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCCAAGCCACTTTGGGGTC -3'
(R):5'- GGTTACCATTGCATATCAACACC -3'

Sequencing Primer
(F):5'- CCAAGCCACTTTGGGGTCTAAATG -3'
(R):5'- CCAAAAGTGAATCTGCTGAGACTTTC -3'
Posted On 2016-12-15