Mutagenetix > Incidental Mutations

Incidental Mutation 'R5818:Fbxw26'

449170

Institutional Source

Beutler Lab

Gene Symbol

Fbxw26

Ensembl Gene

ENSMUSG00000059547

Gene Name

F-box and WD-40 domain protein 26

Synonyms

Gm5163

MMRRC Submission

043398-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5818 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

109717566-109746089 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 109732566 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 187 (R187S)

Ref Sequence

ENSEMBL: ENSMUSP00000071811 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071917]

AlphaFold

Q8BI58

Predicted Effect

probably benign
Transcript: ENSMUST00000071917
AA Change: R187S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: R187S

Domain	Start	End	E-Value	Type
FBOX	5	45	2.54e-6	SMART
SCOP:d1tbga_	128	249	1e-5	SMART
Blast:WD40	137	176	4e-7	BLAST

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.1%

Validation Efficiency

100% (64/64)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	A	T	11: 110,219,643	V560D	probably damaging	Het
Actn4	A	G	7: 28,919,019	I72T	probably damaging	Het
Adam33	A	T	2: 131,054,358	C440S	possibly damaging	Het
Bace1	T	C	9: 45,859,049	I361T	possibly damaging	Het
Bend6	T	C	1: 33,883,573		probably benign	Het
Bpifb9a	T	G	2: 154,262,295	N219K	probably damaging	Het
Cacna1g	C	A	11: 94,418,120	K1634N	probably damaging	Het
Ccdc155	C	T	7: 45,193,959		probably null	Het
Cdk18	A	G	1: 132,119,098		probably null	Het
Chrng	G	A	1: 87,209,801	V320I	probably benign	Het
Corin	G	T	5: 72,435,395	H87N	probably benign	Het
Cps1	A	T	1: 67,166,488	I557F	possibly damaging	Het
Cyp4a29	T	C	4: 115,247,032	V99A	possibly damaging	Het
Dach1	T	C	14: 98,168,684	D209G	probably damaging	Het
Dgat1	G	A	15: 76,502,207		probably benign	Het
Gabrd	G	A	4: 155,388,361	P122S	probably damaging	Het
Gm11677	C	T	11: 111,724,711		noncoding transcript	Het
Gm8300	T	G	12: 87,517,060	V55G	possibly damaging	Het
Hif1a	A	G	12: 73,939,564	Q343R	possibly damaging	Het
Hyou1	G	A	9: 44,388,926		probably null	Het
Igfn1	A	T	1: 135,966,126	I2072K	possibly damaging	Het
Kctd8	C	T	5: 69,296,711	A328T	probably benign	Het
Krt10	A	G	11: 99,388,771	Y188H	probably damaging	Het
Krtap4-16	T	A	11: 99,851,523	Q17L	unknown	Het
Larp4b	T	A	13: 9,158,560	S416R	probably benign	Het
Lmtk2	G	A	5: 144,156,900	V232M	probably benign	Het
Mroh4	A	G	15: 74,611,982	I571T	probably damaging	Het
Myo15	G	A	11: 60,497,951	R2021Q	probably benign	Het
Npl	G	A	1: 153,535,915	R63C	probably damaging	Het
Ntn4	A	G	10: 93,644,764	I80V	probably benign	Het
Numb	C	T	12: 83,825,254		probably null	Het
Nusap1	A	C	2: 119,635,513	M205L	possibly damaging	Het
Olfr149	T	C	9: 39,702,365	S135G	probably benign	Het
Onecut2	T	A	18: 64,340,975	M180K	possibly damaging	Het
Pmfbp1	T	C	8: 109,538,679		probably null	Het
Ppfia1	T	C	7: 144,520,568		probably benign	Het
Ppm1b	A	G	17: 84,993,719	K9R	probably benign	Het
Rab11fip3	T	C	17: 26,016,116	S608G	probably damaging	Het
Smim8	TTTAATGAAGAGCT	TT	4: 34,771,261		probably benign	Het
Sohlh2	A	G	3: 55,190,501	T125A	probably damaging	Het
Ssfa2	T	A	2: 79,644,593	S299T	probably damaging	Het
Tet1	C	A	10: 62,816,408	M1610I	possibly damaging	Het
Tgfbr3	A	T	5: 107,133,003	D630E	probably benign	Het
Thnsl2	T	C	6: 71,134,143	D247G	probably benign	Het
Tmem198b	G	A	10: 128,802,188	R169W	probably benign	Het
Tmem201	G	A	4: 149,727,392	A332V	probably benign	Het
Tsku	T	C	7: 98,352,098	D342G	possibly damaging	Het
Ucn2	A	T	9: 108,986,497	H109L	probably benign	Het
Virma	T	G	4: 11,513,319	L391R	possibly damaging	Het
Vmn1r60	T	A	7: 5,545,099	M1L	probably benign	Het
Vmn2r76	T	C	7: 86,229,934	H386R	probably benign	Het
Zfp608	C	T	18: 54,895,396	R1315Q	probably benign	Het
Zmym2	A	G	14: 56,946,529	T983A	probably benign	Het
Zscan26	A	G	13: 21,445,761	S65P	probably benign	Het

