Incidental Mutation 'R5787:Or4a76'
ID 448063
Institutional Source Beutler Lab
Gene Symbol Or4a76
Ensembl Gene ENSMUSG00000075079
Gene Name olfactory receptor family 4 subfamily A member 76
Synonyms Olfr1249, GA_x6K02T2Q125-51072323-51071367, MOR231-16P, Olfr1541-ps1, MOR231-17P, MOR231-25_p, MOR231-16P
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5787 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89460284-89461240 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 89461018 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 75 (I75F)
Ref Sequence ENSEMBL: ENSMUSP00000149072 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099769] [ENSMUST00000216124]
AlphaFold L7MU51
Predicted Effect probably benign
Transcript: ENSMUST00000099769
AA Change: I75F

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097357
Gene: ENSMUSG00000075079
AA Change: I75F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 4.9e-47 PFAM
Pfam:7tm_1 39 285 1.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216124
AA Change: I75F

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Adam24 A G 8: 41,133,941 (GRCm39) N470D possibly damaging Het
Adcy8 T C 15: 64,576,067 (GRCm39) D1027G probably damaging Het
Amph A T 13: 19,132,624 (GRCm39) I8F possibly damaging Het
Ankrd60 TGGCCACGCGG TGG 2: 173,419,882 (GRCm39) probably null Het
Ano5 G A 7: 51,216,066 (GRCm39) D348N possibly damaging Het
Atp6v0a1 A G 11: 100,909,400 (GRCm39) D43G probably benign Het
Bltp1 T C 3: 37,046,882 (GRCm39) probably null Het
Btnl10 T A 11: 58,811,169 (GRCm39) I164N probably damaging Het
Ccdc174 C T 6: 91,858,291 (GRCm39) Q71* probably null Het
Ceacam3 G A 7: 16,888,971 (GRCm39) E247K possibly damaging Het
Chrna2 A G 14: 66,386,457 (GRCm39) D201G probably benign Het
Clasp2 G A 9: 113,691,310 (GRCm39) D448N probably damaging Het
Clcn2 C A 16: 20,522,183 (GRCm39) R829L probably damaging Het
Clock A G 5: 76,384,898 (GRCm39) S440P probably damaging Het
Cntn2 T C 1: 132,450,797 (GRCm39) D29G probably damaging Het
Cpne4 A G 9: 104,899,600 (GRCm39) T428A probably benign Het
Cul3 T C 1: 80,260,438 (GRCm39) I304V probably benign Het
Cyp11a1 C A 9: 57,922,550 (GRCm39) Q77K probably benign Het
Cyp3a25 A G 5: 145,935,313 (GRCm39) V101A probably benign Het
Cyp4f15 T C 17: 32,921,782 (GRCm39) F485L probably damaging Het
Des T A 1: 75,340,290 (GRCm39) V399E probably damaging Het
Dhx58 T C 11: 100,592,145 (GRCm39) D301G possibly damaging Het
Ear6 A G 14: 52,091,855 (GRCm39) E134G probably benign Het
Eif2b3 A G 4: 116,901,637 (GRCm39) D100G probably damaging Het
Erich1 T C 8: 14,083,776 (GRCm39) probably null Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Htr4 T C 18: 62,546,693 (GRCm39) V82A probably damaging Het
Hydin A G 8: 111,052,985 (GRCm39) D219G probably damaging Het
Ifit1 T A 19: 34,624,975 (GRCm39) V37E probably benign Het
Isg20 T A 7: 78,569,558 (GRCm39) D176E probably benign Het
Islr2 A G 9: 58,105,637 (GRCm39) V585A probably damaging Het
Kat6a A G 8: 23,422,663 (GRCm39) E991G probably damaging Het
Kcnv1 T C 15: 44,977,726 (GRCm39) Y104C probably damaging Het
Lrtm1 G C 14: 28,743,947 (GRCm39) E138D possibly damaging Het
Mllt3 A T 4: 87,759,057 (GRCm39) D330E probably damaging Het
Mpp7 T C 18: 7,461,682 (GRCm39) N64D probably benign Het
Naip6 G T 13: 100,436,724 (GRCm39) Q600K probably benign Het
Nop9 T G 14: 55,983,791 (GRCm39) C141G possibly damaging Het
