Mutagenetix > Incidental Mutation

Incidental Mutation 'R5785:Xirp2'

447949

Institutional Source

Beutler Lab

Gene Symbol

Xirp2

Ensembl Gene

ENSMUSG00000027022

Gene Name

xin actin-binding repeat containing 2

Synonyms

2310003D02Rik, 2310008C07Rik, myomaxin, Cmya3, A530024P18Rik, mXin beta

MMRRC Submission

043206-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.429) question?

Stock #

R5785 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

67446002-67526614 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 67509662 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 749 (E749G)

Ref Sequence

ENSEMBL: ENSMUSP00000107966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028410] [ENSMUST00000112347]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000028410
AA Change: E749G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000028410
Gene: ENSMUSG00000027022
AA Change: E749G

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4e-9	PFAM
Pfam:Xin	384	398	7.6e-10	PFAM
Pfam:Xin	420	435	6.4e-9	PFAM
Pfam:Xin	458	473	5.3e-9	PFAM
Pfam:Xin	536	551	4.1e-12	PFAM
Pfam:Xin	574	588	2.1e-8	PFAM
Pfam:Xin	609	623	6e-9	PFAM
Pfam:Xin	642	656	5.6e-8	PFAM
Pfam:Xin	679	693	5.9e-8	PFAM
Pfam:Xin	784	799	1.1e-10	PFAM
Pfam:Xin	822	837	3.9e-11	PFAM
Pfam:Xin	861	875	8.6e-12	PFAM
Pfam:Xin	894	909	2.8e-10	PFAM
Pfam:Xin	1006	1021	3.1e-9	PFAM
Pfam:Xin	1079	1094	6.7e-10	PFAM
Pfam:Xin	1117	1132	1.5e-10	PFAM
Pfam:Xin	1154	1169	2.4e-8	PFAM
Pfam:Xin	1256	1271	4.6e-8	PFAM
Pfam:Xin	1292	1305	1.6e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC
LIM	3256	3308	4.45e-12	SMART
low complexity region	3356	3367	N/A	INTRINSIC
low complexity region	3549	3565	N/A	INTRINSIC
low complexity region	3614	3625	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112347
AA Change: E749G

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000107966
Gene: ENSMUSG00000027022
AA Change: E749G

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4.3e-8	PFAM
Pfam:Xin	383	398	6.9e-9	PFAM
Pfam:Xin	420	435	1.8e-8	PFAM
Pfam:Xin	458	473	6.9e-8	PFAM
Pfam:Xin	536	551	2.8e-10	PFAM
Pfam:Xin	608	623	2.4e-8	PFAM
Pfam:Xin	642	657	1.7e-7	PFAM
Pfam:Xin	784	799	3.5e-9	PFAM
Pfam:Xin	822	837	8.9e-10	PFAM
Pfam:Xin	861	876	3.9e-10	PFAM
Pfam:Xin	894	909	5.4e-9	PFAM
Pfam:Xin	1006	1021	6.2e-8	PFAM
Pfam:Xin	1079	1094	2.4e-8	PFAM
Pfam:Xin	1117	1132	9.5e-9	PFAM
Pfam:Xin	1291	1306	5.8e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142314

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.6%

Validation Efficiency

MGI Phenotype

Strain: 4947971; 4453315
Lethality: D3-D21
PHENOTYPE: Homozygous null mice have an abnormal heart shape, ventricular septal defects, a failure of mature intercalated disc formation, severe growth retardation, and postnatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted(5)