Other mutations in Fbxw26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00589:Fbxw26	APN	9	109717948	utr 3 prime	probably benign
IGL01072:Fbxw26	APN	9	109723837	missense	probably damaging	1.00
IGL01151:Fbxw26	APN	9	109721780	missense	possibly damaging	0.50
IGL01394:Fbxw26	APN	9	109717989	missense	probably benign	0.00
IGL01432:Fbxw26	APN	9	109717975	missense	probably benign	0.32
IGL02559:Fbxw26	APN	9	109722164	missense	probably benign	0.34
IGL02981:Fbxw26	APN	9	109744794	missense	probably benign	0.09
IGL03370:Fbxw26	APN	9	109746019	missense	probably damaging	1.00
R0023:Fbxw26	UTSW	9	109718011	missense	probably benign	0.01
R0087:Fbxw26	UTSW	9	109724938	missense	probably benign
R0369:Fbxw26	UTSW	9	109723712	critical splice donor site	probably null
R0446:Fbxw26	UTSW	9	109743720	missense	probably benign	0.03
R1844:Fbxw26	UTSW	9	109724878	missense	probably benign	0.42
R1891:Fbxw26	UTSW	9	109722164	missense	probably benign	0.34
R2042:Fbxw26	UTSW	9	109732704	missense	probably damaging	1.00
R3615:Fbxw26	UTSW	9	109743760	nonsense	probably null
R3616:Fbxw26	UTSW	9	109743760	nonsense	probably null
R4659:Fbxw26	UTSW	9	109744871	missense	probably damaging	0.97
R4785:Fbxw26	UTSW	9	109724800	missense	possibly damaging	0.50
R4898:Fbxw26	UTSW	9	109717969	missense	possibly damaging	0.95
R5791:Fbxw26	UTSW	9	109745153	missense	probably damaging	1.00
R5921:Fbxw26	UTSW	9	109746018	missense	probably damaging	1.00
R5983:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6145:Fbxw26	UTSW	9	109732623	missense	probably benign	0.09
R6209:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6412:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.97
R6842:Fbxw26	UTSW	9	109724920	missense	probably damaging	1.00
R7228:Fbxw26	UTSW	9	109724944	missense	possibly damaging	0.93
R7451:Fbxw26	UTSW	9	109732623	missense	probably benign	0.03
R7467:Fbxw26	UTSW	9	109732697	missense	probably benign	0.00
R8397:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.99
R8912:Fbxw26	UTSW	9	109732649	missense	probably damaging	1.00
X0020:Fbxw26	UTSW	9	109732632	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGTTCCCAGAGACTCTAAGAAG -3'
(R):5'- TTGTGGGTGAAAGCAGTTGAAC -3'

Sequencing Primer
(F):5'- TTCCCAGAGACTCTAAGAAGGTAAG -3'
(R):5'- GAGGTGTTCAGACATGATGATACTC -3'

Posted On

2016-12-20