Incidental Mutation 'R5782:Brwd1'
| ID |
447830 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| MMRRC Submission |
043379-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5782 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 95844243 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 770
(Y770*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117066
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
[ENSMUST00000113829]
[ENSMUST00000124370]
[ENSMUST00000131322]
[ENSMUST00000153398]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000023631
AA Change: Y770*
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: Y770*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000099502
AA Change: Y770*
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: Y770*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000113829
AA Change: Y770*
|
| SMART Domains |
Protein: ENSMUSP00000109460
Gene: ENSMUSG00000022914
AA Change: Y770*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.13e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.13e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2177 |
2188 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000124370
AA Change: Y493*
|
| SMART Domains |
Protein: ENSMUSP00000118423
Gene: ENSMUSG00000022914
AA Change: Y493*
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
34 |
75 |
3.82e1 |
SMART |
|
WD40
|
80 |
119 |
4.27e-8 |
SMART |
|
WD40
|
140 |
177 |
8.59e-1 |
SMART |
|
WD40
|
180 |
220 |
1.47e-6 |
SMART |
|
WD40
|
227 |
267 |
9.21e0 |
SMART |
|
low complexity region
|
383 |
399 |
N/A |
INTRINSIC |
|
low complexity region
|
476 |
490 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
547 |
N/A |
INTRINSIC |
|
low complexity region
|
585 |
602 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126629
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000131322
AA Change: Y217*
|
| SMART Domains |
Protein: ENSMUSP00000118327
Gene: ENSMUSG00000022914
AA Change: Y217*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
299 |
315 |
N/A |
INTRINSIC |
|
low complexity region
|
353 |
374 |
N/A |
INTRINSIC |
|
Blast:BROMO
|
496 |
582 |
4e-37 |
BLAST |
|
Blast:BROMO
|
603 |
627 |
5e-8 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146222
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000153398
AA Change: Y770*
|
| SMART Domains |
Protein: ENSMUSP00000117066
Gene: ENSMUSG00000022914
AA Change: Y770*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
internal_repeat_1
|
1491 |
1957 |
1.45e-251 |
PROSPERO |
|
internal_repeat_1
|
1956 |
2422 |
1.45e-251 |
PROSPERO |
|
low complexity region
|
2630 |
2639 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184285
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actl9 |
A |
T |
17: 33,652,735 (GRCm39) |
Q265L |
probably benign |
Het |
| Adamtsl3 |
T |
A |
7: 82,189,494 (GRCm39) |
|
probably null |
Het |
| Agt |
A |
T |
8: 125,283,870 (GRCm39) |
|
probably null |
Het |
| Ankrd11 |
A |
G |
8: 123,626,756 (GRCm39) |
L142P |
probably damaging |
Het |
| Arhgef19 |
C |
A |
4: 140,983,623 (GRCm39) |
Q719K |
probably damaging |
Het |
| Armh3 |
A |
G |
19: 45,874,466 (GRCm39) |
V569A |
probably benign |
Het |
| Atrnl1 |
G |
T |
19: 57,741,718 (GRCm39) |
W1159L |
possibly damaging |
Het |
| Atxn2 |
T |
C |
5: 121,935,373 (GRCm39) |
Y325H |
probably damaging |
Het |
| Cdc20 |
T |
C |
4: 118,290,239 (GRCm39) |
E474G |
probably benign |
Het |
| Cdk5rap3 |
A |
G |
11: 96,802,412 (GRCm39) |
L254P |
probably benign |
Het |
| Cep83 |
A |
T |
10: 94,584,894 (GRCm39) |
N333I |
probably damaging |
Het |
| Cox4i2 |
A |
C |
2: 152,606,731 (GRCm39) |
D150A |
probably damaging |
Het |
| Cse1l |
A |
G |
2: 166,770,921 (GRCm39) |
I314M |
probably damaging |
Het |
| Cuedc1 |
A |
G |
11: 88,060,858 (GRCm39) |
Y67C |
probably damaging |
Het |
| Cyp2j9 |
C |
T |
4: 96,462,142 (GRCm39) |
V380I |
probably benign |
Het |
| Fancd2 |
A |
G |
6: 113,525,833 (GRCm39) |
N302S |
probably benign |
Het |
| Foxa1 |
T |
A |
12: 57,589,302 (GRCm39) |
H306L |
probably benign |
Het |
| Gse1 |
T |
C |
8: 121,293,260 (GRCm39) |
S204P |
probably damaging |
Het |
| Hspa13 |
C |
A |
