Incidental Mutation 'R5811:Zfp873'
ID |
447523 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp873
|
Ensembl Gene |
ENSMUSG00000061371 |
Gene Name |
zinc finger protein 873 |
Synonyms |
|
MMRRC Submission |
043213-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.083)
|
Stock # |
R5811 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
10 |
Chromosomal Location |
81883957-81900579 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 81896567 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Cysteine to Serine
at position 470
(C470S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148219
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105313]
[ENSMUST00000209622]
[ENSMUST00000210325]
|
AlphaFold |
A0A1B0GT64 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000105313
AA Change: C433S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000100950 Gene: ENSMUSG00000061371 AA Change: C433S
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
68 |
90 |
1.12e2 |
SMART |
ZnF_C2H2
|
96 |
117 |
4.69e0 |
SMART |
ZnF_C2H2
|
123 |
145 |
2.06e1 |
SMART |
ZnF_C2H2
|
151 |
173 |
5.5e-3 |
SMART |
ZnF_C2H2
|
179 |
201 |
3.69e-4 |
SMART |
ZnF_C2H2
|
207 |
229 |
3.89e-3 |
SMART |
ZnF_C2H2
|
235 |
257 |
9.88e-5 |
SMART |
ZnF_C2H2
|
263 |
285 |
5.59e-4 |
SMART |
ZnF_C2H2
|
291 |
313 |
2.99e-4 |
SMART |
ZnF_C2H2
|
319 |
341 |
1.95e-3 |
SMART |
ZnF_C2H2
|
347 |
369 |
2.75e-3 |
SMART |
ZnF_C2H2
|
375 |
397 |
7.37e-4 |
SMART |
ZnF_C2H2
|
403 |
425 |
2.53e-2 |
SMART |
ZnF_C2H2
|
431 |
453 |
9.08e-4 |
SMART |
ZnF_C2H2
|
459 |
481 |
5.99e-4 |
SMART |
ZnF_C2H2
|
487 |
509 |
1.22e-4 |
SMART |
ZnF_C2H2
|
515 |
537 |
1.82e-3 |
SMART |
ZnF_C2H2
|
543 |
565 |
2.53e-2 |
SMART |
ZnF_C2H2
|
571 |
593 |
9.73e-4 |
SMART |
ZnF_C2H2
|
599 |
619 |
3.13e1 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209614
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000209622
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000210325
AA Change: C470S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211338
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219748
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.9%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Btnl1 |
A |
T |
17: 34,604,503 (GRCm39) |
K428M |
probably damaging |
Het |
Chid1 |
G |
A |
7: 141,110,166 (GRCm39) |
T53M |
probably damaging |
Het |
Clnk |
A |
G |
5: 38,870,490 (GRCm39) |
V356A |
probably damaging |
Het |
Cryba4 |
C |
T |
5: 112,398,937 (GRCm39) |
V36I |
probably benign |
Het |
Dct |
A |
G |
14: 118,250,600 (GRCm39) |
V466A |
probably benign |
Het |
Dnmt3l |
A |
G |
10: 77,887,929 (GRCm39) |
D146G |
possibly damaging |
Het |
Epas1 |
A |
G |
17: 87,131,203 (GRCm39) |
N328D |
probably damaging |
Het |
Fat4 |
C |
T |
3: 38,945,936 (GRCm39) |
R1610W |
probably damaging |
Het |
Filip1l |
T |
C |
16: 57,390,657 (GRCm39) |
V415A |
probably damaging |
Het |
Garnl3 |
A |
G |
2: 32,896,911 (GRCm39) |
L576P |
probably damaging |
Het |
Gjd3 |
A |
T |
11: 98,873,226 (GRCm39) |
V206E |
possibly damaging |
Het |
Gpr135 |
A |
T |
12: 72,116,641 (GRCm39) |
D375E |
possibly damaging |
Het |
Gsdme |
T |
A |
6: 50,222,925 (GRCm39) |
Q130L |
probably benign |
Het |
Hcls1 |
A |
G |
16: 36,777,702 (GRCm39) |
M274V |
probably null |
Het |
Kcnn4 |
T |
C |
7: 24,077,030 (GRCm39) |
V193A |
probably damaging |
Het |
Kctd16 |
T |
C |
18: 40,391,505 (GRCm39) |
V31A |
probably damaging |
Het |
Lamc2 |
C |
T |
1: 153,041,999 (GRCm39) |
R45Q |
possibly damaging |
Het |
Lrrc66 |
T |
A |
5: 73,772,860 (GRCm39) |
I203F |
possibly damaging |
Het |
Mark4 |
T |
C |
7: 19,182,564 (GRCm39) |
D91G |
probably damaging |
Het |
Mcm6 |
A |
T |
1: 128,263,465 (GRCm39) |
|
probably benign |
Het |
Mecom |
C |
T |
3: 30,015,149 (GRCm39) |
S602N |
probably benign |
Het |
Muc5ac |
T |
C |
7: 141,352,721 (GRCm39) |
V736A |
possibly damaging |
Het |
Nr2e3 |
TCCATCGGAGTGTTCCC |
TC |
9: 59,850,701 (GRCm39) |
