Incidental Mutation 'R5825:Fam110a'
ID 450110
Institutional Source Beutler Lab
Gene Symbol Fam110a
Ensembl Gene ENSMUSG00000027459
Gene Name family with sequence similarity 110, member A
Synonyms 1700008J10Rik, 5430432M24Rik
MMRRC Submission 044053-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.272) question?
Stock # R5825 (G1)
Quality Score 87
Status Not validated
Chromosome 2
Chromosomal Location 151811318-151822096 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 151811961 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 270 (S270P)
Ref Sequence ENSEMBL: ENSMUSP00000105491 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062047] [ENSMUST00000109863] [ENSMUST00000109864] [ENSMUST00000109865]
AlphaFold Q8R184
Predicted Effect probably damaging
Transcript: ENSMUST00000062047
AA Change: S270P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053266
Gene: ENSMUSG00000027459
AA Change: S270P

DomainStartEndE-ValueType
Pfam:FAM110_N 4 103 1.8e-39 PFAM
low complexity region 137 155 N/A INTRINSIC
Pfam:FAM110_C 182 288 4.8e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000109863
AA Change: S270P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105489
Gene: ENSMUSG00000027459
AA Change: S270P

DomainStartEndE-ValueType
Pfam:FAM110_N 2 104 3.9e-41 PFAM
low complexity region 137 155 N/A INTRINSIC
Pfam:FAM110_C 180 289 1.7e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000109864
AA Change: S270P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105490
Gene: ENSMUSG00000027459
AA Change: S270P

DomainStartEndE-ValueType
Pfam:FAM110_N 2 104 3.9e-41 PFAM
low complexity region 137 155 N/A INTRINSIC
Pfam:FAM110_C 180 289 1.7e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000109865
AA Change: S270P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105491
Gene: ENSMUSG00000027459
AA Change: S270P

