Incidental Mutation 'R5837:Vmn2r116'
ID 449678
Institutional Source Beutler Lab
Gene Symbol Vmn2r116
Ensembl Gene ENSMUSG00000090966
Gene Name vomeronasal 2, receptor 116
Synonyms V2Rp5, EG619697
MMRRC Submission 044057-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R5837 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 23384803-23401864 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23387080 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 322 (F322S)
Ref Sequence ENSEMBL: ENSMUSP00000128106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164856]
AlphaFold E9Q6I0
Predicted Effect probably damaging
Transcript: ENSMUST00000164856
AA Change: F322S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128106
Gene: ENSMUSG00000090966
AA Change: F322S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 4.4e-30 PFAM
Pfam:NCD3G 511 564 1.2e-22 PFAM
low complexity region 589 594 N/A INTRINSIC
Pfam:7tm_3 595 832 8.7e-57 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 99% (72/73)
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 G A 2: 25,433,359 (GRCm38) R113Q probably benign Het
Ank1 A G 8: 23,104,790 (GRCm38) N605D probably damaging Het
Apob A G 12: 8,003,277 (GRCm38) M1240V probably benign Het
Atf1 T A 15: 100,254,384 (GRCm38) I86N probably damaging Het
Best1 T A 19: 9,989,119 (GRCm38) probably null Het
Bet1l C A 7: 140,854,781 (GRCm38) R51L probably benign Het
Bpifa5 A G 2: 154,163,678 (GRCm38) Y60C probably damaging Het
Ccdc141 G T 2: 77,108,437 (GRCm38) Q275K possibly damaging Het
Cep295 T A 9: 15,346,984 (GRCm38) H241L probably damaging Het
Commd7 A G 2: 153,629,224 (GRCm38) V36A possibly damaging Het
Cyld G A 8: 88,741,404 (GRCm38) S555N probably damaging Het
Cyp2j13 A T 4: 96,071,682 (GRCm38) I79N probably damaging Het
Dact2 A G 17: 14,196,253 (GRCm38) S562P probably damaging Het
Dnajc13 T A 9: 104,176,666 (GRCm38) I1664F possibly damaging Het
Ehmt1 A G 2: 24,863,914 (GRCm38) V277A probably damaging Het
Fbn1 A T 2: 125,379,134 (GRCm38) probably null Het
Galnt6 G A 15: 100,694,646 (GRCm38) T560M possibly damaging Het
Glra1 G T 11: 55,536,507 (GRCm38) probably null Het
Gm10762 C T 2: 128,967,157 (GRCm38) probably benign Het
Greb1 C T 12: 16,688,585 (GRCm38) R1459H probably damaging Het
Ift140 A G 17: 25,089,540 (GRCm38) K1048E probably damaging Het
Ilk T C 7: 105,741,171 (GRCm38) probably null Het
Lgi4 C T 7: 31,070,783 (GRCm38) probably benign Het
Loxhd1 A G 18: 77,286,409 (GRCm38) T59A possibly damaging Het
Lzic G T 4: 149,486,000 (GRCm38) probably null Het
Mef2d A G 3: 88,161,781 (GRCm38) T286A probably benign Het
Mycbp2 C A 14: 103,124,403 (GRCm38) C4447F probably damaging Het
Ncoa2 A G 1: 13,224,706 (GRCm38) probably benign Het
Nolc1 T C 19: 46,083,183 (GRCm38) probably benign Het
Npl T C 1: 153,503,525 (GRCm38) T271A probably benign Het
Nudt1 A G 5: 140,334,540 (GRCm38) R25G probably damaging Het
Nudt19 T C 7: 35,551,636 (GRCm38) E226G possibly damaging Het
Oc90 T C 15: 65,876,446 (GRCm38) D405G probably benign Het
Or10q1b T A 19: 13,704,960 (GRCm38) C44* probably null Het
Or1e1c A G 11: 73,375,648 (GRCm38) M300V probably benign Het
Or5as1 A T 2: 87,150,355 (GRCm38) F102Y probably benign Het
Or9k2b A T 10: 130,180,397 (GRCm38) L161H probably damaging Het
Pcdhb1 T C 18: 37,265,827 (GRCm38) I277T possibly damaging Het
Pcdhb9 C A 18: 37,402,798 (GRCm38) A615E probably damaging Het
Phrf1 C G 7: 141,260,061 (GRCm38) D1056E probably benign Het
