Incidental Mutation 'R5813:Or8g33'
ID 447631
Institutional Source Beutler Lab
Gene Symbol Or8g33
Ensembl Gene ENSMUSG00000058856
Gene Name olfactory receptor family 8 subfamily G member 33
Synonyms GA_x6K02T2PVTD-33124064-33123120, MOR171-21, Olfr952
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R5813 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39337389-39338444 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39338032 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 112 (C112R)
Ref Sequence ENSEMBL: ENSMUSP00000073558 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073895]
AlphaFold Q8VFD7
Predicted Effect probably damaging
Transcript: ENSMUST00000073895
AA Change: C112R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073558
Gene: ENSMUSG00000058856
AA Change: C112R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.5e-42 PFAM
Pfam:7tm_1 41 294 3.2e-18 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam15 A G 3: 89,253,135 (GRCm39) Y230H probably benign Het
Ano7 G T 1: 93,312,641 (GRCm39) probably null Het
Arap2 T C 5: 62,834,506 (GRCm39) Y792C probably damaging Het
Art3 C A 5: 92,560,100 (GRCm39) probably benign Het
Atad2 C T 15: 57,963,250 (GRCm39) G1085D probably benign Het
Birc6 C A 17: 74,953,497 (GRCm39) A3253E probably damaging Het
C9 C T 15: 6,526,607 (GRCm39) P547L probably benign Het
Cecr2 T C 6: 120,739,169 (GRCm39) S1271P probably damaging Het
Ces1e T A 8: 93,948,305 (GRCm39) K105* probably null Het
Cpsf4 A G 5: 145,115,683 (GRCm39) N204S probably benign Het
Cracd A G 5: 77,006,275 (GRCm39) T879A unknown Het
Dgkz T C 2: 91,769,733 (GRCm39) D615G possibly damaging Het
Disp1 G T 1: 182,869,974 (GRCm39) N815K probably damaging Het
Enah A G 1: 181,758,750 (GRCm39) probably benign Het
Fcgbp A G 7: 27,800,919 (GRCm39) T1322A possibly damaging Het
Frem1 A G 4: 82,918,395 (GRCm39) F516L probably damaging Het
Fry G A 5: 150,323,136 (GRCm39) A1096T probably damaging Het
Fyco1 T C 9: 123,660,413 (GRCm39) Y190C probably damaging Het
Gfra1 T C 19: 58,227,687 (GRCm39) D417G probably benign Het
Gigyf2 T C 1: 87,368,485 (GRCm39) I1055T probably damaging Het
Invs A G 4: 48,398,146 (GRCm39) E444G probably damaging Het
Itga10 A G 3: 96,559,901 (GRCm39) T519A probably benign Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kdm2b A G 5: 123,009,931 (GRCm39) S727P probably benign Het
Kidins220 A T 12: 25,107,139 (GRCm39) K1531* probably null Het
Ksr1 C T 11: 78,929,024 (GRCm39) V266M probably damaging Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lipi T C 16: 75,370,798 (GRCm39) R140G possibly damaging Het
Lrrc32 T C 7: 98,147,618 (GRCm39) S133P probably damaging Het
Map3k7 T A 4: 31,964,318 (GRCm39) I19N probably damaging Het
Marf1 A G 16: 13,970,449 (GRCm39) V90A probably benign Het
Mark3 T C 12: 111,621,877 (GRCm39) L673P probably damaging Het
Meis1 T C 11: 18,966,229 (GRCm39) H48R probably benign Het
Mettl26 G A 17: 26,094,995 (GRCm39) V87M probably damaging Het
Mknk2 T C 10: 80,511,696 (GRCm39) R5G probably benign Het
Mtcl3 G T 10: 29,026,240 (GRCm39) V441F probably damaging Het
Mterf1b T C 5: 4,246,956 (GRCm39) V199A possibly damaging Het
Ncs1 T A 2: 31,170,666 (GRCm39) probably null Het
Nek10 T C 14: 14,986,704 (GRCm38) V1014A probably benign Het
Notch2 A G 3: 98,042,744 (GRCm39) N1370D probably benign Het
Nr2e3 TCCATCGGAGTGTTCCC TC 9: 59,850,701 (GRCm39) probably benign Het
Opn5 C G 17: 42,903,897 (GRCm39) R146T probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or5m3 T C 2: 85,838,636 (GRCm39) I172T probably damaging Het
Or8b55 T A 9: 38,726,952 (GRCm39) M51K probably benign Het
Pcdhb18 G A 18: 37,623,537 (GRCm39) R289Q probably benign Het
Pcyox1l C T 18: 61,832,359 (GRCm39) probably null Het
Plxnb2 T C 15: 89,044,962 (GRCm39) T1128A possibly damaging Het
Prex1 T C 2: 166,425,127 (GRCm39) T960A probably benign Het
Prkaa2 A C 4: 104,893,291 (GRCm39) *553G probably null Het
