Incidental Mutation 'R5823:Tex15'
ID 450037
Institutional Source Beutler Lab
Gene Symbol Tex15
Ensembl Gene ENSMUSG00000009628
Gene Name testis expressed gene 15
Synonyms 2210014E14Rik
MMRRC Submission 043215-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.241) question?
Stock # R5823 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 33516738-33585582 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33570934 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 405 (I405V)
Ref Sequence ENSEMBL: ENSMUSP00000120744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000009772
AA Change: I131V

PolyPhen 2 Score 0.422 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: I131V

DomainStartEndE-ValueType
low complexity region 262 274 N/A INTRINSIC
low complexity region 302 313 N/A INTRINSIC
low complexity region 524 536 N/A INTRINSIC
low complexity region 665 674 N/A INTRINSIC
low complexity region 713 725 N/A INTRINSIC
low complexity region 946 961 N/A INTRINSIC
low complexity region 1497 1508 N/A INTRINSIC
Pfam:TEX15 1572 1788 1.3e-109 PFAM
Pfam:TEX15 1901 2119 1.1e-16 PFAM
low complexity region 2758 2770 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000124496
AA Change: I405V

PolyPhen 2 Score 0.670 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628
AA Change: I405V

DomainStartEndE-ValueType
Pfam:DUF3715 89 251 1.6e-58 PFAM
low complexity region 536 548 N/A INTRINSIC
low complexity region 576 587 N/A INTRINSIC
low complexity region 798 810 N/A INTRINSIC
low complexity region 939 948 N/A INTRINSIC
low complexity region 987 999 N/A INTRINSIC
low complexity region 1220 1235 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124501
SMART Domains Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

DomainStartEndE-ValueType
Pfam:DUF3715 96 251 2.4e-52 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype Strain: 3526165
PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600015I10Rik T A 6: 48,930,552 (GRCm38) I162N probably damaging Het
4930505A04Rik C T 11: 30,426,349 (GRCm38) V173M probably damaging Het
Acsl3 G T 1: 78,688,286 (GRCm38) R143L probably benign Het
Ankrd11 A T 8: 122,895,790 (GRCm38) I420K probably benign Het
Cwh43 A G 5: 73,411,870 (GRCm38) E85G probably benign Het
Dnah1 G T 14: 31,266,418 (GRCm38) F3442L possibly damaging Het
Dock6 T A 9: 21,804,828 (GRCm38) N1737I probably damaging Het
Fcf1 A G 12: 84,974,147 (GRCm38) Y55C possibly damaging Het
Fer1l6 T A 15: 58,590,503 (GRCm38) Y802* probably null Het
Fgf9 T G 14: 58,083,302 (GRCm38) S10A probably damaging Het
Fhad1 A G 4: 141,955,306 (GRCm38) I508T possibly damaging Het
Flnc T C 6: 29,461,202 (GRCm38) V2692A probably damaging Het
Gm38119 G T 3: 92,738,073 (GRCm38) H71Q unknown Het
Hcn1 A T 13: 117,602,852 (GRCm38) H50L unknown Het
Helz2 T C 2: 181,236,396 (GRCm38) T870A possibly damaging Het
