Incidental Mutation 'R5824:Btnl10'
ID 450077
Institutional Source Beutler Lab
Gene Symbol Btnl10
Ensembl Gene ENSMUSG00000020490
Gene Name butyrophilin-like 10
Synonyms BUTR-1, Butr1
MMRRC Submission 043216-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5824 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58808703-58817791 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 58814266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 315 (M315I)
Ref Sequence ENSEMBL: ENSMUSP00000124234 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020792] [ENSMUST00000069941] [ENSMUST00000108818] [ENSMUST00000142499]
AlphaFold Q9JK39
Predicted Effect probably benign
Transcript: ENSMUST00000020792
SMART Domains Protein: ENSMUSP00000020792
Gene: ENSMUSG00000020490

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 3.6e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000069941
AA Change: M315I

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000063279
Gene: ENSMUSG00000020490
AA Change: M315I

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 5.5e-7 PFAM
PRY 300 352 1.11e-11 SMART
SPRY 353 474 6.55e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108818
SMART Domains Protein: ENSMUSP00000104446
Gene: ENSMUSG00000020490

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 150 233 3.6e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142499
AA Change: M315I

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000124234
Gene: ENSMUSG00000020490
AA Change: M315I

DomainStartEndE-ValueType
IGv 49 130 2.62e-7 SMART
Pfam:C2-set_2 151 233 1e-8 PFAM
PRY 300 352 1.11e-11 SMART
SPRY 353 474 6.55e-24 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtpbp1 A T 13: 59,613,913 (GRCm39) H66Q probably damaging Het
Ap1g1 T A 8: 110,565,544 (GRCm39) probably null Het
Ap4b1 A T 3: 103,720,701 (GRCm39) I124F probably benign Het
Arhgap10 A T 8: 78,085,181 (GRCm39) Y462* probably null Het
Cep295 A G 9: 15,236,952 (GRCm39) V1994A possibly damaging Het
Cherp G A 8: 73,216,102 (GRCm39) probably benign Het
Ckap5 G A 2: 91,389,481 (GRCm39) A318T probably benign Het
Cma1 T C 14: 56,179,182 (GRCm39) K238E possibly damaging Het
Cspg4b T A 13: 113,505,154 (GRCm39) H2094Q probably damaging Het
Ctif T C 18: 75,743,749 (GRCm39) D141G possibly damaging Het
Ctnna1 T C 18: 35,312,939 (GRCm39) S264P probably benign Het
Dnah12 G T 14: 26,492,475 (GRCm39) probably null Het
Dnah5 A G 15: 28,313,967 (GRCm39) T1928A probably benign Het
Etfdh G A 3: 79,517,252 (GRCm39) P379L probably damaging Het
Gfra3 T C 18: 34,844,264 (GRCm39) N92S probably damaging Het
Gpr161 C A 1: 165,138,560 (GRCm39) T382K possibly damaging Het
Gspt2 T C X: 93,680,071 (GRCm39) V70A possibly damaging Het
Hmcn1 A G 1: 150,868,774 (GRCm39) V10A probably benign Het
Iqgap2 C T 13: 95,811,880 (GRCm39) R707H probably damaging Het
Kpna1 A G 16: 35,840,575 (GRCm39) D205G possibly damaging Het
Man2a2 T G 7: 80,002,780 (GRCm39) D1067A probably benign Het
Map3k4 G A 17: 12,448,526 (GRCm39) H1551Y probably damaging Het
Moxd1 A T 10: 24,162,995 (GRCm39) I486F probably damaging Het
Notch3 G T 17: 32,372,835 (GRCm39) R579S possibly damaging Het
Or2r3 C A 6: 42,448,906 (GRCm39) V69L probably benign Het
Or6c65 T C 10: 129,604,250 (GRCm39) V295A probably damaging Het
Or8b4 A G 9: 37,830,861 (GRCm39) T308A probably benign Het
Pira13 T C 7: 3,827,753 (GRCm39) T135A probably damaging Het
Recql4 C T 15: 76,592,785 (GRCm39) C302Y probably damaging Het
Reg3b G A 6: 78,349,104 (GRCm39) V77I possibly damaging Het
Terb1 T C 8: 105,212,079 (GRCm39) T301A probably benign Het
Tmem260 G A 14: 48,742,785 (GRCm39) C540Y probably damaging Het
Tmprss15 A T 16: 78,831,201 (GRCm39) F385I probably damaging Het
Trbv12-2 G A 6: 41,095,774 (GRCm39) probably benign Het
Upk3bl T A 5: 136,089,133 (GRCm39) Y196* probably null Het
Vmn1r199 A T 13: 22,567,748 (GRCm39) K304N probably benign Het
Other mutations in Btnl10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02033:Btnl10 APN 11 58,810,141 (GRCm39) missense probably damaging 0.98
IGL03368:Btnl10 APN 11 58,810,212 (GRCm39) missense possibly damaging 0.61
FR4304:Btnl10 UTSW 11 58,814,756 (GRCm39) small insertion probably benign
