Incidental Mutation 'R5811:Vmn2r89'
ID 447526
Institutional Source Beutler Lab
Gene Symbol Vmn2r89
Ensembl Gene ENSMUSG00000070448
Gene Name vomeronasal 2, receptor 89
Synonyms V2r10, V2r11
MMRRC Submission 043213-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R5811 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 51689419-51698750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 51693565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 305 (N305I)
Ref Sequence ENSEMBL: ENSMUSP00000124256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159611] [ENSMUST00000159734] [ENSMUST00000161670] [ENSMUST00000162998]
AlphaFold O35199
Predicted Effect probably benign
Transcript: ENSMUST00000159611
AA Change: N305I

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000124065
Gene: ENSMUSG00000070448
AA Change: N305I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 449 4.8e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159734
AA Change: N305I

PolyPhen 2 Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000124256
Gene: ENSMUSG00000070448
AA Change: N305I

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 420 1.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161670
SMART Domains Protein: ENSMUSP00000124261
Gene: ENSMUSG00000070448

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162998
SMART Domains Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

DomainStartEndE-ValueType
Pfam:Takusan 35 115 2.2e-25 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Btnl1 A T 17: 34,604,503 (GRCm39) K428M probably damaging Het
Chid1 G A 7: 141,110,166 (GRCm39) T53M probably damaging Het
Clnk A G 5: 38,870,490 (GRCm39) V356A probably damaging Het
Cryba4 C T 5: 112,398,937 (GRCm39) V36I probably benign Het
Dct A G 14: 118,250,600 (GRCm39) V466A probably benign Het
Dnmt3l A G 10: 77,887,929 (GRCm39) D146G possibly damaging Het
Epas1 A G 17: 87,131,203 (GRCm39) N328D probably damaging Het
Fat4 C T 3: 38,945,936 (GRCm39) R1610W probably damaging Het
Filip1l T C 16: 57,390,657 (GRCm39) V415A probably damaging Het
Garnl3 A G 2: 32,896,911 (GRCm39) L576P probably damaging Het
Gjd3 A T 11: 98,873,226 (GRCm39) V206E possibly damaging Het
Gpr135 A T 12: 72,116,641 (GRCm39) D375E possibly damaging Het
Gsdme T A 6: 50,222,925 (GRCm39) Q130L probably benign Het
Hcls1 A G 16: 36,777,702 (GRCm39) M274V probably null Het
Kcnn4 T C 7: 24,077,030 (GRCm39) V193A probably damaging Het
Kctd16 T C 18: 40,391,505 (GRCm39) V31A probably damaging Het
Lamc2 C T 1: 153,041,999 (GRCm39) R45Q possibly damaging Het
Lrrc66 T A 5: 73,772,860 (GRCm39) I203F possibly damaging Het
Mark4 T C 7: 19,182,564 (GRCm39) D91G probably damaging Het
Mcm6 A T 1: 128,263,465 (GRCm39) probably benign Het
Mecom C T 3: 30,015,149 (GRCm39) S602N probably benign Het
Muc5ac T C 7: 141,352,721 (GRCm39) V736A possibly damaging Het
Nr2e3 TCCATCGGAGTGTTCCC TC 9: 59,850,701 (GRCm39) probably benign Het
Or2h2c C A 17: 37,422,649 (GRCm39) C75F probably benign Het
Pdia5 A T 16: 35,269,790 (GRCm39) M173K possibly damaging Het
Pih1d2 T C 9: 50,532,374 (GRCm39) L144P probably damaging Het
Plch2 C T 4: 155,077,024 (GRCm39) E577K possibly damaging Het
Samd4b T C 7: 28,107,445 (GRCm39) S275G probably damaging Het
Sap130 T C 18: 31,822,495 (GRCm39) V668A probably benign Het
Sema3c T A 5: 17,880,188 (GRCm39) probably null Het
Slc9a8 C T 2: 167,313,307 (GRCm39) R390* probably null Het
Wdr33 T C 18: 32,035,673 (GRCm39) F1164L unknown Het
Zfp873 T A 10: 81,896,567 (GRCm39) C470S probably damaging Het
