Incidental Mutation 'R5813:Wdr64'
ID 447592
Institutional Source Beutler Lab
Gene Symbol Wdr64
Ensembl Gene ENSMUSG00000026523
Gene Name WD repeat domain 64
Synonyms 4930415O10Rik, 4930511H01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5813 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 175526159-175643300 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 175639623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 1031 (E1031K)
Ref Sequence ENSEMBL: ENSMUSP00000141740 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094288] [ENSMUST00000171939] [ENSMUST00000194087] [ENSMUST00000194783]
AlphaFold Q9D565
Predicted Effect possibly damaging
Transcript: ENSMUST00000094288
AA Change: E1041K

PolyPhen 2 Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091846
Gene: ENSMUSG00000026523
AA Change: E1041K

DomainStartEndE-ValueType
WD40 118 159 2.65e1 SMART
WD40 162 200 2.13e1 SMART
low complexity region 259 271 N/A INTRINSIC
Blast:WD40 277 316 5e-19 BLAST
WD40 323 361 2.4e-1 SMART
WD40 365 404 8.29e-1 SMART
WD40 407 449 1.7e2 SMART
WD40 457 493 1.19e1 SMART
WD40 497 538 4.55e-3 SMART
WD40 643 684 3.31e0 SMART
WD40 742 806 7.4e0 SMART
Blast:WD40 811 851 7e-17 BLAST
WD40 864 903 4.62e-4 SMART
Blast:XPGN 921 964 9e-19 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000171939
AA Change: E1031K

PolyPhen 2 Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000128678
Gene: ENSMUSG00000026523
AA Change: E1031K

DomainStartEndE-ValueType
WD40 151 190 5.73e0 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 306 4e-19 BLAST
WD40 313 351 2.4e-1 SMART
WD40 355 394 8.29e-1 SMART
WD40 397 439 1.7e2 SMART
WD40 447 483 1.19e1 SMART
WD40 487 528 4.55e-3 SMART
WD40 633 674 3.31e0 SMART
WD40 732 796 7.4e0 SMART
Blast:WD40 801 841 5e-17 BLAST
WD40 854 893 4.62e-4 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000194087
AA Change: E1031K

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141740
Gene: ENSMUSG00000026523
AA Change: E1031K

DomainStartEndE-ValueType
WD40 151 190 3.6e-2 SMART
low complexity region 249 261 N/A INTRINSIC
Blast:WD40 267 305 5e-19 BLAST
WD40 313 351 1.5e-3 SMART
WD40 355 394 5.2e-3 SMART
WD40 397 439 1.1e0 SMART
WD40 447 483 7.6e-2 SMART
WD40 487 528 2.9e-5 SMART
WD40 633 674 2.1e-2 SMART
WD40 732 796 4.7e-2 SMART
Blast:WD40 801 841 6e-17 BLAST
WD40 854 893 2.9e-6 SMART
Blast:XPGN 911 954 1e-18 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000194783
SMART Domains Protein: ENSMUSP00000141384
Gene: ENSMUSG00000026523

