Incidental Mutation 'R5809:Or5k17'
ID 448938
Institutional Source Beutler Lab
Gene Symbol Or5k17
Ensembl Gene ENSMUSG00000090951
Gene Name olfactory receptor family 5 subfamily K member 17
Synonyms Olfr181, MOR184-4, GA_x54KRFPKG5P-55145984-55145034
MMRRC Submission 043394-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5809 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58745920-58749007 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58746860 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 25 (T25A)
Ref Sequence ENSEMBL: ENSMUSP00000145877 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075361] [ENSMUST00000205668] [ENSMUST00000205742] [ENSMUST00000205986] [ENSMUST00000206168]
AlphaFold Q8VGQ7
Predicted Effect probably benign
Transcript: ENSMUST00000075361
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074825
Gene: ENSMUSG00000090951
AA Change: T25A

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 5.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 308 6.1e-6 PFAM
Pfam:7tm_1 41 308 3.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205668
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000205742
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000205986
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000206168
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214942
Meta Mutation Damage Score 0.0935 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(1) : Gene trapped(1) 

Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A230072I06Rik A G 8: 12,329,556 (GRCm39) S4G unknown Het
AA623943 T C 11: 94,703,828 (GRCm39) noncoding transcript Het
Abca13 T A 11: 9,243,692 (GRCm39) S1852T probably damaging Het
Ackr2 G A 9: 121,738,540 (GRCm39) C305Y probably damaging Het
Aebp1 T C 11: 5,820,257 (GRCm39) V411A probably benign Het
Akp3 G A 1: 87,054,270 (GRCm39) R269H probably benign Het
Alox15 C A 11: 70,241,708 (GRCm39) G58W probably damaging Het
Ankle2 A G 5: 110,385,856 (GRCm39) N369S probably damaging Het
Ankrd28 T A 14: 31,465,311 (GRCm39) I289L probably benign Het
Atp13a4 T A 16: 29,252,805 (GRCm39) T714S possibly damaging Het
Birc6 A C 17: 74,977,369 (GRCm39) N4388T probably damaging Het
Blm A T 7: 80,114,592 (GRCm39) L1159Q probably damaging Het
Caskin1 G A 17: 24,723,521 (GRCm39) V770I probably benign Het
Ccdc148 T A 2: 58,713,657 (GRCm39) H498L probably damaging Het
Cdh26 T A 2: 178,101,919 (GRCm39) Y179* probably null Het
Cela2a T A 4: 141,552,864 (GRCm39) T38S probably benign Het
Cep350 A T 1: 155,809,087 (GRCm39) N496K probably damaging Het
Cep89 A G 7: 35,117,151 (GRCm39) Y251C probably damaging Het
Cluh T C 11: 74,552,526 (GRCm39) S524P probably damaging Het
Cpeb4 T C 11: 31,822,801 (GRCm39) S172P probably damaging Het
Ctnnd2 T C 15: 30,847,523 (GRCm39) S705P probably damaging Het
Dock2 T G 11: 34,212,445 (GRCm39) D1232A probably benign Het
Donson T C 16: 91,484,738 (GRCm39) N9S possibly damaging Het
