Incidental Mutation 'R5800:Fyttd1'
ID 447370
Institutional Source Beutler Lab
Gene Symbol Fyttd1
Ensembl Gene ENSMUSG00000022800
Gene Name forty-two-three domain containing 1
Synonyms 3830411L18Rik, 2010005M05Rik, 4933423A17Rik, 3830421F13Rik
MMRRC Submission 043389-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R5800 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 32697870-32729245 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 32711658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 86 (R86C)
Ref Sequence ENSEMBL: ENSMUSP00000131446 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023489] [ENSMUST00000120345] [ENSMUST00000171325] [ENSMUST00000232272]
AlphaFold Q91Z49
Predicted Effect probably damaging
Transcript: ENSMUST00000023489
AA Change: R86C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023489
Gene: ENSMUSG00000022800
AA Change: R86C

DomainStartEndE-ValueType
Pfam:FYTT 10 317 1.7e-176 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120345
SMART Domains Protein: ENSMUSP00000113541
Gene: ENSMUSG00000022800

DomainStartEndE-ValueType
Pfam:FYTT 2 129 1e-83 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141590
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143151
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145146
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149183
Predicted Effect probably damaging
Transcript: ENSMUST00000171325
AA Change: R86C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131446
Gene: ENSMUSG00000022800
AA Change: R86C

