Incidental Mutation 'R5838:Or5b120'
ID 449770
Institutional Source Beutler Lab
Gene Symbol Or5b120
Ensembl Gene ENSMUSG00000071629
Gene Name olfactory receptor family 5 subfamily B member 120
Synonyms Olfr1477, MOR202-10, GA_x6K02T2RE5P-3834960-3835907
MMRRC Submission 044058-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R5838 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13477910-13480656 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13479922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 72 (Y72N)
Ref Sequence ENSEMBL: ENSMUSP00000149565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096201] [ENSMUST00000214274] [ENSMUST00000217001]
AlphaFold Q7TQQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000096201
AA Change: Y72N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093915
Gene: ENSMUSG00000095189
AA Change: Y72N

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 3.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 34 304 2.6e-6 PFAM
Pfam:7tm_1 40 289 1.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208393
Predicted Effect probably damaging
Transcript: ENSMUST00000214274
AA Change: Y72N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217001
AA Change: Y72N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace G A 11: 105,863,706 (GRCm39) V385I probably benign Het
Apmap T C 2: 150,427,777 (GRCm39) Y315C probably damaging Het
Arhgef12 G A 9: 42,916,904 (GRCm39) T414I probably damaging Het
Cd200r1 C A 16: 44,586,397 (GRCm39) A9D possibly damaging Het
Cdkal1 T C 13: 29,875,669 (GRCm39) D183G probably benign Het
Clk1 C A 1: 58,451,819 (GRCm39) C432F probably damaging Het
Col27a1 G T 4: 63,143,765 (GRCm39) L484F probably damaging Het
Col7a1 A G 9: 108,807,211 (GRCm39) E2480G unknown Het
Dnah5 A G 15: 28,290,341 (GRCm39) I1244V probably benign Het
Dock3 G T 9: 106,772,687 (GRCm39) P522Q possibly damaging Het
Drc1 T A 5: 30,523,857 (GRCm39) probably null Het
Epas1 C T 17: 87,131,114 (GRCm39) T298I possibly damaging Het
Epha1 A T 6: 42,338,580 (GRCm39) I699N probably damaging Het
Ephb3 T C 16: 21,040,437 (GRCm39) S558P probably damaging Het
Epn1 T A 7: 5,100,165 (GRCm39) L426* probably null Het
Fam234b T C 6: 135,202,265 (GRCm39) V329A probably benign Het
Fasn G T 11: 120,706,950 (GRCm39) R901S probably damaging Het
Fbln2 T C 6: 91,248,830 (GRCm39) M1165T possibly damaging Het
Fer1l4 T C 2: 155,893,913 (GRCm39) R103G probably benign Het
G6pd2 T A 5: 61,966,568 (GRCm39) D114E probably benign Het
Galnt10 A G 11: 57,671,882 (GRCm39) K391E probably damaging Het
Gpr150 C A 13: 76,204,045 (GRCm39) C300F probably benign Het
Hhipl2 A G 1: 183,204,479 (GRCm39) T151A probably damaging Het
Hmcn2 C A 2: 31,347,819 (GRCm39) L4822M probably damaging Het
Ifi207 T A 1: 173,559,953 (GRCm39) Q173L unknown Het
Inca1 T C 11: 70,580,707 (GRCm39) E86G probably damaging Het
Iqca1 A G 1: 90,072,667 (GRCm39) L71P probably benign Het
Kank2 G T 9: 21,706,689 (GRCm39) Q110K probably damaging Het
Katnip A T 7: 125,466,827 (GRCm39) M1361L possibly damaging Het
Kif13b A T 14: 64,975,004 (GRCm39) M407L probably damaging Het
Kif5a A C 10: 127,081,310 (GRCm39) I208S probably damaging Het
Kmt2c T C 5: 25,489,469 (GRCm39) K4490R probably damaging Het
Ltbp2 C T 12: 84,835,875 (GRCm39) R1352H probably benign Het
Macf1 T C 4: 123,345,947 (GRCm39) Q2061R possibly damaging Het
Marcks A G 10: 37,012,163 (GRCm39) S291P probably benign Het
Mccc1 A G 3: 36,039,231 (GRCm39) V254A possibly damaging Het
Mdn1 C T 4: 32,754,547 (GRCm39) R4683W probably damaging Het
Mon2 A G 10: 122,846,397 (GRCm39) probably null Het
Ndrg4 A T 8: 96,433,421 (GRCm39) H134L probably damaging Het
Nek7 C A 1: 138,462,101 (GRCm39) probably null Het
Nlrc3 C T 16: 3,771,859 (GRCm39) S151N probably damaging Het
Nsl1 C A 1: 190,802,310 (GRCm39) A146E probably benign Het
Or10a3n A T 7: 108,493,292 (GRCm39) F107L probably benign Het
Or2y1e A C 11: 49,218,760 (GRCm39) N174T probably damaging Het
Or52ac1 A G 7: 104,246,104 (GRCm39) Y95H probably benign Het