Iqcf4 T C 9: 106,568,601 (GRCm38) I116V probably benign Het
Lama5 T A 2: 180,192,492 (GRCm38) I1383F probably benign Het
Lmo2 C T 2: 103,981,072 (GRCm38) T150I probably damaging Het
Mgat4f T A 1: 134,390,917 (GRCm38) W476R probably damaging Het
Myh13 A G 11: 67,360,468 (GRCm38) E1391G probably damaging Het
Mylk T A 16: 34,894,947 (GRCm38) probably null Het
Nat10 A T 2: 103,730,267 (GRCm38) V731D probably damaging Het
Ncapd2 A G 6: 125,168,700 (GRCm38) V1328A probably benign Het
Nfu1 C A 6: 87,025,559 (GRCm38) Q207K probably damaging Het
Nipsnap2 T A 5: 129,739,769 (GRCm38) probably null Het
Npc1 T C 18: 12,191,789 (GRCm38) K1216E possibly damaging Het
Or2r3 C A 6: 42,471,972 (GRCm38) V69L probably benign Het
Phf3 T C 1: 30,804,683 (GRCm38) I1732V probably damaging Het
Rasgrp4 G T 7: 29,137,717 (GRCm38) R67L probably benign Het
Rubcn T C 16: 32,849,721 (GRCm38) D88G probably damaging Het
Slc30a2 T C 4: 134,345,978 (GRCm38) I112T probably damaging Het
Slc35d2 A G 13: 64,120,605 (GRCm38) I78T probably damaging Het
Slc9a4 T A 1: 40,619,117 (GRCm38) M600K probably damaging Het
Slfn8 A G 11: 83,016,736 (GRCm38) I327T probably benign Het
Tas2r118 A G 6: 23,969,471 (GRCm38) I197T probably benign Het
Thsd7b T C 1: 129,678,084 (GRCm38) S521P probably benign Het
Trim36 A G 18: 46,169,340 (GRCm38) L535P probably damaging Het
Trim63 A T 4: 134,316,531 (GRCm38) I102F probably damaging Het
Wdr47 G A 3: 108,643,085 (GRCm38) V809M probably damaging Het
Other mutations in Tex15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00639:Tex15 APN 8 33,575,311 (GRCm38) missense probably benign 0.18
IGL00705:Tex15 APN 8 33,581,592 (GRCm38) missense probably damaging 1.00
IGL00820:Tex15 APN 8 33,579,006 (GRCm38) splice site probably benign
IGL01288:Tex15 APN 8 33,571,384 (GRCm38) missense probably benign 0.02
IGL01328:Tex15 APN 8 33,571,396 (GRCm38) nonsense probably null
IGL01359:Tex15 APN 8 33,581,898 (GRCm38) missense probably damaging 0.99
IGL01603:Tex15 APN 8 33,573,547 (GRCm38) missense possibly damaging 0.93
IGL01861:Tex15 APN 8 33,570,689 (GRCm38) missense probably damaging 1.00
IGL02052:Tex15 APN 8 33,582,465 (GRCm38) missense probably benign 0.28
IGL02560:Tex15 APN 8 33,581,751 (GRCm38) missense probably benign 0.00
IGL02677:Tex15 APN 8 33,571,080 (GRCm38) missense probably benign 0.03
IGL02739:Tex15 APN 8 33,581,693 (GRCm38) missense possibly damaging 0.68
Big_gulp UTSW 8 33,581,734 (GRCm38) missense probably damaging 1.00
P0005:Tex15 UTSW 8 33,570,868 (GRCm38) missense probably benign 0.00
P0037:Tex15 UTSW 8 33,581,580 (GRCm38) missense probably benign 0.00
PIT4377001:Tex15 UTSW 8 33,571,101 (GRCm38) missense probably damaging 1.00
R0056:Tex15 UTSW 8 33,582,027 (GRCm38) missense probably benign 0.00
R0056:Tex15 UTSW 8 33,582,027 (GRCm38) missense probably benign 0.00
