Incidental Mutation 'R5807:Fcamr'
ID 448562
Institutional Source Beutler Lab
Gene Symbol Fcamr
Ensembl Gene ENSMUSG00000026415
Gene Name Fc receptor, IgA, IgM, high affinity
Synonyms
MMRRC Submission 043393-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R5807 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 130728639-130742477 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130739263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 188 (S188P)
Ref Sequence ENSEMBL: ENSMUSP00000108096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000112477]
AlphaFold Q2TB54
Predicted Effect probably damaging
Transcript: ENSMUST00000027670
AA Change: S132P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415
AA Change: S132P

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
IG 87 191 1.19e-5 SMART
low complexity region 208 220 N/A INTRINSIC
low complexity region 241 253 N/A INTRINSIC
transmembrane domain 456 475 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112477
AA Change: S188P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415
AA Change: S188P

DomainStartEndE-ValueType
low complexity region 80 87 N/A INTRINSIC
IG 143 247 1.19e-5 SMART
low complexity region 264 276 N/A INTRINSIC
low complexity region 297 309 N/A INTRINSIC
transmembrane domain 512 531 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122968
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125056
Meta Mutation Damage Score 0.1860 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 98% (65/66)
MGI Phenotype PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,342,651 (GRCm39) L943P probably damaging Het
Abcg5 C A 17: 84,979,719 (GRCm39) V214F probably damaging Het
Ang T A 14: 51,338,886 (GRCm39) probably benign Het
Arfgef3 A G 10: 18,523,546 (GRCm39) probably null Het
Arhgef4 A G 1: 34,846,696 (GRCm39) probably benign Het
Atp11b T C 3: 35,866,428 (GRCm39) I409T probably damaging Het
Atp5f1b G A 10: 127,924,431 (GRCm39) probably benign Het
Atp9a G A 2: 168,495,454 (GRCm39) A660V probably damaging Het
Avpr1a A G 10: 122,285,376 (GRCm39) T223A probably benign Het
Bmp2k T C 5: 97,211,353 (GRCm39) M507T unknown Het
Cep295 A G 9: 15,243,828 (GRCm39) S287P probably damaging Het
Chrna7 T A 7: 62,798,349 (GRCm39) D111V probably damaging Het
Clxn A T 16: 14,734,836 (GRCm39) I69F probably benign Het
Cnr2 A G 4: 135,644,747 (GRCm39) D275G probably benign Het
Col28a1 T A 6: 8,158,144 (GRCm39) M305L probably benign Het
Cpb1 T A 3: 20,317,906 (GRCm39) D206V probably damaging Het
Cyp2c50 T C 19: 40,101,944 (GRCm39) L453S probably damaging Het
Ddx52 T G 11: 83,840,508 (GRCm39) S284A probably benign Het
Eif2ak4 G T 2: 118,219,332 (GRCm39) R48L probably benign Het
Esrrb A G 12: 86,561,175 (GRCm39) E303G possibly damaging Het
Fbxo21 A G 5: 118,114,933 (GRCm39) E23G probably benign Het
Fer1l6 C A 15: 58,462,399 (GRCm39) S818* probably null Het
Fn1 T C 1: 71,687,218 (GRCm39) D213G probably damaging Het
Gcg A G 2: 62,306,069 (GRCm39) I176T possibly damaging Het
Glis1 T A 4: 107,425,279 (GRCm39) S109T probably benign Het
Gm266 T C 12: 111,452,173 (GRCm39) D11G probably benign Het
Gm5070 C A 3: 95,317,965 (GRCm39) noncoding transcript Het
Gm8444 T C 15: 81,727,654 (GRCm39) probably benign Het
Golga4 A G 9: 118,356,198 (GRCm39) T117A probably damaging Het
Gpr132 G A 12: 112,816,416 (GRCm39) R137C probably damaging Het
Gvin-ps5 T A 7: 105,929,430 (GRCm39) noncoding transcript Het
Herc2 T A 7: 55,880,667 (GRCm39) F4766L probably damaging Het
Inhbc C A 10: 127,193,411 (GRCm39) E202* probably null Het
Kcnu1 C T 8: 26,339,742 (GRCm39) T20I possibly damaging Het
Klhdc3 T C 17: 46,988,391 (GRCm39) D161G probably damaging Het
Krt84 T A 15: 101,438,647 (GRCm39) K280M probably damaging Het
Krtap9-5 T A 11: 99,839,895 (GRCm39) C199S unknown Het
Mrgprb3 A G 7: 48,293,110 (GRCm39) V147A probably benign Het
Ndufs6 A T 13: 73,475,553 (GRCm39) F48L probably damaging Het
Obscn T C 11: 58,970,476 (GRCm39) S2586G probably damaging Het
Or10n1 A G 9: 39,525,759 (GRCm39) R299G probably benign Het
Or13c7b C A 4: 43,820,912 (GRCm39) V150L probably benign Het
Or51a25 C T 7: 102,373,409 (GRCm39) R96H possibly damaging Het
Osbpl6 A G 2: 76,414,857 (GRCm39) D416G probably damaging Het
Pdilt A G 7: 119,099,766 (GRCm39) probably benign Het
Phf12 C A 11: 77,913,252 (GRCm39) D401E probably benign Het
Pla2r1 C T 2: 60,259,065 (GRCm39) V1108M possibly damaging Het
Prim2 A G 1: 33,519,487 (GRCm39) probably benign Het
Ptpn6 T C 6: 124,701,947 (GRCm39) H406R probably benign Het
Qpctl G T 7: 18,877,132 (GRCm39) H329N probably damaging Het
Ripk3 T A 14: 56,022,755 (GRCm39) N390Y probably damaging Het
Rnase1 A G 14: 51,382,907 (GRCm39) V149A probably benign Het
Rtn3 T A 19: 7,434,192 (GRCm39) D581V probably damaging Het
Slamf1 A G 1: 171,602,630 (GRCm39) Y119C probably damaging Het
Slc25a34 A G 4: 141,350,973 (GRCm39) M12T probably benign Het
Tmem38a A G 8: 73,333,944 (GRCm39) Y141C probably damaging Het
Tnr C T 1: 159,714,500 (GRCm39) T793I possibly damaging Het
