Incidental Mutation 'R0547:Gpr26'
ID 44905
Institutional Source Beutler Lab
Gene Symbol Gpr26
Ensembl Gene ENSMUSG00000040125
Gene Name G protein-coupled receptor 26
Synonyms 9630036A11Rik
MMRRC Submission 038739-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R0547 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 131567891-131587362 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 131586026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 332 (I332T)
Ref Sequence ENSEMBL: ENSMUSP00000041664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045840] [ENSMUST00000124096]
AlphaFold Q8BZA7
Predicted Effect probably benign
Transcript: ENSMUST00000045840
AA Change: I332T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000041664
Gene: ENSMUSG00000040125
AA Change: I332T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 15 309 1.9e-7 PFAM
Pfam:7tm_1 22 294 1.4e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Meta Mutation Damage Score 0.0732 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057N15Rik A G 16: 88,570,498 (GRCm39) Y181H probably benign Het
A530084C06Rik A G 13: 31,742,813 (GRCm39) probably benign Het
Adamtsl1 A G 4: 86,274,592 (GRCm39) D1208G probably benign Het
Ankrd55 T C 13: 112,504,757 (GRCm39) F501S probably benign Het
Aox1 G A 1: 58,349,201 (GRCm39) D656N probably damaging Het
Atr A T 9: 95,781,218 (GRCm39) probably benign Het
Bicra G A 7: 15,706,173 (GRCm39) R1423W probably damaging Het
Cabyr T A 18: 12,884,073 (GRCm39) S187T probably benign Het
Car5b G A X: 162,762,297 (GRCm39) R282C probably damaging Het
Cdon A T 9: 35,368,794 (GRCm39) T343S possibly damaging Het
Cep350 C T 1: 155,777,181 (GRCm39) probably null Het
Cimap1a A G 7: 140,428,728 (GRCm39) probably null Het
Copa T C 1: 171,949,254 (GRCm39) probably benign Het
Cyp4f18 T C 8: 72,749,854 (GRCm39) D265G probably benign Het
Dgkb T A 12: 38,654,157 (GRCm39) C759S probably benign Het
Dnah6 T C 6: 73,021,757 (GRCm39) M3470V probably benign Het
Eif4g2 T C 7: 110,677,500 (GRCm39) N177S probably damaging Het
Etfb C T 7: 43,104,002 (GRCm39) Q145* probably null Het
Flnb T A 14: 7,912,943 (GRCm38) probably null Het
G430095P16Rik G A 8: 85,453,271 (GRCm39) probably benign Het
Gfral A T 9: 76,115,924 (GRCm39) S17T probably benign Het
Greb1 T A 12: 16,773,412 (GRCm39) T221S probably benign Het
Haus5 A T 7: 30,358,508 (GRCm39) S289T probably damaging Het
Ighv6-4 T C 12: 114,370,221 (GRCm39) Y77C probably damaging Het
Il23r A T 6: 67,400,685 (GRCm39) D548E probably benign Het
Il23r A T 6: 67,463,235 (GRCm39) F86Y possibly damaging Het
Inppl1 A T 7: 101,480,210 (GRCm39) M424K probably benign Het
Jam3 A G 9: 27,010,184 (GRCm39) Y267H probably damaging Het
Lrrc37 T C 11: 103,510,990 (GRCm39) N326S unknown Het
Mms19 A T 19: 41,951,857 (GRCm39) M160K probably damaging Het
Muc2 CGTG CGTGTG 7: 141,699,185 (GRCm38) probably null Het
Mup5 A G 4: 61,751,237 (GRCm39) L137P probably damaging Het
Mylk G C 16: 34,699,845 (GRCm39) E403Q possibly damaging Het
Ntrk2 G A 13: 59,022,184 (GRCm39) S413N probably damaging Het
Nuak2 C A 1: 132,259,941 (GRCm39) T573N probably benign Het
Or4m1 A T 14: 50,557,575 (GRCm39) I239K probably benign Het
Or52h9 G A 7: 104,202,563 (GRCm39) V146M probably benign Het