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	A	T	9: 99,620,672 (GRCm38)	N295I	probably damaging	Het
Abcg3	G	A	5: 104,968,170 (GRCm38)	A266V	probably damaging	Het
Apbb1	C	A	7: 105,567,715 (GRCm38)	D254Y	probably damaging	Het
Arhgap39	T	C	15: 76,737,418 (GRCm38)	M328V	probably benign	Het
Bub1b	T	A	2: 118,609,844 (GRCm38)	V143D	probably damaging	Het
Celsr3	A	G	9: 108,827,797 (GRCm38)	D493G	probably damaging	Het
Cers4	T	A	8: 4,516,992 (GRCm38)		probably null	Het
Clec4d	A	G	6: 123,274,770 (GRCm38)	R204G	probably benign	Het
Cngb1	C	A	8: 95,254,195 (GRCm38)	R910L	possibly damaging	Het
Coro2a	A	T	4: 46,564,691 (GRCm38)	N18K	probably benign	Het
Cwf19l1	A	G	19: 44,121,941 (GRCm38)	F290S	probably damaging	Het
Esp18	C	T	17: 39,409,948 (GRCm38)	T28I	probably damaging	Het
Hdac10	A	T	15: 89,126,945 (GRCm38)	F205Y	probably benign	Het
Hhip	T	A	8: 79,998,192 (GRCm38)	H317L	possibly damaging	Het
Il1f8	G	A	2: 24,154,649 (GRCm38)	M20I	probably benign	Het
Ilf3	T	A	9: 21,394,872 (GRCm38)	N276K	probably damaging	Het
Jchain	T	C	5: 88,522,517 (GRCm38)	N81S	probably benign	Het
Mei4	A	G	9: 82,025,547 (GRCm38)	Y211C	probably damaging	Het
Mx2	A	T	16: 97,538,704 (GRCm38)	E20V	possibly damaging	Het
Ndufa10	A	G	1: 92,460,374 (GRCm38)		probably null	Het
Nodal	A	G	10: 61,423,677 (GRCm38)	T298A	probably damaging	Het
Nvl	T	C	1: 181,139,298 (GRCm38)	Y47C	probably damaging	Het
Olfr1500	T	C	19: 13,827,619 (GRCm38)	Y259C	probably damaging	Het
Onecut1	C	T	9: 74,863,392 (GRCm38)	R366C	probably damaging	Het
Plekha6	G	C	1: 133,272,307 (GRCm38)	R208P	possibly damaging	Het
Ppp5c	A	G	7: 17,027,691 (GRCm38)		probably null	Het
Prag1	A	G	8: 36,103,487 (GRCm38)	E408G	probably benign	Het
Ptpn21	T	C	12: 98,682,550 (GRCm38)	N949S	probably damaging	Het
Scn7a	A	C	2: 66,697,568 (GRCm38)	N859K	possibly damaging	Het
Smarca4	T	C	9: 21,686,026 (GRCm38)	I1362T	probably damaging	Het
Syt12	T	C	19: 4,450,994 (GRCm38)	R343G	possibly damaging	Het
Topbp1	T	C	9: 103,323,528 (GRCm38)	S587P	probably benign	Het
Trim80	C	T	11: 115,446,475 (GRCm38)	Q388*	probably null	Het
Tsc2	T	C	17: 24,599,887 (GRCm38)		probably null	Het
Vmn2r3	T	A	3: 64,259,023 (GRCm38)	T896S	possibly damaging	Het
Vmn2r-ps130	T	A	17: 23,061,487 (GRCm38)	S41T	probably benign	Het
Zbtb24	G	A	10: 41,451,853 (GRCm38)	G245E	probably benign	Het
Zfp507	A	G	7: 35,787,742 (GRCm38)	V767A	probably benign	Het