Gdf9 T C 11: 53,324,381 (GRCm39) L50P probably benign Het
Gm10300 C T 4: 131,802,458 (GRCm39) probably benign Het
Gm8369 A G 19: 11,482,248 (GRCm39) probably benign Het
Gm8674 T A 13: 50,055,924 (GRCm39) noncoding transcript Het
Hepacam T A 9: 37,296,101 (GRCm39) S417R possibly damaging Het
Hibch T A 1: 52,892,859 (GRCm39) L23Q probably benign Het
Hmcn1 G A 1: 150,525,358 (GRCm39) R3389C probably damaging Het
Hsp90ab1 G T 17: 45,881,575 (GRCm39) probably benign Het
Hunk C A 16: 90,272,791 (GRCm39) T365K probably damaging Het
Il12a A T 3: 68,602,595 (GRCm39) probably benign Het
Ints13 A G 6: 146,477,847 (GRCm39) V34A probably benign Het
Intu A C 3: 40,634,020 (GRCm39) M418L probably damaging Het
Khdc4 A G 3: 88,616,192 (GRCm39) R460G probably damaging Het
Klra9 A G 6: 130,156,036 (GRCm39) S240P probably damaging Het
Mtpn C T 6: 35,489,225 (GRCm39) D100N probably benign Het
Ndrg1 A G 15: 66,802,699 (GRCm39) probably benign Het
Or11g24 T C 14: 50,662,905 (GRCm39) *310Q probably null Het
Pate6 C T 9: 35,700,297 (GRCm39) C96Y probably damaging Het
Pax7 A G 4: 139,557,682 (GRCm39) S30P probably damaging Het
Pdcd11 A T 19: 47,082,247 (GRCm39) T54S probably benign Het
Pex19 T C 1: 171,958,306 (GRCm39) V95A probably damaging Het
Pkhd1l1 A G 15: 44,383,103 (GRCm39) I1121V probably benign Het
Pklr A T 3: 89,049,091 (GRCm39) I146F probably benign Het
Plcb1 T C 2: 135,104,164 (GRCm39) Y278H possibly damaging Het
Plcl1 T A 1: 55,735,160 (GRCm39) I167N probably damaging Het
Plekhh1 A T 12: 79,125,461 (GRCm39) I1241F probably benign Het
Plxnb2 G T 15: 89,051,774 (GRCm39) D148E possibly damaging Het
Pthlh T C 6: 147,158,745 (GRCm39) I72V probably damaging Het
Ptpru C T 4: 131,513,067 (GRCm39) R880Q probably benign Het
Rrp36 T C 17: 46,978,932 (GRCm39) K209E probably damaging Het
Scarb1 A G 5: 125,381,286 (GRCm39) V86A probably damaging Het
Sh2d7 A C 9: 54,446,860 (GRCm39) S37R probably benign Het
Slc13a2 A T 11: 78,288,647 (GRCm39) V543E probably damaging Het
Smarcal1 A G 1: 72,630,296 (GRCm39) T117A probably benign Het
Smok2a A G 17: 13,445,865 (GRCm39) R481G possibly damaging Het
Smr2 G A 5: 88,256,699 (GRCm39) A126T probably benign Het
Sspo G T 6: 48,436,979 (GRCm39) W1304C possibly damaging Het
Svep1 A G 4: 58,116,524 (GRCm39) S909P possibly damaging Het
Tchh A T 3: 93,352,880 (GRCm39) K773N unknown Het
Tmem156 T C 5: 65,232,950 (GRCm39) N140S possibly damaging Het
Tmem213 T C 6: 38,092,589 (GRCm39) I107T possibly damaging Het
Tpd52l2 A G 2: 181,153,372 (GRCm39) Y161C probably damaging Het
Trappc8 C T 18: 20,951,139 (GRCm39) A1436T probably benign Het
Ubr3 A G 2: 69,795,855 (GRCm39) Y933C possibly damaging Het
Ufm1 A T 3: 53,765,303 (GRCm39) probably benign Het
Wdr27 A T 17: 15,103,931 (GRCm39) L725Q probably damaging Het
Zdbf2 A G 1: 63,345,035 (GRCm39) D1138G possibly damaging Het
Zkscan16 G A 4: 58,946,481 (GRCm39) V119M probably damaging Het
Zmat5 A G 11: 4,672,431 (GRCm39) D16G probably damaging Het
