Incidental Mutation 'R5804:Cdk10'
ID 448407
Institutional Source Beutler Lab
Gene Symbol Cdk10
Ensembl Gene ENSMUSG00000033862
Gene Name cyclin dependent kinase 10
Synonyms
MMRRC Submission 043211-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R5804 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 123951581-123958989 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 123955579 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148435 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036880] [ENSMUST00000036880] [ENSMUST00000036880] [ENSMUST00000098327] [ENSMUST00000127664] [ENSMUST00000166768] [ENSMUST00000212193] [ENSMUST00000212193] [ENSMUST00000212361] [ENSMUST00000212361] [ENSMUST00000213005] [ENSMUST00000213005] [ENSMUST00000213005]
AlphaFold Q3UMM4
Predicted Effect probably null
Transcript: ENSMUST00000036880
SMART Domains Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862

DomainStartEndE-ValueType
S_TKc 39 323 1.52e-87 SMART
Predicted Effect probably null
Transcript: ENSMUST00000036880
SMART Domains Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862

DomainStartEndE-ValueType
S_TKc 39 323 1.52e-87 SMART
Predicted Effect probably null
Transcript: ENSMUST00000036880
SMART Domains Protein: ENSMUSP00000045527
Gene: ENSMUSG00000033862

DomainStartEndE-ValueType
S_TKc 39 323 1.52e-87 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000098327
SMART Domains Protein: ENSMUSP00000095932
Gene: ENSMUSG00000033594

DomainStartEndE-ValueType
low complexity region 74 91 N/A INTRINSIC
low complexity region 209 214 N/A INTRINSIC
low complexity region 294 308 N/A INTRINSIC
low complexity region 309 318 N/A INTRINSIC
low complexity region 340 347 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166768
SMART Domains Protein: ENSMUSP00000130306
Gene: ENSMUSG00000033594

