Incidental Mutation 'R5811:Zfp873'
ID 447523
Institutional Source Beutler Lab
Gene Symbol Zfp873
Ensembl Gene ENSMUSG00000061371
Gene Name zinc finger protein 873
Synonyms
MMRRC Submission 043213-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5811 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 81883957-81900579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 81896567 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 470 (C470S)
Ref Sequence ENSEMBL: ENSMUSP00000148219 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105313] [ENSMUST00000209622] [ENSMUST00000210325]
AlphaFold A0A1B0GT64
Predicted Effect probably damaging
Transcript: ENSMUST00000105313
AA Change: C433S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100950
Gene: ENSMUSG00000061371
AA Change: C433S

DomainStartEndE-ValueType
ZnF_C2H2 68 90 1.12e2 SMART
ZnF_C2H2 96 117 4.69e0 SMART
ZnF_C2H2 123 145 2.06e1 SMART
ZnF_C2H2 151 173 5.5e-3 SMART
ZnF_C2H2 179 201 3.69e-4 SMART
ZnF_C2H2 207 229 3.89e-3 SMART
ZnF_C2H2 235 257 9.88e-5 SMART
ZnF_C2H2 263 285 5.59e-4 SMART
ZnF_C2H2 291 313 2.99e-4 SMART
ZnF_C2H2 319 341 1.95e-3 SMART
ZnF_C2H2 347 369 2.75e-3 SMART
ZnF_C2H2 375 397 7.37e-4 SMART
ZnF_C2H2 403 425 2.53e-2 SMART
ZnF_C2H2 431 453 9.08e-4 SMART
ZnF_C2H2 459 481 5.99e-4 SMART
ZnF_C2H2 487 509 1.22e-4 SMART
ZnF_C2H2 515 537 1.82e-3 SMART
ZnF_C2H2 543 565 2.53e-2 SMART
ZnF_C2H2 571 593 9.73e-4 SMART
ZnF_C2H2 599 619 3.13e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209614
Predicted Effect probably benign
Transcript: ENSMUST00000209622
Predicted Effect probably damaging
Transcript: ENSMUST00000210325
AA Change: C470S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219748
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Btnl1 A T 17: 34,604,503 (GRCm39) K428M probably damaging Het
Chid1 G A 7: 141,110,166 (GRCm39) T53M probably damaging Het
Clnk A G 5: 38,870,490 (GRCm39) V356A probably damaging Het
Cryba4 C T 5: 112,398,937 (GRCm39) V36I probably benign Het
Dct A G 14: 118,250,600 (GRCm39) V466A probably benign Het
Dnmt3l A G 10: 77,887,929 (GRCm39) D146G possibly damaging Het
Epas1 A G 17: 87,131,203 (GRCm39) N328D probably damaging Het
Fat4 C T 3: 38,945,936 (GRCm39) R1610W probably damaging Het
Filip1l T C 16: 57,390,657 (GRCm39) V415A probably damaging Het
Garnl3 A G 2: 32,896,911 (GRCm39) L576P probably damaging Het
Gjd3 A T 11: 98,873,226 (GRCm39) V206E possibly damaging Het
Gpr135 A T 12: 72,116,641 (GRCm39) D375E possibly damaging Het
Gsdme T A 6: 50,222,925 (GRCm39) Q130L probably benign Het
Hcls1 A G 16: 36,777,702 (GRCm39) M274V probably null Het
Kcnn4 T C 7: 24,077,030 (GRCm39) V193A probably damaging Het
Kctd16 T C 18: 40,391,505 (GRCm39) V31A probably damaging Het
Lamc2 C T 1: 153,041,999 (GRCm39) R45Q possibly damaging Het
Lrrc66 T A 5: 73,772,860 (GRCm39) I203F possibly damaging Het
Mark4 T C 7: 19,182,564 (GRCm39) D91G probably damaging Het
Mcm6 A T 1: 128,263,465 (GRCm39) probably benign Het
Mecom C T 3: 30,015,149 (GRCm39) S602N probably benign Het
Muc5ac T C 7: 141,352,721 (GRCm39) V736A possibly damaging Het
Nr2e3 TCCATCGGAGTGTTCCC TC 9: 59,850,701 (GRCm39) probably benign Het
Or2h2c C A 17: 37,422,649 (GRCm39) C75F probably benign Het