Other mutations in Xirp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Xirp2	APN	2	67,513,375 (GRCm38)	missense	probably benign	0.37
IGL00336:Xirp2	APN	2	67,512,598 (GRCm38)	missense	possibly damaging	0.93
IGL00596:Xirp2	APN	2	67,514,882 (GRCm38)	missense	probably benign	0.08
IGL00862:Xirp2	APN	2	67,516,903 (GRCm38)	missense	probably benign	0.00
IGL01124:Xirp2	APN	2	67,508,615 (GRCm38)	missense	probably damaging	0.99
IGL01289:Xirp2	APN	2	67,513,181 (GRCm38)	missense	probably damaging	0.99
IGL01293:Xirp2	APN	2	67,515,184 (GRCm38)	missense	possibly damaging	0.51
IGL01372:Xirp2	APN	2	67,513,990 (GRCm38)	missense	possibly damaging	0.93
IGL01385:Xirp2	APN	2	67,509,677 (GRCm38)	missense	probably damaging	0.99
IGL01411:Xirp2	APN	2	67,514,083 (GRCm38)	missense	probably benign	0.00
IGL01413:Xirp2	APN	2	67,509,926 (GRCm38)	missense	probably damaging	1.00
IGL01551:Xirp2	APN	2	67,513,505 (GRCm38)	missense	probably benign
IGL01672:Xirp2	APN	2	67,508,502 (GRCm38)	missense	probably benign
IGL01724:Xirp2	APN	2	67,526,067 (GRCm38)	missense	probably benign
IGL01739:Xirp2	APN	2	67,515,138 (GRCm38)	missense	probably benign	0.15
IGL01807:Xirp2	APN	2	67,515,031 (GRCm38)	missense	probably benign
IGL02006:Xirp2	APN	2	67,511,962 (GRCm38)	missense	possibly damaging	0.85
IGL02030:Xirp2	APN	2	67,508,981 (GRCm38)	missense	probably benign	0.06
IGL02066:Xirp2	APN	2	67,526,071 (GRCm38)	missense	probably benign
IGL02138:Xirp2	APN	2	67,516,956 (GRCm38)	missense	probably benign	0.15
IGL02250:Xirp2	APN	2	67,514,012 (GRCm38)	missense	probably benign	0.03
IGL02265:Xirp2	APN	2	67,517,150 (GRCm38)	missense	possibly damaging	0.94
IGL02274:Xirp2	APN	2	67,508,651 (GRCm38)	missense	probably benign	0.12
IGL02322:Xirp2	APN	2	67,508,738 (GRCm38)	missense	probably benign	0.00
IGL02327:Xirp2	APN	2	67,510,100 (GRCm38)	missense	probably damaging	1.00
IGL02378:Xirp2	APN	2	67,513,768 (GRCm38)	missense	probably benign	0.00
IGL02492:Xirp2	APN	2	67,516,167 (GRCm38)	missense	probably damaging	0.99
IGL02549:Xirp2	APN	2	67,513,102 (GRCm38)	missense	probably benign	0.03
IGL02578:Xirp2	APN	2	67,511,247 (GRCm38)	missense	probably damaging	0.96
IGL02635:Xirp2	APN	2	67,507,910 (GRCm38)	missense	possibly damaging	0.86
IGL02654:Xirp2	APN	2	67,514,671 (GRCm38)	missense	possibly damaging	0.86
IGL02663:Xirp2	APN	2	67,509,458 (GRCm38)	missense	possibly damaging	0.92
IGL02795:Xirp2	APN	2	67,509,136 (GRCm38)	missense	probably damaging	1.00
IGL02934:Xirp2	APN	2	67,515,676 (GRCm38)	missense	probably benign	0.33
IGL03003:Xirp2	APN	2	67,515,562 (GRCm38)	missense	possibly damaging	0.93
IGL03069:Xirp2	APN	2	67,509,532 (GRCm38)	missense	possibly damaging	0.91
IGL03286:Xirp2	APN	2	67,516,310 (GRCm38)	missense	probably damaging	0.99