FR4449:Btnl10 UTSW 11 58,814,754 (GRCm39) small insertion probably benign
FR4589:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
FR4737:Btnl10 UTSW 11 58,814,757 (GRCm39) small insertion probably benign
FR4976:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
R0420:Btnl10 UTSW 11 58,814,277 (GRCm39) missense probably damaging 1.00
R1875:Btnl10 UTSW 11 58,814,586 (GRCm39) missense probably damaging 0.97
R1908:Btnl10 UTSW 11 58,811,367 (GRCm39) missense possibly damaging 0.74
R3176:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3177:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3276:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R3277:Btnl10 UTSW 11 58,813,216 (GRCm39) missense probably benign 0.00
R4600:Btnl10 UTSW 11 58,814,426 (GRCm39) missense probably benign 0.01
R4611:Btnl10 UTSW 11 58,811,183 (GRCm39) missense probably damaging 1.00
R5447:Btnl10 UTSW 11 58,813,144 (GRCm39) missense probably benign 0.13
R5484:Btnl10 UTSW 11 58,814,651 (GRCm39) missense probably damaging 0.98
R5787:Btnl10 UTSW 11 58,811,169 (GRCm39) missense probably damaging 1.00
R5859:Btnl10 UTSW 11 58,813,138 (GRCm39) missense probably benign 0.10
R6109:Btnl10 UTSW 11 58,811,130 (GRCm39) missense probably damaging 0.98
R6123:Btnl10 UTSW 11 58,811,130 (GRCm39) missense probably damaging 0.98
R6318:Btnl10 UTSW 11 58,817,691 (GRCm39) utr 3 prime probably benign
R7064:Btnl10 UTSW 11 58,810,134 (GRCm39) missense possibly damaging 0.74
R7083:Btnl10 UTSW 11 58,809,963 (GRCm39) missense probably damaging 1.00
R7152:Btnl10 UTSW 11 58,813,223 (GRCm39) missense probably benign
R7393:Btnl10 UTSW 11 58,814,532 (GRCm39) missense probably damaging 1.00
R7507:Btnl10 UTSW 11 58,811,384 (GRCm39) missense probably benign 0.05
R7893:Btnl10 UTSW 11 58,814,635 (GRCm39) missense probably benign 0.01
R8485:Btnl10 UTSW 11 58,811,142 (GRCm39) missense possibly damaging 0.92
R8529:Btnl10 UTSW 11 58,813,238 (GRCm39) missense probably benign 0.00
R8909:Btnl10 UTSW 11 58,813,198 (GRCm39) missense probably benign 0.00
R9205:Btnl10 UTSW 11 58,811,345 (GRCm39) missense probably damaging 1.00
R9564:Btnl10 UTSW 11 58,813,189 (GRCm39) missense probably benign 0.13
R9565:Btnl10 UTSW 11 58,813,189 (GRCm39) missense probably benign 0.13
R9675:Btnl10 UTSW 11 58,814,442 (GRCm39) missense probably damaging 1.00
RF018:Btnl10 UTSW 11 58,814,752 (GRCm39) small insertion probably benign
RF043:Btnl10 UTSW 11 58,814,752 (GRCm39) small insertion probably benign
X0064:Btnl10 UTSW 11 58,814,436 (GRCm39) missense probably damaging 1.00
Z1186:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1186:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1186:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1187:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
Z1187:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1187:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1187:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1188:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1188:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1188:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1189:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1189:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1189:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1190:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1190:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1190:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1191:Btnl10 UTSW 11 58,814,755 (GRCm39) small insertion probably benign
Z1191:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1191:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1191:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1192:Btnl10 UTSW 11 58,814,754 (GRCm39) small insertion probably benign
Z1192:Btnl10 UTSW 11 58,814,753 (GRCm39) small insertion probably benign
Z1192:Btnl10 UTSW 11 58,810,138 (GRCm39) missense probably benign
Z1192:Btnl10 UTSW 11 58,817,650 (GRCm39) missense unknown
Z1192:Btnl10 UTSW 11 58,814,757 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- TTAGTGCACACTGGGAGCTG -3'
(R):5'- GACTTGGGGATCCTTCCTTC -3'

Sequencing Primer
(F):5'- AGCTGTCTCAGGCTGTGCTC -3'
(R):5'- TTCCCGTACCAAACTCTCTAGAC -3'
Posted On 2016-12-20