Incidental Mutation 'R0549:Lrrc28'
ID 45022
Institutional Source Beutler Lab
Gene Symbol Lrrc28
Ensembl Gene ENSMUSG00000030556
Gene Name leucine rich repeat containing 28
Synonyms 2310058O11Rik, 2210012C09Rik, 1300004K21Rik
MMRRC Submission 038741-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R0549 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 67163158-67295016 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 67278090 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032775] [ENSMUST00000053950] [ENSMUST00000187953] [ENSMUST00000189836] [ENSMUST00000190276] [ENSMUST00000191035]
AlphaFold Q3TX51
Predicted Effect probably benign
Transcript: ENSMUST00000032775
SMART Domains Protein: ENSMUSP00000032775
Gene: ENSMUSG00000030556

DomainStartEndE-ValueType
LRR 40 63 1.33e-1 SMART
LRR 64 86 3.24e0 SMART
LRR 87 109 1.06e1 SMART
LRR_TYP 110 132 7.78e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000053950
SMART Domains Protein: ENSMUSP00000052177
Gene: ENSMUSG00000030556

DomainStartEndE-ValueType
LRR 40 63 1.33e-1 SMART
LRR 64 86 3.24e0 SMART
LRR 87 109 1.06e1 SMART
LRR_TYP 110 132 6.67e-2 SMART
LRR 133 156 6.4e0 SMART
LRR 179 202 1.64e-1 SMART
low complexity region 304 318 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000187953
Predicted Effect probably benign
Transcript: ENSMUST00000189836
SMART Domains Protein: ENSMUSP00000139606
Gene: ENSMUSG00000030556

DomainStartEndE-ValueType
Pfam:LRR_1 42 64 5.5e-2 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190276
SMART Domains Protein: ENSMUSP00000140972
Gene: ENSMUSG00000030556

DomainStartEndE-ValueType
LRR 40 59 3.7e-3 SMART
LRR 64 83 1.2e0 SMART
LRR 87 109 4.4e-2 SMART
LRR_TYP 110 133 2.3e-6 SMART
LRR 133 153 1.1e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191035
SMART Domains Protein: ENSMUSP00000140382
Gene: ENSMUSG00000030556