DomainStartEndE-ValueType
WD40 6 42 7.6e-2 SMART
WD40 46 87 2.9e-5 SMART
WD40 192 233 2.1e-2 SMART
WD40 291 355 4.7e-2 SMART
Blast:WD40 360 400 4e-17 BLAST
WD40 413 452 2.9e-6 SMART
Blast:XPGN 470 519 3e-19 BLAST
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam15 A G 3: 89,253,135 (GRCm39) Y230H probably benign Het
Ano7 G T 1: 93,312,641 (GRCm39) probably null Het
Arap2 T C 5: 62,834,506 (GRCm39) Y792C probably damaging Het
Art3 C A 5: 92,560,100 (GRCm39) probably benign Het
Atad2 C T 15: 57,963,250 (GRCm39) G1085D probably benign Het
Birc6 C A 17: 74,953,497 (GRCm39) A3253E probably damaging Het
C9 C T 15: 6,526,607 (GRCm39) P547L probably benign Het
Cecr2 T C 6: 120,739,169 (GRCm39) S1271P probably damaging Het
Ces1e T A 8: 93,948,305 (GRCm39) K105* probably null Het
Cpsf4 A G 5: 145,115,683 (GRCm39) N204S probably benign Het
Cracd A G 5: 77,006,275 (GRCm39) T879A unknown Het
Dgkz T C 2: 91,769,733 (GRCm39) D615G possibly damaging Het
Disp1 G T 1: 182,869,974 (GRCm39) N815K probably damaging Het
Enah A G 1: 181,758,750 (GRCm39) probably benign Het
Fcgbp A G 7: 27,800,919 (GRCm39) T1322A possibly damaging Het
Frem1 A G 4: 82,918,395 (GRCm39) F516L probably damaging Het
Fry G A 5: 150,323,136 (GRCm39) A1096T probably damaging Het
Fyco1 T C 9: 123,660,413 (GRCm39) Y190C probably damaging Het
Gfra1 T C 19: 58,227,687 (GRCm39) D417G probably benign Het
Gigyf2 T C 1: 87,368,485 (GRCm39) I1055T probably damaging Het
Invs A G 4: 48,398,146 (GRCm39) E444G probably damaging Het
Itga10 A G 3: 96,559,901 (GRCm39) T519A probably benign Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kdm2b A G 5: 123,009,931 (GRCm39) S727P probably benign Het
Kidins220 A T 12: 25,107,139 (GRCm39) K1531* probably null Het
Ksr1 C T 11: 78,929,024 (GRCm39) V266M probably damaging Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lipi T C 16: 75,370,798 (GRCm39) R140G possibly damaging Het
Lrrc32 T C 7: 98,147,618 (GRCm39) S133P probably damaging Het
Map3k7 T A 4: 31,964,318 (GRCm39) I19N probably damaging Het
Marf1 A G 16: 13,970,449 (GRCm39) V90A probably benign Het
Mark3 T C 12: 111,621,877 (GRCm39) L673P probably damaging Het
Meis1 T C 11: 18,966,229 (GRCm39) H48R probably benign Het
Mettl26 G A 17: 26,094,995 (GRCm39) V87M probably damaging Het
Mknk2 T C 10: 80,511,696 (GRCm39) R5G probably benign Het
Mtcl3 G T 10: 29,026,240 (GRCm39) V441F probably damaging Het
Mterf1b T C 5: 4,246,956 (GRCm39) V199A possibly damaging Het
Ncs1 T A 2: 31,170,666 (GRCm39) probably null Het
Nek10 T C 14: 14,986,704 (GRCm38) V1014A probably benign Het
Notch2 A G 3: 98,042,744 (GRCm39) N1370D probably benign Het
Nr2e3 TCCATCGGAGTGTTCCC TC 9: 59,850,701 (GRCm39) probably benign Het
Opn5 C G 17: 42,903,897 (GRCm39) R146T probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or5m3 T C 2: 85,838,636 (GRCm39) I172T probably damaging Het
Or8b55 T A 9: 38,726,952 (GRCm39) M51K probably benign Het
Or8g33 A G 9: 39,338,032 (GRCm39) C112R probably damaging Het
Pcdhb18 G A 18: 37,623,537 (GRCm39) R289Q probably benign Het
Pcyox1l C T 18: 61,832,359 (GRCm39) probably null Het
Plxnb2 T C 15: 89,044,962 (GRCm39) T1128A possibly damaging Het
Prex1 T C 2: 166,425,127 (GRCm39) T960A probably benign Het
Prkaa2 A C 4: 104,893,291 (GRCm39) *553G probably null Het
Rasgrp4 A G 7: 28,844,639 (GRCm39) D297G probably damaging Het
Sdf4 G A 4: 156,083,856 (GRCm39) V109I probably benign Het
Serpinb3d T C 1: 107,007,027 (GRCm39) K227R probably benign Het
Sgsm1 A T 5: 113,398,822 (GRCm39) I750N probably damaging Het