Rasgrp4 A G 7: 28,844,639 (GRCm39) D297G probably damaging Het
Sdf4 G A 4: 156,083,856 (GRCm39) V109I probably benign Het
Serpinb3d T C 1: 107,007,027 (GRCm39) K227R probably benign Het
Sgsm1 A T 5: 113,398,822 (GRCm39) I750N probably damaging Het
Shtn1 T A 19: 59,020,673 (GRCm39) K183M probably damaging Het
Skic3 A G 13: 76,303,852 (GRCm39) T1257A probably benign Het
Slc22a30 T C 19: 8,381,945 (GRCm39) T109A probably benign Het
Slco1c1 A G 6: 141,487,929 (GRCm39) D99G probably damaging Het
Tcf25 T A 8: 124,122,354 (GRCm39) probably null Het
Tex10 A G 4: 48,452,928 (GRCm39) V677A probably benign Het
Tmem131l A G 3: 83,847,879 (GRCm39) S329P probably benign Het
Trappc10 T A 10: 78,058,573 (GRCm39) N136I probably damaging Het
Trpt1 T C 19: 6,975,906 (GRCm39) F173L probably benign Het
Ube4b G A 4: 149,421,925 (GRCm39) R955C probably damaging Het
Usp34 C A 11: 23,371,340 (GRCm39) P1840T probably benign Het
Vmn1r27 A T 6: 58,192,985 (GRCm39) N6K possibly damaging Het
Wdr25 T C 12: 108,993,347 (GRCm39) V521A possibly damaging Het
Wdr64 G A 1: 175,639,623 (GRCm39) E1031K possibly damaging Het
Wnt10a A G 1: 74,839,755 (GRCm39) N147S probably damaging Het
Zbed5 T C 5: 129,931,059 (GRCm39) I336T possibly damaging Het
Zfp758 T A 17: 22,594,796 (GRCm39) H427Q probably damaging Het
Zfp961 C A 8: 72,722,070 (GRCm39) H194Q probably damaging Het
Other mutations in Or8g33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00976:Or8g33 APN 9 39,337,953 (GRCm39) missense probably benign 0.02
IGL01368:Or8g33 APN 9 39,337,476 (GRCm39) missense probably damaging 1.00
IGL01866:Or8g33 APN 9 39,338,025 (GRCm39) missense probably damaging 0.99
IGL01939:Or8g33 APN 9 39,337,634 (GRCm39) missense probably damaging 1.00
IGL03048:Or8g33 UTSW 9 39,338,065 (GRCm39) missense probably benign 0.00
R0069:Or8g33 UTSW 9 39,338,188 (GRCm39) missense probably damaging 0.98
R1460:Or8g33 UTSW 9 39,337,503 (GRCm39) missense probably benign 0.43
R1478:Or8g33 UTSW 9 39,337,888 (GRCm39) missense possibly damaging 0.91
R1737:Or8g33 UTSW 9 39,338,254 (GRCm39) missense probably damaging 0.99
R2112:Or8g33 UTSW 9 39,337,966 (GRCm39) missense probably benign 0.26
R2169:Or8g33 UTSW 9 39,337,654 (GRCm39) missense possibly damaging 0.95
R2225:Or8g33 UTSW 9 39,337,915 (GRCm39) missense probably benign 0.00
R3731:Or8g33 UTSW 9 39,338,365 (GRCm39) start codon destroyed probably benign 0.23
R3777:Or8g33 UTSW 9 39,337,901 (GRCm39) missense possibly damaging 0.75
R3802:Or8g33 UTSW 9 39,337,582 (GRCm39) missense probably damaging 1.00
R4600:Or8g33 UTSW 9 39,337,731 (GRCm39) missense probably benign 0.27
R4887:Or8g33 UTSW 9 39,337,531 (GRCm39) missense possibly damaging 0.80
R5215:Or8g33 UTSW 9 39,337,919 (GRCm39) nonsense probably null
R6140:Or8g33 UTSW 9 39,337,543 (GRCm39) missense possibly damaging 0.91
R6180:Or8g33 UTSW 9 39,338,008 (GRCm39) missense probably damaging 1.00
R6383:Or8g33 UTSW 9 39,337,530 (GRCm39) missense probably damaging 1.00
R6416:Or8g33 UTSW 9 39,338,187 (GRCm39) missense probably damaging 0.98
R6808:Or8g33 UTSW 9 39,337,836 (GRCm39) missense probably damaging 0.99
R7099:Or8g33 UTSW 9 39,337,599 (GRCm39) missense probably benign 0.01
R7826:Or8g33 UTSW 9 39,337,423 (GRCm39) makesense probably null
R8309:Or8g33 UTSW 9 39,337,966 (GRCm39) missense probably benign 0.40
R8870:Or8g33 UTSW 9 39,337,548 (GRCm39) missense probably damaging 0.97
R8879:Or8g33 UTSW 9 39,337,515 (GRCm39) missense possibly damaging 0.86
R9084:Or8g33 UTSW 9 39,337,521 (GRCm39) missense probably damaging 1.00
R9209:Or8g33 UTSW 9 39,337,635 (GRCm39) missense probably damaging 0.99
R9435:Or8g33 UTSW 9 39,337,506 (GRCm39) missense probably benign
R9583:Or8g33 UTSW 9 39,337,851 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CAATGATGGTCATGGCTGGTAC -3'
(R):5'- AGTTCTCAGCTACATACACCTATG -3'

Sequencing Primer
(F):5'- CAGCTCAAGTAATGGGAAAAGATCAC -3'
(R):5'- GTATTATTTACTCAGCAGTCTGTCC -3'
Posted On 2016-12-15