Incidental Mutation 'R5696:Zfp1005'
ID 450644
Institutional Source Beutler Lab
Gene Symbol Zfp1005
Ensembl Gene ENSMUSG00000079008
Gene Name zinc finger protein 1005
Synonyms Gm10749, EG640962, Gm14124
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R5696 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 150099437-150112220 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 150111394 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 695 (H695Y)
Ref Sequence ENSEMBL: ENSMUSP00000105548 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109922]
AlphaFold A2AU83
Predicted Effect possibly damaging
Transcript: ENSMUST00000109922
AA Change: H695Y

PolyPhen 2 Score 0.518 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000105548
Gene: ENSMUSG00000079008
AA Change: H695Y

DomainStartEndE-ValueType
KRAB 4 66 9.26e-19 SMART
ZnF_C2H2 103 125 7.49e-5 SMART
ZnF_C2H2 131 151 9.46e0 SMART
ZnF_C2H2 159 181 5.9e-3 SMART
ZnF_C2H2 187 209 6.67e-2 SMART
ZnF_C2H2 215 237 4.87e-4 SMART
ZnF_C2H2 243 265 2.82e0 SMART
ZnF_C2H2 271 293 2.2e2 SMART
ZnF_C2H2 299 321 1.4e-4 SMART
ZnF_C2H2 327 349 1.6e-4 SMART
ZnF_C2H2 355 377 1.18e-2 SMART
ZnF_C2H2 383 405 1.38e-3 SMART
ZnF_C2H2 411 433 9.56e1 SMART
ZnF_C2H2 439 461 6.99e-5 SMART
ZnF_C2H2 467 489 2.99e-4 SMART
ZnF_C2H2 495 517 7.78e-3 SMART
ZnF_C2H2 523 545 1.04e-3 SMART
ZnF_C2H2 551 573 1.6e-4 SMART
ZnF_C2H2 579 601 1.18e-2 SMART
ZnF_C2H2 607 629 4.54e-4 SMART
ZnF_C2H2 635 657 4.24e-4 SMART
ZnF_C2H2 663 685 1.2e-3 SMART
ZnF_C2H2 691 713 8.47e-4 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam8 G A 7: 139,569,159 (GRCm39) R186W probably benign Het
Afg3l2 A G 18: 67,540,529 (GRCm39) I660T probably damaging Het
Amtn T A 5: 88,532,944 (GRCm39) Y186* probably null Het
Atosa A G 9: 74,917,399 (GRCm39) E666G probably benign Het
Atrip A G 9: 108,894,569 (GRCm39) S453P possibly damaging Het
Bahcc1 T C 11: 120,164,813 (GRCm39) L840P probably damaging Het
Capn2 T C 1: 182,306,165 (GRCm39) E527G possibly damaging Het
Caprin2 A T 6: 148,779,316 (GRCm39) Y164N possibly damaging Het
Ccnh T A 13: 85,344,446 (GRCm39) probably null Het
Cdon G T 9: 35,403,162 (GRCm39) V1091F possibly damaging Het
Ceacam14 A G 7: 17,548,267 (GRCm39) Y119C probably damaging Het
Ces2h A G 8: 105,745,611 (GRCm39) K445E possibly damaging Het
Cfap46 A G 7: 139,191,947 (GRCm39) S2357P probably damaging Het
Commd4 A T 9: 57,063,499 (GRCm39) S86R possibly damaging Het
Cpsf6 A T 10: 117,196,934 (GRCm39) probably benign Het
Dag1 A T 9: 108,086,646 (GRCm39) V165E probably benign Het
Dmxl1 A T 18: 50,065,008 (GRCm39) K2618* probably null Het
Dnah17 A G 11: 117,991,882 (GRCm39) Y1229H probably benign Het
Endov T A 11: 119,382,625 (GRCm39) L24Q probably damaging Het
Fap C T 2: 62,332,803 (GRCm39) V717M probably damaging Het
Fbxl2 A G 9: 113,815,546 (GRCm39) L239P probably damaging Het
Fbxl5 A T 5: 43,916,182 (GRCm39) V367D possibly damaging Het
Fkbp10 G T 11: 100,314,352 (GRCm39) W384L probably damaging Het
Gbp8 C T 5: 105,166,682 (GRCm39) V216I possibly damaging Het
Gclm G A 3: 122,059,936 (GRCm39) A239T probably benign Het
Gm11569 C T 11: 99,689,556 (GRCm39) probably benign Het
Gnas C A 2: 174,141,468 (GRCm39) probably benign Het
Grb10 T A 11: 11,883,566 (GRCm39) N508I probably benign Het