Or6c210 A T 10: 129,495,907 (GRCm39) R77S probably benign Het
Pde4d A C 13: 109,876,976 (GRCm39) S41R probably damaging Het
Phlpp1 T A 1: 106,274,862 (GRCm39) L875* probably null Het
Pkd1 T A 17: 24,799,186 (GRCm39) S2802T possibly damaging Het
Polr3b A G 10: 84,510,454 (GRCm39) T500A probably benign Het
Ppp2r2c T C 5: 37,097,531 (GRCm39) V239A probably benign Het
Pramel11 A G 4: 143,623,490 (GRCm39) V228A probably benign Het
Reln T A 5: 22,104,111 (GRCm39) I3287F probably damaging Het
Scube2 T C 7: 109,407,651 (GRCm39) D763G probably damaging Het
Setd5 T C 6: 113,096,396 (GRCm39) V534A probably benign Het
Slc10a4 T A 5: 73,169,373 (GRCm39) C333S probably benign Het
Slc15a1 G A 14: 121,722,283 (GRCm39) A206V probably damaging Het
Snx14 A G 9: 88,273,829 (GRCm39) L654P probably damaging Het
Sowahc G A 10: 59,059,012 (GRCm39) A383T possibly damaging Het
Taf1b A G 12: 24,550,448 (GRCm39) D11G possibly damaging Het
Tap1 C T 17: 34,412,279 (GRCm39) Q164* probably null Het
Tbcel T A 9: 42,327,168 (GRCm39) R430W probably damaging Het
Trappc11 A T 8: 47,965,594 (GRCm39) probably null Het
Trim15 T C 17: 37,173,732 (GRCm39) I259V probably damaging Het
Trpt1 T C 19: 6,975,668 (GRCm39) S141P probably damaging Het
Tsc2 T A 17: 24,832,190 (GRCm39) Q732L probably benign Het
Tstd3 C A 4: 21,759,622 (GRCm39) probably null Het
Unc13d T C 11: 115,955,451 (GRCm39) K914R possibly damaging Het
Unk A G 11: 115,940,157 (GRCm39) E170G probably damaging Het
Uqcc2 T A 17: 27,344,860 (GRCm39) K62* probably null Het
Vim A G 2: 13,585,001 (GRCm39) D394G probably damaging Het
Wdr47 G A 3: 108,532,052 (GRCm39) probably null Het
Other mutations in Or5b120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01926:Or5b120 APN 19 13,480,105 (GRCm39) missense possibly damaging 0.55
IGL02394:Or5b120 APN 19 13,480,228 (GRCm39) missense probably damaging 0.97
R0047:Or5b120 UTSW 19 13,479,953 (GRCm39) missense probably benign 0.30
R0047:Or5b120 UTSW 19 13,479,953 (GRCm39) missense probably benign 0.30
R0356:Or5b120 UTSW 19 13,480,441 (GRCm39) missense possibly damaging 0.74
R0617:Or5b120 UTSW 19 13,479,900 (GRCm39) missense probably damaging 1.00
R1589:Or5b120 UTSW 19 13,480,121 (GRCm39) missense probably benign 0.03
R1725:Or5b120 UTSW 19 13,479,883 (GRCm39) missense probably damaging 1.00
R2153:Or5b120 UTSW 19 13,479,852 (GRCm39) missense probably damaging 1.00
R2362:Or5b120 UTSW 19 13,479,872 (GRCm39) missense probably damaging 1.00
R3402:Or5b120 UTSW 19 13,480,312 (GRCm39) missense probably benign 0.11
R4513:Or5b120 UTSW 19 13,479,986 (GRCm39) missense probably benign 0.05
R5197:Or5b120 UTSW 19 13,479,748 (GRCm39) missense possibly damaging 0.68
R5205:Or5b120 UTSW 19 13,480,163 (GRCm39) missense probably damaging 1.00
R5511:Or5b120 UTSW 19 13,480,556 (GRCm39) missense probably benign 0.12
R6023:Or5b120 UTSW 19 13,480,067 (GRCm39) missense probably damaging 1.00
R6232:Or5b120 UTSW 19 13,480,427 (GRCm39) missense probably damaging 1.00
R6700:Or5b120 UTSW 19 13,480,177 (GRCm39) missense probably damaging 0.97
R6769:Or5b120 UTSW 19 13,480,318 (GRCm39) missense possibly damaging 0.83
R6771:Or5b120 UTSW 19 13,480,318 (GRCm39) missense possibly damaging 0.83
R7002:Or5b120 UTSW 19 13,480,039 (GRCm39) missense probably benign 0.00
R7057:Or5b120 UTSW 19 13,480,243 (GRCm39) missense probably damaging 1.00
R7320:Or5b120 UTSW 19 13,480,544 (GRCm39) missense possibly damaging 0.89
R7827:Or5b120 UTSW 19 13,480,587 (GRCm39) missense probably damaging 1.00
R7913:Or5b120 UTSW 19 13,480,571 (GRCm39) missense probably damaging 1.00
R9199:Or5b120 UTSW 19 13,480,436 (GRCm39) missense probably damaging 1.00
R9286:Or5b120 UTSW 19 13,479,791 (GRCm39) missense possibly damaging 0.88
R9523:Or5b120 UTSW 19 13,479,712 (GRCm39) missense probably benign
R9606:Or5b120 UTSW 19 13,479,943 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAGATGCACCATTCCTGC -3'
(R):5'- TGTAAGAGTCCACTCAAGTAAGATCC -3'

Sequencing Primer
(F):5'- TGCACCATTCCTGCAAACTC -3'
(R):5'- GCAAGACACATATCGTAGTTGTC -3'
Posted On 2016-12-20