Padi4 GCTGCGTACCTCCAC GC 4: 140,475,760 (GRCm39) probably benign Het
Pclo T A 5: 14,842,086 (GRCm39) I4787N unknown Het
Pde8a G T 7: 80,973,878 (GRCm39) V612L probably benign Het
Pear1 A T 3: 87,696,107 (GRCm39) probably null Het
Pgbd1 A G 13: 21,607,688 (GRCm39) Y169H probably damaging Het
Pkd1l1 A G 11: 8,786,448 (GRCm39) probably benign Het
Prkag3 C T 1: 74,783,879 (GRCm39) probably null Het
Rsph9 A T 17: 46,455,050 (GRCm39) S9T possibly damaging Het
Rxfp1 A T 3: 79,612,876 (GRCm39) probably null Het
Senp7 A G 16: 55,996,189 (GRCm39) E756G probably damaging Het
Serpina1e G T 12: 103,915,450 (GRCm39) T252K probably benign Het
Sipa1l1 T A 12: 82,484,510 (GRCm39) S1555T probably benign Het
Slain1 T C 14: 103,932,711 (GRCm39) S432P probably damaging Het
Slc37a2 A T 9: 37,144,418 (GRCm39) probably null Het
Thg1l C T 11: 45,845,018 (GRCm39) R18Q probably damaging Het
Tnn A G 1: 159,943,907 (GRCm39) probably benign Het
Trim32 G A 4: 65,531,491 (GRCm39) R16Q probably damaging Het
Tshz3 A G 7: 36,470,842 (GRCm39) T944A probably damaging Het
Ttn C G 2: 76,684,774 (GRCm39) probably benign Het
Ythdc2 T C 18: 44,973,331 (GRCm39) S323P possibly damaging Het
Zfp827 A G 8: 79,786,939 (GRCm39) N35S probably damaging Het
Other mutations in Gpr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Gpr26 APN 7 131,569,230 (GRCm39) missense probably damaging 1.00
IGL01345:Gpr26 APN 7 131,569,161 (GRCm39) missense possibly damaging 0.90
IGL01658:Gpr26 APN 7 131,585,834 (GRCm39) missense probably benign
IGL02724:Gpr26 APN 7 131,576,121 (GRCm39) critical splice donor site probably null
R0408:Gpr26 UTSW 7 131,576,001 (GRCm39) splice site probably null
R0408:Gpr26 UTSW 7 131,569,249 (GRCm39) missense possibly damaging 0.81
R2508:Gpr26 UTSW 7 131,568,823 (GRCm39) missense probably damaging 0.98
R4088:Gpr26 UTSW 7 131,568,805 (GRCm39) missense probably benign 0.00
R4630:Gpr26 UTSW 7 131,568,709 (GRCm39) missense probably damaging 1.00
R4680:Gpr26 UTSW 7 131,576,082 (GRCm39) missense probably benign 0.34
R4756:Gpr26 UTSW 7 131,569,230 (GRCm39) missense probably damaging 1.00
R5229:Gpr26 UTSW 7 131,585,976 (GRCm39) missense probably damaging 1.00
R5610:Gpr26 UTSW 7 131,568,694 (GRCm39) missense possibly damaging 0.94
R6605:Gpr26 UTSW 7 131,585,893 (GRCm39) missense possibly damaging 0.91
R6653:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
R7213:Gpr26 UTSW 7 131,569,219 (GRCm39) missense probably damaging 1.00
R7351:Gpr26 UTSW 7 131,576,094 (GRCm39) missense probably damaging 1.00
R7768:Gpr26 UTSW 7 131,576,077 (GRCm39) missense probably damaging 0.99
R7887:Gpr26 UTSW 7 131,568,702 (GRCm39) missense probably benign
R8822:Gpr26 UTSW 7 131,568,997 (GRCm39) missense probably damaging 0.98
R9382:Gpr26 UTSW 7 131,568,963 (GRCm39) missense probably damaging 1.00
R9508:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
Z1088:Gpr26 UTSW 7 131,585,823 (GRCm39) frame shift probably null
Z1176:Gpr26 UTSW 7 131,568,954 (GRCm39) missense probably damaging 1.00
Z1176:Gpr26 UTSW 7 131,568,777 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTCTGAACACATGCCCACAGC -3'
(R):5'- TGACATCTACCCTGGAAGAGCCAAG -3'

Sequencing Primer
(F):5'- GGTGGAACTCTTCTCCACAG -3'
(R):5'- CAAGAAGCAGGCCCCAG -3'
Posted On 2013-06-11