Incidental Mutation 'R5818:Or10d1b'
ID 449165
Institutional Source Beutler Lab
Gene Symbol Or10d1b
Ensembl Gene ENSMUSG00000062121
Gene Name olfactory receptor family 10 subfamily D member 1B
Synonyms M31, Olfr149, MOR224-8, GA_x6K02T2PVTD-33400306-33399371
MMRRC Submission 043398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R5818 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39613128-39614063 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39613661 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 135 (S135G)
Ref Sequence ENSEMBL: ENSMUSP00000149664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082027] [ENSMUST00000215192]
AlphaFold Q60888
Predicted Effect probably benign
Transcript: ENSMUST00000082027
AA Change: S135G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000080686
Gene: ENSMUSG00000062121
AA Change: S135G

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 223 3.8e-9 PFAM
Pfam:7tm_1 39 286 1.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215192
AA Change: S135G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,110,469 (GRCm39) V560D probably damaging Het
Actn4 A G 7: 28,618,444 (GRCm39) I72T probably damaging Het
Adam33 A T 2: 130,896,278 (GRCm39) C440S possibly damaging Het
Bace1 T C 9: 45,770,347 (GRCm39) I361T possibly damaging Het
Bend6 T C 1: 33,922,654 (GRCm39) probably benign Het
Bpifb9a T G 2: 154,104,215 (GRCm39) N219K probably damaging Het
Cacna1g C A 11: 94,308,946 (GRCm39) K1634N probably damaging Het
Cdk18 A G 1: 132,046,836 (GRCm39) probably null Het
Chrng G A 1: 87,137,523 (GRCm39) V320I probably benign Het
Corin G T 5: 72,592,738 (GRCm39) H87N probably benign Het
Cps1 A T 1: 67,205,647 (GRCm39) I557F possibly damaging Het
Cyp4a29 T C 4: 115,104,229 (GRCm39) V99A possibly damaging Het
Dach1 T C 14: 98,406,120 (GRCm39) D209G probably damaging Het
Dgat1 G A 15: 76,386,407 (GRCm39) probably benign Het
Eif1ad8 T G 12: 87,563,830 (GRCm39) V55G possibly damaging Het
Fbxw26 G T 9: 109,561,634 (GRCm39) R187S probably benign Het
Gabrd G A 4: 155,472,818 (GRCm39) P122S probably damaging Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Hif1a A G 12: 73,986,338 (GRCm39) Q343R possibly damaging Het
Hyou1 G A 9: 44,300,223 (GRCm39) probably null Het
Igfn1 A T 1: 135,893,864 (GRCm39) I2072K possibly damaging Het
Itprid2 T A 2: 79,474,937 (GRCm39) S299T probably damaging Het
Kash5 C T 7: 44,843,383 (GRCm39) probably null Het
Kctd8 C T 5: 69,454,054 (GRCm39) A328T probably benign Het
Krt10 A G 11: 99,279,597 (GRCm39) Y188H probably damaging Het
Krtap4-16 T A 11: 99,742,349 (GRCm39) Q17L unknown Het
Larp4b T A 13: 9,208,596 (GRCm39) S416R probably benign Het
Lmtk2 G A 5: 144,093,718 (GRCm39) V232M probably benign Het
Mroh4 A G 15: 74,483,831 (GRCm39) I571T probably damaging Het
Myo15a G A 11: 60,388,777 (GRCm39) R2021Q probably benign Het
Npl G A 1: 153,411,661 (GRCm39) R63C probably damaging Het
Ntn4 A G 10: 93,480,626 (GRCm39) I80V probably benign Het
Numb C T 12: 83,872,028 (GRCm39) probably null Het
Nusap1 A C 2: 119,465,994 (GRCm39) M205L possibly damaging Het
Onecut2 T A 18: 64,474,046 (GRCm39) M180K possibly damaging Het
Pmfbp1 T C 8: 110,265,311 (GRCm39) probably null Het
Ppfia1 T C 7: 144,074,305 (GRCm39) probably benign Het
Ppm1b A G 17: 85,301,147 (GRCm39) K9R probably benign Het
Rab11fip3 T C 17: 26,235,090 (GRCm39) S608G probably damaging Het
Smim8 TTTAATGAAGAGCT TT 4: 34,771,261 (GRCm39) probably benign Het
Sohlh2 A G 3: 55,097,922 (GRCm39) T125A probably damaging Het
Tet1 C A 10: 62,652,187 (GRCm39) M1610I possibly damaging Het
Tgfbr3 A T 5: 107,280,869 (GRCm39) D630E probably benign Het
Thnsl2 T C 6: 71,111,127 (GRCm39) D247G probably benign Het
Tmem198b G A 10: 128,638,057 (GRCm39) R169W probably benign Het
Tmem201 G A 4: 149,811,849 (GRCm39) A332V probably benign Het
Tsku T C 7: 98,001,305 (GRCm39) D342G possibly damaging Het
Ucn2 A T 9: 108,815,565 (GRCm39) H109L probably benign Het
Virma T G 4: 11,513,319 (GRCm39) L391R possibly damaging Het
Vmn1r60 T A 7: 5,548,098 (GRCm39) M1L probably benign Het
Vmn2r76 T C 7: 85,879,142 (GRCm39) H386R probably benign Het
Zfp608 C T 18: 55,028,468 (GRCm39) R1315Q probably benign Het
Zmym2 A G 14: 57,183,986 (GRCm39) T983A probably benign Het
Zscan26 A G 13: 21,629,931 (GRCm39) S65P probably benign Het
Other mutations in Or10d1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Or10d1b APN 9 39,613,549 (GRCm39) missense probably damaging 1.00
IGL02707:Or10d1b APN 9 39,613,937 (GRCm39) missense probably damaging 0.99
IGL02730:Or10d1b APN 9 39,613,534 (GRCm39) missense probably damaging 1.00
IGL03375:Or10d1b APN 9 39,613,871 (GRCm39) missense probably damaging 1.00
R0244:Or10d1b UTSW 9 39,613,469 (GRCm39) missense probably damaging 0.97
R0358:Or10d1b UTSW 9 39,613,297 (GRCm39) missense possibly damaging 0.95
R4179:Or10d1b UTSW 9 39,613,387 (GRCm39) missense probably benign 0.30
R5120:Or10d1b UTSW 9 39,613,366 (GRCm39) missense probably benign 0.00
R5185:Or10d1b UTSW 9 39,613,172 (GRCm39) missense probably benign
R6029:Or10d1b UTSW 9 39,613,696 (GRCm39) missense probably damaging 1.00
R6207:Or10d1b UTSW 9 39,613,606 (GRCm39) missense probably benign 0.06
R6454:Or10d1b UTSW 9 39,613,130 (GRCm39) makesense probably null
R7451:Or10d1b UTSW 9 39,613,423 (GRCm39) missense probably damaging 0.99
R8193:Or10d1b UTSW 9 39,613,498 (GRCm39) missense possibly damaging 0.90
R8263:Or10d1b UTSW 9 39,613,453 (GRCm39) missense possibly damaging 0.50
R9102:Or10d1b UTSW 9 39,613,984 (GRCm39) missense probably benign 0.24
R9624:Or10d1b UTSW 9 39,613,822 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- ATCTCCAGGGTCGATGTGTC -3'
(R):5'- GGCTTCACACTCCCATGTAC -3'

Sequencing Primer
(F):5'- GTGTCTGCACAAGCCAGCTTC -3'
(R):5'- TGTGAGTTCTCCCAAGATGC -3'
Posted On 2016-12-20