Tns3 T C 11: 8,443,211 (GRCm39) D384G probably damaging Het
Vmn2r116 T A 17: 23,606,281 (GRCm39) Y398N probably damaging Het
Wee1 TCCCC TCCC 7: 109,723,776 (GRCm39) probably null Het
Other mutations in Fcamr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00840:Fcamr APN 1 130,740,951 (GRCm39) missense probably benign 0.01
IGL02880:Fcamr APN 1 130,741,071 (GRCm39) missense probably benign 0.00
IGL03199:Fcamr APN 1 130,740,655 (GRCm39) missense probably damaging 1.00
IGL03392:Fcamr APN 1 130,728,685 (GRCm39) utr 5 prime probably benign
IGL03398:Fcamr APN 1 130,730,985 (GRCm39) missense probably damaging 0.97
R1101:Fcamr UTSW 1 130,742,223 (GRCm39) splice site probably null
R1312:Fcamr UTSW 1 130,739,224 (GRCm39) missense probably damaging 1.00
R1351:Fcamr UTSW 1 130,740,757 (GRCm39) missense possibly damaging 0.83
R1387:Fcamr UTSW 1 130,732,379 (GRCm39) missense possibly damaging 0.85
R1475:Fcamr UTSW 1 130,742,221 (GRCm39) splice site probably null
R1728:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1728:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,732,306 (GRCm39) missense probably benign 0.06
R1728:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1728:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1728:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1728:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1729:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1729:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1729:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1729:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1729:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1730:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1730:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1730:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1730:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1730:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1730:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1730:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1739:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1739:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1739:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1739:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1739:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1762:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1762:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1762:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1762:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1762:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1783:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1783:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1783:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1783:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1784:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1784:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1784:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1784:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1784:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1785:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1785:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,732,306 (GRCm39) missense probably benign 0.06
R1785:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1793:Fcamr UTSW 1 130,739,284 (GRCm39) missense probably benign 0.03
R2085:Fcamr UTSW 1 130,739,335 (GRCm39) missense probably damaging 1.00
R3937:Fcamr UTSW 1 130,732,313 (GRCm39) missense probably damaging 0.97
R4529:Fcamr UTSW 1 130,732,313 (GRCm39) missense probably damaging 0.99
R4624:Fcamr UTSW 1 130,730,999 (GRCm39) missense probably damaging 0.99
R4822:Fcamr UTSW 1 130,740,423 (GRCm39) missense possibly damaging 0.82
R5055:Fcamr UTSW 1 130,739,174 (GRCm39) missense probably damaging 1.00
R5514:Fcamr UTSW 1 130,741,793 (GRCm39) missense probably damaging 1.00
R6077:Fcamr UTSW 1 130,740,663 (GRCm39) missense probably damaging 1.00
R6200:Fcamr UTSW 1 130,730,927 (GRCm39) missense probably benign 0.16
R6653:Fcamr UTSW 1 130,740,939 (GRCm39) missense possibly damaging 0.89
R7081:Fcamr UTSW 1 130,740,949 (GRCm39) missense probably damaging 1.00
R7362:Fcamr UTSW 1 130,741,760 (GRCm39) missense possibly damaging 0.52
R7828:Fcamr UTSW 1 130,739,443 (GRCm39) missense probably damaging 1.00
R7861:Fcamr UTSW 1 130,742,375 (GRCm39) missense probably benign
R8188:Fcamr UTSW 1 130,730,665 (GRCm39) splice site probably null
R8869:Fcamr UTSW 1 130,739,335 (GRCm39) missense probably damaging 1.00
R8907:Fcamr UTSW 1 130,740,328 (GRCm39) missense probably damaging 1.00
R9568:Fcamr UTSW 1 130,732,356 (GRCm39) missense probably damaging 0.99
X0012:Fcamr UTSW 1 130,740,471 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TTTCTGACAAGTGGAGTCGG -3'
(R):5'- AGACACAGTCAGATTCACGCTG -3'

Sequencing Primer
(F):5'- CAAGTGGAGTCGGTAATTAACTCTCC -3'
(R):5'- CGCTGAAGAATAGCATGTCGTTTC -3'
Posted On 2016-12-15