Incidental Mutation 'R5782:Zfp267'
ID 447778
Institutional Source Beutler Lab
Gene Symbol Zfp267
Ensembl Gene ENSMUSG00000033883
Gene Name zinc finger protein 267
Synonyms D3Ertd254e
MMRRC Submission 043379-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R5782 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 36205233-36224491 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36219128 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 384 (S384P)
Ref Sequence ENSEMBL: ENSMUSP00000142829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165956] [ENSMUST00000197653] [ENSMUST00000205077]
AlphaFold A0A0G2JEM5
Predicted Effect possibly damaging
Transcript: ENSMUST00000165956
AA Change: S383P

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: S383P

DomainStartEndE-ValueType
KRAB 3 63 2.91e-34 SMART
ZnF_C2H2 342 364 1.08e-1 SMART
ZnF_C2H2 395 417 1.56e-2 SMART
ZnF_C2H2 423 445 3.11e-2 SMART
ZnF_C2H2 451 473 5.9e-3 SMART
ZnF_C2H2 479 501 1.82e-3 SMART
ZnF_C2H2 507 529 5.21e-4 SMART
ZnF_C2H2 535 557 1.84e-4 SMART
ZnF_C2H2 563 585 1.95e-3 SMART
ZnF_C2H2 591 613 2.05e-2 SMART
ZnF_C2H2 619 641 1.6e-4 SMART
ZnF_C2H2 647 669 5.21e-4 SMART
ZnF_C2H2 675 697 1.69e-3 SMART
ZnF_C2H2 703 725 2.61e-4 SMART
ZnF_C2H2 731 753 1.12e-3 SMART
ZnF_C2H2 759 779 3.85e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000197653
AA Change: S384P

