Incidental Mutation 'R5822:Fyb1'
ID 449996
Institutional Source Beutler Lab
Gene Symbol Fyb1
Ensembl Gene ENSMUSG00000022148
Gene Name FYN binding protein 1
Synonyms B630013F22Rik, Fyb, ADAP, FYB-120/130
MMRRC Submission 044052-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5822 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 6552334-6692794 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 6692707 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000090461]
AlphaFold O35601
Predicted Effect probably benign
Transcript: ENSMUST00000090461
SMART Domains Protein: ENSMUSP00000087947
Gene: ENSMUSG00000022148

DomainStartEndE-ValueType
low complexity region 67 85 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
low complexity region 236 246 N/A INTRINSIC
low complexity region 335 353 N/A INTRINSIC
low complexity region 371 409 N/A INTRINSIC
low complexity region 440 451 N/A INTRINSIC
low complexity region 457 494 N/A INTRINSIC
SH3 502 559 1.24e-3 SMART
low complexity region 611 626 N/A INTRINSIC
Pfam:hSH3 731 819 2.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161947
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162154
Predicted Effect probably benign
Transcript: ENSMUST00000163073
SMART Domains Protein: ENSMUSP00000123895
Gene: ENSMUSG00000022148

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
Pfam:hSH3 86 170 4.1e-42 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 96% (54/56)
MGI Phenotype FUNCTION: The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
Abca8a C T 11: 109,921,705 (GRCm39) E1450K probably damaging Het
B4galnt2 T C 11: 95,756,985 (GRCm39) Y482C probably damaging Het
Bud23 A G 5: 135,092,775 (GRCm39) F9L probably damaging Het
Cacna1s A T 1: 136,039,816 (GRCm39) E1214V probably damaging Het
Cdh20 T C 1: 104,861,823 (GRCm39) M1T probably null Het
Chkb T C 15: 89,313,715 (GRCm39) E30G probably benign Het
Crp A C 1: 172,525,635 (GRCm39) probably benign Het
Cyp11b1 T C 15: 74,708,670 (GRCm39) R375G probably null Het
Ddx11 C T 17: 66,436,976 (GRCm39) S90L probably benign Het
Flnc A C 6: 29,459,429 (GRCm39) I2510L probably damaging Het
Ftdc1 C A 16: 58,436,075 (GRCm39) probably null Het
Gbp3 C T 3: 142,272,239 (GRCm39) P247L probably benign Het
Ggn C T 7: 28,871,981 (GRCm39) P454S probably damaging Het
Herc1 T A 9: 66,352,894 (GRCm39) S2127T probably benign Het
Ipo11 A G 13: 106,984,926 (GRCm39) probably benign Het
Kcnh7 G A 2: 62,546,582 (GRCm39) R1000W probably benign Het
Kdm5b A T 1: 134,516,511 (GRCm39) probably benign Het
Klc3 C T 7: 19,129,724 (GRCm39) probably null Het
Lst1 A T 17: 35,407,359 (GRCm39) M3K unknown Het
Madd C T 2: 90,982,878 (GRCm39) R1355Q probably damaging Het
Map3k10 A G 7: 27,356,159 (GRCm39) L920P probably damaging Het
Mdga2 A G 12: 66,702,109 (GRCm39) V423A probably damaging Het
Mogat2 T C 7: 98,869,112 (GRCm39) D302G possibly damaging Het
Nkapl A C 13: 21,652,593 (GRCm39) S7A unknown Het
Npas2 A G 1: 39,386,647 (GRCm39) S639G probably benign Het
Nr1h5 T G 3: 102,856,644 (GRCm39) H260P probably damaging Het
Or2g25 T C 17: 37,971,122 (GRCm39) Y34C probably damaging Het
Or2t49 A T 11: 58,392,464 (GRCm39) L306Q possibly damaging Het
Or4c35 T C 2: 89,808,787 (GRCm39) S222P probably damaging Het
Or7a36 C T 10: 78,820,023 (GRCm39) T133I possibly damaging Het
Or8a1b T C 9: 37,623,087 (GRCm39) M163V probably benign Het
Pan2 T C 10: 128,156,249 (GRCm39) L1142P probably damaging Het
Pdik1l C T 4: 134,014,474 (GRCm39) E11K possibly damaging Het
Ppp1r15a A G 7: 45,172,727 (GRCm39) V555A probably damaging Het
Ppp6c G A 2: 39,090,064 (GRCm39) Q81* probably null Het
Pramel18 A G 4: 101,767,440 (GRCm39) M230V probably damaging Het
Ptprz1 A T 6: 23,001,444 (GRCm39) Y1178F probably benign Het
Relch G A 1: 105,646,581 (GRCm39) V660M probably damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Rims2 T A 15: 39,339,886 (GRCm39) L860Q probably damaging Het
Sdr39u1 A G 14: 56,135,196 (GRCm39) V249A probably benign Het
Serhl T C 15: 83,000,528 (GRCm39) V305A probably benign Het
Slc5a11 T C 7: 122,851,654 (GRCm39) I201T probably damaging Het
Stk32a A T 18: 43,446,552 (GRCm39) E334V probably benign Het
Tmem217 A G 17: 29,745,529 (GRCm39) L67P probably damaging Het