DomainStartEndE-ValueType
low complexity region 74 91 N/A INTRINSIC
low complexity region 209 214 N/A INTRINSIC
low complexity region 294 308 N/A INTRINSIC
low complexity region 309 318 N/A INTRINSIC
low complexity region 340 347 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211845
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211876
Predicted Effect probably benign
Transcript: ENSMUST00000212193
Predicted Effect probably benign
Transcript: ENSMUST00000212193
Predicted Effect probably benign
Transcript: ENSMUST00000212361
Predicted Effect probably benign
Transcript: ENSMUST00000212361
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212749
Predicted Effect probably null
Transcript: ENSMUST00000213005
Predicted Effect probably null
Transcript: ENSMUST00000213005
Predicted Effect probably null
Transcript: ENSMUST00000213005
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212021
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212784
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212035
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212532
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212904
Predicted Effect probably benign
Transcript: ENSMUST00000212028
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene belongs to the CDK (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 1. [provided by RefSeq, Jan 2010]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat A T 16: 8,396,100 (GRCm39) R19* probably null Het
Abcb9 A G 5: 124,218,118 (GRCm39) M406T probably benign Het
Ager A G 17: 34,817,157 (GRCm39) E32G probably damaging Het
Cfap97d1 A G 11: 101,881,640 (GRCm39) N112S probably damaging Het
Ctsl A T 13: 64,514,302 (GRCm39) Y259N probably damaging Het
Ctu2 T C 8: 123,207,965 (GRCm39) probably null Het
Dse T A 10: 34,029,375 (GRCm39) I572F possibly damaging Het
Flt1 A T 5: 147,517,247 (GRCm39) probably null Het
Gatm T A 2: 122,433,083 (GRCm39) Y193F probably benign Het
Gpaa1 T C 15: 76,216,826 (GRCm39) F170S probably damaging Het
Grm3 A G 5: 9,620,155 (GRCm39) L363P probably benign Het
Heatr5b G A 17: 79,138,951 (GRCm39) P64S probably damaging Het
Hfm1 A G 5: 107,026,455 (GRCm39) probably null Het
Hivep2 A C 10: 14,009,519 (GRCm39) K1725N probably benign Het
Hmcn1 A T 1: 150,550,098 (GRCm39) C2695* probably null Het
Hmgcr G A 13: 96,802,695 (GRCm39) T68M probably damaging Het
Igsf21 A T 4: 139,755,385 (GRCm39) D423E possibly damaging Het
Jag1 T C 2: 136,930,124 (GRCm39) N751S probably benign Het
Klrc2 A T 6: 129,637,436 (GRCm39) N28K possibly damaging Het
Lrrc8c A T 5: 105,727,423 (GRCm39) D29V possibly damaging Het
Mtcl1 A C 17: 66,650,132 (GRCm39) S1329A probably benign Het
Nin C T 12: 70,092,375 (GRCm39) V645I possibly damaging Het
Or4c127 T C 2: 89,833,332 (GRCm39) I194T possibly damaging Het
Or51i1 T C 7: 103,671,439 (GRCm39) I29V probably benign Het
Or8s2 T A 15: 98,276,215 (GRCm39) M259L probably benign Het
Or9g4 T A 2: 85,504,682 (GRCm39) D271V probably damaging Het
Pfpl A T 19: 12,407,027 (GRCm39) H426L probably benign Het
Poteg A G 8: 27,946,826 (GRCm39) D238G probably damaging Het
Psen1 T C 12: 83,778,474 (GRCm39) F386L probably damaging Het
Rassf9 A T 10: 102,380,905 (GRCm39) I96F probably damaging Het
Robo1 T C 16: 72,840,077 (GRCm39) probably null Het
Slc16a4 A T 3: 107,206,280 (GRCm39) M117L probably benign Het
Slc4a8 A G 15: 100,689,506 (GRCm39) N372S possibly damaging Het
Stmn4 G A 14: 66,593,748 (GRCm39) G47D probably benign Het
Tex26 A G 5: 149,386,612 (GRCm39) N137S possibly damaging Het
Ttn T A 2: 76,747,163 (GRCm39) I4629F probably benign Het
Ubash3a G A 17: 31,427,206 (GRCm39) probably null Het
Ube3d T C 9: 86,307,401 (GRCm39) I233V probably benign Het
Utrn T A 10: 12,297,369 (GRCm39) T680S probably damaging Het
Vps13d G A 4: 144,826,640 (GRCm39) T2846I probably benign Het
Zbtb22 TGGACCCGGGAC TGGACCCGGGACCCGGGAC 17: 34,137,593 (GRCm39) probably null Het
Zfp41 C T 15: 75,490,557 (GRCm39) P170S probably damaging Het
Other mutations in Cdk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Cdk10 APN 8 123,957,063 (GRCm39) missense possibly damaging 0.78
IGL01613:Cdk10 APN 8 123,955,126 (GRCm39) missense probably damaging 0.99
IGL01682:Cdk10 APN 8 123,954,397 (GRCm39) critical splice acceptor site probably null
IGL02536:Cdk10 APN 8 123,953,754 (GRCm39) missense possibly damaging 0.64
R0612:Cdk10 UTSW 8 123,957,419 (GRCm39) missense probably benign 0.16
R1159:Cdk10 UTSW 8 123,955,062 (GRCm39) splice site probably benign
R2356:Cdk10 UTSW 8 123,955,908 (GRCm39) missense probably damaging 0.99
R4838:Cdk10 UTSW 8 123,957,353 (GRCm39) missense probably damaging 1.00
R5453:Cdk10 UTSW 8 123,953,131 (GRCm39) missense probably benign 0.42
R5517:Cdk10 UTSW 8 123,957,326 (GRCm39) splice site probably null
R6930:Cdk10 UTSW 8 123,957,347 (GRCm39) missense probably damaging 1.00
R6971:Cdk10 UTSW 8 123,954,413 (GRCm39) missense probably damaging 1.00
R7910:Cdk10 UTSW 8 123,953,105 (GRCm39) missense probably damaging 1.00
R8356:Cdk10 UTSW 8 123,955,096 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGAGCTGCTGTCTCTAGAG -3'
(R):5'- GACAAACAAGCTGCTGTCTG -3'

Sequencing Primer
(F):5'- AGCTGCTGTCTCTAGAGATGCC -3'
(R):5'- CTGCTGTCTGGAAAGAGAACTG -3'
Posted On 2016-12-15