Other mutations in Vmn2r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Vmn2r89 APN 14 51,692,422 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r89 APN 14 51,694,950 (GRCm39) missense probably benign
IGL00990:Vmn2r89 APN 14 51,693,428 (GRCm39) missense probably benign 0.14
IGL01991:Vmn2r89 APN 14 51,689,676 (GRCm39) missense probably benign 0.00
IGL03073:Vmn2r89 APN 14 51,693,528 (GRCm39) missense possibly damaging 0.95
IGL03085:Vmn2r89 APN 14 51,689,615 (GRCm39) missense probably damaging 0.99
IGL03278:Vmn2r89 APN 14 51,692,557 (GRCm39) missense probably damaging 0.99
R0115:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0127:Vmn2r89 UTSW 14 51,693,160 (GRCm39) missense probably damaging 0.98
R0391:Vmn2r89 UTSW 14 51,693,435 (GRCm39) missense probably damaging 0.99
R0481:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0538:Vmn2r89 UTSW 14 51,695,048 (GRCm39) splice site probably null
R1210:Vmn2r89 UTSW 14 51,692,427 (GRCm39) missense probably benign 0.01
R1332:Vmn2r89 UTSW 14 51,692,559 (GRCm39) missense probably benign 0.00
R1660:Vmn2r89 UTSW 14 51,693,693 (GRCm39) missense possibly damaging 0.48
R1959:Vmn2r89 UTSW 14 51,694,897 (GRCm39) missense probably benign 0.22
R2876:Vmn2r89 UTSW 14 51,692,541 (GRCm39) missense possibly damaging 0.47
R3410:Vmn2r89 UTSW 14 51,693,628 (GRCm39) missense probably damaging 0.98
R4026:Vmn2r89 UTSW 14 51,689,500 (GRCm39) start codon destroyed probably null 1.00
R4398:Vmn2r89 UTSW 14 51,689,551 (GRCm39) missense probably damaging 1.00
R4700:Vmn2r89 UTSW 14 51,694,942 (GRCm39) missense probably damaging 1.00
R4714:Vmn2r89 UTSW 14 51,689,688 (GRCm39) missense probably damaging 0.97
R5162:Vmn2r89 UTSW 14 51,693,620 (GRCm39) missense possibly damaging 0.88
R5294:Vmn2r89 UTSW 14 51,692,570 (GRCm39) missense probably benign 0.00
R6087:Vmn2r89 UTSW 14 51,695,033 (GRCm39) splice site probably null
R6229:Vmn2r89 UTSW 14 51,693,178 (GRCm39) missense probably benign 0.05
R6246:Vmn2r89 UTSW 14 51,693,503 (GRCm39) missense probably damaging 1.00
R6572:Vmn2r89 UTSW 14 51,693,450 (GRCm39) missense probably damaging 1.00
R7351:Vmn2r89 UTSW 14 51,693,739 (GRCm39) missense probably benign 0.30
R7683:Vmn2r89 UTSW 14 51,692,651 (GRCm39) missense probably benign
R7974:Vmn2r89 UTSW 14 51,693,459 (GRCm39) missense probably damaging 1.00
R8047:Vmn2r89 UTSW 14 51,692,549 (GRCm39) missense probably benign 0.05
R8093:Vmn2r89 UTSW 14 51,693,699 (GRCm39) missense probably benign 0.00
R8348:Vmn2r89 UTSW 14 51,692,548 (GRCm39) missense possibly damaging 0.90
R8723:Vmn2r89 UTSW 14 51,693,910 (GRCm39) missense probably benign
R8737:Vmn2r89 UTSW 14 51,693,722 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r89 UTSW 14 51,693,170 (GRCm39) missense probably benign
R9183:Vmn2r89 UTSW 14 51,692,501 (GRCm39) missense probably benign 0.01
R9197:Vmn2r89 UTSW 14 51,693,596 (GRCm39) missense possibly damaging 0.70
R9377:Vmn2r89 UTSW 14 51,692,601 (GRCm39) missense probably benign 0.02
R9395:Vmn2r89 UTSW 14 51,693,783 (GRCm39) missense probably damaging 1.00
R9452:Vmn2r89 UTSW 14 51,693,288 (GRCm39) missense probably damaging 0.99
R9457:Vmn2r89 UTSW 14 51,693,469 (GRCm39) missense probably damaging 0.99
R9678:Vmn2r89 UTSW 14 51,693,511 (GRCm39) missense probably benign 0.09
X0019:Vmn2r89 UTSW 14 51,693,872 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCAGATATACATGACAAGGGCTAC -3'
(R):5'- CAGTGCTGTCCATTCCAATGTG -3'

Sequencing Primer
(F):5'- TGACATCTTCAGCAAAGGT -3'
(R):5'- GATCCATTTTACTGCTGTTCTTAGAG -3'
Posted On 2016-12-15