Shtn1 T A 19: 59,020,673 (GRCm39) K183M probably damaging Het
Skic3 A G 13: 76,303,852 (GRCm39) T1257A probably benign Het
Slc22a30 T C 19: 8,381,945 (GRCm39) T109A probably benign Het
Slco1c1 A G 6: 141,487,929 (GRCm39) D99G probably damaging Het
Tcf25 T A 8: 124,122,354 (GRCm39) probably null Het
Tex10 A G 4: 48,452,928 (GRCm39) V677A probably benign Het
Tmem131l A G 3: 83,847,879 (GRCm39) S329P probably benign Het
Trappc10 T A 10: 78,058,573 (GRCm39) N136I probably damaging Het
Trpt1 T C 19: 6,975,906 (GRCm39) F173L probably benign Het
Ube4b G A 4: 149,421,925 (GRCm39) R955C probably damaging Het
Usp34 C A 11: 23,371,340 (GRCm39) P1840T probably benign Het
Vmn1r27 A T 6: 58,192,985 (GRCm39) N6K possibly damaging Het
Wdr25 T C 12: 108,993,347 (GRCm39) V521A possibly damaging Het
Wnt10a A G 1: 74,839,755 (GRCm39) N147S probably damaging Het
Zbed5 T C 5: 129,931,059 (GRCm39) I336T possibly damaging Het
Zfp758 T A 17: 22,594,796 (GRCm39) H427Q probably damaging Het
Zfp961 C A 8: 72,722,070 (GRCm39) H194Q probably damaging Het
Other mutations in Wdr64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00563:Wdr64 APN 1 175,526,366 (GRCm39) missense probably benign 0.00
IGL00902:Wdr64 APN 1 175,556,391 (GRCm39) missense probably damaging 1.00
IGL01347:Wdr64 APN 1 175,547,899 (GRCm39) missense probably benign 0.12
IGL01353:Wdr64 APN 1 175,559,151 (GRCm39) missense probably damaging 0.96
IGL01583:Wdr64 APN 1 175,594,722 (GRCm39) critical splice donor site probably null
IGL01643:Wdr64 APN 1 175,599,877 (GRCm39) missense probably damaging 1.00
IGL01673:Wdr64 APN 1 175,627,922 (GRCm39) missense possibly damaging 0.68
IGL01992:Wdr64 APN 1 175,533,637 (GRCm39) missense probably damaging 1.00
IGL02613:Wdr64 APN 1 175,594,613 (GRCm39) nonsense probably null
IGL02834:Wdr64 APN 1 175,633,415 (GRCm39) splice site probably benign
IGL03214:Wdr64 APN 1 175,571,201 (GRCm39) splice site probably benign
IGL03305:Wdr64 APN 1 175,583,152 (GRCm39) missense possibly damaging 0.94
IGL03308:Wdr64 APN 1 175,594,562 (GRCm39) unclassified probably benign
PIT4418001:Wdr64 UTSW 1 175,571,160 (GRCm39) nonsense probably null
R0036:Wdr64 UTSW 1 175,556,496 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0041:Wdr64 UTSW 1 175,554,037 (GRCm39) nonsense probably null
R0079:Wdr64 UTSW 1 175,622,668 (GRCm39) missense probably benign 0.02
R0380:Wdr64 UTSW 1 175,597,208 (GRCm39) splice site probably benign
R0486:Wdr64 UTSW 1 175,622,769 (GRCm39) splice site probably benign
R0520:Wdr64 UTSW 1 175,553,958 (GRCm39) missense probably damaging 1.00
R0598:Wdr64 UTSW 1 175,633,465 (GRCm39) missense probably damaging 1.00
R0711:Wdr64 UTSW 1 175,599,751 (GRCm39) missense probably benign 0.39
R0746:Wdr64 UTSW 1 175,620,539 (GRCm39) missense possibly damaging 0.92
R0927:Wdr64 UTSW 1 175,620,647 (GRCm39) missense probably damaging 0.97
R0947:Wdr64 UTSW 1 175,603,315 (GRCm39) missense probably benign
R1014:Wdr64 UTSW 1 175,583,192 (GRCm39) missense probably damaging 1.00
R1332:Wdr64 UTSW 1 175,622,706 (GRCm39) missense possibly damaging 0.82
R1416:Wdr64 UTSW 1 175,633,568 (GRCm39) missense probably benign 0.01
R1421:Wdr64 UTSW 1 175,594,716 (GRCm39) missense possibly damaging 0.85
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1467:Wdr64 UTSW 1 175,603,288 (GRCm39) missense probably benign 0.00
R1796:Wdr64 UTSW 1 175,544,897 (GRCm39) missense probably damaging 1.00
R1797:Wdr64 UTSW 1 175,639,585 (GRCm39) missense probably damaging 1.00
R2145:Wdr64 UTSW 1 175,594,661 (GRCm39) missense probably benign 0.01