Pdia5 A T 16: 35,269,790 (GRCm39) M173K possibly damaging Het
Pih1d2 T C 9: 50,532,374 (GRCm39) L144P probably damaging Het
Plch2 C T 4: 155,077,024 (GRCm39) E577K possibly damaging Het
Samd4b T C 7: 28,107,445 (GRCm39) S275G probably damaging Het
Sap130 T C 18: 31,822,495 (GRCm39) V668A probably benign Het
Sema3c T A 5: 17,880,188 (GRCm39) probably null Het
Slc9a8 C T 2: 167,313,307 (GRCm39) R390* probably null Het
Vmn2r89 A T 14: 51,693,565 (GRCm39) N305I probably benign Het
Wdr33 T C 18: 32,035,673 (GRCm39) F1164L unknown Het
Other mutations in Zfp873
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02250:Zfp873 APN 10 81,894,252 (GRCm39) start codon destroyed probably null 0.45
G1Funyon:Zfp873 UTSW 10 81,896,713 (GRCm39) missense probably damaging 1.00
R0666:Zfp873 UTSW 10 81,896,595 (GRCm39) missense possibly damaging 0.75
R1568:Zfp873 UTSW 10 81,896,113 (GRCm39) missense probably damaging 1.00
R1739:Zfp873 UTSW 10 81,896,541 (GRCm39) missense probably damaging 1.00
R1848:Zfp873 UTSW 10 81,896,406 (GRCm39) missense probably benign 0.33
R1892:Zfp873 UTSW 10 81,897,080 (GRCm39) missense probably damaging 1.00
R2061:Zfp873 UTSW 10 81,895,991 (GRCm39) missense probably benign 0.01
R3735:Zfp873 UTSW 10 81,897,015 (GRCm39) missense probably benign 0.15
R4422:Zfp873 UTSW 10 81,896,708 (GRCm39) missense probably benign 0.13
R4674:Zfp873 UTSW 10 81,895,814 (GRCm39) missense possibly damaging 0.53
R4839:Zfp873 UTSW 10 81,896,353 (GRCm39) missense probably damaging 0.98
R5146:Zfp873 UTSW 10 81,896,058 (GRCm39) missense probably damaging 1.00
R5154:Zfp873 UTSW 10 81,896,025 (GRCm39) missense possibly damaging 0.54
R5160:Zfp873 UTSW 10 81,896,876 (GRCm39) missense possibly damaging 0.54
R6625:Zfp873 UTSW 10 81,896,138 (GRCm39) missense probably damaging 1.00
R6667:Zfp873 UTSW 10 81,896,423 (GRCm39) missense probably benign 0.22
R6742:Zfp873 UTSW 10 81,894,256 (GRCm39) missense probably damaging 1.00
R6878:Zfp873 UTSW 10 81,896,529 (GRCm39) missense probably benign 0.33
R7055:Zfp873 UTSW 10 81,895,832 (GRCm39) missense probably damaging 1.00
R7296:Zfp873 UTSW 10 81,897,071 (GRCm39) missense probably damaging 1.00
R7381:Zfp873 UTSW 10 81,896,805 (GRCm39) missense probably damaging 1.00
R7448:Zfp873 UTSW 10 81,896,461 (GRCm39) missense probably damaging 1.00
R7464:Zfp873 UTSW 10 81,896,210 (GRCm39) missense possibly damaging 0.51
R7470:Zfp873 UTSW 10 81,895,773 (GRCm39) missense probably benign 0.19
R7640:Zfp873 UTSW 10 81,896,109 (GRCm39) missense possibly damaging 0.72
R7862:Zfp873 UTSW 10 81,896,109 (GRCm39) missense probably benign 0.03
R8017:Zfp873 UTSW 10 81,896,193 (GRCm39) missense probably benign 0.01
R8301:Zfp873 UTSW 10 81,896,713 (GRCm39) missense probably damaging 1.00
R8765:Zfp873 UTSW 10 81,896,072 (GRCm39) missense probably damaging 1.00
R8997:Zfp873 UTSW 10 81,896,990 (GRCm39) missense probably benign 0.03
R9305:Zfp873 UTSW 10 81,896,514 (GRCm39) missense probably benign 0.00
R9462:Zfp873 UTSW 10 81,897,131 (GRCm39) missense probably benign 0.31
Z1177:Zfp873 UTSW 10 81,896,999 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCCTATGAGTGTAGTCAGTGC -3'
(R):5'- CATCCATAGGGCTTCTCTCCAG -3'

Sequencing Primer
(F):5'- GAAACCCTATGATTGCAGTGACTGTG -3'
(R):5'- CGAAGGCTTTTCCACACTGATTACAG -3'
Posted On 2016-12-15