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: S384P

DomainStartEndE-ValueType
KRAB 4 64 1.2e-36 SMART
ZnF_C2H2 343 365 4.4e-4 SMART
ZnF_C2H2 396 418 6.7e-5 SMART
ZnF_C2H2 424 446 1.3e-4 SMART
ZnF_C2H2 452 474 2.5e-5 SMART
ZnF_C2H2 480 502 7.9e-6 SMART
ZnF_C2H2 508 530 2.2e-6 SMART
ZnF_C2H2 536 558 7.7e-7 SMART
ZnF_C2H2 564 586 8e-6 SMART
ZnF_C2H2 592 614 8.9e-5 SMART
ZnF_C2H2 620 642 6.6e-7 SMART
ZnF_C2H2 648 670 2.2e-6 SMART
ZnF_C2H2 676 698 7.1e-6 SMART
ZnF_C2H2 704 726 1.1e-6 SMART
ZnF_C2H2 732 754 4.8e-6 SMART
ZnF_C2H2 760 780 1.6e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205077
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl9 A T 17: 33,652,735 (GRCm39) Q265L probably benign Het
Adamtsl3 T A 7: 82,189,494 (GRCm39) probably null Het
Agt A T 8: 125,283,870 (GRCm39) probably null Het
Ankrd11 A G 8: 123,626,756 (GRCm39) L142P probably damaging Het
Arhgef19 C A 4: 140,983,623 (GRCm39) Q719K probably damaging Het
Armh3 A G 19: 45,874,466 (GRCm39) V569A probably benign Het
Atrnl1 G T 19: 57,741,718 (GRCm39) W1159L possibly damaging Het
Atxn2 T C 5: 121,935,373 (GRCm39) Y325H probably damaging Het
Brwd1 A T 16: 95,844,243 (GRCm39) Y770* probably null Het
Cdc20 T C 4: 118,290,239 (GRCm39) E474G probably benign Het
Cdk5rap3 A G 11: 96,802,412 (GRCm39) L254P probably benign Het
Cep83 A T 10: 94,584,894 (GRCm39) N333I probably damaging Het
Cox4i2 A C 2: 152,606,731 (GRCm39) D150A probably damaging Het
Cse1l A G 2: 166,770,921 (GRCm39) I314M probably damaging Het
Cuedc1 A G 11: 88,060,858 (GRCm39) Y67C probably damaging Het
Cyp2j9 C T 4: 96,462,142 (GRCm39) V380I probably benign Het
Fancd2 A G 6: 113,525,833 (GRCm39) N302S probably benign Het
Foxa1 T A 12: 57,589,302 (GRCm39) H306L probably benign Het
Gse1 T C 8: 121,293,260 (GRCm39) S204P probably damaging Het
Hspa13 C A 16: 75,554,985 (GRCm39) R367L probably damaging Het
Kcnk2 T G 1: 188,988,776 (GRCm39) D267A probably damaging Het
Kctd18 A G 1: 57,998,396 (GRCm39) Y68H probably damaging Het
Khdc4 T G 3: 88,618,985 (GRCm39) V563G probably damaging Het
Klf7 C T 1: 64,081,570 (GRCm39) E253K possibly damaging Het
Lcn12 A T 2: 25,383,769 (GRCm39) F34I probably damaging Het
Lrrk2 A T 15: 91,586,386 (GRCm39) R401W probably damaging Het
Lzts1 A T 8: 69,593,350 (GRCm39) S86T probably benign Het
Mtres1 T C 10: 43,408,899 (GRCm39) I81M probably benign Het
Mtus1 T A 8: 41,535,764 (GRCm39) I651F probably damaging Het
Myl2 T A 5: 122,242,933 (GRCm39) F106L probably damaging Het
Neb T A 2: 52,154,059 (GRCm39) K2351* probably null Het
Or14c45 T A 7: 86,176,421 (GRCm39) I152N probably damaging Het
Or52e5 T C 7: 104,718,956 (GRCm39) I94T probably damaging Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Parg A T 14: 31,996,862 (GRCm39) R318* probably null Het
Pcdhga3 C T 18: 37,809,353 (GRCm39) S602F possibly damaging Het
Pcnx2 A G 8: 126,480,223 (GRCm39) V2028A probably damaging Het
Pkhd1 T C 1: 20,128,824 (GRCm39) T3960A probably benign Het
Psen1 T A 12: 83,759,233 (GRCm39) H81Q possibly damaging Het
Psma6 A G 12: 55,457,041 (GRCm39) N109S possibly damaging Het
Ptpro A T 6: 137,376,496 (GRCm39) I659F possibly damaging Het
Rap1gds1 C G 3: 138,664,840 (GRCm39) E288D possibly damaging Het
Reln C T 5: 22,223,054 (GRCm39) R993K probably benign Het
Saxo1 T A 4: 86,364,044 (GRCm39) L146F probably damaging Het
Six4 A G 12: 73,150,832 (GRCm39) V571A probably benign Het
Slc2a10 C A 2: 165,356,758 (GRCm39) Y139* probably null Het
Slc34a1 A G 13: 55,550,501 (GRCm39) I66V possibly damaging Het
Slfn8 G T 11: 82,907,867 (GRCm39) N46K probably damaging Het
Smc6 G C 12: 11,340,835 (GRCm39) A496P probably damaging Het
Stk31 T G 6: 49,446,070 (GRCm39) N902K probably benign Het
Stk36 T A 1: 74,644,584 (GRCm39) Y114N possibly damaging Het
Sult2b1 C T 7: 45,380,770 (GRCm39) V271M probably damaging Het