IGL03326:Xirp2	APN	2	67,482,246 (GRCm38)	missense	probably benign	0.01
IGL03381:Xirp2	APN	2	67,514,226 (GRCm38)	missense	probably benign	0.34
IGL03394:Xirp2	APN	2	67,515,194 (GRCm38)	missense	probably damaging	0.99
Ordovician	UTSW	2	67,482,363 (GRCm38)	missense	possibly damaging	0.72
silurian	UTSW	2	67,519,265 (GRCm38)	missense	probably damaging	0.99
3-1:Xirp2	UTSW	2	67,508,198 (GRCm38)	missense	possibly damaging	0.95
H8562:Xirp2	UTSW	2	67,515,457 (GRCm38)	missense	probably benign
PIT4142001:Xirp2	UTSW	2	67,519,362 (GRCm38)	splice site	probably benign
PIT4260001:Xirp2	UTSW	2	67,511,597 (GRCm38)	missense	possibly damaging	0.96
PIT4445001:Xirp2	UTSW	2	67,509,772 (GRCm38)	missense	possibly damaging	0.84
PIT4531001:Xirp2	UTSW	2	67,515,482 (GRCm38)	missense	possibly damaging	0.73
R0015:Xirp2	UTSW	2	67,510,899 (GRCm38)	nonsense	probably null
R0063:Xirp2	UTSW	2	67,509,083 (GRCm38)	missense	probably damaging	0.99
R0063:Xirp2	UTSW	2	67,509,083 (GRCm38)	missense	probably damaging	0.99
R0066:Xirp2	UTSW	2	67,512,140 (GRCm38)	missense	possibly damaging	0.85
R0109:Xirp2	UTSW	2	67,519,278 (GRCm38)	missense	probably damaging	1.00
R0111:Xirp2	UTSW	2	67,508,378 (GRCm38)	missense	probably damaging	0.99
R0115:Xirp2	UTSW	2	67,509,909 (GRCm38)	missense	possibly damaging	0.92
R0117:Xirp2	UTSW	2	67,517,120 (GRCm38)	missense	possibly damaging	0.94
R0133:Xirp2	UTSW	2	67,517,124 (GRCm38)	missense	probably benign
R0282:Xirp2	UTSW	2	67,513,380 (GRCm38)	missense	probably damaging	0.96
R0463:Xirp2	UTSW	2	67,514,918 (GRCm38)	missense	probably benign	0.02
R0481:Xirp2	UTSW	2	67,509,909 (GRCm38)	missense	possibly damaging	0.92
R0488:Xirp2	UTSW	2	67,514,821 (GRCm38)	missense	possibly damaging	0.90
R0548:Xirp2	UTSW	2	67,514,414 (GRCm38)	missense	probably benign	0.00
R0557:Xirp2	UTSW	2	67,516,351 (GRCm38)	missense	probably benign	0.33
R0582:Xirp2	UTSW	2	67,508,866 (GRCm38)	missense	probably benign
R0723:Xirp2	UTSW	2	67,512,215 (GRCm38)	missense	probably damaging	0.98
R0835:Xirp2	UTSW	2	67,507,910 (GRCm38)	missense	possibly damaging	0.86
R1160:Xirp2	UTSW	2	67,509,887 (GRCm38)	missense	possibly damaging	0.92
R1189:Xirp2	UTSW	2	67,513,461 (GRCm38)	missense	probably damaging	0.96
R1474:Xirp2	UTSW	2	67,525,067 (GRCm38)	missense	probably benign	0.00
R1513:Xirp2	UTSW	2	67,511,530 (GRCm38)	missense	probably benign	0.00
R1514:Xirp2	UTSW	2	67,514,323 (GRCm38)	nonsense	probably null
R1519:Xirp2	UTSW	2	67,515,679 (GRCm38)	missense	probably benign	0.44
R1532:Xirp2	UTSW	2	67,513,939 (GRCm38)	missense	probably benign	0.00
R1537:Xirp2	UTSW	2	67,510,013 (GRCm38)	missense	probably damaging	0.98
R1541:Xirp2	UTSW	2	67,512,290 (GRCm38)	missense	possibly damaging	0.70
R1543:Xirp2	UTSW	2	67,508,039 (GRCm38)	missense	probably benign
