|Institutional Source||Beutler Lab|
|Gene Name||argonaute RISC catalytic subunit 2|
|Synonyms||2310051F07Rik, argonaute 2, Eif2c2, 1110029L17Rik|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R5815 (G1)|
|Chromosomal Location||73095844-73184935 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to C at 73107366 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000042207 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000044113]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygous null mice display embryonic lethality with neural tube defects, abnormal forebrain patterning, enlarged hearts, pericardial swelling, delayed development, and defects in the yolk sac and placenta. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ago2||
(F):5'- GCGACACTCACCTGTCATGTTC -3'
(R):5'- CCTAAACTAATGCTGCAAGGC -3'
(F):5'- GTCATGTTCTTTATCCACCAGGTG -3'
(R):5'- CTGCAAGGCTTGGAGGG -3'