Incidental Mutation 'R5822:Or4c35'
ID 449965
Institutional Source Beutler Lab
Gene Symbol Or4c35
Ensembl Gene ENSMUSG00000042894
Gene Name olfactory receptor family 4 subfamily C member 35
Synonyms GA_x6K02T2Q125-51409740-51410672, Olfr1260, MOR232-2
MMRRC Submission 044052-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R5822 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89808124-89809056 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89808787 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 222 (S222P)
Ref Sequence ENSEMBL: ENSMUSP00000107137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061830] [ENSMUST00000111512] [ENSMUST00000144710] [ENSMUST00000214630] [ENSMUST00000216678]
AlphaFold Q8VGN9
Predicted Effect probably damaging
Transcript: ENSMUST00000061830
AA Change: S222P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053523
Gene: ENSMUSG00000042894
AA Change: S222P

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.7e-45 PFAM
Pfam:7tm_1 39 285 1.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111512
AA Change: S222P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107137
Gene: ENSMUSG00000042894
AA Change: S222P

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 7.4e-27 PFAM
Pfam:7tm_4 137 278 2.4e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141685
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144613
Predicted Effect probably benign
Transcript: ENSMUST00000144710
SMART Domains Protein: ENSMUSP00000119512
Gene: ENSMUSG00000042894