R1607:Xirp2	UTSW	2	67,510,295 (GRCm38)	nonsense	probably null
R1620:Xirp2	UTSW	2	67,510,835 (GRCm38)	missense	probably damaging	0.98
R1709:Xirp2	UTSW	2	67,509,871 (GRCm38)	missense	probably benign	0.33
R1713:Xirp2	UTSW	2	67,512,418 (GRCm38)	missense	probably benign	0.25
R1828:Xirp2	UTSW	2	67,515,238 (GRCm38)	missense	possibly damaging	0.86
R1834:Xirp2	UTSW	2	67,511,140 (GRCm38)	missense	probably damaging	0.99
R1905:Xirp2	UTSW	2	67,516,356 (GRCm38)	missense	probably damaging	0.98
R1907:Xirp2	UTSW	2	67,516,356 (GRCm38)	missense	probably damaging	0.98
R1943:Xirp2	UTSW	2	67,512,615 (GRCm38)	missense	probably benign	0.34
R1971:Xirp2	UTSW	2	67,511,695 (GRCm38)	missense	possibly damaging	0.48
R1998:Xirp2	UTSW	2	67,509,049 (GRCm38)	missense	probably damaging	0.97
R2075:Xirp2	UTSW	2	67,510,201 (GRCm38)	missense	probably benign	0.33
R2132:Xirp2	UTSW	2	67,508,048 (GRCm38)	missense	possibly damaging	0.72
R2175:Xirp2	UTSW	2	67,509,914 (GRCm38)	missense	probably damaging	0.99
R2310:Xirp2	UTSW	2	67,526,247 (GRCm38)	missense	probably benign	0.19
R2338:Xirp2	UTSW	2	67,510,770 (GRCm38)	missense	probably damaging	0.98
R2426:Xirp2	UTSW	2	67,514,471 (GRCm38)	missense	probably benign	0.02
R2483:Xirp2	UTSW	2	67,524,992 (GRCm38)	missense	probably benign
R3084:Xirp2	UTSW	2	67,509,049 (GRCm38)	missense	probably damaging	0.97
R3113:Xirp2	UTSW	2	67,510,147 (GRCm38)	missense	probably benign	0.33
R3903:Xirp2	UTSW	2	67,508,036 (GRCm38)	missense	probably benign	0.40
R3916:Xirp2	UTSW	2	67,511,422 (GRCm38)	missense	probably benign	0.25
R3928:Xirp2	UTSW	2	67,511,669 (GRCm38)	missense	possibly damaging	0.85
R4025:Xirp2	UTSW	2	67,511,402 (GRCm38)	missense	probably benign	0.12
R4135:Xirp2	UTSW	2	67,525,397 (GRCm38)	missense	probably benign	0.00
R4223:Xirp2	UTSW	2	67,516,493 (GRCm38)	missense	possibly damaging	0.66
R4257:Xirp2	UTSW	2	67,516,039 (GRCm38)	missense	probably benign	0.31
R4499:Xirp2	UTSW	2	67,513,438 (GRCm38)	missense	probably benign	0.08
R4577:Xirp2	UTSW	2	67,513,897 (GRCm38)	missense	probably damaging	0.99
R4739:Xirp2	UTSW	2	67,519,265 (GRCm38)	missense	probably damaging	0.99
R4758:Xirp2	UTSW	2	67,516,535 (GRCm38)	missense	probably damaging	0.98
R4834:Xirp2	UTSW	2	67,516,406 (GRCm38)	missense	probably benign	0.26
R4855:Xirp2	UTSW	2	67,511,064 (GRCm38)	missense	possibly damaging	0.96
R4923:Xirp2	UTSW	2	67,512,893 (GRCm38)	missense	probably benign
R4936:Xirp2	UTSW	2	67,509,819 (GRCm38)	missense	possibly damaging	0.85
R5032:Xirp2	UTSW	2	67,525,670 (GRCm38)	missense	possibly damaging	0.84
R5049:Xirp2	UTSW	2	67,517,134 (GRCm38)	missense	probably benign	0.03
R5077:Xirp2	UTSW	2	67,514,477 (GRCm38)	missense	probably benign