R0058:Tex15 UTSW 8 33,581,502 (GRCm38) splice site probably benign
R0058:Tex15 UTSW 8 33,581,502 (GRCm38) splice site probably benign
R0595:Tex15 UTSW 8 33,572,617 (GRCm38) missense probably damaging 1.00
R0646:Tex15 UTSW 8 33,582,326 (GRCm38) missense possibly damaging 0.83
R0688:Tex15 UTSW 8 33,573,500 (GRCm38) missense probably damaging 1.00
R0842:Tex15 UTSW 8 33,571,547 (GRCm38) missense possibly damaging 0.95
R0987:Tex15 UTSW 8 33,576,847 (GRCm38) missense probably damaging 1.00
R1084:Tex15 UTSW 8 33,577,004 (GRCm38) missense probably benign 0.28
R1183:Tex15 UTSW 8 33,574,865 (GRCm38) missense probably benign 0.35
R1186:Tex15 UTSW 8 33,571,633 (GRCm38) missense probably benign 0.19
R1378:Tex15 UTSW 8 33,575,216 (GRCm38) missense probably damaging 0.99
R1500:Tex15 UTSW 8 33,575,092 (GRCm38) missense probably damaging 0.96
R1508:Tex15 UTSW 8 33,576,852 (GRCm38) missense probably damaging 1.00
R1597:Tex15 UTSW 8 33,571,483 (GRCm38) missense probably damaging 0.96
R1636:Tex15 UTSW 8 33,576,387 (GRCm38) nonsense probably null
R1639:Tex15 UTSW 8 33,570,817 (GRCm38) missense possibly damaging 0.94
R1809:Tex15 UTSW 8 33,574,234 (GRCm38) missense probably benign
R1843:Tex15 UTSW 8 33,576,654 (GRCm38) missense probably benign 0.27
R2029:Tex15 UTSW 8 33,571,274 (GRCm38) missense probably damaging 0.99
R2228:Tex15 UTSW 8 33,571,237 (GRCm38) missense probably benign 0.05
R2229:Tex15 UTSW 8 33,571,237 (GRCm38) missense probably benign 0.05
R2245:Tex15 UTSW 8 33,571,496 (GRCm38) missense possibly damaging 0.77
R2246:Tex15 UTSW 8 33,582,512 (GRCm38) missense possibly damaging 0.49
R2880:Tex15 UTSW 8 33,574,907 (GRCm38) nonsense probably null
R2881:Tex15 UTSW 8 33,574,907 (GRCm38) nonsense probably null
R2882:Tex15 UTSW 8 33,574,907 (GRCm38) nonsense probably null
R3001:Tex15 UTSW 8 33,574,528 (GRCm38) missense probably benign 0.15
R3002:Tex15 UTSW 8 33,574,528 (GRCm38) missense probably benign 0.15
R3020:Tex15 UTSW 8 33,576,670 (GRCm38) missense probably damaging 1.00
R3084:Tex15 UTSW 8 33,574,885 (GRCm38) missense probably benign 0.11
R3085:Tex15 UTSW 8 33,574,885 (GRCm38) missense probably benign 0.11
R3701:Tex15 UTSW 8 33,574,166 (GRCm38) missense probably benign 0.00
R3702:Tex15 UTSW 8 33,574,166 (GRCm38) missense probably benign 0.00
R3752:Tex15 UTSW 8 33,571,415 (GRCm38) missense probably benign
R4162:Tex15 UTSW 8 33,581,558 (GRCm38) missense probably damaging 1.00
R4231:Tex15 UTSW 8 33,572,137 (GRCm38) missense probably damaging 0.99
R4589:Tex15 UTSW 8 33,557,373 (GRCm38) missense probably damaging 1.00
R4707:Tex15 UTSW 8 33,582,497 (GRCm38) missense probably benign 0.00
R4773:Tex15 UTSW 8 33,582,732 (GRCm38) missense probably benign 0.42
R4967:Tex15 UTSW 8 33,574,470 (GRCm38) missense probably benign 0.34
R5063:Tex15 UTSW 8 33,582,610 (GRCm38) missense possibly damaging 0.59