Phyhip C A 14: 70,467,010 (GRCm38) A223E probably damaging Het
Polr2h T A 16: 20,717,932 (GRCm38) I4N probably damaging Het
Ppp1r12c C A 7: 4,497,404 (GRCm38) probably benign Het
Pramel11 A G 4: 143,896,920 (GRCm38) V228A probably benign Het
Psg17 T A 7: 18,820,215 (GRCm38) T37S possibly damaging Het
Ptprz1 T C 6: 23,001,418 (GRCm38) V1169A probably benign Het
Rabgap1l T C 1: 160,307,222 (GRCm38) probably benign Het
Rapgef3 C T 15: 97,757,342 (GRCm38) probably benign Het
Rbp3 C A 14: 33,954,273 (GRCm38) H59Q probably benign Het
Robo3 T A 9: 37,429,816 (GRCm38) probably null Het
Slco4c1 C T 1: 96,818,982 (GRCm38) E712K probably benign Het
Ssh3 T C 19: 4,266,400 (GRCm38) T168A probably benign Het
Stoml2 G T 4: 43,028,989 (GRCm38) N248K probably damaging Het
Tmigd1 A G 11: 76,916,085 (GRCm38) probably benign Het
Tnc T A 4: 64,013,214 (GRCm38) D753V probably damaging Het
Tnik A T 3: 28,668,053 (GRCm38) probably benign Het
Treml1 A G 17: 48,360,152 (GRCm38) S22G possibly damaging Het
Trmt2a C T 16: 18,249,462 (GRCm38) probably benign Het
Ttn T C 2: 76,717,374 (GRCm38) T32151A probably damaging Het
Utp25 A T 1: 193,118,393 (GRCm38) F373Y probably damaging Het
Vmn1r67 T C 7: 10,447,022 (GRCm38) I10T probably benign Het
Wdr19 A G 5: 65,202,957 (GRCm38) D35G probably benign Het
Zfp365 A T 10: 67,889,040 (GRCm38) H339Q probably damaging Het
Zfp677 A T 17: 21,397,386 (GRCm38) H235L probably damaging Het
Zpbp2 G A 11: 98,551,271 (GRCm38) probably benign Het
Other mutations in Vmn2r116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00898:Vmn2r116 APN 17 23,385,995 (GRCm38) missense possibly damaging 0.94
IGL00985:Vmn2r116 APN 17 23,401,515 (GRCm38) missense probably damaging 1.00
IGL00990:Vmn2r116 APN 17 23,387,236 (GRCm38) missense probably benign 0.12
IGL00990:Vmn2r116 APN 17 23,397,727 (GRCm38) missense probably damaging 1.00
IGL01383:Vmn2r116 APN 17 23,401,601 (GRCm38) missense probably damaging 1.00
IGL01459:Vmn2r116 APN 17 23,384,929 (GRCm38) missense probably damaging 1.00
IGL01725:Vmn2r116 APN 17 23,386,645 (GRCm38) missense probably damaging 1.00
IGL02125:Vmn2r116 APN 17 23,397,627 (GRCm38) splice site probably benign
IGL02170:Vmn2r116 APN 17 23,384,933 (GRCm38) missense probably benign
IGL02209:Vmn2r116 APN 17 23,388,787 (GRCm38) missense probably damaging 1.00
IGL02226:Vmn2r116 APN 17 23,384,834 (GRCm38) missense probably null
IGL02272:Vmn2r116 APN 17 23,386,004 (GRCm38) missense probably damaging 1.00
IGL02272:Vmn2r116 APN 17 23,385,999 (GRCm38) missense probably benign 0.06
IGL02403:Vmn2r116 APN 17 23,387,364 (GRCm38) missense probably damaging 1.00
IGL02686:Vmn2r116 APN 17 23,388,793 (GRCm38) missense probably damaging 0.99
IGL02750:Vmn2r116 APN 17 23,397,634 (GRCm38) splice site probably benign
IGL02977:Vmn2r116 APN 17 23,388,774 (GRCm38) missense possibly damaging 0.90
PIT4449001:Vmn2r116 UTSW 17 23,388,947 (GRCm38) missense probably benign 0.41
R0015:Vmn2r116 UTSW 17 23,401,849 (GRCm38) missense probably benign 0.03
R0219:Vmn2r116 UTSW 17 23,386,098 (GRCm38) nonsense probably null
R0281:Vmn2r116 UTSW 17 23,401,413 (GRCm38) missense possibly damaging 0.90
R0415:Vmn2r116 UTSW 17 23,387,279 (GRCm38) missense possibly damaging 0.55
R0592:Vmn2r116 UTSW 17 23,386,915 (GRCm38) missense probably damaging 0.99
R0610:Vmn2r116 UTSW 17 23,387,312 (GRCm38) missense probably damaging 1.00
R0635:Vmn2r116 UTSW 17 23,386,887 (GRCm38) missense possibly damaging 0.95
R0843:Vmn2r116 UTSW 17 23,400,960 (GRCm38) missense probably benign 0.01
