Incidental Mutation 'R5825:Or5h22'
ID 450146
Institutional Source Beutler Lab
Gene Symbol Or5h22
Ensembl Gene ENSMUSG00000064006
Gene Name olfactory receptor family 5 subfamily H member 22
Synonyms GA_x54KRFPKG5P-55303207-55302284, Olfr190, MOR183-4
MMRRC Submission 044053-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5825 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 58894518-58895441 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58895024 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 140 (I140V)
Ref Sequence ENSEMBL: ENSMUSP00000148991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071243] [ENSMUST00000206214] [ENSMUST00000215687] [ENSMUST00000216495]
AlphaFold K7N5T5
Predicted Effect probably benign
Transcript: ENSMUST00000071243
AA Change: I140V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000071224
Gene: ENSMUSG00000064006
AA Change: I140V

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-46 PFAM
Pfam:7tm_1 39 288 2.8e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206214
AA Change: I140V
Predicted Effect probably benign
Transcript: ENSMUST00000215687
AA Change: I140V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000216495
AA Change: I140V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.1%
  • 10x: 95.3%
  • 20x: 83.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,791,976 (GRCm39) Y217* probably null Het
Abca2 A T 2: 25,326,748 (GRCm39) I567F probably benign Het
Acss2 T A 2: 155,391,098 (GRCm39) probably null Het
Atxn7l2 C A 3: 108,112,127 (GRCm39) A320S probably damaging Het
Bfsp1 C T 2: 143,669,379 (GRCm39) G400D probably benign Het
Ces5a G T 8: 94,252,295 (GRCm39) A199D probably damaging Het
Cfhr4 T A 1: 139,702,336 (GRCm39) probably null Het
Chd2 A T 7: 73,134,350 (GRCm39) probably null Het
Crebbp A G 16: 3,905,606 (GRCm39) V1705A probably damaging Het
Cyp2j8 T A 4: 96,395,451 (GRCm39) Q58L probably benign Het
Dlec1 T A 9: 118,972,036 (GRCm39) I1379N probably damaging Het
Dnah9 T C 11: 66,017,427 (GRCm39) H593R probably benign Het
Ep300 T A 15: 81,495,673 (GRCm39) C412S probably benign Het
Fam110a A G 2: 151,811,961 (GRCm39) S270P probably damaging Het
Gcc2 A G 10: 58,130,643 (GRCm39) T1412A probably damaging Het
Helz2 T C 2: 180,874,449 (GRCm39) E2015G probably benign Het
Hormad1 T C 3: 95,469,870 (GRCm39) V39A probably damaging Het
Igf2 G T 7: 142,207,592 (GRCm39) H168Q probably damaging Het
Il18rap A G 1: 40,570,726 (GRCm39) T223A probably benign Het
Itpr2 T C 6: 146,045,647 (GRCm39) E2573G probably damaging Het
Jcad T A 18: 4,674,896 (GRCm39) V886E probably benign Het
Klra1 T C 6: 130,357,592 (GRCm39) R12G probably damaging Het
Lamb1 A G 12: 31,368,613 (GRCm39) I1248V probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mapk7 C T 11: 61,381,207 (GRCm39) R465Q possibly damaging Het
Mogs T C 6: 83,095,193 (GRCm39) V670A possibly damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Ninl A T 2: 150,782,644 (GRCm39) I1182N probably damaging Het
Nup160 A G 2: 90,510,114 (GRCm39) probably null Het
Nynrin A G 14: 56,101,683 (GRCm39) R451G probably benign Het
Or12e7 A G 2: 87,287,794 (GRCm39) D95G probably benign Het
