Mutagenetix > Incidental Mutation

Incidental Mutation 'R5783:Gm1110'

447869

Institutional Source

Beutler Lab

Gene Symbol

Gm1110

Ensembl Gene

ENSMUSG00000079644

Gene Name

predicted gene 1110

Synonyms

LOC382064

MMRRC Submission

043380-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R5783 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

26879567-26923111 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 26882336 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 532 (I532T)

Ref Sequence

ENSEMBL: ENSMUSP00000110916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115261]

AlphaFold

F6Y113

Predicted Effect

probably benign
Transcript: ENSMUST00000115261
AA Change: I532T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000110916
Gene: ENSMUSG00000079644
AA Change: I532T

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Glyco_hydro_35	55	368	2e-93	PFAM
Pfam:Glyco_hydro_42	70	229	1e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214847

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217197

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.6%
20x: 96.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700093K21Rik	T	A	11: 23,518,787	Y48F	probably damaging	Het
4930402H24Rik	A	C	2: 130,739,083	F582L	possibly damaging	Het
AI481877	A	T	4: 59,076,239	L568*	probably null	Het
Apob	A	G	12: 8,001,022	D1082G	probably damaging	Het
Cald1	G	A	6: 34,753,533	A236T	possibly damaging	Het
Ccdc88b	A	C	19: 6,853,916	C553G	probably benign	Het
Cenpe	A	G	3: 135,261,580	D2161G	probably benign	Het
Cep78	G	T	19: 15,956,359	N618K	probably benign	Het
Chka	A	G	19: 3,864,661	N118D	probably damaging	Het
Dennd5a	A	C	7: 109,894,636	I1263S	probably damaging	Het
Dnm3	T	C	1: 162,355,471	T92A	possibly damaging	Het
Dpp9	T	C	17: 56,211,655	K50E	probably damaging	Het
Fen1	G	T	19: 10,200,830	Y83*	probably null	Het
Hist2h2be	T	C	3: 96,221,299	V45A	possibly damaging	Het
Impdh1	A	T	6: 29,206,343	F140Y	possibly damaging	Het
Kcnc4	T	C	3: 107,447,872	D420G	possibly damaging	Het
Kctd19	A	G	8: 105,386,980	V664A	probably benign	Het
Krt80	C	T	15: 101,359,479		probably null	Het
Lars2	T	G	9: 123,461,596	M876R	probably benign	Het
Lrrc9	A	G	12: 72,456,053	E266G	possibly damaging	Het
Mesd	T	A	7: 83,895,675	V120E	probably damaging	Het
Mogs	C	T	6: 83,118,671	T823I	probably damaging	Het
Mrgprh	C	A	17: 12,877,446	T191N	probably benign	Het
Mtss1	C	T	15: 58,943,524	S729N	probably benign	Het
Muc5b	G	T	7: 141,858,428	E1704*	probably null	Het
Olfr1076	T	C	2: 86,508,638	Y60H	probably damaging	Het
Olfr631	A	T	7: 103,928,942	I40F	probably damaging	Het
Olfr695	C	A	7: 106,873,334	V304F	probably damaging	Het
Osbpl8	T	A	10: 111,267,783	L216*	probably null	Het
Pcdha5	T	C	18: 36,962,481	V681A	probably benign	Het
Pgap3	A	C	11: 98,390,464	V190G	probably benign	Het
Ppp2r5a	A	T	1: 191,354,640	Y373N	probably damaging	Het
Prkdc	T	C	16: 15,717,801	L1675P	probably damaging	Het
Rapgef2	T	G	3: 79,087,993	I635L	probably benign	Het
Rusc1	T	C	3: 89,088,145	D193G	probably damaging	Het
Ryr3	C	T	2: 112,652,998	V4140I	probably benign	Het
Scamp5	A	G	9: 57,446,070		probably null	Het
Slc41a3	T	C	6: 90,619,542	I31T	probably benign	Het
Smad9	T	C	3: 54,794,442	V368A	probably benign	Het
Smim8	TTTAATGAAGAGCT	TT	4: 34,771,261		probably benign	Het
St8sia1	T	C	6: 142,963,614	N52S	possibly damaging	Het
Svop	T	G	5: 114,064,935	D72A	possibly damaging	Het
Sybu	T	C	15: 44,746,414	I153V	probably damaging	Het
Tmem266	G	T	9: 55,397,803	S32I	probably damaging	Het
Trpm4	G	T	7: 45,310,389	R694S	probably benign	Het
Uqcrfs1	A	G	13: 30,545,204	L15P	probably damaging	Het
Vrtn	T	A	12: 84,650,477	L667Q	probably benign	Het
Zc3h14	T	A	12: 98,757,175	S241R	probably damaging	Het
Zfp318	TGAAGAAGAAGAAGAAGAAGAAGAAGAAG	TGAAGAAGAAGAAGAAGAAGAAG	17: 46,412,514		probably benign	Het
Zfp617	C	A	8: 71,932,464	H213N	probably damaging	Het
Zfp638	G	A	6: 83,944,847	G652D	possibly damaging	Het
Zmiz2	T	C	11: 6,405,081	L916P	probably damaging	Het