R5090:Xirp2	UTSW	2	67,525,470 (GRCm38)	missense	possibly damaging	0.83
R5107:Xirp2	UTSW	2	67,511,861 (GRCm38)	missense	probably damaging	1.00
R5107:Xirp2	UTSW	2	67,509,710 (GRCm38)	missense	probably damaging	0.99
R5187:Xirp2	UTSW	2	67,515,367 (GRCm38)	missense	probably benign	0.01
R5241:Xirp2	UTSW	2	67,482,360 (GRCm38)	nonsense	probably null
R5307:Xirp2	UTSW	2	67,511,162 (GRCm38)	missense	probably damaging	0.99
R5342:Xirp2	UTSW	2	67,513,461 (GRCm38)	missense	probably damaging	0.96
R5370:Xirp2	UTSW	2	67,512,152 (GRCm38)	missense	possibly damaging	0.72
R5375:Xirp2	UTSW	2	67,511,906 (GRCm38)	missense	probably damaging	0.99
R5407:Xirp2	UTSW	2	67,510,969 (GRCm38)	missense	probably benign	0.33
R5514:Xirp2	UTSW	2	67,505,121 (GRCm38)	missense	probably benign	0.03
R5531:Xirp2	UTSW	2	67,515,302 (GRCm38)	missense	probably benign	0.42
R5590:Xirp2	UTSW	2	67,514,035 (GRCm38)	missense	probably benign	0.23
R5646:Xirp2	UTSW	2	67,510,790 (GRCm38)	missense	probably damaging	0.99
R5649:Xirp2	UTSW	2	67,516,895 (GRCm38)	missense	probably benign	0.00
R5686:Xirp2	UTSW	2	67,482,298 (GRCm38)	missense	probably damaging	0.99
R5761:Xirp2	UTSW	2	67,510,967 (GRCm38)	missense	probably benign	0.00
R5777:Xirp2	UTSW	2	67,510,004 (GRCm38)	missense	possibly damaging	0.92
R5843:Xirp2	UTSW	2	67,476,785 (GRCm38)	start gained	probably benign
R5846:Xirp2	UTSW	2	67,509,243 (GRCm38)	missense	probably damaging	0.98
R5875:Xirp2	UTSW	2	67,505,080 (GRCm38)	missense	probably benign	0.00
R5896:Xirp2	UTSW	2	67,509,946 (GRCm38)	missense	possibly damaging	0.91
R5896:Xirp2	UTSW	2	67,508,698 (GRCm38)	missense	probably benign	0.32
R5901:Xirp2	UTSW	2	67,513,066 (GRCm38)	missense	possibly damaging	0.91
R5934:Xirp2	UTSW	2	67,524,804 (GRCm38)	missense	possibly damaging	0.92
R5950:Xirp2	UTSW	2	67,511,320 (GRCm38)	missense	possibly damaging	0.95
R5996:Xirp2	UTSW	2	67,511,650 (GRCm38)	missense	possibly damaging	0.91
R6013:Xirp2	UTSW	2	67,510,943 (GRCm38)	missense	possibly damaging	0.48
R6048:Xirp2	UTSW	2	67,508,243 (GRCm38)	missense	possibly damaging	0.96
R6111:Xirp2	UTSW	2	67,511,817 (GRCm38)	missense	possibly damaging	0.86
R6180:Xirp2	UTSW	2	67,505,577 (GRCm38)	critical splice donor site	probably null
R6342:Xirp2	UTSW	2	67,511,650 (GRCm38)	missense	possibly damaging	0.91
R6346:Xirp2	UTSW	2	67,516,081 (GRCm38)	missense	probably benign	0.00
R6603:Xirp2	UTSW	2	67,516,544 (GRCm38)	missense	probably benign
R6604:Xirp2	UTSW	2	67,509,845 (GRCm38)	missense	possibly damaging	0.86
R6669:Xirp2	UTSW	2	67,513,355 (GRCm38)	missense	possibly damaging	0.78
R6701:Xirp2	UTSW	2	67,516,225 (GRCm38)	missense	possibly damaging	0.94
R6726:Xirp2	UTSW	2	67,512,868 (GRCm38)	missense	possibly damaging	0.88
R6833:Xirp2	UTSW	2	67,509,950 (GRCm38)	missense	probably benign	0.12