Tenm4 A G 7: 96,542,246 (GRCm39) I1920V probably benign Het
Trbc2 A G 6: 41,523,871 (GRCm39) probably benign Het
Trpc2 A G 7: 101,733,186 (GRCm39) D419G possibly damaging Het
Trpm7 T C 2: 126,639,634 (GRCm39) N1654S probably benign Het
Tsku A T 7: 98,002,057 (GRCm39) D91E probably damaging Het
Ttn T A 2: 76,606,355 (GRCm39) R18151S probably damaging Het
Tyr C T 7: 87,142,224 (GRCm39) C112Y probably damaging Het
Ubash3a G A 17: 31,454,477 (GRCm39) G435S probably benign Het
Vav1 T C 17: 57,603,001 (GRCm39) I51T probably damaging Het
Vmn2r61 T A 7: 41,949,253 (GRCm39) C558S probably damaging Het
Zan C T 5: 137,418,269 (GRCm39) C2943Y unknown Het
Zfp1002 T C 2: 150,097,438 (GRCm39) E25G probably benign Het
Zfp318 TGAAGAAGAAGAAGAAGAAGAAGAAGAAG TGAAGAAGAAGAAGAAGAAGAAG 17: 46,723,440 (GRCm39) probably benign Het
Zfp575 C A 7: 24,285,027 (GRCm39) G205C possibly damaging Het
Zfp740 G T 15: 102,116,801 (GRCm39) probably benign Het
Zzz3 A G 3: 152,133,737 (GRCm39) E265G possibly damaging Het
Other mutations in Zfp267
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Zfp267 APN 3 36,218,729 (GRCm39) missense possibly damaging 0.86
IGL02089:Zfp267 APN 3 36,218,877 (GRCm39) missense possibly damaging 0.53
IGL02162:Zfp267 APN 3 36,218,210 (GRCm39) missense probably benign 0.18
R0243:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R0512:Zfp267 UTSW 3 36,220,262 (GRCm39) missense probably damaging 0.96
R0722:Zfp267 UTSW 3 36,219,218 (GRCm39) missense probably benign 0.35
R0762:Zfp267 UTSW 3 36,220,016 (GRCm39) missense possibly damaging 0.92
R0792:Zfp267 UTSW 3 36,218,711 (GRCm39) missense probably benign 0.01
R0894:Zfp267 UTSW 3 36,218,935 (GRCm39) nonsense probably null
R1731:Zfp267 UTSW 3 36,218,620 (GRCm39) missense probably benign 0.18
R2098:Zfp267 UTSW 3 36,220,289 (GRCm39) missense probably benign
R2099:Zfp267 UTSW 3 36,218,361 (GRCm39) missense possibly damaging 0.86
R3709:Zfp267 UTSW 3 36,213,725 (GRCm39) missense possibly damaging 0.71
R3808:Zfp267 UTSW 3 36,219,792 (GRCm39) splice site probably null
R4035:Zfp267 UTSW 3 36,218,989 (GRCm39) missense possibly damaging 0.53
R4288:Zfp267 UTSW 3 36,213,747 (GRCm39) missense possibly damaging 0.71
R4289:Zfp267 UTSW 3 36,213,747 (GRCm39) missense possibly damaging 0.71
R4959:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R4973:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R5102:Zfp267 UTSW 3 36,216,814 (GRCm39) missense possibly damaging 0.73
R5462:Zfp267 UTSW 3 36,219,969 (GRCm39) missense possibly damaging 0.95
R5548:Zfp267 UTSW 3 36,219,640 (GRCm39) missense possibly damaging 0.90
R6153:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R6225:Zfp267 UTSW 3 36,220,352 (GRCm39) missense probably benign 0.18
R6602:Zfp267 UTSW 3 36,219,004 (GRCm39) missense possibly damaging 0.86
R6785:Zfp267 UTSW 3 36,219,601 (GRCm39) nonsense probably null
R7513:Zfp267 UTSW 3 36,218,792 (GRCm39) missense possibly damaging 0.53
R7846:Zfp267 UTSW 3 36,219,738 (GRCm39) missense probably benign 0.43
R8120:Zfp267 UTSW 3 36,218,640 (GRCm39) missense possibly damaging 0.96
R8265:Zfp267 UTSW 3 36,213,677 (GRCm39) start gained probably benign
R8415:Zfp267 UTSW 3 36,219,182 (GRCm39) missense probably damaging 0.98
R8826:Zfp267 UTSW 3 36,218,255 (GRCm39) missense possibly damaging 0.86
R9026:Zfp267 UTSW 3 36,219,066 (GRCm39) missense possibly damaging 0.96
R9159:Zfp267 UTSW 3 36,219,902 (GRCm39) missense possibly damaging 0.47
R9786:Zfp267 UTSW 3 36,219,853 (GRCm39) nonsense probably null
X0021:Zfp267 UTSW 3 36,218,340 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- ATCTTCAGGACGTGTATATCGG -3'
(R):5'- CTGAGTAACAGTCGATCTTTGATTG -3'

Sequencing Primer
(F):5'- CTTCAGGACGTGTATATCGGAGAGAC -3'
(R):5'- TACAGCAGTAGGGTTTCTTTCCAGC -3'
Posted On 2016-12-15