R2321:Wdr64 UTSW 1 175,622,653 (GRCm39) missense possibly damaging 0.57
R2449:Wdr64 UTSW 1 175,526,479 (GRCm39) missense probably benign
R4049:Wdr64 UTSW 1 175,633,422 (GRCm39) missense probably benign 0.21
R4155:Wdr64 UTSW 1 175,597,172 (GRCm39) missense probably benign 0.03
R4624:Wdr64 UTSW 1 175,599,829 (GRCm39) missense probably benign
R4661:Wdr64 UTSW 1 175,554,060 (GRCm39) missense probably damaging 1.00
R4711:Wdr64 UTSW 1 175,626,795 (GRCm39) missense probably damaging 1.00
R4891:Wdr64 UTSW 1 175,526,345 (GRCm39) unclassified probably benign
R4925:Wdr64 UTSW 1 175,552,268 (GRCm39) splice site probably null
R4943:Wdr64 UTSW 1 175,547,882 (GRCm39) missense probably benign 0.01
R5000:Wdr64 UTSW 1 175,553,941 (GRCm39) splice site probably null
R5001:Wdr64 UTSW 1 175,620,525 (GRCm39) critical splice acceptor site probably null
R5143:Wdr64 UTSW 1 175,553,979 (GRCm39) missense probably damaging 1.00
R5395:Wdr64 UTSW 1 175,583,164 (GRCm39) missense probably damaging 1.00
R6014:Wdr64 UTSW 1 175,633,556 (GRCm39) missense possibly damaging 0.56
R6417:Wdr64 UTSW 1 175,553,956 (GRCm39) missense probably damaging 1.00
R6456:Wdr64 UTSW 1 175,613,175 (GRCm39) critical splice donor site probably null
R6555:Wdr64 UTSW 1 175,547,856 (GRCm39) missense probably damaging 1.00
R6576:Wdr64 UTSW 1 175,633,494 (GRCm39) missense possibly damaging 0.82
R6797:Wdr64 UTSW 1 175,638,176 (GRCm39) critical splice donor site probably null
R6891:Wdr64 UTSW 1 175,533,634 (GRCm39) missense probably damaging 1.00
R6959:Wdr64 UTSW 1 175,533,555 (GRCm39) missense probably damaging 1.00
R7205:Wdr64 UTSW 1 175,617,499 (GRCm39) missense probably benign 0.34
R7252:Wdr64 UTSW 1 175,603,240 (GRCm39) missense probably benign 0.00
R7552:Wdr64 UTSW 1 175,613,147 (GRCm39) missense possibly damaging 0.71
R7732:Wdr64 UTSW 1 175,617,495 (GRCm39) missense probably benign
R7777:Wdr64 UTSW 1 175,617,564 (GRCm39) missense possibly damaging 0.71
R7780:Wdr64 UTSW 1 175,556,542 (GRCm39) missense probably damaging 1.00
R7810:Wdr64 UTSW 1 175,559,092 (GRCm39) missense probably benign 0.01
R7833:Wdr64 UTSW 1 175,591,511 (GRCm39) missense probably damaging 1.00
R7843:Wdr64 UTSW 1 175,639,668 (GRCm39) missense probably benign 0.00
R7887:Wdr64 UTSW 1 175,613,111 (GRCm39) missense not run
R7991:Wdr64 UTSW 1 175,554,051 (GRCm39) missense probably benign 0.36
R8124:Wdr64 UTSW 1 175,626,844 (GRCm39) splice site probably null
R8129:Wdr64 UTSW 1 175,603,154 (GRCm39) missense probably damaging 0.96
R8673:Wdr64 UTSW 1 175,633,584 (GRCm39) missense probably damaging 1.00
R8728:Wdr64 UTSW 1 175,559,079 (GRCm39) missense probably benign 0.01
R8786:Wdr64 UTSW 1 175,636,327 (GRCm39) nonsense probably null
R8822:Wdr64 UTSW 1 175,544,920 (GRCm39) missense probably damaging 1.00
R8842:Wdr64 UTSW 1 175,599,893 (GRCm39) missense probably benign 0.02
R8887:Wdr64 UTSW 1 175,599,850 (GRCm39) missense probably benign 0.17
R9014:Wdr64 UTSW 1 175,526,395 (GRCm39) missense probably benign
R9330:Wdr64 UTSW 1 175,554,024 (GRCm39) missense possibly damaging 0.93
R9332:Wdr64 UTSW 1 175,599,871 (GRCm39) missense possibly damaging 0.71
R9465:Wdr64 UTSW 1 175,618,823 (GRCm39) missense possibly damaging 0.53
R9716:Wdr64 UTSW 1 175,622,658 (GRCm39) missense probably benign
R9717:Wdr64 UTSW 1 175,544,854 (GRCm39) missense probably damaging 1.00
Z1088:Wdr64 UTSW 1 175,533,551 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- TGTGGAGTAAGGCCAGCTTG -3'
(R):5'- TCCCTTTCTATCCAACAGACATATGG -3'

Sequencing Primer
(F):5'- CAGTGGTTAAGAACATTTGCTGCTC -3'
(R):5'- AAGAGCACATTTTGTCTGTCTGTC -3'
Posted On 2016-12-15