Incidental Mutation 'R5825:Klra1'
ID 450125
Institutional Source Beutler Lab
Gene Symbol Klra1
Ensembl Gene ENSMUSG00000079853
Gene Name killer cell lectin-like receptor, subfamily A, member 1
Synonyms Ly49A, Ly49o<129>
MMRRC Submission 044053-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R5825 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 130340881-130363837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130357592 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 12 (R12G)
Ref Sequence ENSEMBL: ENSMUSP00000032288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032288]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000032288
AA Change: R12G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032288
Gene: ENSMUSG00000079853
AA Change: R12G

DomainStartEndE-ValueType
Blast:CLECT 73 118 9e-8 BLAST
CLECT 139 254 4.02e-15 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.1%
  • 10x: 95.3%
  • 20x: 83.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,791,976 (GRCm39) Y217* probably null Het
Abca2 A T 2: 25,326,748 (GRCm39) I567F probably benign Het
Acss2 T A 2: 155,391,098 (GRCm39) probably null Het
Atxn7l2 C A 3: 108,112,127 (GRCm39) A320S probably damaging Het
Bfsp1 C T 2: 143,669,379 (GRCm39) G400D probably benign Het
Ces5a G T 8: 94,252,295 (GRCm39) A199D probably damaging Het
Cfhr4 T A 1: 139,702,336 (GRCm39) probably null Het
Chd2 A T 7: 73,134,350 (GRCm39) probably null Het
Crebbp A G 16: 3,905,606 (GRCm39) V1705A probably damaging Het
Cyp2j8 T A 4: 96,395,451 (GRCm39) Q58L probably benign Het
Dlec1 T A 9: 118,972,036 (GRCm39) I1379N probably damaging Het
Dnah9 T C 11: 66,017,427 (GRCm39) H593R probably benign Het
Ep300 T A 15: 81,495,673 (GRCm39) C412S probably benign Het
Fam110a A G 2: 151,811,961 (GRCm39) S270P probably damaging Het
Gcc2 A G 10: 58,130,643 (GRCm39) T1412A probably damaging Het
Helz2 T C 2: 180,874,449 (GRCm39) E2015G probably benign Het
Hormad1 T C 3: 95,469,870 (GRCm39) V39A probably damaging Het
Igf2 G T 7: 142,207,592 (GRCm39) H168Q probably damaging Het
Il18rap A G 1: 40,570,726 (GRCm39) T223A probably benign Het
Itpr2 T C 6: 146,045,647 (GRCm39) E2573G probably damaging Het
Jcad T A 18: 4,674,896 (GRCm39) V886E probably benign Het
Lamb1 A G 12: 31,368,613 (GRCm39) I1248V probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mapk7 C T 11: 61,381,207 (GRCm39) R465Q possibly damaging Het
Mogs T C 6: 83,095,193 (GRCm39) V670A possibly damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Ninl A T 2: 150,782,644 (GRCm39) I1182N probably damaging Het
Nup160 A G 2: 90,510,114 (GRCm39) probably null Het
Nynrin A G 14: 56,101,683 (GRCm39) R451G probably benign Het
Or12e7 A G 2: 87,287,794 (GRCm39) D95G probably benign Het
Or5h22 T C 16: 58,895,024 (GRCm39) I140V probably benign Het
Osbp A G 19: 11,948,085 (GRCm39) T131A probably damaging Het
Pcdhga12 A C 18: 37,901,556 (GRCm39) D796A possibly damaging Het
Pcdhgb8 G A 18: 37,895,289 (GRCm39) V120I probably benign Het
Pdgfb A T 15: 79,881,869 (GRCm39) V213E probably benign Het
Phldb2 T C 16: 45,583,460 (GRCm39) M1013V probably benign Het
Pnma8a A G 7: 16,695,020 (GRCm39) S292G probably benign Het
Prrt4 A G 6: 29,177,182 (GRCm39) S196P probably benign Het
Rap1gds1 T C 3: 138,661,136 (GRCm39) M463V possibly damaging Het
Tmprss11g A T 5: 86,646,392 (GRCm39) S58R probably damaging Het
Traf3 C A 12: 111,221,795 (GRCm39) Q319K probably benign Het
Trappc8 C T 18: 21,006,977 (GRCm39) V194M probably damaging Het
Tyw1 A G 5: 130,296,929 (GRCm39) K182R probably damaging Het
Usp48 A G 4: 137,350,689 (GRCm39) T585A probably benign Het
Xkr6 G T 14: 64,056,481 (GRCm39) V387L probably benign Het
Yod1 T C 1: 130,646,743 (GRCm39) W207R probably damaging Het
Zdhhc8 T C 16: 18,046,538 (GRCm39) S63G probably null Het
Zfp827 A G 8: 79,905,645 (GRCm39) E874G probably damaging Het
Zfy1 T A Y: 726,531 (GRCm39) K411N possibly damaging Het
Other mutations in Klra1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01132:Klra1 APN 6 130,341,237 (GRCm39) nonsense probably null
IGL01320:Klra1 APN 6 130,341,224 (GRCm39) missense probably benign 0.02
IGL01322:Klra1 APN 6 130,341,224 (GRCm39) missense probably benign 0.02
IGL02149:Klra1 APN 6 130,352,293 (GRCm39) missense probably damaging 1.00
IGL02666:Klra1 APN 6 130,341,278 (GRCm39) missense probably damaging 1.00
IGL02895:Klra1 APN 6 130,352,203 (GRCm39) missense possibly damaging 0.51
R0004:Klra1 UTSW 6 130,349,836 (GRCm39) missense probably damaging 1.00
R0408:Klra1 UTSW 6 130,354,737 (GRCm39) missense probably benign 0.13
R0442:Klra1 UTSW 6 130,349,835 (GRCm39) missense probably damaging 1.00
R0498:Klra1 UTSW 6 130,349,782 (GRCm39) critical splice donor site probably null
R0765:Klra1 UTSW 6 130,356,055 (GRCm39) splice site probably benign
R1761:Klra1 UTSW 6 130,349,836 (GRCm39) missense probably damaging 1.00
R1922:Klra1 UTSW 6 130,349,828 (GRCm39) missense probably benign 0.01
R1987:Klra1 UTSW 6 130,354,742 (GRCm39) missense probably benign
R2882:Klra1 UTSW 6 130,354,826 (GRCm39) splice site probably null
R5054:Klra1 UTSW 6 130,352,247 (GRCm39) missense probably damaging 0.99
R5190:Klra1 UTSW 6 130,352,241 (GRCm39) missense probably damaging 1.00
R5572:Klra1 UTSW 6 130,349,802 (GRCm39) missense possibly damaging 0.73
R6784:Klra1 UTSW 6 130,349,817 (GRCm39) missense probably benign 0.00
R8957:Klra1 UTSW 6 130,357,609 (GRCm39) missense possibly damaging 0.89
R9154:Klra1 UTSW 6 130,357,607 (GRCm39) missense
Z1176:Klra1 UTSW 6 130,349,814 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AACTCAGCCCCGATGAGATG -3'
(R):5'- TGGGTCAGTCCATGTCAGTG -3'

Sequencing Primer
(F):5'- CCCCGATGAGATGGATCATTATAG -3'
(R):5'- GCATTAAGTGAGTTAGTCAGACCCC -3'
Posted On 2016-12-20