DomainStartEndE-ValueType
LRR 40 63 1.33e-1 SMART
LRR 64 86 3.24e0 SMART
LRR 87 109 1.06e1 SMART
LRR 110 132 8.09e-1 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A G 17: 46,633,216 (GRCm39) F498L probably damaging Het
Adamts6 A T 13: 104,433,763 (GRCm39) D64V possibly damaging Het
Agbl2 T C 2: 90,620,187 (GRCm39) probably benign Het
Angptl3 A G 4: 98,919,692 (GRCm39) S151G probably benign Het
Arhgap39 C T 15: 76,619,086 (GRCm39) D833N probably damaging Het
C4b G T 17: 34,954,389 (GRCm39) L927I probably damaging Het
Ccl3 T C 11: 83,539,162 (GRCm39) T66A probably damaging Het
Cdh20 T C 1: 110,036,674 (GRCm39) L618P probably damaging Het
Cfap65 T C 1: 74,957,603 (GRCm39) T989A probably benign Het
Cfhr4 A T 1: 139,667,226 (GRCm39) D377E probably damaging Het
Cnpy4 T C 5: 138,185,899 (GRCm39) F18S possibly damaging Het
Col6a5 A G 9: 105,781,778 (GRCm39) probably benign Het
Dppa2 G A 16: 48,139,034 (GRCm39) R289H probably benign Het
Evx2 T C 2: 74,489,478 (GRCm39) T96A probably benign Het
Frmd4a A G 2: 4,608,778 (GRCm39) E577G possibly damaging Het
Gcgr G A 11: 120,427,387 (GRCm39) G166S probably benign Het
Gm5316 T C 6: 122,877,150 (GRCm39) noncoding transcript Het
Gria1 G A 11: 57,119,799 (GRCm39) R292Q probably damaging Het
Hars2 T A 18: 36,919,261 (GRCm39) probably null Het
Hkdc1 T A 10: 62,236,019 (GRCm39) T508S probably benign Het
Kif2b A T 11: 91,467,410 (GRCm39) I291N probably damaging Het
Lmbrd1 A T 1: 24,784,001 (GRCm39) T377S probably benign Het
Mmp3 A T 9: 7,455,638 (GRCm39) N463I probably benign Het
Myh6 A G 14: 55,196,065 (GRCm39) F578S probably damaging Het
Ncbp1 T A 4: 46,168,476 (GRCm39) M608K possibly damaging Het
Nf1 T C 11: 79,359,597 (GRCm39) F1412L probably damaging Het
Nlrp5 T A 7: 23,141,227 (GRCm39) W1083R probably damaging Het
Nrsn1 T C 13: 25,446,241 (GRCm39) Y45C probably benign Het
Or3a1b T G 11: 74,012,301 (GRCm39) M62R probably damaging Het
Osbpl7 G T 11: 96,958,368 (GRCm39) R881L probably damaging Het
Papss1 A G 3: 131,324,974 (GRCm39) E456G possibly damaging Het
Pbxip1 T A 3: 89,350,899 (GRCm39) probably benign Het
Pcca A G 14: 122,875,789 (GRCm39) probably benign Het
Pde1a T A 2: 79,695,414 (GRCm39) N511I probably damaging Het
Prpf39 A T 12: 65,103,030 (GRCm39) I435F probably benign Het
Rnf213 C T 11: 119,355,908 (GRCm39) T4117M probably damaging Het
Sel1l2 A T 2: 140,107,802 (GRCm39) M216K probably damaging Het
Sidt2 A G 9: 45,864,417 (GRCm39) probably null Het
Sirt3 A T 7: 140,449,400 (GRCm39) probably null Het
Smpd4 T C 16: 17,457,176 (GRCm39) V378A probably benign Het
Svil T A 18: 5,064,566 (GRCm39) S642T possibly damaging Het
Tcp10a A G 17: 7,593,950 (GRCm39) K92E probably benign Het
Tmem144 T C 3: 79,730,051 (GRCm39) D233G probably damaging Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Tnik T C 3: 28,625,069 (GRCm39) S335P possibly damaging Het
Ush2a T C 1: 188,679,150 (GRCm39) L4786P probably damaging Het
Utp11 A T 4: 124,579,872 (GRCm39) probably benign Het
Vmn1r67 A G 7: 10,181,641 (GRCm39) N241D probably damaging Het
Vmn2r11 A T 5: 109,199,963 (GRCm39) C497S possibly damaging Het
Other mutations in Lrrc28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Lrrc28 APN 7 67,278,042 (GRCm39) critical splice donor site probably null
IGL01583:Lrrc28 APN 7 67,195,223 (GRCm39) splice site probably null
IGL02033:Lrrc28 APN 7 67,209,605 (GRCm39) critical splice donor site probably null
IGL02483:Lrrc28 APN 7 67,267,731 (GRCm39) splice site probably benign
IGL02750:Lrrc28 APN 7 67,181,431 (GRCm39) missense probably damaging 0.96
BB002:Lrrc28 UTSW 7 67,268,857 (GRCm39) missense probably damaging 1.00
BB012:Lrrc28 UTSW 7 67,268,857 (GRCm39) missense probably damaging 1.00
R0563:Lrrc28 UTSW 7 67,195,135 (GRCm39) missense probably damaging 1.00
R0650:Lrrc28 UTSW 7 67,267,833 (GRCm39) missense probably damaging 1.00
R0652:Lrrc28 UTSW 7 67,267,833 (GRCm39) missense probably damaging 1.00
R1557:Lrrc28 UTSW 7 67,209,677 (GRCm39) missense probably damaging 1.00
R1820:Lrrc28 UTSW 7 67,290,859 (GRCm39) missense probably damaging 0.98
R2149:Lrrc28 UTSW 7 67,181,430 (GRCm39) missense probably damaging 0.96
R2185:Lrrc28 UTSW 7 67,195,201 (GRCm39) missense possibly damaging 0.70
R4479:Lrrc28 UTSW 7 67,181,362 (GRCm39) critical splice donor site probably null
R5205:Lrrc28 UTSW 7 67,181,516 (GRCm39) missense probably benign 0.00
R7008:Lrrc28 UTSW 7 67,245,459 (GRCm39) intron probably benign
R7925:Lrrc28 UTSW 7 67,268,857 (GRCm39) missense probably damaging 1.00
R8323:Lrrc28 UTSW 7 67,245,455 (GRCm39) missense unknown
R8360:Lrrc28 UTSW 7 67,290,909 (GRCm39) missense probably benign 0.01
R8898:Lrrc28 UTSW 7 67,278,042 (GRCm39) critical splice donor site probably null
R8919:Lrrc28 UTSW 7 67,268,833 (GRCm39) missense possibly damaging 0.88
R9412:Lrrc28 UTSW 7 67,181,512 (GRCm39) missense probably damaging 1.00
Z1088:Lrrc28 UTSW 7 67,179,379 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- GGGTTAGCAAAGCCTCCCATCTAC -3'
(R):5'- TTCCTTACATGCCCTGAGAGGTGC -3'

Sequencing Primer
(F):5'- TCTACCCAGAGCAGCAGC -3'
(R):5'- gggggtggggtagggtg -3'
Posted On 2013-06-11