R6897:Xirp2	UTSW	2	67,508,567 (GRCm38)	missense	probably damaging	1.00
R6933:Xirp2	UTSW	2	67,514,857 (GRCm38)	missense	probably benign	0.34
R7020:Xirp2	UTSW	2	67,525,569 (GRCm38)	missense	probably benign
R7042:Xirp2	UTSW	2	67,513,289 (GRCm38)	missense	probably benign	0.12
R7060:Xirp2	UTSW	2	67,515,608 (GRCm38)	missense	probably damaging	1.00
R7179:Xirp2	UTSW	2	67,509,833 (GRCm38)	missense	probably benign	0.00
R7229:Xirp2	UTSW	2	67,525,551 (GRCm38)	missense	probably damaging	0.99
R7253:Xirp2	UTSW	2	67,513,482 (GRCm38)	missense	probably benign
R7284:Xirp2	UTSW	2	67,516,829 (GRCm38)	missense	probably benign
R7450:Xirp2	UTSW	2	67,509,815 (GRCm38)	missense	possibly damaging	0.86
R7476:Xirp2	UTSW	2	67,510,634 (GRCm38)	missense	probably benign	0.01
R7489:Xirp2	UTSW	2	67,525,560 (GRCm38)	missense	possibly damaging	0.83
R7513:Xirp2	UTSW	2	67,510,764 (GRCm38)	missense	possibly damaging	0.86
R7549:Xirp2	UTSW	2	67,508,897 (GRCm38)	missense	possibly damaging	0.91
R7563:Xirp2	UTSW	2	67,509,901 (GRCm38)	missense	probably damaging	0.99
R7567:Xirp2	UTSW	2	67,515,982 (GRCm38)	missense	probably benign	0.02
R7577:Xirp2	UTSW	2	67,514,965 (GRCm38)	missense	possibly damaging	0.65
R7597:Xirp2	UTSW	2	67,525,755 (GRCm38)	missense	possibly damaging	0.84
R7610:Xirp2	UTSW	2	67,525,962 (GRCm38)	missense	possibly damaging	0.92
R7613:Xirp2	UTSW	2	67,514,498 (GRCm38)	missense	probably benign	0.00
R7669:Xirp2	UTSW	2	67,512,177 (GRCm38)	missense	probably benign	0.00
R7670:Xirp2	UTSW	2	67,510,573 (GRCm38)	missense	possibly damaging	0.91
R7673:Xirp2	UTSW	2	67,517,087 (GRCm38)	missense	probably damaging	1.00
R7682:Xirp2	UTSW	2	67,508,849 (GRCm38)	missense	probably damaging	0.99
R7755:Xirp2	UTSW	2	67,515,182 (GRCm38)	missense	probably benign
R7805:Xirp2	UTSW	2	67,509,981 (GRCm38)	missense	probably benign	0.23
R7815:Xirp2	UTSW	2	67,509,412 (GRCm38)	missense	probably damaging	1.00
R7823:Xirp2	UTSW	2	67,511,774 (GRCm38)	missense	probably damaging	1.00
R7842:Xirp2	UTSW	2	67,524,945 (GRCm38)	missense	probably benign	0.00
R7863:Xirp2	UTSW	2	67,512,730 (GRCm38)	missense	probably benign	0.03
R7895:Xirp2	UTSW	2	67,509,497 (GRCm38)	missense	probably damaging	0.96
R7948:Xirp2	UTSW	2	67,519,314 (GRCm38)	missense	possibly damaging	0.95
R8083:Xirp2	UTSW	2	67,508,699 (GRCm38)	missense	possibly damaging	0.71
R8125:Xirp2	UTSW	2	67,512,035 (GRCm38)	missense	probably benign	0.25
R8154:Xirp2	UTSW	2	67,511,673 (GRCm38)	missense	possibly damaging	0.48
R8169:Xirp2	UTSW	2	67,513,199 (GRCm38)	missense	probably benign	0.00
R8213:Xirp2	UTSW	2	67,476,866 (GRCm38)	missense	probably damaging	0.96
R8215:Xirp2	UTSW	2	67,516,509 (GRCm38)	missense	probably benign	0.08
R8230:Xirp2	UTSW	2	67,515,665 (GRCm38)	missense	probably damaging	0.99