Gykl1 T G 18: 52,827,267 (GRCm39) I158M probably benign Het
Ide G A 19: 37,295,420 (GRCm39) T214M unknown Het
Il12rb2 T A 6: 67,272,262 (GRCm39) Q341H possibly damaging Het
Ints1 T C 5: 139,740,744 (GRCm39) E1946G probably benign Het
Kdelr3 T C 15: 79,410,100 (GRCm39) probably null Het
Kif1b A C 4: 149,358,306 (GRCm39) probably null Het
Kri1 A G 9: 21,191,533 (GRCm39) I320T probably damaging Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Lin9 T C 1: 180,486,646 (GRCm39) S111P probably benign Het
Lpcat2b C A 5: 107,580,773 (GRCm39) P34Q probably damaging Het
Ltk T A 2: 119,590,080 (GRCm39) T49S probably benign Het
Map3k9 A T 12: 81,780,896 (GRCm39) H421Q probably benign Het
Mapkbp1 T A 2: 119,852,201 (GRCm39) probably null Het
Mcm4 A G 16: 15,443,434 (GRCm39) S830P probably damaging Het
Nek10 T A 14: 14,860,736 (GRCm38) probably null Het
Nlrp9b A T 7: 19,758,417 (GRCm39) R551S probably benign Het
Nol4l T C 2: 153,260,026 (GRCm39) T143A probably damaging Het
Or1r1 T C 11: 73,875,362 (GRCm39) H24R possibly damaging Het
Or51g1 T A 7: 102,633,748 (GRCm39) T208S probably benign Het
Or6z5 T C 7: 6,477,742 (GRCm39) probably null Het
Or7a39 A T 10: 78,715,919 (GRCm39) R304S probably benign Het
Pde4dip G T 3: 97,616,806 (GRCm39) A1812D probably damaging Het
Plekhb1 C A 7: 100,305,960 (GRCm39) G26C probably damaging Het
Polr1a T A 6: 71,906,410 (GRCm39) F409I probably benign Het
Ptpn13 T A 5: 103,702,625 (GRCm39) M1197K probably benign Het
Qrich2 T C 11: 116,335,828 (GRCm39) I2114V probably damaging Het
Rbm27 T C 18: 42,450,731 (GRCm39) Y449H probably damaging Het
Rp1l1 A G 14: 64,267,195 (GRCm39) D927G probably damaging Het
Secisbp2 C A 13: 51,833,857 (GRCm39) Q666K probably damaging Het
Slc45a2 T C 15: 11,001,219 (GRCm39) I106T probably damaging Het
Slx4 G T 16: 3,797,831 (GRCm39) Q1518K probably damaging Het
Smim10l1 T C 6: 133,082,489 (GRCm39) F12S probably damaging Het
Son T C 16: 91,468,301 (GRCm39) V306A possibly damaging Het
Stab1 A G 14: 30,882,178 (GRCm39) S506P probably benign Het
Syne2 A C 12: 76,040,919 (GRCm39) D3859A probably benign Het
Tab1 T A 15: 80,032,930 (GRCm39) Y71* probably null Het
Tarbp1 A C 8: 127,174,079 (GRCm39) M909R probably damaging Het
Tex15 T G 8: 34,063,220 (GRCm39) S1157R probably benign Het
Tnni3 G A 7: 4,523,453 (GRCm39) T120I probably benign Het
Ttn T C 2: 76,747,888 (GRCm39) E4387G probably benign Het
Ugt3a1 G A 15: 9,361,534 (GRCm39) silent Het
Unc5d T C 8: 29,156,870 (GRCm39) I783V probably benign Het
Usp40 T C 1: 87,923,474 (GRCm39) T266A probably benign Het
Vmn2r59 C T 7: 41,695,468 (GRCm39) V315I probably benign Het
Zbtb48 G T 4: 152,105,067 (GRCm39) H532N probably damaging Het
Other mutations in Zfp1005
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Zfp1005 APN 2 150,108,363 (GRCm39) splice site probably benign
R0220:Zfp1005 UTSW 2 150,110,595 (GRCm39) missense unknown
R0396:Zfp1005 UTSW 2 150,109,973 (GRCm39) missense probably damaging 1.00
R0402:Zfp1005 UTSW 2 150,111,136 (GRCm39) missense possibly damaging 0.93
R0446:Zfp1005 UTSW 2 150,109,993 (GRCm39) missense possibly damaging 0.71
R0462:Zfp1005 UTSW 2 150,111,122 (GRCm39) missense possibly damaging 0.80
R0507:Zfp1005 UTSW 2 150,110,044 (GRCm39) missense possibly damaging 0.69