Tnnt1 A T 7: 4,519,345 (GRCm39) L12* probably null Het
Trim80 C T 11: 115,338,747 (GRCm39) R526C probably damaging Het
Unc5b A T 10: 60,608,306 (GRCm39) F635I possibly damaging Het
Utp20 T G 10: 88,653,147 (GRCm39) N311T probably benign Het
Zfp276 A G 8: 123,982,457 (GRCm39) T74A probably benign Het
Other mutations in Fyb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00417:Fyb1 APN 15 6,610,258 (GRCm39) missense probably damaging 0.99
IGL00801:Fyb1 APN 15 6,674,305 (GRCm39) missense possibly damaging 0.86
IGL00974:Fyb1 APN 15 6,672,066 (GRCm39) unclassified probably benign
IGL01377:Fyb1 APN 15 6,609,801 (GRCm39) missense probably benign 0.01
IGL01982:Fyb1 APN 15 6,609,658 (GRCm39) missense probably null 0.99
IGL02173:Fyb1 APN 15 6,610,176 (GRCm39) missense probably benign 0.00
IGL02177:Fyb1 APN 15 6,688,047 (GRCm39) critical splice donor site probably null
IGL02345:Fyb1 APN 15 6,649,143 (GRCm39) missense possibly damaging 0.94
IGL02695:Fyb1 APN 15 6,610,402 (GRCm39) missense probably damaging 1.00
IGL02820:Fyb1 APN 15 6,688,040 (GRCm39) missense possibly damaging 0.65
IGL02867:Fyb1 APN 15 6,609,527 (GRCm39) missense probably damaging 1.00
baddie UTSW 15 6,681,972 (GRCm39) missense probably damaging 1.00
luegner UTSW 15 6,610,350 (GRCm39) nonsense probably null
uebeltaeter UTSW 15 6,668,388 (GRCm39) missense probably damaging 1.00
P0023:Fyb1 UTSW 15 6,681,335 (GRCm39) missense probably damaging 1.00
R0028:Fyb1 UTSW 15 6,674,395 (GRCm39) intron probably benign
R0364:Fyb1 UTSW 15 6,610,272 (GRCm39) missense probably damaging 1.00
R0507:Fyb1 UTSW 15 6,664,297 (GRCm39) missense probably benign 0.39
R0588:Fyb1 UTSW 15 6,609,940 (GRCm39) missense probably benign 0.03
R0742:Fyb1 UTSW 15 6,664,297 (GRCm39) missense probably benign 0.39
R0930:Fyb1 UTSW 15 6,668,309 (GRCm39) missense probably damaging 1.00
R1184:Fyb1 UTSW 15 6,668,381 (GRCm39) missense probably damaging 1.00
R1446:Fyb1 UTSW 15 6,681,947 (GRCm39) missense probably benign 0.02
R1481:Fyb1 UTSW 15 6,649,128 (GRCm39) missense probably benign 0.01
R1711:Fyb1 UTSW 15 6,609,960 (GRCm39) missense probably damaging 1.00
R2041:Fyb1 UTSW 15 6,674,268 (GRCm39) missense possibly damaging 0.78
R2176:Fyb1 UTSW 15 6,609,435 (GRCm39) missense probably damaging 1.00
R2224:Fyb1 UTSW 15 6,681,864 (GRCm39) missense probably damaging 1.00
R2372:Fyb1 UTSW 15 6,681,388 (GRCm39) splice site probably benign
R3236:Fyb1 UTSW 15 6,659,597 (GRCm39) missense probably damaging 0.96
R4117:Fyb1 UTSW 15 6,659,597 (GRCm39) missense probably damaging 0.96
R4181:Fyb1 UTSW 15 6,610,404 (GRCm39) missense probably benign 0.00
R4322:Fyb1 UTSW 15 6,610,300 (GRCm39) missense possibly damaging 0.84
R4952:Fyb1 UTSW 15 6,668,292 (GRCm39) missense probably damaging 1.00
R4981:Fyb1 UTSW 15 6,676,092 (GRCm39) splice site probably benign
R5055:Fyb1 UTSW 15 6,614,630 (GRCm39) unclassified probably benign
R5368:Fyb1 UTSW 15 6,610,159 (GRCm39) splice site probably null
R5719:Fyb1 UTSW 15 6,610,350 (GRCm39) nonsense probably null
R6064:Fyb1 UTSW 15 6,668,349 (GRCm39) missense probably damaging 1.00
R6929:Fyb1 UTSW 15 6,668,388 (GRCm39) missense probably damaging 1.00
R7125:Fyb1 UTSW 15 6,674,337 (GRCm39) missense possibly damaging 0.77
R7243:Fyb1 UTSW 15 6,673,180 (GRCm39) missense probably benign 0.19
R7748:Fyb1 UTSW 15 6,668,307 (GRCm39) missense probably damaging 1.00
R7750:Fyb1 UTSW 15 6,690,184 (GRCm39) missense probably damaging 1.00
R7902:Fyb1 UTSW 15 6,690,197 (GRCm39) critical splice donor site probably null
R8182:Fyb1 UTSW 15 6,681,293 (GRCm39) missense probably benign
R8841:Fyb1 UTSW 15 6,681,972 (GRCm39) missense probably damaging 1.00
R9103:Fyb1 UTSW 15 6,673,232 (GRCm39) missense possibly damaging 0.66
R9256:Fyb1 UTSW 15 6,674,358 (GRCm39) missense possibly damaging 0.61
R9385:Fyb1 UTSW 15 6,664,297 (GRCm39) missense probably benign 0.39
R9739:Fyb1 UTSW 15 6,670,063 (GRCm39) missense probably benign 0.00
Z1088:Fyb1 UTSW 15 6,688,021 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- ACTTGAAACACTTAAGGTATGTTGT -3'
(R):5'- ACAGTAAGAAACCCTTGATCACA -3'

Sequencing Primer
(F):5'- GAACGACACTAGAGGTTGTCTTCC -3'
(R):5'- GTAAGAAACCCTTGATCACAACAAC -3'
Posted On 2016-12-20