R8266:Xirp2	UTSW	2	67,508,574 (GRCm38)	missense	probably damaging	0.98
R8350:Xirp2	UTSW	2	67,525,369 (GRCm38)	missense	probably benign
R8432:Xirp2	UTSW	2	67,510,618 (GRCm38)	missense	probably benign
R8441:Xirp2	UTSW	2	67,512,815 (GRCm38)	missense	possibly damaging	0.85
R8677:Xirp2	UTSW	2	67,516,634 (GRCm38)	missense	probably damaging	0.98
R8773:Xirp2	UTSW	2	67,525,183 (GRCm38)	missense	probably benign
R8794:Xirp2	UTSW	2	67,511,213 (GRCm38)	missense	probably damaging	0.98
R8930:Xirp2	UTSW	2	67,482,363 (GRCm38)	missense	possibly damaging	0.72
R8932:Xirp2	UTSW	2	67,482,363 (GRCm38)	missense	possibly damaging	0.72
R8939:Xirp2	UTSW	2	67,516,144 (GRCm38)	missense	probably benign	0.04
R9263:Xirp2	UTSW	2	67,514,945 (GRCm38)	missense	possibly damaging	0.76
R9313:Xirp2	UTSW	2	67,516,978 (GRCm38)	missense	probably damaging	0.99
R9350:Xirp2	UTSW	2	67,519,309 (GRCm38)	missense	probably damaging	1.00
R9375:Xirp2	UTSW	2	67,511,774 (GRCm38)	missense	probably damaging	1.00
R9442:Xirp2	UTSW	2	67,511,891 (GRCm38)	nonsense	probably null
R9447:Xirp2	UTSW	2	67,508,606 (GRCm38)	missense	probably damaging	0.98
R9457:Xirp2	UTSW	2	67,515,632 (GRCm38)	missense	probably benign	0.03
R9507:Xirp2	UTSW	2	67,513,936 (GRCm38)	missense	possibly damaging	0.95
R9529:Xirp2	UTSW	2	67,525,196 (GRCm38)	missense	possibly damaging	0.93
R9569:Xirp2	UTSW	2	67,510,898 (GRCm38)	missense	probably damaging	1.00
R9607:Xirp2	UTSW	2	67,510,762 (GRCm38)	missense	possibly damaging	0.72
R9648:Xirp2	UTSW	2	67,516,255 (GRCm38)	missense	probably benign
R9651:Xirp2	UTSW	2	67,513,823 (GRCm38)	missense	possibly damaging	0.72
R9678:Xirp2	UTSW	2	67,509,444 (GRCm38)	missense	possibly damaging	0.91
R9691:Xirp2	UTSW	2	67,510,195 (GRCm38)	missense	possibly damaging	0.91
R9777:Xirp2	UTSW	2	67,517,035 (GRCm38)	missense	possibly damaging	0.85
RF035:Xirp2	UTSW	2	67,525,544 (GRCm38)	utr 3 prime	probably benign
RF040:Xirp2	UTSW	2	67,525,544 (GRCm38)	utr 3 prime	probably benign
X0063:Xirp2	UTSW	2	67,516,123 (GRCm38)	missense	probably benign	0.04
X0065:Xirp2	UTSW	2	67,515,118 (GRCm38)	missense	probably benign	0.34
Z1088:Xirp2	UTSW	2	67,513,321 (GRCm38)	missense	probably benign	0.03
Z1176:Xirp2	UTSW	2	67,514,579 (GRCm38)	missense	probably benign	0.17
Z1176:Xirp2	UTSW	2	67,511,393 (GRCm38)	missense	probably damaging	0.99
Z1176:Xirp2	UTSW	2	67,525,232 (GRCm38)	missense	probably damaging	1.00
Z1177:Xirp2	UTSW	2	67,525,371 (GRCm38)	missense	probably benign
Z1177:Xirp2	UTSW	2	67,510,193 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AAAAGACAGCCCGGATATCG -3'
(R):5'- AGCAGATTTCACATTCCCTGC -3'

Sequencing Primer
(F):5'- TCACTGCCTCTGAAGAAGAAAAG -3'
(R):5'- GCCTGTATTTCTTGAGCAGATATTC -3'

Posted On

2016-12-15