16: 75,554,985 (GRCm39) |
R367L |
probably damaging |
Het |
| Kcnk2 |
T |
G |
1: 188,988,776 (GRCm39) |
D267A |
probably damaging |
Het |
| Kctd18 |
A |
G |
1: 57,998,396 (GRCm39) |
Y68H |
probably damaging |
Het |
| Khdc4 |
T |
G |
3: 88,618,985 (GRCm39) |
V563G |
probably damaging |
Het |
| Klf7 |
C |
T |
1: 64,081,570 (GRCm39) |
E253K |
possibly damaging |
Het |
| Lcn12 |
A |
T |
2: 25,383,769 (GRCm39) |
F34I |
probably damaging |
Het |
| Lrrk2 |
A |
T |
15: 91,586,386 (GRCm39) |
R401W |
probably damaging |
Het |
| Lzts1 |
A |
T |
8: 69,593,350 (GRCm39) |
S86T |
probably benign |
Het |
| Mtres1 |
T |
C |
10: 43,408,899 (GRCm39) |
I81M |
probably benign |
Het |
| Mtus1 |
T |
A |
8: 41,535,764 (GRCm39) |
I651F |
probably damaging |
Het |
| Myl2 |
T |
A |
5: 122,242,933 (GRCm39) |
F106L |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,154,059 (GRCm39) |
K2351* |
probably null |
Het |
| Or14c45 |
T |
A |
7: 86,176,421 (GRCm39) |
I152N |
probably damaging |
Het |
| Or52e5 |
T |
C |
7: 104,718,956 (GRCm39) |
I94T |
probably damaging |
Het |
| Otogl |
G |
A |
10: 107,612,978 (GRCm39) |
|
silent |
Het |
| Parg |
A |
T |
14: 31,996,862 (GRCm39) |
R318* |
probably null |
Het |
| Pcdhga3 |
C |
T |
18: 37,809,353 (GRCm39) |
S602F |
possibly damaging |
Het |
| Pcnx2 |
A |
G |
8: 126,480,223 (GRCm39) |
V2028A |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,128,824 (GRCm39) |
T3960A |
probably benign |
Het |
| Psen1 |
T |
A |
12: 83,759,233 (GRCm39) |
H81Q |
possibly damaging |
Het |
| Psma6 |
A |
G |
12: 55,457,041 (GRCm39) |
N109S |
possibly damaging |
Het |
| Ptpro |
A |
T |
6: 137,376,496 (GRCm39) |
I659F |
possibly damaging |
Het |
| Rap1gds1 |
C |
G |
3: 138,664,840 (GRCm39) |
E288D |
possibly damaging |
Het |
| Reln |
C |
T |
5: 22,223,054 (GRCm39) |
R993K |
probably benign |
Het |
| Saxo1 |
T |
A |
4: 86,364,044 (GRCm39) |
L146F |
probably damaging |
Het |
| Six4 |
A |
G |
12: 73,150,832 (GRCm39) |
V571A |
probably benign |
Het |
| Slc2a10 |
C |
A |
2: 165,356,758 (GRCm39) |
Y139* |
probably null |
Het |
| Slc34a1 |
A |
G |
13: 55,550,501 (GRCm39) |
I66V |
possibly damaging |
Het |
| Slfn8 |
G |
T |
11: 82,907,867 (GRCm39) |
N46K |
probably damaging |
Het |
| Smc6 |
G |
C |
12: 11,340,835 (GRCm39) |
A496P |
probably damaging |
Het |
| Stk31 |
T |
G |
6: 49,446,070 (GRCm39) |
N902K |
probably benign |
Het |
| Stk36 |
T |
A |
1: 74,644,584 (GRCm39) |
Y114N |
possibly damaging |
Het |
| Sult2b1 |
C |
T |
7: 45,380,770 (GRCm39) |
V271M |
probably damaging |
Het |
| Tenm4 |
A |
G |
7: 96,542,246 (GRCm39) |
I1920V |
probably benign |
Het |
| Trbc2 |
A |
G |
6: 41,523,871 (GRCm39) |
|
probably benign |
Het |
| Trpc2 |
A |
G |
7: 101,733,186 (GRCm39) |
D419G |
possibly damaging |
Het |
| Trpm7 |
T |
C |
2: 126,639,634 (GRCm39) |
N1654S |
probably benign |
Het |
| Tsku |
A |
T |
7: 98,002,057 (GRCm39) |
D91E |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,606,355 (GRCm39) |
R18151S |
probably damaging |
Het |
| Tyr |
C |
T |
7: 87,142,224 (GRCm39) |
C112Y |
probably damaging |
Het |
| Ubash3a |
G |
A |
17: 31,454,477 (GRCm39) |
G435S |
probably benign |
Het |
| Vav1 |
T |
C |
17: 57,603,001 (GRCm39) |
I51T |
probably damaging |
Het |
| Vmn2r61 |
T |
A |
7: 41,949,253 (GRCm39) |
C558S |
probably damaging |
Het |
| Zan |
C |
T |
5: 137,418,269 (GRCm39) |
C2943Y |
unknown |
Het |
| Zfp1002 |
T |
C |
2: 150,097,438 (GRCm39) |
E25G |
probably benign |
Het |
| Zfp267 |
T |
C |
3: 36,219,128 (GRCm39) |
S384P |
possibly damaging |
Het |
| Zfp318 |
TGAAGAAGAAGAAGAAGAAGAAGAAGAAG |
TGAAGAAGAAGAAGAAGAAGAAG |
17: 46,723,440 (GRCm39) |
|
probably benign |
Het |
| Zfp575 |
C |
A |
7: 24,285,027 (GRCm39) |
G205C |
possibly damaging |
Het |
| Zfp740 |
G |
T |
15: 102,116,801 (GRCm39) |
|
probably benign |
Het |
| Zzz3 |
A |
G |
3: 152,133,737 (GRCm39) |
E265G |
possibly damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL03328:Brwd1
|
APN |
16 |
95,803,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTTAAATGCCCAACAAAAG -3'
(R):5'- AGTCTTGACCGTGATGAGGC -3'
Sequencing Primer
(F):5'- TGCCCAACAAAAGACTTTAAGC -3'
(R):5'- GCTGAAGCGTCTTCTCATTTCAATAG -3'
|
| Posted On |
2016-12-15 |
Incidental Mutation