Other mutations in Or5k17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01845:Or5k17 APN 16 58,746,929 (GRCm39) missense probably benign
IGL02477:Or5k17 APN 16 58,746,126 (GRCm39) missense probably benign 0.07
IGL02545:Or5k17 APN 16 58,746,833 (GRCm39) missense possibly damaging 0.88
IGL02690:Or5k17 APN 16 58,746,214 (GRCm39) missense possibly damaging 0.78
IGL02718:Or5k17 APN 16 58,746,459 (GRCm39) missense possibly damaging 0.57
IGL02945:Or5k17 APN 16 58,746,703 (GRCm39) missense probably damaging 1.00
IGL03349:Or5k17 APN 16 58,746,323 (GRCm39) missense probably benign 0.00
B5639:Or5k17 UTSW 16 58,746,889 (GRCm39) missense probably benign 0.00
R0550:Or5k17 UTSW 16 58,746,748 (GRCm39) missense probably damaging 1.00
R0659:Or5k17 UTSW 16 58,746,772 (GRCm39) missense possibly damaging 0.94
R1433:Or5k17 UTSW 16 58,746,049 (GRCm39) missense probably benign
R1957:Or5k17 UTSW 16 58,746,530 (GRCm39) missense probably benign
R2155:Or5k17 UTSW 16 58,746,486 (GRCm39) missense probably benign 0.01
R2404:Or5k17 UTSW 16 58,745,998 (GRCm39) missense probably benign 0.01
R2568:Or5k17 UTSW 16 58,746,286 (GRCm39) missense probably benign 0.27
R4022:Or5k17 UTSW 16 58,746,483 (GRCm39) missense possibly damaging 0.94
R4592:Or5k17 UTSW 16 58,746,455 (GRCm39) missense probably benign 0.00
R4673:Or5k17 UTSW 16 58,746,053 (GRCm39) missense possibly damaging 0.61
R4880:Or5k17 UTSW 16 58,746,463 (GRCm39) missense probably damaging 0.98
R5109:Or5k17 UTSW 16 58,746,422 (GRCm39) missense probably benign 0.10
R5231:Or5k17 UTSW 16 58,746,077 (GRCm39) missense possibly damaging 0.94
R5291:Or5k17 UTSW 16 58,746,764 (GRCm39) missense possibly damaging 0.96
R5477:Or5k17 UTSW 16 58,746,393 (GRCm39) missense possibly damaging 0.61
R5524:Or5k17 UTSW 16 58,746,172 (GRCm39) missense probably benign 0.00
R5830:Or5k17 UTSW 16 58,746,457 (GRCm39) missense possibly damaging 0.64
R6119:Or5k17 UTSW 16 58,746,895 (GRCm39) missense possibly damaging 0.94
R6217:Or5k17 UTSW 16 58,746,877 (GRCm39) missense probably benign 0.03
R6861:Or5k17 UTSW 16 58,746,867 (GRCm39) missense probably benign
R6939:Or5k17 UTSW 16 58,746,648 (GRCm39) nonsense probably null
R7376:Or5k17 UTSW 16 58,746,121 (GRCm39) missense possibly damaging 0.82
R7650:Or5k17 UTSW 16 58,746,416 (GRCm39) nonsense probably null
R8153:Or5k17 UTSW 16 58,746,149 (GRCm39) missense possibly damaging 0.47
R8947:Or5k17 UTSW 16 58,746,433 (GRCm39) missense probably benign
R9205:Or5k17 UTSW 16 58,746,486 (GRCm39) missense probably benign 0.01
R9205:Or5k17 UTSW 16 58,746,485 (GRCm39) missense probably benign 0.00
R9318:Or5k17 UTSW 16 58,746,271 (GRCm39) missense probably damaging 1.00
R9654:Or5k17 UTSW 16 58,746,752 (GRCm39) missense probably benign 0.00
R9678:Or5k17 UTSW 16 58,746,640 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- ATCTTGGGAGTGATGGCAC -3'
(R):5'- TGACCCATGACCTATCCTGG -3'

Sequencing Primer
(F):5'- CAGGAGCAGCAGGAGTCCATC -3'
(R):5'- ATGACCTATCCTGGGCTTGCTG -3'
Posted On 2016-12-15