|
probably benign |
Het |
Or2h2c |
C |
A |
17: 37,422,649 (GRCm39) |
C75F |
probably benign |
Het |
Pdia5 |
A |
T |
16: 35,269,790 (GRCm39) |
M173K |
possibly damaging |
Het |
Pih1d2 |
T |
C |
9: 50,532,374 (GRCm39) |
L144P |
probably damaging |
Het |
Plch2 |
C |
T |
4: 155,077,024 (GRCm39) |
E577K |
possibly damaging |
Het |
Samd4b |
T |
C |
7: 28,107,445 (GRCm39) |
S275G |
probably damaging |
Het |
Sap130 |
T |
C |
18: 31,822,495 (GRCm39) |
V668A |
probably benign |
Het |
Sema3c |
T |
A |
5: 17,880,188 (GRCm39) |
|
probably null |
Het |
Slc9a8 |
C |
T |
2: 167,313,307 (GRCm39) |
R390* |
probably null |
Het |
Vmn2r89 |
A |
T |
14: 51,693,565 (GRCm39) |
N305I |
probably benign |
Het |
Wdr33 |
T |
C |
18: 32,035,673 (GRCm39) |
F1164L |
unknown |
Het |
|
Other mutations in Zfp873 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02250:Zfp873
|
APN |
10 |
81,894,252 (GRCm39) |
start codon destroyed |
probably null |
0.45 |
G1Funyon:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
R0666:Zfp873
|
UTSW |
10 |
81,896,595 (GRCm39) |
missense |
possibly damaging |
0.75 |
R1568:Zfp873
|
UTSW |
10 |
81,896,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R1739:Zfp873
|
UTSW |
10 |
81,896,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R1848:Zfp873
|
UTSW |
10 |
81,896,406 (GRCm39) |
missense |
probably benign |
0.33 |
R1892:Zfp873
|
UTSW |
10 |
81,897,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R2061:Zfp873
|
UTSW |
10 |
81,895,991 (GRCm39) |
missense |
probably benign |
0.01 |
R3735:Zfp873
|
UTSW |
10 |
81,897,015 (GRCm39) |
missense |
probably benign |
0.15 |
R4422:Zfp873
|
UTSW |
10 |
81,896,708 (GRCm39) |
missense |
probably benign |
0.13 |
R4674:Zfp873
|
UTSW |
10 |
81,895,814 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4839:Zfp873
|
UTSW |
10 |
81,896,353 (GRCm39) |
missense |
probably damaging |
0.98 |
R5146:Zfp873
|
UTSW |
10 |
81,896,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R5154:Zfp873
|
UTSW |
10 |
81,896,025 (GRCm39) |
missense |
possibly damaging |
0.54 |
R5160:Zfp873
|
UTSW |
10 |
81,896,876 (GRCm39) |
missense |
possibly damaging |
0.54 |
R6625:Zfp873
|
UTSW |
10 |
81,896,138 (GRCm39) |
missense |
probably damaging |
1.00 |
R6667:Zfp873
|
UTSW |
10 |
81,896,423 (GRCm39) |
missense |
probably benign |
0.22 |
R6742:Zfp873
|
UTSW |
10 |
81,894,256 (GRCm39) |
missense |
probably damaging |
1.00 |
R6878:Zfp873
|
UTSW |
10 |
81,896,529 (GRCm39) |
missense |
probably benign |
0.33 |
R7055:Zfp873
|
UTSW |
10 |
81,895,832 (GRCm39) |
missense |
probably damaging |
1.00 |
R7296:Zfp873
|
UTSW |
10 |
81,897,071 (GRCm39) |
missense |
probably damaging |
1.00 |
R7381:Zfp873
|
UTSW |
10 |
81,896,805 (GRCm39) |
missense |
probably damaging |
1.00 |
R7448:Zfp873
|
UTSW |
10 |
81,896,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R7464:Zfp873
|
UTSW |
10 |
81,896,210 (GRCm39) |
missense |
possibly damaging |
0.51 |
R7470:Zfp873
|
UTSW |
10 |
81,895,773 (GRCm39) |
missense |
probably benign |
0.19 |
R7640:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7862:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
probably benign |
0.03 |
R8017:Zfp873
|
UTSW |
10 |
81,896,193 (GRCm39) |
missense |
probably benign |
0.01 |
R8301:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
R8765:Zfp873
|
UTSW |
10 |
81,896,072 (GRCm39) |
missense |
probably damaging |
1.00 |
R8997:Zfp873
|
UTSW |
10 |
81,896,990 (GRCm39) |
missense |
probably benign |
0.03 |
R9305:Zfp873
|
UTSW |
10 |
81,896,514 (GRCm39) |
missense |
probably benign |
0.00 |
R9462:Zfp873
|
UTSW |
10 |
81,897,131 (GRCm39) |
missense |
probably benign |
0.31 |
Z1177:Zfp873
|
UTSW |
10 |
81,896,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACCCTATGAGTGTAGTCAGTGC -3'
(R):5'- CATCCATAGGGCTTCTCTCCAG -3'
Sequencing Primer
(F):5'- GAAACCCTATGATTGCAGTGACTGTG -3'
(R):5'- CGAAGGCTTTTCCACACTGATTACAG -3'
|
Posted On |
2016-12-15 |