R5121:Tex15 UTSW 8 33,571,766 (GRCm38) missense probably damaging 1.00
R5147:Tex15 UTSW 8 33,572,312 (GRCm38) nonsense probably null
R5166:Tex15 UTSW 8 33,576,392 (GRCm38) missense probably benign 0.07
R5173:Tex15 UTSW 8 33,571,740 (GRCm38) missense possibly damaging 0.73
R5439:Tex15 UTSW 8 33,574,171 (GRCm38) missense possibly damaging 0.93
R5537:Tex15 UTSW 8 33,571,613 (GRCm38) missense probably damaging 1.00
R5580:Tex15 UTSW 8 33,572,429 (GRCm38) missense probably damaging 1.00
R5588:Tex15 UTSW 8 33,577,187 (GRCm38) missense probably damaging 1.00
R5696:Tex15 UTSW 8 33,573,192 (GRCm38) missense probably benign 0.01
R5734:Tex15 UTSW 8 33,546,336 (GRCm38) missense probably benign 0.01
R5756:Tex15 UTSW 8 33,575,833 (GRCm38) missense probably benign 0.17
R6126:Tex15 UTSW 8 33,573,563 (GRCm38) missense probably benign 0.19
R6129:Tex15 UTSW 8 33,574,130 (GRCm38) missense possibly damaging 0.90
R6276:Tex15 UTSW 8 33,577,189 (GRCm38) missense possibly damaging 0.93
R6374:Tex15 UTSW 8 33,575,912 (GRCm38) missense probably damaging 1.00
R6430:Tex15 UTSW 8 33,571,301 (GRCm38) missense probably benign 0.01
R6452:Tex15 UTSW 8 33,572,816 (GRCm38) missense probably damaging 1.00
R6471:Tex15 UTSW 8 33,581,734 (GRCm38) missense probably damaging 1.00
R6700:Tex15 UTSW 8 33,574,889 (GRCm38) missense possibly damaging 0.93
R6918:Tex15 UTSW 8 33,573,184 (GRCm38) missense probably benign 0.27
R6958:Tex15 UTSW 8 33,570,871 (GRCm38) missense probably benign 0.01
R6970:Tex15 UTSW 8 33,557,428 (GRCm38) missense probably benign 0.03
R7059:Tex15 UTSW 8 33,574,730 (GRCm38) missense possibly damaging 0.57
R7069:Tex15 UTSW 8 33,570,720 (GRCm38) missense probably benign
R7072:Tex15 UTSW 8 33,575,431 (GRCm38) missense possibly damaging 0.85
R7212:Tex15 UTSW 8 33,572,995 (GRCm38) missense probably damaging 1.00
R7212:Tex15 UTSW 8 33,570,826 (GRCm38) nonsense probably null
R7216:Tex15 UTSW 8 33,572,986 (GRCm38) missense possibly damaging 0.93
R7219:Tex15 UTSW 8 33,546,240 (GRCm38) missense probably benign 0.40
R7313:Tex15 UTSW 8 33,574,817 (GRCm38) missense possibly damaging 0.82
R7315:Tex15 UTSW 8 33,581,516 (GRCm38) missense probably benign 0.01
R7444:Tex15 UTSW 8 33,576,562 (GRCm38) missense possibly damaging 0.92
R7455:Tex15 UTSW 8 33,576,997 (GRCm38) missense possibly damaging 0.91
R7643:Tex15 UTSW 8 33,575,120 (GRCm38) missense probably damaging 1.00
R7644:Tex15 UTSW 8 33,574,417 (GRCm38) missense probably benign 0.01
R7724:Tex15 UTSW 8 33,546,263 (GRCm38) missense possibly damaging 0.60
R7779:Tex15 UTSW 8 33,575,281 (GRCm38) missense probably damaging 1.00
R7798:Tex15 UTSW 8 33,581,847 (GRCm38) missense possibly damaging 0.69
R7816:Tex15 UTSW 8 33,581,655 (GRCm38) missense probably benign 0.14
R7820:Tex15 UTSW 8 33,575,062 (GRCm38) missense probably damaging 0.98
