Mutagenetix > Incidental Mutation

Incidental Mutation 'R5800:Vmn2r98'

447371

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

043389-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

R5800 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19273755-19301573 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19286260 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 253 (T253S)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: T253S

PolyPhen 2 Score 0.168 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: T253S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.4%

Validation Efficiency

96% (50/52)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	T	1: 71,360,591 (GRCm39)	V540D	possibly damaging	Het
Adamts8	A	T	9: 30,865,778 (GRCm39)	D442V	probably damaging	Het
B3galt9	T	C	2: 34,728,654 (GRCm39)	F151S	possibly damaging	Het
Bltp1	A	G	3: 37,106,592 (GRCm39)	D4974G	probably damaging	Het
Casp4	G	A	9: 5,308,915 (GRCm39)		probably null	Het
Cfap45	T	A	1: 172,366,167 (GRCm39)	V30E	probably damaging	Het
Col6a4	A	G	9: 105,957,474 (GRCm39)	F117L	probably damaging	Het
Dnah7c	A	T	1: 46,686,175 (GRCm39)	T1810S	probably benign	Het
Drosha	C	T	15: 12,865,153 (GRCm39)	T627M	probably damaging	Het
Drosha	C	A	15: 12,902,733 (GRCm39)	A1001D	probably damaging	Het
Efhc1	G	A	1: 21,049,005 (GRCm39)	V473I	probably benign	Het
Ephx2	T	C	14: 66,344,751 (GRCm39)	K191R	probably benign	Het
Ero1b	T	A	13: 12,617,190 (GRCm39)		probably null	Het
Esyt2	A	T	12: 116,333,808 (GRCm39)	D837V	possibly damaging	Het
Fip1l1	T	A	5: 74,706,742 (GRCm39)	D126E	possibly damaging	Het
Fyttd1	C	T	16: 32,711,658 (GRCm39)	R86C	probably damaging	Het
Gm12888	T	A	4: 121,176,625 (GRCm39)	T59S	probably damaging	Het
Gm7353	A	T	7: 3,160,168 (GRCm39)		noncoding transcript	Het
Gpr153	C	T	4: 152,364,534 (GRCm39)	Q197*	probably null	Het
Grep1	G	A	17: 23,936,966 (GRCm39)	P72S	probably damaging	Het
H2-T23	G	T	17: 36,342,496 (GRCm39)		probably benign	Het
Ighv1-16	T	A	12: 114,629,531 (GRCm39)	R85S	probably benign	Het
Ipcef1	T	A	10: 6,840,569 (GRCm39)	D376V	probably damaging	Het
Kdm1a	T	A	4: 136,300,381 (GRCm39)		probably null	Het
Klk1b27	A	T	7: 43,705,088 (GRCm39)	Q85L	probably benign	Het
Krt39	A	T	11: 99,411,971 (GRCm39)	D38E	probably benign	Het
L1td1	T	C	4: 98,621,999 (GRCm39)	L187P	possibly damaging	Het
Lrrc8b	C	T	5: 105,629,208 (GRCm39)	S518L	probably benign	Het
Lyg1	C	T	1: 37,986,034 (GRCm39)	D176N	probably damaging	Het
Mctp1	A	G	13: 76,836,678 (GRCm39)	N82D	probably damaging	Het
Muc6	T	C	7: 141,226,690 (GRCm39)		probably benign	Het
Nynrin	T	C	14: 56,108,088 (GRCm39)	L1065P	probably damaging	Het
Or5b118	T	C	19: 13,449,260 (GRCm39)	S309P	probably benign	Het
Pcdh7	T	A	5: 57,879,567 (GRCm39)	S1041T	probably damaging	Het
Pkd1l1	T	A	11: 8,811,302 (GRCm39)	M1518L	probably benign	Het
Prl8a6	G	T	13: 27,619,453 (GRCm39)	Q90K	probably benign	Het
Ptcd1	T	A	5: 145,096,475 (GRCm39)	D206V	probably damaging	Het
Rap1gap	C	A	4: 137,447,688 (GRCm39)	D478E	probably benign	Het
Scn5a	A	G	9: 119,330,732 (GRCm39)	Y1269H	probably damaging	Het
Sdc2	A	T	15: 33,028,290 (GRCm39)	H136L	probably benign	Het
Senp6	A	T	9: 80,033,715 (GRCm39)	I120F	probably damaging	Het
Shisa5	G	A	9: 108,885,162 (GRCm39)		probably null	Het
Slc19a1	A	G	10: 76,878,103 (GRCm39)	S213G	probably null	Het
Smim8	TTTAATGAAGAGCT	TT	4: 34,771,261 (GRCm39)		probably benign	Het
Tbc1d20	T	A	2: 152,150,245 (GRCm39)		probably null	Het
Tll2	T	C	19: 41,093,373 (GRCm39)	H481R	probably benign	Het
Tmc7	A	G	7: 118,138,663 (GRCm39)	V692A	probably benign	Het
Tmem234	T	C	4: 129,500,924 (GRCm39)		probably null	Het
Vmn1r237	C	G	17: 21,535,069 (GRCm39)	T264S	probably benign	Het
Zfyve27	T	C	19: 42,171,102 (GRCm39)	Y191H	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,286,007 (GRCm39)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,285,447 (GRCm39)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,286,020 (GRCm39)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,286,713 (GRCm39)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,286,548 (GRCm39)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,300,941 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,286,113 (GRCm39)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,286,083 (GRCm39)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,301,223 (GRCm39)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,285,521 (GRCm39)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,286,275 (GRCm39)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,301,283 (GRCm39)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,286,242 (GRCm39)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,290,107 (GRCm39)	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19,301,223 (GRCm39)	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19,286,662 (GRCm39)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,286,609 (GRCm39)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,286,089 (GRCm39)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,273,875 (GRCm39)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,300,759 (GRCm39)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,300,782 (GRCm39)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,301,011 (GRCm39)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,286,210 (GRCm39)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,285,440 (GRCm39)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,301,170 (GRCm39)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,286,702 (GRCm39)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,286,680 (GRCm39)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,285,595 (GRCm39)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,301,553 (GRCm39)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,286,213 (GRCm39)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,300,698 (GRCm39)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,286,081 (GRCm39)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,301,439 (GRCm39)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,287,664 (GRCm39)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,286,125 (GRCm39)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,300,887 (GRCm39)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,286,354 (GRCm39)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,290,007 (GRCm39)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,286,602 (GRCm39)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,286,419 (GRCm39)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,286,306 (GRCm39)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,273,815 (GRCm39)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,300,981 (GRCm39)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,290,016 (GRCm39)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,290,015 (GRCm39)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,287,645 (GRCm39)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,301,161 (GRCm39)	missense	probably benign	0.37
R6089:Vmn2r98	UTSW	17	19,286,336 (GRCm39)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,286,143 (GRCm39)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,286,063 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,285,510 (GRCm39)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,286,530 (GRCm39)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,301,184 (GRCm39)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,285,575 (GRCm39)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,287,570 (GRCm39)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,300,797 (GRCm39)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,287,460 (GRCm39)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,287,493 (GRCm39)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,273,912 (GRCm39)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,301,425 (GRCm39)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,301,031 (GRCm39)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,286,532 (GRCm39)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,285,531 (GRCm39)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,286,383 (GRCm39)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,301,481 (GRCm39)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,286,777 (GRCm39)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,287,517 (GRCm39)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,301,496 (GRCm39)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,285,665 (GRCm39)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,287,685 (GRCm39)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,285,398 (GRCm39)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- GATCTTCTCCTGAGTGACCG -3'
(R):5'- AGGCTCCCATGGAATGAGTC -3'

Sequencing Primer
(F):5'- TCTCCTGAGTGACCGTGGTC -3'
(R):5'- GGCTCCCATGGAATGAGTCTAATATG -3'

Posted On

2016-12-15