Nos1ap T C 1: 170,146,141 (GRCm39) E471G probably benign Het
Npr2 A G 4: 43,633,593 (GRCm39) T246A possibly damaging Het
Or2t1 A C 14: 14,328,725 (GRCm38) M205L probably damaging Het
Or6z1 A T 7: 6,504,989 (GRCm39) S79T probably damaging Het
Pdlim4 T A 11: 53,946,042 (GRCm39) D271V probably damaging Het
Pik3r6 T C 11: 68,430,753 (GRCm39) V518A possibly damaging Het
Rab5a C T 17: 53,804,650 (GRCm39) P87S probably damaging Het
Rbsn C T 6: 92,176,797 (GRCm39) V239I possibly damaging Het
Rsph14 T A 10: 74,793,460 (GRCm39) I314F possibly damaging Het
S1pr2 A T 9: 20,879,232 (GRCm39) S199T probably benign Het
Scrib A G 15: 75,931,151 (GRCm39) L902P probably damaging Het
Slc25a23 T C 17: 57,360,825 (GRCm39) T200A probably damaging Het
Slc8a1 A T 17: 81,696,166 (GRCm39) I956N probably damaging Het
Spef2 A G 15: 9,748,812 (GRCm39) V15A possibly damaging Het
Stim1 T A 7: 102,084,647 (GRCm39) V533E possibly damaging Het
Tbck A T 3: 132,443,329 (GRCm39) D585V probably damaging Het
Tpr T A 1: 150,271,037 (GRCm39) L80Q probably benign Het
Trim67 C T 8: 125,521,051 (GRCm39) R138* probably null Het
Ttn T C 2: 76,580,627 (GRCm39) N23422S probably damaging Het
Uba6 A G 5: 86,260,511 (GRCm39) *1023Q probably null Het
Vmn1r208 T C 13: 22,956,841 (GRCm39) N219D possibly damaging Het
Vmn1r8 T A 6: 57,013,244 (GRCm39) S98R probably damaging Het
Other mutations in Or4a76
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01387:Or4a76 APN 2 89,460,964 (GRCm39) nonsense probably null
IGL02127:Or4a76 APN 2 89,461,098 (GRCm39) missense probably damaging 0.97
IGL02555:Or4a76 APN 2 89,460,547 (GRCm39) missense probably damaging 0.99
IGL02645:Or4a76 APN 2 89,460,679 (GRCm39) missense probably benign 0.05
IGL03112:Or4a76 APN 2 89,460,678 (GRCm39) missense probably benign 0.11
BB008:Or4a76 UTSW 2 89,460,448 (GRCm39) missense possibly damaging 0.78
BB018:Or4a76 UTSW 2 89,460,448 (GRCm39) missense possibly damaging 0.78
R1460:Or4a76 UTSW 2 89,460,282 (GRCm39) splice site probably null
R1496:Or4a76 UTSW 2 89,460,358 (GRCm39) missense possibly damaging 0.96
R4634:Or4a76 UTSW 2 89,460,516 (GRCm39) missense possibly damaging 0.93
R4635:Or4a76 UTSW 2 89,460,516 (GRCm39) missense possibly damaging 0.93
R4636:Or4a76 UTSW 2 89,460,516 (GRCm39) missense possibly damaging 0.93
R5668:Or4a76 UTSW 2 89,460,688 (GRCm39) missense probably damaging 1.00
R5888:Or4a76 UTSW 2 89,461,143 (GRCm39) missense probably damaging 0.99
R6267:Or4a76 UTSW 2 89,460,975 (GRCm39) missense probably damaging 0.98
R6296:Or4a76 UTSW 2 89,460,975 (GRCm39) missense probably damaging 0.98
R7324:Or4a76 UTSW 2 89,460,447 (GRCm39) missense possibly damaging 0.78
R7421:Or4a76 UTSW 2 89,460,915 (GRCm39) missense probably damaging 0.98
R7459:Or4a76 UTSW 2 89,461,012 (GRCm39) missense probably damaging 1.00
R7931:Or4a76 UTSW 2 89,460,448 (GRCm39) missense possibly damaging 0.78
R8129:Or4a76 UTSW 2 89,460,792 (GRCm39) missense probably damaging 1.00
R8239:Or4a76 UTSW 2 89,460,907 (GRCm39) missense probably damaging 0.97
R9053:Or4a76 UTSW 2 89,461,161 (GRCm39) missense probably benign 0.01
R9339:Or4a76 UTSW 2 89,460,555 (GRCm39) missense probably damaging 1.00
R9408:Or4a76 UTSW 2 89,460,388 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATACCCTTCGATTCATGATGATC -3'
(R):5'- GGCCAGAGCAACAATGTCAC -3'

Sequencing Primer
(F):5'- CATGATGATCAAATAATGCAGTGGC -3'
(R):5'- CAATGTCACAGAATTTGTCCTGCTGG -3'
Posted On 2016-12-15