Incidental Mutation 'R5816:Mllt6'
ID 449058
Institutional Source Beutler Lab
Gene Symbol Mllt6
Ensembl Gene ENSMUSG00000038437
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms Af17
MMRRC Submission 043214-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5816 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 97554240-97576289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 97563400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 328 (K328E)
Ref Sequence ENSEMBL: ENSMUSP00000103212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044730] [ENSMUST00000107586]
AlphaFold B1AR10
Predicted Effect possibly damaging
Transcript: ENSMUST00000044730
AA Change: K328E

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000045445
Gene: ENSMUSG00000038437
AA Change: K328E

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 358 380 N/A INTRINSIC
low complexity region 398 412 N/A INTRINSIC
low complexity region 487 498 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 520 536 N/A INTRINSIC
low complexity region 559 573 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 649 666 N/A INTRINSIC
coiled coil region 703 744 N/A INTRINSIC
low complexity region 746 756 N/A INTRINSIC
low complexity region 773 782 N/A INTRINSIC
low complexity region 802 848 N/A INTRINSIC
low complexity region 860 901 N/A INTRINSIC
coiled coil region 915 942 N/A INTRINSIC
low complexity region 995 1018 N/A INTRINSIC
low complexity region 1026 1037 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000107586
AA Change: K328E

PolyPhen 2 Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000103212
Gene: ENSMUSG00000038437
AA Change: K328E