DomainStartEndE-ValueType
Pfam:7tm_1 39 121 4.2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213162
Predicted Effect probably benign
Transcript: ENSMUST00000214630
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216744
Predicted Effect probably benign
Transcript: ENSMUST00000216678
Meta Mutation Damage Score 0.5488 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 96% (54/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
Abca8a C T 11: 109,921,705 (GRCm39) E1450K probably damaging Het
B4galnt2 T C 11: 95,756,985 (GRCm39) Y482C probably damaging Het
Bud23 A G 5: 135,092,775 (GRCm39) F9L probably damaging Het
Cacna1s A T 1: 136,039,816 (GRCm39) E1214V probably damaging Het
Cdh20 T C 1: 104,861,823 (GRCm39) M1T probably null Het
Chkb T C 15: 89,313,715 (GRCm39) E30G probably benign Het
Crp A C 1: 172,525,635 (GRCm39) probably benign Het
Cyp11b1 T C 15: 74,708,670 (GRCm39) R375G probably null Het
Ddx11 C T 17: 66,436,976 (GRCm39) S90L probably benign Het
Flnc A C 6: 29,459,429 (GRCm39) I2510L probably damaging Het
Ftdc1 C A 16: 58,436,075 (GRCm39) probably null Het
Fyb1 T A 15: 6,692,707 (GRCm39) probably benign Het
Gbp3 C T 3: 142,272,239 (GRCm39) P247L probably benign Het
Ggn C T 7: 28,871,981 (GRCm39) P454S probably damaging Het
Herc1 T A 9: 66,352,894 (GRCm39) S2127T probably benign Het
Ipo11 A G 13: 106,984,926 (GRCm39) probably benign Het
Kcnh7 G A 2: 62,546,582 (GRCm39) R1000W probably benign Het
Kdm5b A T 1: 134,516,511 (GRCm39) probably benign Het
Klc3 C T 7: 19,129,724 (GRCm39) probably null Het
Lst1 A T 17: 35,407,359 (GRCm39) M3K unknown Het
Madd C T 2: 90,982,878 (GRCm39) R1355Q probably damaging Het
Map3k10 A G 7: 27,356,159 (GRCm39) L920P probably damaging Het
Mdga2 A G 12: 66,702,109 (GRCm39) V423A probably damaging Het
Mogat2 T C 7: 98,869,112 (GRCm39) D302G possibly damaging Het
Nkapl A C 13: 21,652,593 (GRCm39) S7A unknown Het
Npas2 A G 1: 39,386,647 (GRCm39) S639G probably benign Het
Nr1h5 T G 3: 102,856,644 (GRCm39) H260P probably damaging Het
Or2g25 T C 17: 37,971,122 (GRCm39) Y34C probably damaging Het
Or2t49 A T 11: 58,392,464 (GRCm39) L306Q possibly damaging Het
Or7a36 C T 10: 78,820,023 (GRCm39) T133I possibly damaging Het
Or8a1b T C 9: 37,623,087 (GRCm39) M163V probably benign Het
Pan2 T C 10: 128,156,249 (GRCm39) L1142P probably damaging Het
Pdik1l C T 4: 134,014,474 (GRCm39) E11K possibly damaging Het
Ppp1r15a A G 7: 45,172,727 (GRCm39) V555A probably damaging Het
Ppp6c G A 2: 39,090,064 (GRCm39) Q81* probably null Het
Pramel18 A G 4: 101,767,440 (GRCm39) M230V probably damaging Het
Ptprz1 A T 6: 23,001,444 (GRCm39) Y1178F probably benign Het
Relch G A 1: 105,646,581 (GRCm39) V660M probably damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Rims2 T A 15: 39,339,886 (GRCm39) L860Q probably damaging Het
Sdr39u1 A G 14: 56,135,196 (GRCm39) V249A probably benign Het
Serhl T C 15: 83,000,528 (GRCm39) V305A probably benign Het
Slc5a11 T C 7: 122,851,654 (GRCm39) I201T probably damaging Het
Stk32a A T 18: 43,446,552 (GRCm39) E334V probably benign Het
Tmem217 A G 17: 29,745,529 (GRCm39) L67P probably damaging Het
Tnnt1 A T 7: 4,519,345 (GRCm39) L12* probably null Het
Trim80 C T 11: 115,338,747 (GRCm39) R526C probably damaging Het
Unc5b A T 10: 60,608,306 (GRCm39) F635I possibly damaging Het
Utp20 T G 10: 88,653,147 (GRCm39) N311T probably benign Het
Zfp276 A G 8: 123,982,457 (GRCm39) T74A probably benign Het
Other mutations in Or4c35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Or4c35 APN 2 89,808,883 (GRCm39) missense possibly damaging 0.69
IGL01657:Or4c35 APN 2 89,808,221 (GRCm39) missense probably damaging 1.00
IGL01942:Or4c35 APN 2 89,808,322 (GRCm39) missense probably benign 0.03
IGL02139:Or4c35 APN 2 89,808,773 (GRCm39) missense possibly damaging 0.80
IGL02926:Or4c35 APN 2 89,808,506 (GRCm39) missense probably damaging 1.00
IGL03110:Or4c35 APN 2 89,808,493 (GRCm39) missense probably damaging 1.00
IGL03368:Or4c35 APN 2 89,808,133 (GRCm39) missense probably benign
R0046:Or4c35 UTSW 2 89,808,851 (GRCm39) missense probably damaging 1.00
R0046:Or4c35 UTSW 2 89,808,851 (GRCm39) missense probably damaging 1.00
R0087:Or4c35 UTSW 2 89,808,475 (GRCm39) missense probably damaging 1.00
R0599:Or4c35 UTSW 2 89,808,545 (GRCm39) missense probably benign 0.01
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1424:Or4c35 UTSW 2 89,808,415 (GRCm39) nonsense probably null
R1503:Or4c35 UTSW 2 89,808,872 (GRCm39) missense probably damaging 0.99
R1708:Or4c35 UTSW 2 89,808,382 (GRCm39) missense probably benign 0.00
R1863:Or4c35 UTSW 2 89,808,754 (GRCm39) missense probably benign 0.02
R1866:Or4c35 UTSW 2 89,808,671 (GRCm39) missense probably damaging 1.00
R2072:Or4c35 UTSW 2 89,808,557 (GRCm39) missense probably benign 0.04
R2219:Or4c35 UTSW 2 89,808,256 (GRCm39) missense possibly damaging 0.62
R4606:Or4c35 UTSW 2 89,808,350 (GRCm39) missense possibly damaging 0.79
R4674:Or4c35 UTSW 2 89,808,250 (GRCm39) missense possibly damaging 0.52
R4825:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R6487:Or4c35 UTSW 2 89,808,182 (GRCm39) missense probably benign 0.31
R6706:Or4c35 UTSW 2 89,808,929 (GRCm39) missense probably damaging 0.96
R7961:Or4c35 UTSW 2 89,808,131 (GRCm39) missense probably benign
R8812:Or4c35 UTSW 2 89,808,715 (GRCm39) missense possibly damaging 0.94
R9504:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R9618:Or4c35 UTSW 2 89,808,343 (GRCm39) missense probably benign 0.00
X0050:Or4c35 UTSW 2 89,808,360 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CAGGAGAGTATGTGGCTTCCTG -3'
(R):5'- CACTTCTGTGTTCCTGAGGG -3'

Sequencing Primer
(F):5'- AGTATGTGGCTTCCTGGTTTCCAC -3'
(R):5'- AAAGGGTTTAGCATGGGTGTTATCAC -3'
Posted On 2016-12-20