Incidental Mutation 'R5785:Il36b'
ID 447947
Institutional Source Beutler Lab
Gene Symbol Il36b
Ensembl Gene ENSMUSG00000026985
Gene Name interleukin 36B
Synonyms If36b, Il1f8, 2310043N20Rik
MMRRC Submission 043206-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R5785 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 24043184-24050115 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 24044661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 20 (M20I)
Ref Sequence ENSEMBL: ENSMUSP00000028363 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028363]
AlphaFold Q9D6Z6
Predicted Effect probably benign
Transcript: ENSMUST00000028363
AA Change: M20I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000028363
Gene: ENSMUSG00000026985
AA Change: M20I

DomainStartEndE-ValueType
IL1 33 180 3.19e-22 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4gnt A T 9: 99,502,725 (GRCm39) N295I probably damaging Het
Abcg3 G A 5: 105,116,036 (GRCm39) A266V probably damaging Het
Apbb1 C A 7: 105,216,922 (GRCm39) D254Y probably damaging Het
Arhgap39 T C 15: 76,621,618 (GRCm39) M328V probably benign Het
Bub1b T A 2: 118,440,325 (GRCm39) V143D probably damaging Het
Celsr3 A G 9: 108,704,996 (GRCm39) D493G probably damaging Het
Cers4 T A 8: 4,566,992 (GRCm39) probably null Het
Clec4d A G 6: 123,251,729 (GRCm39) R204G probably benign Het
Cngb1 C A 8: 95,980,823 (GRCm39) R910L possibly damaging Het
Coro2a A T 4: 46,564,691 (GRCm39) N18K probably benign Het
Cwf19l1 A G 19: 44,110,380 (GRCm39) F290S probably damaging Het
Esp18 C T 17: 39,720,839 (GRCm39) T28I probably damaging Het
Hdac10 A T 15: 89,011,148 (GRCm39) F205Y probably benign Het
Hhip T A 8: 80,724,821 (GRCm39) H317L possibly damaging Het
Ilf3 T A 9: 21,306,168 (GRCm39) N276K probably damaging Het
Jchain T C 5: 88,670,376 (GRCm39) N81S probably benign Het
Mei4 A G 9: 81,907,600 (GRCm39) Y211C probably damaging Het
Mx2 A T 16: 97,339,904 (GRCm39) E20V possibly damaging Het
Ndufa10 A G 1: 92,388,096 (GRCm39) probably null Het
Nodal A G 10: 61,259,456 (GRCm39) T298A probably damaging Het
Nvl T C 1: 180,966,863 (GRCm39) Y47C probably damaging Het
Onecut1 C T 9: 74,770,674 (GRCm39) R366C probably damaging Het
Or9q1 T C 19: 13,804,983 (GRCm39) Y259C probably damaging Het
Plekha6 G C 1: 133,200,045 (GRCm39) R208P possibly damaging Het
Ppp5c A G 7: 16,761,616 (GRCm39) probably null Het
Prag1 A G 8: 36,570,641 (GRCm39) E408G probably benign Het
Ptpn21 T C 12: 98,648,809 (GRCm39) N949S probably damaging Het
Scn7a A C 2: 66,527,912 (GRCm39) N859K possibly damaging Het
Smarca4 T C 9: 21,597,322 (GRCm39) I1362T probably damaging Het
Syt12 T C 19: 4,501,022 (GRCm39) R343G possibly damaging Het
Topbp1 T C 9: 103,200,727 (GRCm39) S587P probably benign Het
Trim80 C T 11: 115,337,301 (GRCm39) Q388* probably null Het
Tsc2 T C 17: 24,818,861 (GRCm39) probably null Het
Vmn2r130 T A 17: 23,280,461 (GRCm39) S41T probably benign Het
Vmn2r3 T A 3: 64,166,444 (GRCm39) T896S possibly damaging Het
Xirp2 A G 2: 67,340,006 (GRCm39) E749G probably damaging Het
Zbtb24 G A 10: 41,327,849 (GRCm39) G245E probably benign Het
Zfp507 A G 7: 35,487,167 (GRCm39) V767A probably benign Het
Other mutations in Il36b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Il36b APN 2 24,049,925 (GRCm39) missense probably benign 0.00
IGL01944:Il36b APN 2 24,045,291 (GRCm39) missense probably damaging 1.00
IGL02379:Il36b APN 2 24,044,650 (GRCm39) missense probably benign 0.01
R0035:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.19
R0035:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.19
R2137:Il36b UTSW 2 24,044,672 (GRCm39) missense probably benign 0.00
R2139:Il36b UTSW 2 24,044,672 (GRCm39) missense probably benign 0.00
R4052:Il36b UTSW 2 24,049,844 (GRCm39) missense probably damaging 1.00
R4096:Il36b UTSW 2 24,048,826 (GRCm39) missense possibly damaging 0.66
R4705:Il36b UTSW 2 24,044,630 (GRCm39) missense probably benign 0.00
R6541:Il36b UTSW 2 24,049,827 (GRCm39) missense probably damaging 1.00
R7517:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.02
R7752:Il36b UTSW 2 24,048,826 (GRCm39) missense possibly damaging 0.66
R7858:Il36b UTSW 2 24,044,626 (GRCm39) missense probably benign 0.00
R8252:Il36b UTSW 2 24,048,825 (GRCm39) missense possibly damaging 0.46
R8820:Il36b UTSW 2 24,049,892 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CACTTAGGGATTGCTGTCCTTG -3'
(R):5'- TAAGGCAAGAGCTAAGTGACTTC -3'

Sequencing Primer
(F):5'- AAGGTCAGGGTTCCAACTCTAGC -3'
(R):5'- GCAAGAGCTAAGTGACTTCACATTTC -3'
Posted On 2016-12-15