R1329:Vmn2r116 UTSW 17 23,387,188 (GRCm38) missense possibly damaging 0.89
R1396:Vmn2r116 UTSW 17 23,386,141 (GRCm38) missense probably benign
R1401:Vmn2r116 UTSW 17 23,386,596 (GRCm38) splice site probably benign
R1574:Vmn2r116 UTSW 17 23,387,089 (GRCm38) missense probably damaging 0.99
R1574:Vmn2r116 UTSW 17 23,387,089 (GRCm38) missense probably damaging 0.99
R1766:Vmn2r116 UTSW 17 23,401,766 (GRCm38) missense probably damaging 0.98
R2157:Vmn2r116 UTSW 17 23,401,469 (GRCm38) missense probably damaging 1.00
R3622:Vmn2r116 UTSW 17 23,386,051 (GRCm38) missense probably benign 0.11
R3690:Vmn2r116 UTSW 17 23,384,824 (GRCm38) missense unknown
R4298:Vmn2r116 UTSW 17 23,401,827 (GRCm38) missense possibly damaging 0.69
R4373:Vmn2r116 UTSW 17 23,401,421 (GRCm38) missense probably benign 0.01
R4860:Vmn2r116 UTSW 17 23,401,803 (GRCm38) missense probably benign
R4941:Vmn2r116 UTSW 17 23,401,142 (GRCm38) missense probably damaging 1.00
R5119:Vmn2r116 UTSW 17 23,387,164 (GRCm38) missense probably benign 0.01
R5503:Vmn2r116 UTSW 17 23,386,804 (GRCm38) missense probably benign 0.07
R5510:Vmn2r116 UTSW 17 23,386,121 (GRCm38) missense probably damaging 1.00
R5538:Vmn2r116 UTSW 17 23,401,067 (GRCm38) missense probably benign 0.00
R5689:Vmn2r116 UTSW 17 23,397,719 (GRCm38) missense probably benign 0.30
R5765:Vmn2r116 UTSW 17 23,401,404 (GRCm38) missense probably damaging 0.99
R5794:Vmn2r116 UTSW 17 23,385,968 (GRCm38) missense probably damaging 0.99
R5807:Vmn2r116 UTSW 17 23,387,307 (GRCm38) missense probably damaging 1.00
R6262:Vmn2r116 UTSW 17 23,387,377 (GRCm38) missense probably benign 0.03
R6298:Vmn2r116 UTSW 17 23,386,762 (GRCm38) missense probably damaging 1.00
R6651:Vmn2r116 UTSW 17 23,388,831 (GRCm38) nonsense probably null
R6667:Vmn2r116 UTSW 17 23,401,092 (GRCm38) missense probably damaging 1.00
R7393:Vmn2r116 UTSW 17 23,386,125 (GRCm38) missense probably benign 0.14
R7571:Vmn2r116 UTSW 17 23,384,856 (GRCm38) splice site probably null
R7940:Vmn2r116 UTSW 17 23,386,972 (GRCm38) missense probably damaging 0.99
R8510:Vmn2r116 UTSW 17 23,385,931 (GRCm38) nonsense probably null
R8950:Vmn2r116 UTSW 17 23,401,493 (GRCm38) missense probably damaging 1.00
R8956:Vmn2r116 UTSW 17 23,386,762 (GRCm38) missense probably damaging 1.00
R8977:Vmn2r116 UTSW 17 23,386,942 (GRCm38) missense possibly damaging 0.56
R9030:Vmn2r116 UTSW 17 23,384,890 (GRCm38) missense possibly damaging 0.82
R9077:Vmn2r116 UTSW 17 23,385,982 (GRCm38) missense probably benign 0.14
R9223:Vmn2r116 UTSW 17 23,401,167 (GRCm38) missense probably damaging 1.00
R9401:Vmn2r116 UTSW 17 23,401,592 (GRCm38) missense probably damaging 1.00
R9449:Vmn2r116 UTSW 17 23,386,945 (GRCm38) missense probably benign 0.01
R9746:Vmn2r116 UTSW 17 23,401,823 (GRCm38) missense probably benign 0.08
R9755:Vmn2r116 UTSW 17 23,401,091 (GRCm38) missense probably damaging 1.00
R9759:Vmn2r116 UTSW 17 23,401,386 (GRCm38) missense possibly damaging 0.90
R9800:Vmn2r116 UTSW 17 23,401,425 (GRCm38) missense probably damaging 0.97
S24628:Vmn2r116 UTSW 17 23,387,279 (GRCm38) missense possibly damaging 0.55
Z1176:Vmn2r116 UTSW 17 23,401,428 (GRCm38) missense probably damaging 1.00
Z1177:Vmn2r116 UTSW 17 23,388,892 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCAAGAGCTGAAGTGTATTACAACC -3'
(R):5'- GGCCATGTCAAAAGTATGTACC -3'

Sequencing Primer
(F):5'- GAGCTGAAGTGTATTACAACCAAATC -3'
(R):5'- TGTACCATTAACCATTTCAATGAGTG -3'
Posted On 2016-12-20