Incidental Mutation 'R5827:Skint10'
ID 450211
Institutional Source Beutler Lab
Gene Symbol Skint10
Ensembl Gene ENSMUSG00000048766
Gene Name selection and upkeep of intraepithelial T cells 10
Synonyms A030001H23Rik
MMRRC Submission 043218-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R5827 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 112568344-112632063 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 112603972 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 72 (T72A)
Ref Sequence ENSEMBL: ENSMUSP00000058838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060327]
AlphaFold A7TZG1
Predicted Effect probably benign
Transcript: ENSMUST00000060327
AA Change: T72A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000058838
Gene: ENSMUSG00000048766
AA Change: T72A

DomainStartEndE-ValueType
low complexity region 35 48 N/A INTRINSIC
PDB:4F8T|A 50 149 5e-8 PDB
Blast:IG_like 56 143 3e-11 BLAST
transmembrane domain 162 184 N/A INTRINSIC
transmembrane domain 212 229 N/A INTRINSIC
transmembrane domain 249 271 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b C A 11: 109,868,639 (GRCm39) G175V probably damaging Het
Agl T C 3: 116,574,703 (GRCm39) I34V probably damaging Het
Cavin4 A T 4: 48,672,074 (GRCm39) D173V probably damaging Het
Chd9 A G 8: 91,716,078 (GRCm39) D884G probably damaging Het
Col6a5 G A 9: 105,805,319 (GRCm39) R1196* probably null Het
Disc1 T C 8: 125,862,104 (GRCm39) L492P probably damaging Het
Dscam A G 16: 96,451,191 (GRCm39) probably null Het
Fbxw4 T C 19: 45,568,096 (GRCm39) T26A probably benign Het
H1f6 A G 13: 23,880,185 (GRCm39) K113E possibly damaging Het
Klhl24 T A 16: 19,938,871 (GRCm39) Y475* probably null Het
Map4k3 C T 17: 80,900,712 (GRCm39) probably null Het
Mfsd6 T C 1: 52,701,551 (GRCm39) E633G probably damaging Het
Mycn G A 12: 12,989,794 (GRCm39) R201* probably null Het
Nek11 T C 9: 105,191,944 (GRCm39) I155M probably damaging Het
Notch2 G A 3: 97,980,178 (GRCm39) V231I possibly damaging Het
Npnt A C 3: 132,612,536 (GRCm39) V187G possibly damaging Het
Nr1d2 C A 14: 18,222,248 (GRCm38) V8L possibly damaging Het
Nup188 C T 2: 30,229,859 (GRCm39) T1359I probably damaging Het
Or2m12 T A 16: 19,105,182 (GRCm39) I104L probably benign Het
Or4k35 A T 2: 111,100,266 (GRCm39) W149R probably damaging Het
Or5m11b C A 2: 85,805,650 (GRCm39) P21Q probably benign Het
Or8g36 T A 9: 39,422,354 (GRCm39) I221F probably damaging Het
P2rx2 C T 5: 110,488,195 (GRCm39) R453Q probably benign Het
Pcdhb7 A G 18: 37,475,077 (GRCm39) E71G probably benign Het
Pcdhb9 A T 18: 37,535,011 (GRCm39) D335V possibly damaging Het
Pcsk9 C T 4: 106,306,144 (GRCm39) G368R probably damaging Het
Ptgr2 G A 12: 84,342,110 (GRCm39) probably null Het
Rhebl1 T A 15: 98,776,151 (GRCm39) I168F probably damaging Het
Serpina3b A G 12: 104,097,036 (GRCm39) T106A probably benign Het
Sh3pxd2b A G 11: 32,372,422 (GRCm39) I530V probably benign Het
Slx4 G T 16: 3,819,148 (GRCm39) F8L possibly damaging Het
Tdp2 T C 13: 25,015,836 (GRCm39) L41P probably damaging Het
Tiam2 A G 17: 3,498,764 (GRCm39) I847V probably benign Het
Tmem200c A G 17: 69,149,004 (GRCm39) E529G probably benign Het
Tnpo1 T C 13: 98,993,416 (GRCm39) D590G probably damaging Het
Ube3d T C 9: 86,254,489 (GRCm39) T331A possibly damaging Het
Ugt1a2 T A 1: 88,128,787 (GRCm39) S143R probably damaging Het
Zfp58 A T 13: 67,639,412 (GRCm39) C360S probably damaging Het
Other mutations in Skint10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02660:Skint10 APN 4 112,622,227 (GRCm39) unclassified probably benign
IGL02891:Skint10 APN 4 112,586,023 (GRCm39) missense probably benign 0.03
R0067:Skint10 UTSW 4 112,568,753 (GRCm39) missense probably benign
R0067:Skint10 UTSW 4 112,568,753 (GRCm39) missense probably benign
R0540:Skint10 UTSW 4 112,630,224 (GRCm39) critical splice donor site probably null
R0544:Skint10 UTSW 4 112,586,008 (GRCm39) splice site probably benign
R0711:Skint10 UTSW 4 112,573,102 (GRCm39) splice site probably benign
R1135:Skint10 UTSW 4 112,568,660 (GRCm39) nonsense probably null
R1341:Skint10 UTSW 4 112,622,228 (GRCm39) unclassified probably benign
R2845:Skint10 UTSW 4 112,573,023 (GRCm39) missense probably benign 0.00
R3717:Skint10 UTSW 4 112,603,936 (GRCm39) missense probably damaging 1.00
R3718:Skint10 UTSW 4 112,603,936 (GRCm39) missense probably damaging 1.00
R4349:Skint10 UTSW 4 112,626,968 (GRCm39) makesense probably null
R4857:Skint10 UTSW 4 112,603,830 (GRCm39) missense possibly damaging 0.92
R4988:Skint10 UTSW 4 112,586,069 (GRCm39) nonsense probably null
R5010:Skint10 UTSW 4 112,584,869 (GRCm39) missense probably benign 0.14
R5354:Skint10 UTSW 4 112,568,790 (GRCm39) missense possibly damaging 0.57
R5567:Skint10 UTSW 4 112,573,067 (GRCm39) missense probably damaging 0.98
R5716:Skint10 UTSW 4 112,568,844 (GRCm39) missense probably damaging 0.97
R6705:Skint10 UTSW 4 112,630,301 (GRCm39) intron probably benign
R7220:Skint10 UTSW 4 112,586,170 (GRCm39) missense probably benign 0.00
R7620:Skint10 UTSW 4 112,573,014 (GRCm39) missense possibly damaging 0.78
R7724:Skint10 UTSW 4 112,622,289 (GRCm39) nonsense probably null
R7827:Skint10 UTSW 4 112,632,003 (GRCm39) nonsense probably null
R8007:Skint10 UTSW 4 112,568,865 (GRCm39) missense possibly damaging 0.87
R8056:Skint10 UTSW 4 112,573,010 (GRCm39) missense probably benign 0.02
R8816:Skint10 UTSW 4 112,603,892 (GRCm39) missense probably benign 0.15
R9419:Skint10 UTSW 4 112,572,981 (GRCm39) missense probably damaging 1.00
X0028:Skint10 UTSW 4 112,603,862 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACCTGGTAGGACAACGCTTC -3'
(R):5'- TGACTATCCACATTCCCAATGG -3'

Sequencing Primer
(F):5'- CCGATTAGTTGTTACATTGTAAATGG -3'
(R):5'- TCCCAATGGGACACAAGC -3'
Posted On 2016-12-20