Incidental Mutation 'R5840:Gng2'
ID 450397
Institutional Source Beutler Lab
Gene Symbol Gng2
Ensembl Gene ENSMUSG00000043004
Gene Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms 1110003P13Rik
MMRRC Submission 044060-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R5840 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 19922627-20027695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19925882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 70 (I70T)
Ref Sequence ENSEMBL: ENSMUSP00000124153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055100] [ENSMUST00000159028] [ENSMUST00000159073] [ENSMUST00000160013] [ENSMUST00000161247] [ENSMUST00000162425]
AlphaFold P63213
Predicted Effect probably damaging
Transcript: ENSMUST00000055100
AA Change: I70T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055256
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159028
AA Change: I70T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000125141
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000159073
AA Change: I70T

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000125000
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000160013
AA Change: I70T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000125697
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.7e-29 SMART
GGL 9 70 4.3e-34 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000161247
AA Change: I70T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124725
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000162425
AA Change: I70T

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124153
Gene: ENSMUSG00000043004
AA Change: I70T

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224546
Meta Mutation Damage Score 0.3736 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.3%
  • 10x: 96.5%
  • 20x: 88.1%
Validation Efficiency 99% (75/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced vomeronasal basal neurons, reduced posterior glomerular layer of the accessory olfactory bulb and decreased aggression towards male mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 G A 2: 25,323,371 (GRCm39) R113Q probably benign Het
Aip G A 19: 4,166,010 (GRCm39) P147L possibly damaging Het
Anapc1 A C 2: 128,448,957 (GRCm39) probably benign Het
Arhgap42 C T 9: 9,046,518 (GRCm39) V240I possibly damaging Het
Axdnd1 T C 1: 156,176,528 (GRCm39) E684G probably damaging Het
BC005624 G A 2: 30,871,869 (GRCm39) R2W probably benign Het
Cd177 T G 7: 24,457,495 (GRCm39) Q182P probably damaging Het
Cdca5 G A 19: 6,140,399 (GRCm39) E187K possibly damaging Het
Chmp1a T C 8: 123,934,839 (GRCm39) Q39R probably benign Het
Dab2ip A G 2: 35,617,511 (GRCm39) I1079V probably damaging Het
Dip2c A T 13: 9,556,712 (GRCm39) E85D possibly damaging Het
Elmo2 A T 2: 165,137,472 (GRCm39) S497R possibly damaging Het
Ephb6 C T 6: 41,592,507 (GRCm39) A339V possibly damaging Het
Foxred1 T C 9: 35,121,435 (GRCm39) K38E probably damaging Het
Frem2 T A 3: 53,555,342 (GRCm39) T1732S probably damaging Het
Fto A G 8: 92,393,068 (GRCm39) probably benign Het
Gm17430 T A 18: 9,726,528 (GRCm39) Q48L probably damaging Het
Gtf2a2 A G 9: 69,922,575 (GRCm39) probably benign Het
Invs A G 4: 48,396,284 (GRCm39) D263G probably damaging Het
Itga2b C T 11: 102,352,157 (GRCm39) V475M probably damaging Het
Kansl1l A G 1: 66,809,374 (GRCm39) probably benign Het
Klhl25 T C 7: 75,516,440 (GRCm39) F449L possibly damaging Het
Lamb1 T A 12: 31,316,755 (GRCm39) C83S probably damaging Het
Loxl4 G T 19: 42,587,154 (GRCm39) T648K probably damaging Het
Lrit2 T C 14: 36,790,962 (GRCm39) F214L possibly damaging Het
N4bp2 T G 5: 65,965,437 (GRCm39) L1162R probably damaging Het
Naa40 A T 19: 7,207,373 (GRCm39) I117N probably benign Het
Ncapd3 T C 9: 27,006,054 (GRCm39) S1492P probably benign Het
Nf2 T A 11: 4,766,146 (GRCm39) D128V probably benign Het
Nox4 T C 7: 87,010,001 (GRCm39) S401P probably benign Het
Nt5c1b T C 12: 10,427,171 (GRCm39) V323A probably damaging Het
Or52a33 C T 7: 103,288,463 (GRCm39) V295I probably benign Het
Or52s19 T A 7: 103,007,576 (GRCm39) H275L probably damaging Het
Or5b118 G A 19: 13,449,242 (GRCm39) V303I probably benign Het
Pcdhb14 T C 18: 37,581,803 (GRCm39) V303A probably benign Het
Pde8a C A 7: 80,863,713 (GRCm39) H17Q probably benign Het
Pfkl C T 10: 77,824,558 (GRCm39) V716I probably benign Het
Phc3 G A 3: 30,990,732 (GRCm39) S495L possibly damaging Het
Psg18 A G 7: 18,080,527 (GRCm39) probably benign Het
Rcc2 T G 4: 140,439,449 (GRCm39) N175K possibly damaging Het
Rhot2 G A 17: 26,059,032 (GRCm39) T276I probably benign Het
Rnase9 A T 14: 51,276,445 (GRCm39) Y178N probably benign Het
Sema4b T C 7: 79,868,697 (GRCm39) C297R probably damaging Het
Slc35d2 T C 13: 64,266,227 (GRCm39) probably null Het
Sptlc3 A T 2: 139,389,126 (GRCm39) N169Y probably damaging Het
Srsf9 T G 5: 115,469,524 (GRCm39) M29R probably benign Het
Stip1 C A 19: 6,999,436 (GRCm39) D449Y possibly damaging Het
Syne2 T A 12: 75,927,065 (GRCm39) probably null Het
Tgm5 A G 2: 120,916,141 (GRCm39) probably null Het
Thbs2 A T 17: 14,901,692 (GRCm39) probably null Het
Trak2 T C 1: 58,958,432 (GRCm39) E283G probably damaging Het
Trbv21 A G 6: 41,179,792 (GRCm39) Y36C probably damaging Het
Trpm7 A T 2: 126,664,531 (GRCm39) Y949* probably null Het
Ubqln5 T C 7: 103,778,161 (GRCm39) D221G possibly damaging Het
Ubxn4 T A 1: 128,187,262 (GRCm39) V85D possibly damaging Het
Vmn1r172 T A 7: 23,359,600 (GRCm39) W162R probably benign Het
Vrk2 A G 11: 26,484,314 (GRCm39) probably benign Het
Zc3h8 A C 2: 128,771,824 (GRCm39) D276E probably benign Het
Zfp369 C T 13: 65,445,092 (GRCm39) T745I possibly damaging Het
Zfp608 T C 18: 55,031,978 (GRCm39) K654R probably damaging Het
Other mutations in Gng2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0883:Gng2 UTSW 14 19,941,363 (GRCm39) missense probably benign 0.04
R4615:Gng2 UTSW 14 19,941,395 (GRCm39) missense possibly damaging 0.86
R4827:Gng2 UTSW 14 19,925,898 (GRCm39) missense possibly damaging 0.90
R5460:Gng2 UTSW 14 19,941,426 (GRCm39) missense probably benign 0.42
R8711:Gng2 UTSW 14 19,941,438 (GRCm39) start codon destroyed probably null
R9096:Gng2 UTSW 14 19,941,471 (GRCm39) critical splice acceptor site probably null
R9303:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
R9305:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATCAGCTTTCATTCTCATAAGGGGAC -3'
(R):5'- TGATGAGCTCCAAGGTGGTG -3'

Sequencing Primer
(F):5'- GGGGACATTTCTTTAAACATGCACAG -3'
(R):5'- AACGTTGGGGTCCCGAGTG -3'
Posted On 2016-12-20