Other mutations in Gm1110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00591:Gm1110	APN	9	26880874	nonsense	probably null
IGL01089:Gm1110	APN	9	26881860	missense	probably benign
IGL01631:Gm1110	APN	9	26897916	critical splice donor site	probably null
IGL02008:Gm1110	APN	9	26883230	missense	probably benign	0.09
IGL02331:Gm1110	APN	9	26913287	critical splice donor site	probably null
IGL02335:Gm1110	APN	9	26881763	missense	probably benign	0.00
IGL02550:Gm1110	APN	9	26881834	missense	probably benign	0.09
IGL02614:Gm1110	APN	9	26920714	missense	probably benign	0.11
IGL03409:Gm1110	APN	9	26896620	missense	probably benign	0.21
PIT4458001:Gm1110	UTSW	9	26880828	missense	probably benign	0.00
R0189:Gm1110	UTSW	9	26883218	missense	probably null	0.99
R0271:Gm1110	UTSW	9	26920666	missense	probably damaging	1.00
R1034:Gm1110	UTSW	9	26921350	missense	probably damaging	1.00
R1229:Gm1110	UTSW	9	26881806	missense	probably benign
R1355:Gm1110	UTSW	9	26883761	missense	probably benign	0.01
R1566:Gm1110	UTSW	9	26880870	missense	probably damaging	1.00
R1574:Gm1110	UTSW	9	26881126	splice site	probably benign
R1916:Gm1110	UTSW	9	26889638	missense	probably damaging	1.00
R2011:Gm1110	UTSW	9	26894258	missense	probably benign	0.01
R2214:Gm1110	UTSW	9	26902490	missense	probably benign	0.37
R2567:Gm1110	UTSW	9	26920696	missense	probably benign
R2967:Gm1110	UTSW	9	26881043	missense	probably benign	0.05
R4271:Gm1110	UTSW	9	26895648	critical splice donor site	probably null
R4683:Gm1110	UTSW	9	26920594	missense	probably damaging	0.99
R4945:Gm1110	UTSW	9	26920595	missense	possibly damaging	0.46
R5015:Gm1110	UTSW	9	26881866	missense	probably benign	0.01
R5089:Gm1110	UTSW	9	26882387	missense	probably damaging	0.96
R5225:Gm1110	UTSW	9	26902478	missense	probably damaging	1.00
R5239:Gm1110	UTSW	9	26893570	missense	probably benign	0.00
R5395:Gm1110	UTSW	9	26889632	missense	probably benign
R6045:Gm1110	UTSW	9	26883209	critical splice donor site	probably null
R6245:Gm1110	UTSW	9	26920747	missense	probably benign	0.04
R6357:Gm1110	UTSW	9	26914128	splice site	probably null
R6863:Gm1110	UTSW	9	26881064	missense	probably damaging	1.00
R7336:Gm1110	UTSW	9	26914357	missense	probably damaging	0.99
R7454:Gm1110	UTSW	9	26920649	missense	probably benign
R7555:Gm1110	UTSW	9	26893628	missense	probably benign	0.05
R7579:Gm1110	UTSW	9	26883826	missense	possibly damaging	0.93
R7990:Gm1110	UTSW	9	26880841	missense	possibly damaging	0.66
R8062:Gm1110	UTSW	9	26881821	missense	probably damaging	0.99
R8108:Gm1110	UTSW	9	26920661	missense	probably damaging	1.00
R8323:Gm1110	UTSW	9	26902423	critical splice donor site	probably null
R8354:Gm1110	UTSW	9	26883280	missense	probably benign	0.01
R8354:Gm1110	UTSW	9	26883281	missense	probably benign	0.00
R8454:Gm1110	UTSW	9	26883280	missense	probably benign	0.01
R8454:Gm1110	UTSW	9	26883281	missense	probably benign	0.00
R8494:Gm1110	UTSW	9	26880858	missense	probably benign	0.04
R8978:Gm1110	UTSW	9	26895799	splice site	probably benign
R9321:Gm1110	UTSW	9	26920595	missense	probably benign	0.00
R9513:Gm1110	UTSW	9	26883787	missense	possibly damaging	0.95
R9545:Gm1110	UTSW	9	26889681	missense	probably benign	0.00
R9758:Gm1110	UTSW	9	26889598	nonsense	probably null
RF002:Gm1110	UTSW	9	26920640	missense	probably damaging	1.00
X0063:Gm1110	UTSW	9	26894280	missense	probably benign	0.01
Z1088:Gm1110	UTSW	9	26913310	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AAGTCACCTAGAGACCTCTGG -3'
(R):5'- GGGCCCATGGGAGTTTATAG -3'

Sequencing Primer
(F):5'- TAGAGACCTCTGGGCATGCTTC -3'
(R):5'- GCCCATGGGAGTTTATAGAAACCTTC -3'

Posted On

2016-12-15