DomainStartEndE-ValueType
Pfam:FAM110_N 2 104 3.9e-41 PFAM
low complexity region 137 155 N/A INTRINSIC
Pfam:FAM110_C 180 289 1.7e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157866
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.1%
  • 10x: 95.3%
  • 20x: 83.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,791,976 (GRCm39) Y217* probably null Het
Abca2 A T 2: 25,326,748 (GRCm39) I567F probably benign Het
Acss2 T A 2: 155,391,098 (GRCm39) probably null Het
Atxn7l2 C A 3: 108,112,127 (GRCm39) A320S probably damaging Het
Bfsp1 C T 2: 143,669,379 (GRCm39) G400D probably benign Het
Ces5a G T 8: 94,252,295 (GRCm39) A199D probably damaging Het
Cfhr4 T A 1: 139,702,336 (GRCm39) probably null Het
Chd2 A T 7: 73,134,350 (GRCm39) probably null Het
Crebbp A G 16: 3,905,606 (GRCm39) V1705A probably damaging Het
Cyp2j8 T A 4: 96,395,451 (GRCm39) Q58L probably benign Het
Dlec1 T A 9: 118,972,036 (GRCm39) I1379N probably damaging Het
Dnah9 T C 11: 66,017,427 (GRCm39) H593R probably benign Het
Ep300 T A 15: 81,495,673 (GRCm39) C412S probably benign Het
Gcc2 A G 10: 58,130,643 (GRCm39) T1412A probably damaging Het
Helz2 T C 2: 180,874,449 (GRCm39) E2015G probably benign Het
Hormad1 T C 3: 95,469,870 (GRCm39) V39A probably damaging Het
Igf2 G T 7: 142,207,592 (GRCm39) H168Q probably damaging Het
Il18rap A G 1: 40,570,726 (GRCm39) T223A probably benign Het
Itpr2 T C 6: 146,045,647 (GRCm39) E2573G probably damaging Het
Jcad T A 18: 4,674,896 (GRCm39) V886E probably benign Het
Klra1 T C 6: 130,357,592 (GRCm39) R12G probably damaging Het
Lamb1 A G 12: 31,368,613 (GRCm39) I1248V probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mapk7 C T 11: 61,381,207 (GRCm39) R465Q possibly damaging Het
Mogs T C 6: 83,095,193 (GRCm39) V670A possibly damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Ninl A T 2: 150,782,644 (GRCm39) I1182N probably damaging Het
Nup160 A G 2: 90,510,114 (GRCm39) probably null Het
Nynrin A G 14: 56,101,683 (GRCm39) R451G probably benign Het
Or12e7 A G 2: 87,287,794 (GRCm39) D95G probably benign Het
Or5h22 T C 16: 58,895,024 (GRCm39) I140V probably benign Het
Osbp A G 19: 11,948,085 (GRCm39) T131A probably damaging Het
Pcdhga12 A C 18: 37,901,556 (GRCm39) D796A possibly damaging Het
Pcdhgb8 G A 18: 37,895,289 (GRCm39) V120I probably benign Het
Pdgfb A T 15: 79,881,869 (GRCm39) V213E probably benign Het
Phldb2 T C 16: 45,583,460 (GRCm39) M1013V probably benign Het
Pnma8a A G 7: 16,695,020 (GRCm39) S292G probably benign Het
Prrt4 A G 6: 29,177,182 (GRCm39) S196P probably benign Het
Rap1gds1 T C 3: 138,661,136 (GRCm39) M463V possibly damaging Het
Tmprss11g A T 5: 86,646,392 (GRCm39) S58R probably damaging Het
Traf3 C A 12: 111,221,795 (GRCm39) Q319K probably benign Het
Trappc8 C T 18: 21,006,977 (GRCm39) V194M probably damaging Het
Tyw1 A G 5: 130,296,929 (GRCm39) K182R probably damaging Het
Usp48 A G 4: 137,350,689 (GRCm39) T585A probably benign Het
Xkr6 G T 14: 64,056,481 (GRCm39) V387L probably benign Het
Yod1 T C 1: 130,646,743 (GRCm39) W207R probably damaging Het
Zdhhc8 T C 16: 18,046,538 (GRCm39) S63G probably null Het
Zfp827 A G 8: 79,905,645 (GRCm39) E874G probably damaging Het
Zfy1 T A Y: 726,531 (GRCm39) K411N possibly damaging Het
Other mutations in Fam110a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0316:Fam110a UTSW 2 151,812,006 (GRCm39) missense probably benign 0.02
R0321:Fam110a UTSW 2 151,812,587 (GRCm39) missense probably benign 0.01
R0546:Fam110a UTSW 2 151,812,732 (GRCm39) missense probably benign
R0569:Fam110a UTSW 2 151,812,404 (GRCm39) missense probably damaging 0.97
R1761:Fam110a UTSW 2 151,812,125 (GRCm39) missense probably benign 0.13
R1842:Fam110a UTSW 2 151,811,954 (GRCm39) missense probably damaging 0.99
R2173:Fam110a UTSW 2 151,812,429 (GRCm39) missense probably damaging 1.00
R5447:Fam110a UTSW 2 151,812,629 (GRCm39) missense probably damaging 1.00
R7033:Fam110a UTSW 2 151,812,131 (GRCm39) missense probably damaging 1.00
R7128:Fam110a UTSW 2 151,812,642 (GRCm39) missense probably damaging 1.00
R8364:Fam110a UTSW 2 151,812,338 (GRCm39) missense probably damaging 1.00
R8790:Fam110a UTSW 2 151,812,338 (GRCm39) missense probably damaging 1.00
R8951:Fam110a UTSW 2 151,812,461 (GRCm39) missense probably damaging 0.96
R9390:Fam110a UTSW 2 151,812,116 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ATGCTGGTCTAAGTCTTGGCC -3'
(R):5'- TAACTTCTGTGGCCTGGACC -3'

Sequencing Primer
(F):5'- ATTCACCCAAGAGTCTCTGGG -3'
(R):5'- CCTGGACCCAGAGGAAGC -3'
Posted On 2016-12-20