DomainStartEndE-ValueType
Pfam:FYTT 3 210 6.8e-137 PFAM
Pfam:FYTT 209 283 4.6e-48 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232300
Predicted Effect probably benign
Transcript: ENSMUST00000232272
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231751
Meta Mutation Damage Score 0.3576 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,360,591 (GRCm39) V540D possibly damaging Het
Adamts8 A T 9: 30,865,778 (GRCm39) D442V probably damaging Het
B3galt9 T C 2: 34,728,654 (GRCm39) F151S possibly damaging Het
Bltp1 A G 3: 37,106,592 (GRCm39) D4974G probably damaging Het
Casp4 G A 9: 5,308,915 (GRCm39) probably null Het
Cfap45 T A 1: 172,366,167 (GRCm39) V30E probably damaging Het
Col6a4 A G 9: 105,957,474 (GRCm39) F117L probably damaging Het
Dnah7c A T 1: 46,686,175 (GRCm39) T1810S probably benign Het
Drosha C T 15: 12,865,153 (GRCm39) T627M probably damaging Het
Drosha C A 15: 12,902,733 (GRCm39) A1001D probably damaging Het
Efhc1 G A 1: 21,049,005 (GRCm39) V473I probably benign Het
Ephx2 T C 14: 66,344,751 (GRCm39) K191R probably benign Het
Ero1b T A 13: 12,617,190 (GRCm39) probably null Het
Esyt2 A T 12: 116,333,808 (GRCm39) D837V possibly damaging Het
Fip1l1 T A 5: 74,706,742 (GRCm39) D126E possibly damaging Het
Gm12888 T A 4: 121,176,625 (GRCm39) T59S probably damaging Het
Gm7353 A T 7: 3,160,168 (GRCm39) noncoding transcript Het
Gpr153 C T 4: 152,364,534 (GRCm39) Q197* probably null Het
Grep1 G A 17: 23,936,966 (GRCm39) P72S probably damaging Het
H2-T23 G T 17: 36,342,496 (GRCm39) probably benign Het
Ighv1-16 T A 12: 114,629,531 (GRCm39) R85S probably benign Het
Ipcef1 T A 10: 6,840,569 (GRCm39) D376V probably damaging Het
Kdm1a T A 4: 136,300,381 (GRCm39) probably null Het
Klk1b27 A T 7: 43,705,088 (GRCm39) Q85L probably benign Het
Krt39 A T 11: 99,411,971 (GRCm39) D38E probably benign Het
L1td1 T C 4: 98,621,999 (GRCm39) L187P possibly damaging Het
Lrrc8b C T 5: 105,629,208 (GRCm39) S518L probably benign Het
Lyg1 C T 1: 37,986,034 (GRCm39) D176N probably damaging Het
Mctp1 A G 13: 76,836,678 (GRCm39) N82D probably damaging Het
Muc6 T C 7: 141,226,690 (GRCm39) probably benign Het
Nynrin T C 14: 56,108,088 (GRCm39) L1065P probably damaging Het
Or5b118 T C 19: 13,449,260 (GRCm39) S309P probably benign Het
Pcdh7 T A 5: 57,879,567 (GRCm39) S1041T probably damaging Het
Pkd1l1 T A 11: 8,811,302 (GRCm39) M1518L probably benign Het
Prl8a6 G T 13: 27,619,453 (GRCm39) Q90K probably benign Het
Ptcd1 T A 5: 145,096,475 (GRCm39) D206V probably damaging Het
Rap1gap C A 4: 137,447,688 (GRCm39) D478E probably benign Het
Scn5a A G 9: 119,330,732 (GRCm39) Y1269H probably damaging Het
Sdc2 A T 15: 33,028,290 (GRCm39) H136L probably benign Het
Senp6 A T 9: 80,033,715 (GRCm39) I120F probably damaging Het
Shisa5 G A 9: 108,885,162 (GRCm39) probably null Het
Slc19a1 A G 10: 76,878,103 (GRCm39) S213G probably null Het
Smim8 TTTAATGAAGAGCT TT 4: 34,771,261 (GRCm39) probably benign Het
Tbc1d20 T A 2: 152,150,245 (GRCm39) probably null Het
Tll2 T C 19: 41,093,373 (GRCm39) H481R probably benign Het
Tmc7 A G 7: 118,138,663 (GRCm39) V692A probably benign Het
Tmem234 T C 4: 129,500,924 (GRCm39) probably null Het
Vmn1r237 C G 17: 21,535,069 (GRCm39) T264S probably benign Het
Vmn2r98 A T 17: 19,286,260 (GRCm39) T253S probably benign Het
Zfyve27 T C 19: 42,171,102 (GRCm39) Y191H probably damaging Het
Other mutations in Fyttd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02072:Fyttd1 APN 16 32,721,031 (GRCm39) missense probably damaging 0.99
IGL03119:Fyttd1 APN 16 32,721,065 (GRCm39) missense probably benign 0.08
R0014:Fyttd1 UTSW 16 32,725,924 (GRCm39) missense probably damaging 1.00
R0014:Fyttd1 UTSW 16 32,725,924 (GRCm39) missense probably damaging 1.00
R1742:Fyttd1 UTSW 16 32,725,923 (GRCm39) nonsense probably null
R5018:Fyttd1 UTSW 16 32,722,787 (GRCm39) critical splice acceptor site probably null
R5893:Fyttd1 UTSW 16 32,719,283 (GRCm39) missense probably damaging 1.00
R7325:Fyttd1 UTSW 16 32,704,618 (GRCm39) missense probably benign 0.43
R8146:Fyttd1 UTSW 16 32,722,862 (GRCm39) missense probably damaging 1.00
R8702:Fyttd1 UTSW 16 32,704,529 (GRCm39) missense probably damaging 0.99
R9626:Fyttd1 UTSW 16 32,725,915 (GRCm39) missense probably damaging 1.00
R9649:Fyttd1 UTSW 16 32,715,472 (GRCm39) missense probably benign 0.02
Z1177:Fyttd1 UTSW 16 32,698,154 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TCACTTTCGCCAAGCATATGC -3'
(R):5'- TTCAGTAATAAACGTGTGACAGAC -3'

Sequencing Primer
(F):5'- CAGTTCAGACTAGTCAGACTTCG -3'
(R):5'- ACAGACACAGTATAAATGGAAAATGG -3'
Posted On 2016-12-15