R0605:Zfp1005 UTSW 2 150,110,523 (GRCm39) missense unknown
R0838:Zfp1005 UTSW 2 150,111,220 (GRCm39) missense possibly damaging 0.74
R1327:Zfp1005 UTSW 2 150,108,070 (GRCm39) missense possibly damaging 0.71
R1405:Zfp1005 UTSW 2 150,109,620 (GRCm39) nonsense probably null
R1405:Zfp1005 UTSW 2 150,109,620 (GRCm39) nonsense probably null
R2114:Zfp1005 UTSW 2 150,109,819 (GRCm39) missense unknown
R2140:Zfp1005 UTSW 2 150,111,281 (GRCm39) missense probably benign 0.33
R3683:Zfp1005 UTSW 2 150,109,976 (GRCm39) missense probably benign 0.41
R3917:Zfp1005 UTSW 2 150,108,039 (GRCm39) splice site probably benign
R4084:Zfp1005 UTSW 2 150,108,122 (GRCm39) missense possibly damaging 0.85
R4499:Zfp1005 UTSW 2 150,111,362 (GRCm39) missense possibly damaging 0.93
R4683:Zfp1005 UTSW 2 150,108,390 (GRCm39) missense possibly damaging 0.53
R4762:Zfp1005 UTSW 2 150,109,549 (GRCm39) missense possibly damaging 0.53
R4937:Zfp1005 UTSW 2 150,110,680 (GRCm39) missense unknown
R5678:Zfp1005 UTSW 2 150,110,425 (GRCm39) nonsense probably null
R5697:Zfp1005 UTSW 2 150,111,394 (GRCm39) missense possibly damaging 0.52
R5698:Zfp1005 UTSW 2 150,111,394 (GRCm39) missense possibly damaging 0.52
R5769:Zfp1005 UTSW 2 150,110,198 (GRCm39) missense possibly damaging 0.87
R5780:Zfp1005 UTSW 2 150,108,139 (GRCm39) missense probably benign 0.05
R5973:Zfp1005 UTSW 2 150,109,855 (GRCm39) missense unknown
R6662:Zfp1005 UTSW 2 150,108,172 (GRCm39) critical splice donor site probably null
R6878:Zfp1005 UTSW 2 150,108,406 (GRCm39) missense possibly damaging 0.86
R7037:Zfp1005 UTSW 2 150,108,376 (GRCm39) missense possibly damaging 0.86
R7081:Zfp1005 UTSW 2 150,110,189 (GRCm39) missense possibly damaging 0.66
R7413:Zfp1005 UTSW 2 150,108,081 (GRCm39) missense possibly damaging 0.93
R7725:Zfp1005 UTSW 2 150,110,468 (GRCm39) missense unknown
R7781:Zfp1005 UTSW 2 150,109,577 (GRCm39) missense possibly damaging 0.53
R8197:Zfp1005 UTSW 2 150,109,577 (GRCm39) missense possibly damaging 0.53
R8355:Zfp1005 UTSW 2 150,109,876 (GRCm39) missense unknown
R8517:Zfp1005 UTSW 2 150,110,043 (GRCm39) missense probably benign 0.33
R8812:Zfp1005 UTSW 2 150,109,624 (GRCm39) missense possibly damaging 0.83
R9108:Zfp1005 UTSW 2 150,109,969 (GRCm39) missense possibly damaging 0.61
R9488:Zfp1005 UTSW 2 150,110,477 (GRCm39) missense unknown
R9499:Zfp1005 UTSW 2 150,109,856 (GRCm39) missense unknown
R9551:Zfp1005 UTSW 2 150,109,856 (GRCm39) missense unknown
R9567:Zfp1005 UTSW 2 150,109,517 (GRCm39) missense possibly damaging 0.53
R9646:Zfp1005 UTSW 2 150,110,104 (GRCm39) missense probably benign 0.43
R9709:Zfp1005 UTSW 2 150,110,305 (GRCm39) missense possibly damaging 0.47
R9719:Zfp1005 UTSW 2 150,111,304 (GRCm39) missense possibly damaging 0.74
R9779:Zfp1005 UTSW 2 150,108,064 (GRCm39) missense possibly damaging 0.92
X0022:Zfp1005 UTSW 2 150,109,578 (GRCm39) missense possibly damaging 0.53
Z1177:Zfp1005 UTSW 2 150,110,244 (GRCm39) missense possibly damaging 0.94
Z1177:Zfp1005 UTSW 2 150,110,237 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- CCTGTATCATAAACGAACACATACTGG -3'
(R):5'- GCTTGACCACATTGCTTACAC -3'

Sequencing Primer
(F):5'- ACCATATGAATGCAATGAATGTGG -3'
(R):5'- TTGACCACATTGCTTACACTCACAG -3'
Posted On 2017-01-03