DomainStartEndE-ValueType
PHD 7 55 5.92e-7 SMART
PHD 119 178 5e-5 SMART
low complexity region 190 224 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 290 330 N/A INTRINSIC
low complexity region 336 356 N/A INTRINSIC
low complexity region 388 410 N/A INTRINSIC
low complexity region 428 442 N/A INTRINSIC
low complexity region 517 528 N/A INTRINSIC
low complexity region 532 546 N/A INTRINSIC
low complexity region 550 566 N/A INTRINSIC
low complexity region 589 603 N/A INTRINSIC
low complexity region 609 631 N/A INTRINSIC
low complexity region 679 696 N/A INTRINSIC
coiled coil region 733 774 N/A INTRINSIC
low complexity region 776 786 N/A INTRINSIC
low complexity region 803 812 N/A INTRINSIC
low complexity region 832 878 N/A INTRINSIC
low complexity region 890 931 N/A INTRINSIC
coiled coil region 945 972 N/A INTRINSIC
low complexity region 1025 1048 N/A INTRINSIC
low complexity region 1056 1067 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143220
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151729
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155835
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184494
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 T C 11: 94,234,563 (GRCm39) D1501G probably damaging Het
Aldh8a1 A T 10: 21,271,329 (GRCm39) I352F probably damaging Het
Bend7 G A 2: 4,749,143 (GRCm39) E87K probably damaging Het
Bend7 A G 2: 4,757,710 (GRCm39) R251G probably benign Het
Cep72 A T 13: 74,197,150 (GRCm39) S402T probably benign Het
Cer1 A G 4: 82,801,120 (GRCm39) V181A probably damaging Het
Ces1b T C 8: 93,799,890 (GRCm39) N162S probably benign Het
Cyp1a2 T C 9: 57,588,336 (GRCm39) N296S probably benign Het
Cyria A G 12: 12,408,166 (GRCm39) D64G probably benign Het
Dst C T 1: 34,218,315 (GRCm39) A1585V probably benign Het
Dzip1 G A 14: 119,146,892 (GRCm39) P339L probably benign Het
Eif4enif1 T C 11: 3,192,401 (GRCm39) I568T probably benign Het
Eif5a C T 11: 69,808,499 (GRCm39) R109Q possibly damaging Het
Foxj2 G A 6: 122,810,695 (GRCm39) S225N probably benign Het
Foxp1 TTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG TTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG 6: 99,052,926 (GRCm39) probably benign Het
Galnt14 T C 17: 73,881,877 (GRCm39) Y74C probably damaging Het
Glrb T A 3: 80,769,286 (GRCm39) N147I probably damaging Het
Grb14 A T 2: 64,747,628 (GRCm39) M377K probably damaging Het
Kcng1 C T 2: 168,110,643 (GRCm39) E174K possibly damaging Het
Kdm3b A C 18: 34,961,522 (GRCm39) E1433A probably damaging Het
Matn3 G A 12: 9,020,571 (GRCm39) R481H probably damaging Het
Mcm6 A G 1: 128,276,192 (GRCm39) V331A probably benign Het
Mdga2 T C 12: 66,701,956 (GRCm39) Y415C probably damaging Het
Med11 T C 11: 70,343,111 (GRCm39) S65P probably damaging Het
Metrnl T A 11: 121,598,938 (GRCm39) S166T probably benign Het
Nek5 T C 8: 22,586,752 (GRCm39) K353R probably benign Het
Or52ab4 A G 7: 102,988,202 (GRCm39) T314A probably benign Het
Or8g52 T A 9: 39,630,526 (GRCm39) M1K probably null Het
Pfkl A T 10: 77,837,856 (GRCm39) N46K possibly damaging Het
Phactr3 A G 2: 177,944,586 (GRCm39) E428G probably damaging Het
Pkhd1 T C 1: 20,128,902 (GRCm39) S3934G probably benign Het
Pkhd1l1 A G 15: 44,429,718 (GRCm39) D3312G probably benign Het
Prmt8 G A 6: 127,674,701 (GRCm39) T309I probably benign Het
Psd3 A T 8: 68,413,162 (GRCm39) V742E possibly damaging Het
S100a14 A G 3: 90,435,157 (GRCm39) H56R probably damaging Het
Scaf8 T A 17: 3,227,988 (GRCm39) S406T unknown Het
Slc26a4 G T 12: 31,578,684 (GRCm39) H656Q probably damaging Het
Smarcc1 T C 9: 110,026,712 (GRCm39) V724A possibly damaging Het
Thbs2 C T 17: 14,904,333 (GRCm39) probably null Het
Zbtb6 A T 2: 37,319,227 (GRCm39) F234I probably benign Het
Zfp536 C T 7: 37,180,053 (GRCm39) D851N probably damaging Het
Other mutations in Mllt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01745:Mllt6 APN 11 97,567,754 (GRCm39) missense probably damaging 1.00
IGL01808:Mllt6 APN 11 97,563,310 (GRCm39) missense possibly damaging 0.88
IGL01967:Mllt6 APN 11 97,565,603 (GRCm39) missense probably damaging 0.98
IGL02247:Mllt6 APN 11 97,561,158 (GRCm39) missense probably benign 0.01
IGL03161:Mllt6 APN 11 97,557,977 (GRCm39) missense probably benign 0.03
R0284:Mllt6 UTSW 11 97,569,431 (GRCm39) missense probably benign 0.02
R0718:Mllt6 UTSW 11 97,567,185 (GRCm39) splice site probably benign
R0783:Mllt6 UTSW 11 97,556,571 (GRCm39) missense probably damaging 0.99
R0811:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0812:Mllt6 UTSW 11 97,569,387 (GRCm39) missense probably damaging 0.97
R0904:Mllt6 UTSW 11 97,555,824 (GRCm39) missense probably damaging 1.00
R0960:Mllt6 UTSW 11 97,555,772 (GRCm39) splice site probably benign
R1445:Mllt6 UTSW 11 97,563,277 (GRCm39) splice site probably benign
R1523:Mllt6 UTSW 11 97,555,849 (GRCm39) missense probably damaging 1.00
R1781:Mllt6 UTSW 11 97,563,395 (GRCm39) missense probably benign
R1952:Mllt6 UTSW 11 97,568,048 (GRCm39) missense probably damaging 0.99
R2258:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2259:Mllt6 UTSW 11 97,555,802 (GRCm39) missense probably damaging 1.00
R2927:Mllt6 UTSW 11 97,571,602 (GRCm39) missense probably damaging 0.98
R4866:Mllt6 UTSW 11 97,565,285 (GRCm39) missense probably damaging 1.00
R4938:Mllt6 UTSW 11 97,569,233 (GRCm39) missense probably benign
R5039:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5058:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5064:Mllt6 UTSW 11 97,564,775 (GRCm39) missense probably damaging 1.00
R5076:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5115:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5379:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5509:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5510:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5511:Mllt6 UTSW 11 97,560,326 (GRCm39) missense possibly damaging 0.83
R5603:Mllt6 UTSW 11 97,564,331 (GRCm39) missense probably damaging 1.00
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6030:Mllt6 UTSW 11 97,568,051 (GRCm39) missense probably damaging 0.99
R6051:Mllt6 UTSW 11 97,571,569 (GRCm39) nonsense probably null
R6180:Mllt6 UTSW 11 97,569,362 (GRCm39) missense possibly damaging 0.85
R6277:Mllt6 UTSW 11 97,564,774 (GRCm39) missense probably damaging 1.00
R6667:Mllt6 UTSW 11 97,567,760 (GRCm39) missense probably damaging 1.00
R6754:Mllt6 UTSW 11 97,565,273 (GRCm39) missense probably damaging 1.00
R6791:Mllt6 UTSW 11 97,571,428 (GRCm39) missense probably damaging 0.98
R7049:Mllt6 UTSW 11 97,564,637 (GRCm39) missense probably damaging 1.00
R7194:Mllt6 UTSW 11 97,564,394 (GRCm39) missense probably benign 0.23
R7387:Mllt6 UTSW 11 97,565,426 (GRCm39) missense probably benign 0.04
R7484:Mllt6 UTSW 11 97,563,442 (GRCm39) missense probably benign 0.18
R7685:Mllt6 UTSW 11 97,567,790 (GRCm39) missense probably damaging 0.99
R7853:Mllt6 UTSW 11 97,561,142 (GRCm39) missense probably benign
R7862:Mllt6 UTSW 11 97,556,631 (GRCm39) missense probably benign 0.03
R8004:Mllt6 UTSW 11 97,566,966 (GRCm39) missense possibly damaging 0.91
R8498:Mllt6 UTSW 11 97,567,688 (GRCm39) missense possibly damaging 0.86
R9044:Mllt6 UTSW 11 97,554,485 (GRCm39) missense probably damaging 1.00
R9297:Mllt6 UTSW 11 97,563,314 (GRCm39) missense probably damaging 0.96
R9457:Mllt6 UTSW 11 97,556,586 (GRCm39) missense probably benign 0.12
R9557:Mllt6 UTSW 11 97,564,310 (GRCm39) missense probably benign 0.04
Z1177:Mllt6 UTSW 11 97,567,251 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- TCCCAGTTCAGGTTGTGCAC -3'
(R):5'- CTTGTAAGGAAAGGGGCTCTGG -3'

Sequencing Primer
(F):5'- TTGTGCACCCTCCCGAG -3'
(R):5'- AGCCATCAGTAACGGGTTC -3'
Posted On 2016-12-20