Osbp A G 19: 11,948,085 (GRCm39) T131A probably damaging Het
Pcdhga12 A C 18: 37,901,556 (GRCm39) D796A possibly damaging Het
Pcdhgb8 G A 18: 37,895,289 (GRCm39) V120I probably benign Het
Pdgfb A T 15: 79,881,869 (GRCm39) V213E probably benign Het
Phldb2 T C 16: 45,583,460 (GRCm39) M1013V probably benign Het
Pnma8a A G 7: 16,695,020 (GRCm39) S292G probably benign Het
Prrt4 A G 6: 29,177,182 (GRCm39) S196P probably benign Het
Rap1gds1 T C 3: 138,661,136 (GRCm39) M463V possibly damaging Het
Tmprss11g A T 5: 86,646,392 (GRCm39) S58R probably damaging Het
Traf3 C A 12: 111,221,795 (GRCm39) Q319K probably benign Het
Trappc8 C T 18: 21,006,977 (GRCm39) V194M probably damaging Het
Tyw1 A G 5: 130,296,929 (GRCm39) K182R probably damaging Het
Usp48 A G 4: 137,350,689 (GRCm39) T585A probably benign Het
Xkr6 G T 14: 64,056,481 (GRCm39) V387L probably benign Het
Yod1 T C 1: 130,646,743 (GRCm39) W207R probably damaging Het
Zdhhc8 T C 16: 18,046,538 (GRCm39) S63G probably null Het
Zfp827 A G 8: 79,905,645 (GRCm39) E874G probably damaging Het
Zfy1 T A Y: 726,531 (GRCm39) K411N possibly damaging Het
Other mutations in Or5h22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Or5h22 APN 16 58,895,052 (GRCm39) nonsense probably null
IGL01011:Or5h22 APN 16 58,894,793 (GRCm39) missense probably benign 0.10
IGL01453:Or5h22 APN 16 58,895,132 (GRCm39) missense probably benign 0.00
IGL01978:Or5h22 APN 16 58,894,630 (GRCm39) missense probably benign 0.33
IGL02348:Or5h22 APN 16 58,895,312 (GRCm39) missense probably damaging 0.99
IGL02423:Or5h22 APN 16 58,894,630 (GRCm39) missense probably benign 0.33
IGL02628:Or5h22 APN 16 58,895,155 (GRCm39) missense probably benign 0.01
R0220:Or5h22 UTSW 16 58,895,095 (GRCm39) missense probably damaging 1.00
R0471:Or5h22 UTSW 16 58,894,633 (GRCm39) missense probably benign 0.01
R1697:Or5h22 UTSW 16 58,895,270 (GRCm39) missense probably damaging 1.00
R3009:Or5h22 UTSW 16 58,895,350 (GRCm39) missense probably benign 0.01
R3011:Or5h22 UTSW 16 58,895,350 (GRCm39) missense probably benign 0.01
R3027:Or5h22 UTSW 16 58,895,330 (GRCm39) missense probably benign 0.00
R4080:Or5h22 UTSW 16 58,894,619 (GRCm39) missense probably damaging 0.96
R4482:Or5h22 UTSW 16 58,895,286 (GRCm39) missense probably benign 0.02
R4895:Or5h22 UTSW 16 58,895,020 (GRCm39) missense probably benign 0.09
R5409:Or5h22 UTSW 16 58,894,559 (GRCm39) missense possibly damaging 0.94
R6146:Or5h22 UTSW 16 58,895,077 (GRCm39) missense probably benign 0.05
R6249:Or5h22 UTSW 16 58,894,795 (GRCm39) missense probably damaging 1.00
R6996:Or5h22 UTSW 16 58,894,555 (GRCm39) missense probably benign 0.00
R7283:Or5h22 UTSW 16 58,894,555 (GRCm39) missense probably benign
R7707:Or5h22 UTSW 16 58,894,634 (GRCm39) missense possibly damaging 0.52
R8381:Or5h22 UTSW 16 58,895,225 (GRCm39) missense probably damaging 1.00
R8507:Or5h22 UTSW 16 58,895,243 (GRCm39) missense possibly damaging 0.81
R8887:Or5h22 UTSW 16 58,894,846 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GGTGAGGACTTGAATTATTCCAGC -3'
(R):5'- AGTGGCACCAAAGATGTTACTC -3'

Sequencing Primer
(F):5'- AGGACTTGAATTATTCCAGCTAAAAC -3'
(R):5'- GGCACCAAAGATGTTACTCGATTTC -3'
Posted On 2016-12-20