R8041:Tex15 UTSW 8 33,575,846 (GRCm38) missense probably damaging 1.00
R8150:Tex15 UTSW 8 33,573,506 (GRCm38) missense probably benign 0.06
R8152:Tex15 UTSW 8 33,572,893 (GRCm38) missense possibly damaging 0.82
R8237:Tex15 UTSW 8 33,577,399 (GRCm38) missense possibly damaging 0.72
R8250:Tex15 UTSW 8 33,565,205 (GRCm38) missense probably null 0.27
R8264:Tex15 UTSW 8 33,582,362 (GRCm38) missense probably benign 0.18
R8279:Tex15 UTSW 8 33,571,737 (GRCm38) missense probably damaging 0.96
R8353:Tex15 UTSW 8 33,576,871 (GRCm38) nonsense probably null
R8388:Tex15 UTSW 8 33,575,209 (GRCm38) missense probably benign 0.00
R8432:Tex15 UTSW 8 33,576,544 (GRCm38) missense probably damaging 0.99
R8453:Tex15 UTSW 8 33,576,871 (GRCm38) nonsense probably null
R8489:Tex15 UTSW 8 33,577,546 (GRCm38) missense probably benign 0.02
R8670:Tex15 UTSW 8 33,574,718 (GRCm38) missense probably benign 0.19
R8703:Tex15 UTSW 8 33,572,696 (GRCm38) missense probably benign 0.00
R8871:Tex15 UTSW 8 33,576,964 (GRCm38) missense possibly damaging 0.62
R8945:Tex15 UTSW 8 33,574,696 (GRCm38) missense probably benign 0.00
R9104:Tex15 UTSW 8 33,570,922 (GRCm38) missense possibly damaging 0.86
R9132:Tex15 UTSW 8 33,577,526 (GRCm38) missense possibly damaging 0.84
R9207:Tex15 UTSW 8 33,575,756 (GRCm38) missense probably damaging 1.00
R9210:Tex15 UTSW 8 33,574,291 (GRCm38) missense possibly damaging 0.91
R9330:Tex15 UTSW 8 33,575,115 (GRCm38) missense probably benign 0.01
R9354:Tex15 UTSW 8 33,573,316 (GRCm38) missense possibly damaging 0.86
R9365:Tex15 UTSW 8 33,574,536 (GRCm38) missense possibly damaging 0.56
R9440:Tex15 UTSW 8 33,582,245 (GRCm38) missense possibly damaging 0.90
R9534:Tex15 UTSW 8 33,570,971 (GRCm38) missense probably benign 0.45
R9570:Tex15 UTSW 8 33,577,281 (GRCm38) missense probably damaging 0.96
R9574:Tex15 UTSW 8 33,574,481 (GRCm38) missense probably benign 0.09
R9618:Tex15 UTSW 8 33,572,369 (GRCm38) missense probably benign 0.35
R9655:Tex15 UTSW 8 33,576,756 (GRCm38) nonsense probably null
R9786:Tex15 UTSW 8 33,572,429 (GRCm38) missense probably damaging 1.00
R9798:Tex15 UTSW 8 33,572,693 (GRCm38) missense probably damaging 0.98
RF005:Tex15 UTSW 8 33,576,677 (GRCm38) missense probably benign 0.05
X0020:Tex15 UTSW 8 33,576,579 (GRCm38) missense probably benign 0.03
X0065:Tex15 UTSW 8 33,575,517 (GRCm38) nonsense probably null
Z1088:Tex15 UTSW 8 33,571,315 (GRCm38) missense possibly damaging 0.89
Z1088:Tex15 UTSW 8 33,574,870 (GRCm38) missense probably benign
Z1088:Tex15 UTSW 8 33,571,810 (GRCm38) missense possibly damaging 0.68
Z1176:Tex15 UTSW 8 33,574,726 (GRCm38) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GAGATGGGTCCTTTCAGCTC -3'
(R):5'- GTCAGCTTTATTTGTGAATCACCAC -3'

Sequencing Primer
(F):5'- AGATGGGTCCTTTCAGCTCAGATAC -3'
(R):5'- CAACCCAAACTCTTATCCAATGG -3'
Posted On 2016-12-20